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  • SPECT
  • In addition, because collaterals typically have impaired flow reserve, 7 stress SPECT images could still show flow heterogeneity despite the anatomic presence of neovascularization. (ahajournals.org)
  • Moreover, it has been shown that there is considerable variability in consecutive SPECT images even in the same patient, 8 indicating that shortcomings of the imaging technique, and/or true temporal variability in perfusion that may exceed changes resulting from angiogenesis, would confound such assessments. (ahajournals.org)
  • SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. (pubmedcentralcanada.ca)
  • In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed. (pubmedcentralcanada.ca)
  • Radiology
  • Using patient-specific body weight-based protocols during whole-body fluorodeoxyglucose (18F-FDG) PET/CT can greatly reduce radiation dosage while maintaining image quality, according to authors of an Academic Radiology study. (healthimaging.com)
  • characterize
  • This refers to the ability to measure and characterize cellular and molecular activities in living animals or humans, or in their tissues, by using contrast to identify and follow actions of only the specifically labeled molecules. (dana.org)
  • 2 The growing potential for development of biologic agents with little or no systemic toxicity has also increased the need for identification of optimum biologic doses more is no longer necessarily better and MI will likely enable pharmacokinetic studies that will better characterize the biologic behavior of molecular therapies. (appliedradiology.com)
  • There is a growing consensus that MI will become an established means to characterize disease and to validate therapeutic efficacy, particularly of molecular therapy. (appliedradiology.com)
  • anatomic
  • Unlike CT, which provides anatomic images, PET scanning provides information about the body's chemistry, metabolic activity and function not available through other procedures. (eurekalert.org)
  • These advances portend an emerging paradigm shift from traditional anatomic imaging towards using radiologic exams to interrogate disease on genetic, molecular, and pathophysiological levels. (appliedradiology.com)
  • Stanford
  • Researchers from Stanford University and two universities in China have recently developed a PET scan-compatible imaging agent that may help predict which lung cancer patients would benefit from a widely used drug or treatment, according to a recent Stanford news release. (healthimaging.com)
  • In a study published yesterday in Science Translational Medicine , Stanford researchers developed a new way to image the bladder that they say could detect bladder cancer with more accuracy and sensitivity than the standard methods. (stanford.edu)
  • gene
  • The advanced molecular imaging technique may demonstrate the potential for the virus to act as a delivery vehicle for gene therapies, according to research published Sept. 7 in Nature Communications. (healthimaging.com)
  • Investigators will combine molecular imaging with genetics research to determine how a specific gene mutation leads to abnormal brain cell communication in a mouse model of Fragile X syndrome, the most common inherited form of mental retardation. (dana.org)
  • Therapy
  • At Memorial Sloan Kettering, researchers have translated numerous new radiopharmaceuticals into the clinic for both imaging and therapy purposes. (mskcc.org)
  • The important applications in molecular imaging in oncology are at the characterization of tumors (degree of malignancy), optimal dosing determination, differentiation (i.e., inflammation/infection versus recurrence, sensitive versus resistant, low versus high grade), and prediction of treatment response (i.e., select patient who may respond to therapy). (hindawi.com)
  • Optical imaging, using fluorescence or luminescence, is increasingly being used in preclinical studies to evaluate changes following therapy. (appliedradiology.com)
  • tissue
  • and to identify where, within a specific tissue, a particular molecular activity occurs. (dana.org)
  • A team of international researchers has developed new tissue-clearing protocols for the 3D imaging of human brain tissue that may help answer questions around microstructural anatomy. (healthimaging.com)
  • Bruker Daltonics Inc. has added new features to its Maldi Molecular Imager system for biomarker detection, tissue classification and pathology research, and for imaging the distributions of drugs and metabolites in drug development. (photonics.com)
  • The ImagePrep automated tissue sample preparation device introduces sensor-based quality control into the process, providing high-resolution images (50-μm pixel size) and feature-rich mass spectra. (photonics.com)
  • The ClassImaging algorithm provides selectivity and image contrast to assist in the classification of tissue types, such as cancer biopsies, and it determines the class membership of tissue or biopsy samples. (photonics.com)
  • This position will provide the candidate with an opportunity to lead interdisciplinary research projects within these areas with a strong focus on understanding the molecular mechanisms of tissue regeneration. (stanford.edu)
  • MR spectroscopy does involve assessment of molecular profiles within tissue. (appliedradiology.com)
  • That's because a crucial method for detecting bladder cancer is to produce images that allow surgeons to identify abnormal-looking tissue, a method called cystoscopy . (stanford.edu)
  • For many diseases, imaging facilitates diagnosis without the need for exploratory surgery or tissue sampling. (appliedradiology.com)
  • Already underway are the preclinical molecular evaluation of brain gliomas for Epidermal Growth Factor Receptor (EGFR) signaling in cancer and the assessment of breast cancer tissue for HER2/neu, uPA receptor and hormone receptors. (appliedradiology.com)
  • Researchers
  • December 12, 2017 -- Researchers have developed a method to integrate functional MR (fMRI) and PET images to identify epilepsy patients who are at high risk of continued seizures before the patients undergo potentially unsuccessful surgery, according to a study published online December 5 in Frontiers in Neuroscience . (auntminnie.com)
  • Researchers from the Salk Institute in San Diego and the University of Florida have used cryo-electron microscopy (cryo-EM) imaging to analyze a 3D model of the AAV2 virus. (healthimaging.com)
  • Researchers from the Cincinnati Children's Hospital Medical Center used 3D imaging to show molecular transactions that occur during the earliest stages of pregnancy, according to a recent Cincinnati Children's release. (healthimaging.com)
  • In their work, the researchers used a hollow molecular cage called crypto-phane to hold the xenon, giving rise to a magnetic resonance signal shifted from that of free xenon. (photonics.com)
  • The researchers identified a protein known as CD47 as a molecular imaging target to distinguish bladder cancer from benign tissues. (stanford.edu)
  • With CT imaging and N1177 (a nanoparticulate contrast agent used to improve the effectiveness of CT and provided by NanoScan Imaging LLC), researchers "were able to determine the size of plaque, whether it was causing narrowing of the arteries and whether any inflammatory cells were involved," said Rudd. (eurekalert.org)
  • angiogenesis
  • Alternatively, rest imaging after treatment may show improved perfusion of previously hypoperfused areas, but this approach would miss angiogenesis occurring in regions that were not initially ischemic at rest. (ahajournals.org)
  • The microbubbles, which were paired with a new peptide (a molecule that consists of a chain of amino acids) were designed to travel through the vascular system and attach to integrin - a well-characterised molecular marker that acts as a 'red flag' for tumour vessel growth, or angiogenesis. (medgadget.com)
  • laboratory
  • Microscopic techniques are used to image molecules in tissues from humans and laboratory animals, and in live small laboratory animals. (dana.org)
  • this imaging also can be undertaken in small laboratory animals to visualize the actions of labeled cells in a specific location. (dana.org)
  • Additionally, while macroscopic imaging is usually undertaken in small laboratory animals, it also can be used in a few large laboratory animals, such as sheep and pigs. (dana.org)
  • Now two research groups -- one comprising members from the University of California, Berkeley, and from Lawrence Berkeley National Laboratory and the other at Case Western Reserve University in Cleveland -- have come up with ways to boost that signal, thereby making MRI molecular imaging possible. (photonics.com)
  • Yi Gu, of the Molecular Imaging Instrumentation Laboratory, received the Bio-X Program Travel Award to attend the 2008 Medical Imaging Conference in Dresden, Germany. (stanford.edu)
  • Yi Gu, Frances Lau, Guillem Pratx , Paul Reynolds , and Arne Vandenbrouke, members of the Molecular Imaging Instrumentation Laboratory, received Trainee Grants to attend the 2008 Medical Imaging Conference in Dresden, Germany. (stanford.edu)
  • Guillem Pratx, of the Molecular Imaging Instrumentation Laboratory (MIIL) received the top student paper award at the 2008 IEEE Medical Imaging Conference in Dresden, Germany. (stanford.edu)
  • Detection
  • The powerful combination of radiolabeled tracers and PET imaging can provide information on functional changes well ahead of the detection of structural changes by imaging tools such as x-ray or CT. (mskcc.org)
  • Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others. (visualsonics.com)
  • Biological
  • However, when imaging something very small -- like the molecules at the heart of biological processes -- MRI faces some big hurdles. (photonics.com)
  • mechanisms
  • The primary objective of the Journal is to provide a forum to the discovery of molecular mechanisms of health and disease through the use of imaging techniques. (springer.com)
  • There is a critical unmet need to understand the molecular mechanisms of how loss of FMRP alters synaptic plasticity and leads to FXS. (dana.org)
  • Radiopharmaceuticals
  • The Small Molecule Radiochemistry Section incorporates cyclotron-produced positron-emitting radionuclides into precursor molecules to make radiopharmaceuticals used as diagnostic agents in combination with PET imaging. (mskcc.org)
  • fluorescence
  • They will test this hypothesis using a type of molecular imaging called "fluorescence recovery after photobleaching" (FRAP), in a mouse model of Fragile X syndrome. (dana.org)
  • amyloid
  • For patients with Alzheimer's disease, amyloid PET imaging can improve diagnosis, diagnostic confidence and treatment, according to a JAMA Neurology study. (healthimaging.com)
  • Research
  • The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. (springer.com)
  • Molecular Imaging (MIX) is a peer-reviewed open access journal which focusses on the breadth of molecular imaging research from basic science to preclinical studies to human applications. (sagepub.com)
  • A new multimodal imaging approach produced highly-advanced molecular three-dimensional (3D) images of staph infection and may be instrumental in fighting antibiotic resistant infections, according to research published in Science Translational Medicine. (healthimaging.com)
  • Our services support both basic research investigations and patient imaging. (mskcc.org)
  • The availability of these innovative molecular imaging systems can significantly enhance research by enabling the visualization of very early disease states. (wilhelm-research.com)
  • Molecular beacons were originally developed at the Public Health Research Institute in New Jersey in the late 1990s. (innovations-report.com)
  • noninvasive
  • PET is a highly specialized, noninvasive imaging technique that uses short-lived radioactive substances to produce three-dimensional color images of those substances functioning within the body. (eurekalert.org)
  • sensitivity
  • A new molecular technique using modified diamonds could increase the sensitivity of an MRI and improve patient diagnosis, according to a University of Melbourne press release. (healthimaging.com)
  • The sensitivity (ability to discriminate low signal) and resolution (smallest discernible focus) of optical imaging are excellent, and therefore it is increasingly becoming the first imaging modality used to evaluate therapeutic potential in animal and invitro models. (appliedradiology.com)
  • They determined their molecular beacon techniques deliver high-sensitivity and high-specificity results in both bovine and human RSV strains. (innovations-report.com)
  • visualize
  • Moreover, unlike microscopic imaging in live small animals where the image is confined to the exact location under view, intravital macroscopic imaging provides the capacity to visualize labeled light-emitting cells everywhere they are located within the animal's body and anywhere these cells travel to within the body. (dana.org)
  • therapies
  • Imaging of these and other activities provides information about the normal development of cells and their biochemical activities, cells' responses to attack or injury, and how therapies-such as drugs-alter the cells' responses. (dana.org)
  • specific molecular
  • Re-binding experiments are performed to confirm the specific molecular bonds, a unique advantage over single-molecule techniques such as optical tweezers and atomic force microscopy. (nsti.org)
  • Molecular imaging promises to deliver a more precise diagnosis based on a specific molecular disease process (eg, genetic mutation) rather than a phenotype (eg, lung mass). (appliedradiology.com)
  • Cancer
  • We have developed ethylenedicysteine-glucosamine (ECG) as an alternative to 18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) for cancer imaging. (hindawi.com)
  • For bladder-cancer surgeons, an image can be worth many lives. (stanford.edu)
  • Our goal through better imaging is to deliver a higher- quality cancer surgery and better cancer outcomes," Liao told me. (stanford.edu)
  • This burgeoning field is called molecular imaging (MI), and cancer is its initial focus. (appliedradiology.com)
  • Because these contrast agents were developed to target a common cancer marker, the technique may allow the development of next generation imaging technologies for early screening for a variety of cancers. (medgadget.com)
  • PET imaging has grown to become a mainstay in the care of patients with cancer, Alzheimer's and other diseases throughout the world. (ucla.edu)
  • magnetic
  • Molecular imaging usually employs a labeling technique, mainly optical labeling or magnetic labeling, to highlight target molecules. (nsti.org)
  • While optical labeling uses a wavelength parameter to achieve molecular specificity, there is no analogous parameter in magnetic labeling to achieve molecular specificity. (nsti.org)
  • 1.5 What is Magnetic Resonance Imaging (MRI)? (wiley.com)
  • Studies have focused on correlating information derived from new magnetic resonance imaging (MRI) sequences with symptoms and pathologic findings. (appliedradiology.com)
  • Novel
  • This work features the enhanced imaging of atherosclerotic plaques--using a novel combination of technologies," said Josef Machac, SNM's Scientific Program Committee cardiovascular vice chair. (eurekalert.org)
  • Scientists
  • Scientists have used a powerful molecular imaging technique to see inside living cells infected with the most pervasive and potentially fatal childhood respiratory virus known to medicine -- respiratory syncytial virus (RSV). (innovations-report.com)