Molecular half as many chromosomes. Medical search. Frequent questions

In the first half of the quarter, we will introduce elements of classical genetics, including chromosome behavior, Mendel's principles of segregation and independent assortment, and genetic linkage. (evergreen.edu)
Credits may be awarded in introductory genetics and molecular biology, and history and philosophy of science. (evergreen.edu)
We combine structure-based protein engineering and molecular genetics to restrict the activity of the potentially toxic endonuclease to spermatogenesis. (nature.com)
Only with the introduction of the Watson-Crick structure for DNA in 1953 was a window opened through which to glimpse the terrain that was to become "molecular genetics. (jrank.org)
This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. (infertile.com)
In order to observe what happened when the Pds5 went missing from the process, we performed a 'molecular genetics trick' that had never been applied to this particular protein before, and it worked. (medindia.net)
A team of researchers at the Max Planck Institute for Molecular Genetics and Charité - Universitätsmedizin Berlin led by human geneticists Malte Spielmann and Stefan Mundlos analyzed clinical samples from patients with genetic developmental disorders with the Hi-C method. (mpg.de)
In about half of the cases a genetic diagnosis is not possible, leaving the patient with the uncertainty of the origin of the problem", says Stefan Mundlos from the Max Planck Institute for Molecular Genetics and Charité - Universitätsmedizin Berlin. (mpg.de)
Recent research suggests the Y chromosome is also important for health and longevity, said Kenneth Walsh, a professor of biochemistry and molecular genetics at the University of Virginia School of Medicine, who was not involved in the new research. (cnn.com)

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. (wikipedia.org)
The gene for factor XI is located on chromosome 4. (medscape.com)
Here we generate a synthetic sex distortion system by exploiting the specificity of the homing endonuclease I-PpoI, which is able to selectively cleave ribosomal gene sequences of the malaria vector Anopheles gambiae that are located exclusively on the mosquito's X chromosome. (nature.com)
5-7 Molecular analysis of the APC gene in FAP patients has found the pathogenic mutation in 70% of cases, 8 but a substantial minority have no mutation identified. (bmj.com)
10 11 In one family, 10 linkage analysis with flanking and intragenic markers followed by in situ hybridisation with intragenic cosmid clones showed that the deletion was approximately 200 kb and included more than the 3′ half of the APC gene and the 3′ adjacent D5S346 microsatellite. (bmj.com)
Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
MODY5 is due to HNF1B point mutations in half the cases, and is associated to a chromosome 17q12 deletion encompassing the HNF1B gene in the other half ( 3 , 4 ). (diabetesjournals.org)
These results suggest that molecular anomalies of the HNF1B gene may be involved in the development of PE, and expand the clinical spectrum of the HNF1B-associated disease. (diabetesjournals.org)
The gene controlling the production of plasma FXI is on the distal end of the long arm of chromosome 4. (medscape.com)
The construction of BAC-based physical maps of individual chromosomes reduces the complexity of this allohexaploid genome, enables elucidation of gene space and evolutionary relationships, provides tools for map-based cloning, and serves as a framework for reference sequencing efforts. (biomedcentral.com)
In this study, we constructed the first comprehensive physical map of wheat chromosome arm 5DS, thereby exploring its gene space organization and evolution. (biomedcentral.com)
The gene for human factor X is on a chromosome in close proximity to the factor VII gene. (medscape.com)
There is a broad clinical spectrum known, but all patients checked have been found to have some mutation of the same gene on chromosome 22 . (wikidoc.org)
NF II is caused by a defect in the gene that normally gives rise to a product called Merlin or Schwannomin , located on chromosome 22 band q11-13.1. (wikidoc.org)
We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
This condition can also be caused by chromosomal abnormalities involving the region of chromosome 7 that contains the GLI3 gene. (medlineplus.gov)

Your doctor may recommend testing the leukemia cells for specific genes, proteins, chromosome changes, and other factors unique to the leukemia. (cancer.net)
BWS is caused by various epigenetic and/or genetic alterations that dysregulate imprinted genes on chromosome 11p15.5. (orpha.net)
These rearrangements result in the fusion of two genes that are normally located on separate chromosomes. (pcf.org)
The authors consequently stated that while the RNAi core molecular pathway and genes are conserved among eukaryotes (e.g. (biomedcentral.com)
The genes for the constituent chains of fibrinogen are linked and are located on chromosome 4. (mhmedical.com)
We now believe that the major factors determining sexual development are built into male and female cells and derive from basic differences in how sex chromosome genes are expressed. (thepoultrysite.com)
Genes have been identified on the Y chromosome that have been shown to be required for the prevention of cancer and cardiovascular disease," Walsh said via email. (cnn.com)
As a result, only half the normal amount of this protein is available to control the expression of target genes during early development. (medlineplus.gov)
Mitochondria contain DNA in a single circular chromosome containing 37 genes that code for 13 proteins, various RNAs, and several regulating. (msdmanuals.com)

One special type of plasmid used for genome sequencing is a bacterial artificial chromosome (BAC) , which can contain DNA fragments of about 150 kb. (learner.org)
In the absence of a finished quality genome sequence, insights into wheat genome structure and function have been accumulating through survey sequencing of individual chromosomes or chromosome-specific Bacterial Artificial Chromosome (BAC) libraries. (biomedcentral.com)

Because CLL cells divide very slowly, looking at the chromosomes is often less useful than using tests to find specific genetic mutations or changes. (cancer.net)
We find that there is a 1000-fold increase in mutation rate and that about half the mutations have a distinctive "signature" suggesting that the DNA polymerase frequently dissociates and re-anneals with its template. (brandeis.edu)
Among them: tumors containing IDH1/2 mutations alongside chromosome 1 and 9 co-deletions and two clusters of IDH1/2-mutated tumors without the chromosome co-deletions. (genomeweb.com)
Following the observation of a patient with typical MODY5 and PE (case 1, Table 1 ), we have reviewed the files of 59 adult patients (29 males, 30 females) with an HNF1B molecular anomaly (31 mutations, 28 deletions). (diabetesjournals.org)
Through statistics, it is suspected that one-half of cases are inherited, and one-half are the result of new, de novo mutations . (wikidoc.org)

In molecular terms, the nuclease SPO11 generates DSBs throughout the genome. (nature.com)
A genome examination using 85 informative molecular markers was conducted. (cambridge.org)
Here, we provide a chromosome-specific view into the organization and evolution of the D genome of bread wheat, in comparison to one of its ancestors, revealing recent genome rearrangements. (biomedcentral.com)
The Y chromosome has represented the 'dark matter' of the genome," he added. (cnn.com)
Whole-genome sequencing of Colombian C. auris isolates has enhanced molecular epidemiological data, grouping Colombian isolates in clade IV together with other South American isolates. (cdc.gov)

Meiosis is a sexual division that halves the diploid somatic chromosomal complement to a haploid state. (nature.com)
During normal meiosis, the process of division that halves the number of chromosomes per cell, my colleagues and I discovered that Pds5 regulates the pairing and synapsis (joining together) of 'mom and dad' homologs. (medindia.net)

The so-called contact factors include factor XI, factor XII, high-molecular-weight kininogen (HK), and prekallikrein (PK). (medscape.com)
Plasma FXI complexes with high-molecular-weight kininogen, which then aids in the binding of FXI to negatively charged surfaces. (medscape.com)

After joining the Department of Physics at the University of Illinois in 1997, his interest has turned to molecular motors-proteins whose job is moving cargoes around the cell. (illinois.edu)
We are interested in understanding at the molecular level how recombination occurs and what roles are played by the many proteins involved in DNA recombination, repair and replication. (brandeis.edu)
What's significant is that we've developed a molecular model of the proteins involved and how they work together to create crossover interference," said Smith, the study's senior author. (fredhutch.org)
Dicer and Argonaute proteins), the products they produce are not, and hence RNAi might be an example of molecular exaptation [ 19 ]. (biomedcentral.com)
Furthermore, to the best of our knowledge, there are only a few reports on the role of molecular motor and TCA cycle-related proteins in the salivary glands of ticks. (biomedcentral.com)
Using bioinformatics methods to analyze the dynamic changes of a large number of proteins, we found that molecular motor and TCA cycle-related proteins play an important role in the physiological changes of the salivary glands. (biomedcentral.com)
By analyzing these changes, some proteins, such as molecular motor and TCA cycle-related proteins, were screened and RNAi carried out. (biomedcentral.com)
This new analysis will allow us to better understand the regions of the Y chromosome that have regulatory functions and may encode mRNA and proteins. (cnn.com)
Proteins in the GLI family function in the same molecular pathway as a protein called Sonic Hedgehog. (medlineplus.gov)

Chromosome fusions and repetitive sequence accumulations might have occurred in C. semilaevis . (geneticsmr.com)
Participating molecular testing providers will identify eligible fusions with routine diagnostic assays. (onclive.com)

The study sheds new light on the protein Pds5, its crucial regulatory role during meiosis, and the impact of its absence on the molecular-level genesis of human chromosomal birth defects that include Down, Edwards, Patau, Turner, Klinefelter's and XYY syndromes. (medindia.net)
During cell division, both chromatids - the two copies of a chromosome - contain a protein complex that resembles a fairground grappling hook. (uu.nl)
Like the child's rod pulling a toy fish by its magnet, a microtubule catches a chromosome by its kinetochore - a cluster of protein and genetic material at the centre of the chromosome's X shape. (scienceinschool.org)

With stem cell biology and molecular understanding of reproductive failure, new therapies for previously untreatable infertility are currently on the near horizon. (infertile.com)
Geert Kops is Professor of Molecular Tumour Cell Biology at the Hubrecht Institute, and a specialist in eukaryotic cell division. (uu.nl)
Dr. Tomlins earned a BA in Biology, from Willamette University in Salem, Oregon, a PhD in Molecular and Cellular Pathology from the University of Michigan, Ann Arbor, and is currently in his last year of the MD/PhD program at the University of Michigan Medical School. (pcf.org)
Monroe DM HM, Roberts HR. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis. (medscape.com)
This discovery will help our understanding of sexual development in birds and could throw light on the molecular basis for gender differences in their biology and physiology, such as the development of organs including heart and brain. (thepoultrysite.com)

The expression of wild-type I-PpoI during spermatogenesis in transgenic mosquitoes causes cleavage of the paternal X chromosome but also results in complete male sterility because the protein's stability and persistence in mature sperm cells leads to subsequent cleavage of the maternal X chromosome in the zygote 9 . (nature.com)
They occur when sections of the maternal and paternal versions of chromosomes overlap and connect. (fredhutch.org)
Crossovers are formed when the broken end of a maternal chromosome links up with the broken end of its paternal counterpart. (fredhutch.org)
This also allows maternal and paternal chromosomes to increase genetic diversity by swapping large segments. (fredhutch.org)
6 analyzed 80 patients and 148 parents from the Italian CdCS Register and found a paternal origin of the deleted chromosome 5 in 90.2% of the cases. (bvsalud.org)

And there is mounting evidence that molecular features such as IDH1/2 mutation status and chromosome 1 and 19 co-deletions can provide clues to glioma patient outcomes. (genomeweb.com)

This finding is highly important, because failure to generate a crossover between homologs leads to chromosome missegregation and can cause human chromosomal birth defects such as Down syndrome, which affects about one in 800 newborns in the United States," said Yu. (medindia.net)
Specific chromosomal rearrangements in more than half of prostate cancers, using a novel analysis of DNA microarray data, were identified in 2005. (pcf.org)
The researchers applied a method called 'Hi-C' (High-throughput Chromosome Conformation Capture) to samples from patients with developmental disorders suspected to be caused by chromosomal rearrangements. (mpg.de)
The classical analysis of chromosomal defects is done by a karyogram, which is a microscopic view of stained chromosomes. (mpg.de)

The deletion of the long arm of chromosome 13 [del(13q)], which is found in about half of patients. (cancer.net)
Ordering of 80 contigs along the deletion bins of chromosome arm 5DS revealed small-scale breaks in syntenic blocks. (biomedcentral.com)
Cri-du-Chat syndrome (CdCS) (MIM ID # 123450) is a genetic disease resulting from the total or partial deletion of the short arm of chromosome number 5 1,2 . (bvsalud.org)
Clinical evaluation of those patients revealed higher degree severity for microcephaly, dysmorphism, and psychomotor retardation related to the size of deletion of chromosome 5, i.e., the more severe cases were those with larger deletions. (bvsalud.org)

Interstitial deletions of chromosome 5q, which include the APC locus, have been reported in patients with polyposis coli and mental retardation. (bmj.com)
The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)

The resulting recombinase-coated ssDNA filaments can invade the homologous chromosome dsDNA, searching for a complementary sequence (chromosome pairing), which will foster genetic material exchange. (nature.com)
In each of these cells, after DNA duplication, homologous chromosomes exchange genetic material during crossing over. (scienceinschool.org)
Homologous chromosomes line up at the primary egg cell's equator and are then fished apart by microtubules. (scienceinschool.org)

Her family history is significant for a mother with learning disabilities, a father with anxiety, major depressive disorder, and substance abuse, as well as two maternal half-brothers with developmental delays. (nih.gov)
In the absence of a known molecular defect, screening can be undertaken by measurement of maternal serum alpha-fetoprotein and targeted ultrasound screening. (orpha.net)

It has been described as an isolated anomaly or as part of many genetic syndromes, including monogenic diseases and chromosome aberrations (reviewed in 5 ). (diabetesjournals.org)
Testosterone is determined in men when reduced testosterone production is suspected, e.g. in hypogonadism, estrogen therapy, chromosome aberrations (as in the Klinefelter's syndrome) and liver cirrhosis. (cdc.gov)

Both the major rDNA (18S rDNA) and the minor rDNA (5S rDNA) were located on the C. semilaevis chromosomes by fluorescence in situ hybridization (FISH). (geneticsmr.com)
Chromosomes stained with fluorescence dyes under the microscope. (mpg.de)

Tomo used software that had been previously developed in Jan's lab, which allowed him to programme a laser scanning microscope to find the chromosomes in the egg cell's vast inner space, and then film them during cell division. (scienceinschool.org)
By focusing the microscope only on the part of the cell where the chromosomes are, Tomo was able to obtain high-resolution images at short intervals of only one and a half minutes, which gave him a very clear picture of the process. (scienceinschool.org)
A pair of stained chromosomes under the microscope. (mpg.de)

Although a detailed molecular understanding of these distorters has remained elusive, cytological observations indicated that a bias towards male gamete production in Aedes is associated with preferential breakage of the X chromosome during male meiosis, thus suggesting one possible mechanism of action 6 . (nature.com)
We therefore hypothesized that the selective induction of DNA double-stranded breaks in the X chromosome during male meiosis might be a potential strategy to distort the sex ratio of the progeny towards male mosquitoes, if the normal production of Y-bearing gametes was unaffected ( Fig. 1a ). (nature.com)
As an egg cell, or oocyte, matures inside a woman's ovary, it undergoes a type of cell division called meiosis, in which the pairs of chromosomes inside it are lined up and fished apart, and half of them are expelled. (scienceinschool.org)

Shredding of the X chromosome favours the unaffected Y-bearing sperm and results in the production of a male-biased progeny. (nature.com)
Scientists at Fred Hutchinson Cancer Research Center have worked out the molecular underpinnings of how chromosomes make the right number of crossovers - important links that make it possible for developing sex cells (eggs or sperm in humans) to sort those chromosomes properly. (fredhutch.org)
To produce a genetically balanced gamete (sperm and egg), the cell must contend with two sets of chromosome pairs, homologs and sisters. (medindia.net)
The more detailed information provided by the new Y reference sequence will make it easier to study conditions and disorders linked to the chromosome, such as lack of sperm production that leads to infertility. (cnn.com)

An illustration of trisomy, the state of having three copies of the same chromosome (highlighted in purple). (fredhutch.org)
Trisomy can occur if cells can't properly sort chromosomes during sex-cell formation. (fredhutch.org)

This is the process we have studied most intensively, but we are also interested in an alternative process known as break-induced replication (BIR), where only one end of a chromosome break locates a template sequence and assembles a complete replication fork and can copy sequences to the end of a chromosome, producing a nonreciprocal translocation. (brandeis.edu)

The human Y chromosome, because it is enriched in repetitive DNA, has been very intractable to genetic and molecular analyses. (stackexchange.com)
The Y chromosome was a particularly hard nut to crack because it is unusually repetitive. (cnn.com)

Who is questioning whether the conserved molecular mechanisms of nutrient-dependent pheromone-controlled cell type differentiation extend from C. elegans to the morphological and behavioral differences of P. pacificus (a predatory nematode with teeth) and humans? (scentoferos.com)
The group will now study the molecular mechanisms underlying the differences between male and female cells with a £800,000 grant from the Biotechnology and Biological Sciences Research Council (BBSRC), the UK leading's biosciences agency. (thepoultrysite.com)
[ 2 ] All dementia share common molecular mechanisms responsible for disease etiology and progression, such as hypoxia and oxidative stress, neuroinflammation, mitochondrial bioenergetics, neurodegeneration, and blood-brain barrier permeability. (medscape.com)

It also introduces the student to the continuity of life from genetic and molecular perspectives. (uaeu.ac.ae)
Results of genetic and molecular testing can determine how quickly the disease will progress and can help determine your treatment options . (cancer.net)

And both DSBs and crossovers occur at regularly spaced intervals along chromosomes, never getting too close together. (fredhutch.org)
One first constructs a map of the chromosomes, marking them at regular intervals of about 100 kilobases (kb). (learner.org)

A suggested MSc student project in bioinformatics potentially comprising also biochemistry and molecular microbiology studies. (lu.se)

More than half of the tumors were grade IV gliobastomas, though the sample set also included oligodendrogliomas, astrocytomas, and oligoastrocytomas, the team noted. (genomeweb.com)

Hop, Humulus lupulus L, is a dioecious plant (2n=2x=20) with two heteromorphic sex chromosomes X and Y. The Y chromosomes of Native American and European male hops are morphologically different. (usda.gov)
The W chromosome is morphologically larger and has been considered evolutionarily younger than any other chromosome in the set. (geneticsmr.com)

Experimental evidence shows that one of the above Yq12 noncoding RNAs (ncRNAs) trans-splices with CDC2L2 mRNA from chromosome 1p36.3 locus to generate a testis-specific chimeric β sv13 isoform. (stackexchange.com)

A multicopy target sequence (black bars) on the X chromosome (but not present on the Y chromosome) is targeted by an endonuclease (red triangle) during spermatogenesis. (nature.com)
Using synchronized cells undergoing recombination that is initiated at a specific site on a chromosome by an inducible endonuclease, we use physical monitoring techniques (Southern blots, PCR analysis) to follow the sequence of molecular events that occur in real time. (brandeis.edu)

The team saw that one DSB interferes with, or prevents, the formation of another DSB on the same chromosome, so that two DSBs rarely occur close to each other on one DNA molecule. (fredhutch.org)
The NRG1 break point must occur before exon 6 on chromosome 8 to ensure conservation of the EGF domain. (onclive.com)

Cell division in cells with a nucleus: microtubules (red) are pulling the chromosomes (blue) towards both sides of the nucleus. (uu.nl)
Mapping movement: the coloured lines chart the movement (purple to yellow) of kinetochores (green dots) as microtubules hook onto them to separate the chromosomes (cyan). (scienceinschool.org)

We have shown that this regulation involves the action of a small Recombination Enhancer (RE) sequence that enables a donor on the left chromosome arm to recombine preferentially in MATa cells. (brandeis.edu)
While all DNA is stained blue, a specific sequence stained pink appears duplicated in one of the two copies of chromosome 17, but not the other. (mpg.de)
Now, the same group of researchers has filled in the missing information, publishing a complete Y chromosome sequence Wednesday in the journal Nature . (cnn.com)

Molecular subgroups are associated with different recurrence risks and different clinical findings (e.g. tumor risks). (orpha.net)
Finally, by incorporating clinical information for the glioma cases, the researchers were able to find survival differences that seemed to coincide with their newly identified epigenetic classifiers, as well as clues to the molecular events that underlie patient progression from lower-grade glioma to glioblastoma. (genomeweb.com)

The first attempt to determine the building blocks of our genetic code took place 20 years ago, but there were still significant gaps left in the sequences of all 23 pairs of human chromosomes. (cnn.com)

On every chromosome, a kinetochore (light dots) is present. (uu.nl)
This kinetochore ensures that all of the chromosomes form an orderly line in the middle of the nucleus. (uu.nl)

In humans, aneuploidy would be any number of chromosomes other than the usual 46. (genome.gov)
Humans typically have a pair of sex chromosomes in each cell. (cnn.com)

Because males usually have no paired allele to offset the effects of most alleles on the X chromosome, the X chromosome allele is expressed in males even if the trait is recessive. (msdmanuals.com)

Future work incorporating environmental sampling and veterinary surveillance may further elucidate the molecular epidemiology of H. capsulatum in the United States and how genomic sequencing can be applied to the surveillance and outbreak investigation of histoplasmosis. (cdc.gov)

Scientists have finally decoded mysteries of the Y chromosome. (cnn.com)
Scientists have fully sequenced the Y chromosome for the first time, uncovering information that could have implications for the study of male infertility and other health problems. (cnn.com)
Having a complete Y chromosome genetic reference may help scientists and doctors further explore this potential link. (cnn.com)

Conventional drugs become ensnared in the matrix, tangled in a molecular mesh that prevents them from penetrating the biofilm's inner layers. (the-scientist.com)

A phenomenon called crossover interference, in which a crossover at one location along a chromosome reduces the instances of another crossover nearby, was first observed in 1915, Smith said. (fredhutch.org)

If the researchers inserted into a chromosome a new DSB hotspot close to other hotspots, the frequency of DSBs at those other hotspots dropped. (fredhutch.org)

The androgen testosterone (17β -hydroxyandrostenone) has a molecular weight of 288 daltons. (cdc.gov)

Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. (genome.gov)
The chromosome on the right acquired an additional piece by duplication of a section of DNA, which is apparent by the additional band (arrow). (mpg.de)

New possibilities for research on digestive diseases have been set by complete decoding of the Y chromosome. (medindia.net)
These papers likely represent the tip of the iceberg in terms of understanding the role of the Y chromosome in age-associated diseases," Walsh said, adding that the loss of the Y chromosome could partially account for men's shorter life spans. (cnn.com)

We also report on EMBL-EBI's involvement in the Darwin Tree of Life project, which is providing new insights into the dynamics of ecosystems at the molecular level (p. 18). (issuu.com)

We tested three different molecular markers on 66 different male lines from both European and American development. (usda.gov)
Nevertheless, molecular markers that were derived from plants of European descent did not identify males from American descent. (usda.gov)
Molecular markers would allow detecting male hop plants at the seedling stage. (usda.gov)
We tested three presumed male-specific STS molecular markers on 66 male hop plants of American and European origin. (usda.gov)
About half of the male plants including males from Germany and Russia were detected by all three markers. (usda.gov)
Male plants detected by all three STS markers are presumed to have Y chromosomes that originated from European hops. (usda.gov)
The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. (cambridge.org)
Blood tests may also be used to collect leukemia cells for testing for specific genetic markers that may be used to predict the risk that the disease will worsen (see Genomic and molecular testing, below). (cancer.net)

Human infection was confirmed in 2011, when a subconjunctival nematode in the eye of a young woman in Turkey was identified by molecular methods as O. lupi ( 2 ). (cdc.gov)
However, over half of the sequences within the Y chromosome, the smallest and most complicated of the 46 human chromosomes, remained unknown. (cnn.com)
Just a few years ago, half of the human Y chromosome was missing (from the reference)," said Monika Cechova, co-lead author on the paper and postdoctoral scholar in biomolecular engineering at the University of California, Santa Cruz, in a statement. (cnn.com)

It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)

Too few or too many crossovers, and new cells end up with the wrong number of chromosomes, which can cause miscarriages or developmental disorders. (fredhutch.org)

Currently, we are looking for graduate students who are interested in polymer modeling of chromosome organization. (bilkent.edu.tr)

The Online Metabolic and Molecular Bases of Inherited Disease Valle DL, Antonarakis S, Ballabio A, Beaudet AL, Mitchell GA. Valle D.L., & Antonarakis S, & Ballabio A, & Beaudet A.L., & Mitchell G.A.(Eds. (mhmedical.com)

Arul Chinnaiyan, MD, PhD, an eminent professor of pathology and urology who specializes in molecular profiling of cancer at the University of Michigan Medical School, will provide mentorship for Dr. Tomlins. (pcf.org)

Among the many vital steps, genetic material packaged in chromosomes - half from mom and half from dad - must be faithfully copied and precisely parceled out to the new cells. (fredhutch.org)
We were able, for the first time, to keep track of all the kinetochores throughout cell division - so there's not a single time point where it's ambiguous where that part of the chromosome is - and that's really a breakthrough in the field, achieving this in these very large and light-sensitive cells," says Jan Ellenberg, who heads the research group. (scienceinschool.org)
They could also lead to improvements in poultry production - identification of some of the molecular differences between male and female cells should lead to better tests for sexing embryos prior to hatch. (thepoultrysite.com)
Many people begin to lose their Y chromosome in some of their cells as they age , particularly those cells that undergo rapid turnover, such as blood cells. (cnn.com)

This part was duplicated and inserted in another part of the same chromosome, which leads to disease. (mpg.de)

There is already some evidence that organs such as the heart and brain are intrinsically different in males and females and birds may provide a model for understanding the molecular basis for these gender differences. (thepoultrysite.com)

Then, known segments of the marked chromosomes (which can contain very small fragments of DNA) are cloned in plasmids . (learner.org)

In females, there was an additional 18S rDNA signal mapping to the telomeric region of the W chromosome long arm. (geneticsmr.com)

Anatomy66

Organisms11

Diseases28

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes171

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Health Care1

Genetics9

Gene16

Genes9

Bacterial artificial2

Mutations5

Genome5

Division that halves2

High-molecular2

Proteins9

Fusions2

Protein3

Biology5

Paternal5

Mutation1

Chromosomal4

Deletion4

Deletions2

Homologous3

Maternal2

Aberrations2

Fluorescence2

Microscope3

Meiosis3

Sperm4

Trisomy2

Translocation1

Repetitive2

Mechanisms3

Genetic and molecular2

Intervals2

Biochemistry1

Tumors1

Morphologically2

MRNA1

Endonuclease2

Occur2

Microtubules2

Sequence3

Clinical2

Pairs1

Kinetochore2

Humans2

Alleles1

Epidemiology1

Scientists3

Prevents1

Crossover1

DSBs1

Daltons1

Duplication2

Diseases2

EMBL1

Markers8

Human3

Pathways1

Developmental disorders1

Organization1

Metabolic1

Pathology1

Cells4

Disease1

Males1

Segments1

Long arm1