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GlycerolAquaporin 1Aquaporin 5Aquaporin 3Aquaporin 4AquaporinsAquaporin 2Glycerol KinaseAquaporin 6WaterOsmosisMercuric ChlorideGlycerophosphatesAquaglyceroporinsWater-Electrolyte BalanceBlood Group AntigensGlycerolphosphate DehydrogenasePermeabilityCell Membrane PermeabilityOsmotic PressureDihydroxyacetonePropylene GlycolBiological TransportKidney Tubules, CollectingPlant TranspirationGlyceridesMolecular Sequence DataKidney Concentrating AbilityCryoprotective AgentsPlant ProteinsIon ChannelsDiabetes Insipidus, NephrogenicAmino Acid SequenceNeuromyelitis OpticaPolyuriaOsmolar ConcentrationXenopus laevisSugar Alcohol DehydrogenasesOocytesCell MembraneGlycerol-3-Phosphate Dehydrogenase (NAD+)Antidiuretic AgentsFreezingMonoglyceridesMembrane ProteinsBrain EdemaTulipaVapor PressureLipolysisCistaceaeKineticsGlucosePlant RootsBody WaterDehydrationMercury CompoundsLens, CrystallineGene Expression Regulation, PlantEye ProteinsRNA, MessengerImmunohistochemistryDihydroxyacetone PhosphateEthylene GlycolRenal AgentsAnguillaVasopressinsSodium ChlorideBase SequenceKidneyMutationEscherichia coliUreaModels, MolecularPichiaGlomeromycotaGlyceryl EthersPropylene GlycolsMicroscopy, Electron, Scanning TransmissionRats, Sprague-DawleyGene ExpressionSalivary GlandsHydrogen-Ion ConcentrationGlyceraldehydeMyceliumGluconeogenesisDeamino Arginine VasopressinIndustrial MicrobiologySequence Homology, Amino AcidFatty Acids, NonesterifiedTime FactorsReverse Transcriptase Polymerase Chain ReactionMesophyll CellsCloning, MolecularPhloretinSaccharomyces cerevisiaeMesembryanthemumCarbon IsotopesKidney MedullaHypertonic SolutionsPhosphatidylglycerols
AquaglyceroporinsAQPsPermeabilityAQP3ProteinsCharacterizationGeneProteinMechanismTransmembranePhysiologicalGenomicPlasma membraneOxidative StressMultifunctionalTransporterAQP5UreaBiologySoPIP2Cell membraneLocalizationInhibitorsTissuesKinaseArabidopsisInternational JournalChannel2016LipidsMechanismsPhenotypeTranscriptionalElegansActaPathwayHumanAffinityDynamicsRoleHydration
Aquaglyceroporins5
  • Some AQPs (aquaglyceroporins) also exhibit glycerol and urea permeability. (edu.sa)
  • To understand the role of aquaglyceroporins in skin, we examined the relevance to human skin of the conclusion, from studies on mice, that skin AQP3 is only important for glycerol transport. (edu.sa)
  • Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol and other small uncharged solutes across cell membranes, have been recognized for their important role in human physiology and their involvement in multiple disorders, mostly related to disturbed energy homeostasis. (bvsalud.org)
  • This review summarizes the current knowledge of aquaglyceroporins' involvement in several pathologies and the experimental approaches used to evaluate glycerol permeability and aquaglyceroporin modulation. (bvsalud.org)
  • Aquaporins and aquaglyceroporins belong to the ancient superfamily of Major Intrinsic Proteins (MIPs) and facilitate passive transport of water and small solutes across membranes of various organisms [ 1 , 2 ]. (biomedcentral.com)
AQPs10
  • The aquaporins (AQPs) are a family of transmembrane proteins forming water channels. (edu.sa)
  • By RT-PCR on primary cell cultures, we found that up to 6 different AQPs (AQP1, 3, 5, 7, 9 and 10) may be selectively expressed in various cells from human skin. (edu.sa)
  • Aquaporins (AQPs) are found overexpressed in different types of cancers and have recently emerged as promising pharmacological targets. (bvsalud.org)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • History: Aquaporins (AQPs) users of a superfamily of transmembrane channel SP600125 proteins are ubiquitous in all domains of existence. (techuniq.com)
  • Various recent studies suggest that membrane channel proteins, named aquaporin (AQPs), by affecting stomatal conductance behavior could be involved in plant responses to stress conditions. (ac.ir)
  • مطالعات متعدد اخیر نشان می-دهد که پروتئین-های کانال غشایی به نام Aquaporin (AQPs) با تأثیر بر رفتار هدایت روزنه می- توانند در پاسخ گیاهان به شرایط تنش نقش داشته باشند. (ac.ir)
  • Aquaporins (AQPs) facilitate transport of water and small solutes across cell membranes and play an important role in different physiological processes in plants. (biomedcentral.com)
  • Aquaporins (AQPs) are small (21-34 kD) integral membrane proteins, which form channels facilitating movement of water and other small solutes across the cell membrane. (biomedcentral.com)
Permeability3
  • Here, we report the ability of RoT to inhibit human AQP3 activity with an IC50 in the micromolar range (22.8 ± 5.82 µM for water and 6.7 ± 2.97 µM for glycerol permeability inhibition). (bvsalud.org)
  • The identification of selective inhibitors with potential clinical applications has been challenging, relying on accurate assays to measure membrane glycerol permeability and validate effective functional blockers. (bvsalud.org)
  • [6] . Others have shown a similar change in paracellular permeability regulated by AQP5 in salivary glands, however in that system it was associated with alterations in claudin-7, claudin-3, and occludin [5] . (plos.org)
AQP39
  • Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. (wikipedia.org)
  • Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. (wikipedia.org)
  • In conclusion, we suggest that in addition to glycerol, AQP3 may be important for water transport and hydration in human skin epidermis. (edu.sa)
  • Increasing evidence suggests that the water/glycerol channel aquaporin-3 (AQP3) plays a key role in cancer and metastasis. (bvsalud.org)
  • Moreover, we have used molecular docking and molecular dynamics simulations to understand the structural determinants of RoT that explain its ability to inhibit AQP3. (bvsalud.org)
  • Our results show that RoT blocks AQP3-glycerol permeation by establishing strong and stable interactions at the extracellular region of AQP3 pores interacting with residues essential for glycerol permeation. (bvsalud.org)
  • Altogether, our multidisciplinary approach unveiled RoT as an anticancer drug against tumors where AQP3 is highly expressed providing new information to aquaporin research that may boost future drug design. (bvsalud.org)
  • 수분통로단백질인 aquaporin 3 (AQP3)은 백반증, 건선 등 다양한 피부 관련 질병의 발현에 중요한 역할을 한다. (e-ajbc.org)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
Proteins8
  • Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. (wikipedia.org)
  • Dr. King's research focus early in his tenure was the biology of aquaporin water channel proteins in the respiratory tract as well as other tissues. (hopkinsmedicine.org)
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
  • The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)
  • Akt (serine-threonine kinase activated by PI3K, phosphoinositide 3-kinase or PDK1 , phosphoinositide-dependent kinase 1 ) mediated phosphorylation of the FOXO proteins, resulting from intensified insulin and/or insulin growth factor signaling, causes them to move from cell's nucleus to the cytoplasm, preventing them from transcribing to their target genes. (healthknot.com)
  • One study examined the roles of aquaporin 3 and aquaporin 10, which are water/glycerol channel proteins located in the epidermis, and concluded that overexpression of these channels may play a role. (medscape.com)
  • After process membrane and during S mitosis, FANCD2 dissociates to viral such others that cycle with proteins taken in molecular type trans-membrane, neutral as BRCA1 and RAD51. (erik-mill.de)
  • This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (assaygenie.com)
Characterization2
  • Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)
  • Molecular cloning, characterization and three-dimensional structure prediction of Lipoxygenase from Finger millet [Eleusine coracana (L.) Gaertn. (molquest.com)
Gene6
  • Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene. (wikipedia.org)
  • 2002). "Human aquaporin adipose (AQPap) gene. (wikipedia.org)
  • Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
  • Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris. (lu.se)
  • Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)
  • Whereas in the acute phase of the disease immunoregulatory processes prevail in the hippocampus and the cortex, we observed a strong activation of neurogenic processes in the hippocampal dentate gyrus, both by gene expression and immunohistology starting as early as 3 days after infection. (biomedcentral.com)
Protein6
  • Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (hopkinsmedicine.org)
  • Expression of Aquaporin-1 water channel protein in mouse erythro-leukemia cells: genetic regulation of corticosteroid and chemical induction. (hopkinsmedicine.org)
  • Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. (mpg.de)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • The encoded protein is the predominant aquaporin found in brain. (assaygenie.com)
  • This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. (assaygenie.com)
Mechanism6
  • The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. (bvsalud.org)
  • Our study further pinpoints the need to understand the mechanism of glycerol and small molecule permeation as a combination of local structural motifs and global pore conformational changes, which are taking place on the scale of the translocation process and whose study, therefore, require sophisticated molecular dynamics strategies. (bvsalud.org)
  • Here, molecular mechanism involved in the Si uptake by root and subsequent transport to areal tissues is also illustrated. (researchsquare.com)
  • However, Si uptake mechanism at molecular level poorly studied in horticulture crops. (researchsquare.com)
  • The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation. (mpg.de)
  • Structural mechanism of plant aquaporin gating. (lu.se)
Transmembrane1
Physiological1
  • In the present review, molecular and physiological mechanisms explaining the observed beneficial effects plant derive from the Si supplementations, more particularly in horticultural species have been discussed. (researchsquare.com)
Genomic1
  • Genomic organization and developmental expression of aquaporin-5 in lung. (hopkinsmedicine.org)
Plasma membrane1
  • Overexpression of a plasma membrane aquaporin in transgenic tobacco improves plant vigor under favorable growth conditions but not under drought or salt stress. (ac.ir)
Oxidative Stress1
  • Glycerol is basically outcompeting the hydrogen peroxide in getting in there and preventing it from being able to enter and increase oxidative stress," Bollag says. (clinicalnews.org)
Multifunctional1
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
Transporter2
  • Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
  • Dive into the research topics of 'Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
AQP53
  • Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells. (plos.org)
  • Aquaporin-5 (AQP5) is a water-specific channel located on the apical membrane of epithelial cells in several sites in mammals, including corneal and pancreatic epithelium, secretory cells in salivary and lacrimal glands, and airway submucosal glands, bronchial epithelium and type I pneumocytes of the respiratory tract. (plos.org)
  • Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). (hopkinsmedicine.org)
Urea1
Biology1
  • The roundworm Caenorhabditis elegans is an outstanding model organism for studying molecular genetics, developmental biology, neuroscience, and cell biology. (molcells.org)
SoPIP21
  • Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)
Cell membrane1
  • Glycerin gets into the skin through avenues like aquaporin-3, a channel expressed in skin cells, and the MCG scientists have shown that once inside, aquaporin 3 funnels glycerin to phospholipase-D-2, an enzyme that converts fats in the external cell membrane into cell signals, ultimately converting glycerin to phosphatidylglycerol. (clinicalnews.org)
Localization1
  • For this yeast to produce, s is oxidized from the subunits into the Golgi plasma, and B4GALT1 leads with LALBA( glycerol) to choose its transcription localization( Brew and Hill 1975). (erik-mill.de)
Inhibitors3
  • The obtained computational results by metadynamics show that the local arylation of Cys209 in hAQP10 by one of the gold inhibitors is mapped into a global change of the overall free energy of glycerol translocation across the channel. (bvsalud.org)
  • Identification of selective inhibitors of the potassium channel Kv1.1-1.2(3) by high-throughput virtual screening and automated patch clamp. (mpg.de)
  • Use of principal component analysis and molecular docking to identify novel selective plasmepsin II inhibitors. (mpg.de)
Tissues3
  • Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat. (hopkinsmedicine.org)
  • Aquaporins in complex tissues: II. (hopkinsmedicine.org)
  • Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. (benthamscience.com)
Kinase1
  • multiple promoters major, particularly annealing POLZ to DNA aquaporin kinase( Hara et al. (erik-mill.de)
Arabidopsis2
International Journal1
  • International Journal of Molecular Sciences. (lu.se)
Channel2
  • Additionally, topically it appears to compete with hydrogen peroxide for space inside the aquaporin 3 channel. (clinicalnews.org)
  • Reconstitution of water channel function and 2D-crystallization of human aquaporin 8. (lu.se)
20161
Lipids1
  • The research object is small molecular substances with a relative molecular mass less than 1000Da, such as lipids , ketones, organic acids, etc. (creative-proteomics.com)
Mechanisms2
  • Inspired by the work of the 2017 Nobel Prize in Physiology or Medicine, awarded for discoveries on how molecular mechanisms control the circadian rhythm, Clariant Active Ingredients and its partner, BioSpectrum, have further advanced the knowledge of both the biological responses to this critical cycle and what occurs when it is disrupted. (clariant.com)
  • Thus, there is a crucial need for an improved understanding of the molecular mechanisms underlying sexually dimorphic responses in utero, in order to effectively prevent, diagnose and treat the effects of prenatal toxicant exposure. (biomedcentral.com)
Phenotype1
  • Interestingly, however, results suggested that impaired glycerol, rather than water transport was responsible for this phenotype. (edu.sa)
Transcriptional1
  • The major events in the regulation of the host response on a transcriptional level occur within the first 3 days after infection. (biomedcentral.com)
Elegans1
  • This is a true story: it actually happened to undisclosed number of C. elegans ( Caenorhabditis elegans , or roundworm), in an experiment by Dr. Cynthia Kenyon, molecular geneticist at the University of California, San Francisco. (healthknot.com)
Acta1
  • Biochimica et Biophysica Acta (BBA) - Biomembranes 2012, 1818 (3):839-850. (lu.se)
Pathway1
  • Containing two key glycosylated flavonoids directly involved in circadian clock maintenance - carlinoside and isoschaftoside - B-Circadin emulates the ability to resynchronize the circadian cycle within the skin cells, to regulate rhythm-dependent biological functions such as aquaporin-3 and Nrf2 pathway detoxification efficacy. (clariant.com)
Human1
Affinity1
  • 3,300 single IgG-SC from spleen, bone marrow and/or blood of 27 patients with ITP revealing high inter-individual variability in affinity for GPIIbIIIa with variations over 3 logs. (espci.fr)
Dynamics1
  • Molecular dynamics study of potassium channels, thier interaction with non-amino acid compounds and peptidic scorpion toxins. (mpg.de)
Role2
Hydration1
  • Such responses include aquaporin-3, which allows the transportation of water and glycerol involved in the maintenance of epidermal hydration. (clariant.com)