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  • protein
  • ABC transporters are considered to be with the ABC superfamily based on the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins may have evolved independently several times, and thus comprise different protein families. (wikipedia.org)
  • a "2 TMS" protein has 2 transmembrane segments) to give 6 TMS proteins. (wikipedia.org)
  • gene
  • The chvE-gguAB gene in Agrobacterium tumefaciens encodes glucose and galactose importers that are also associated with virulence. (wikipedia.org)
  • humans
  • ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest and is possibly one of the oldest families with representatives in all extant phyla from prokaryotes to humans. (wikipedia.org)
  • pathway
  • The membrane-spanning region of the ABC transporter protects hydrophilic substrates from the lipids of the membrane bilayer thus providing a pathway across the cell membrane. (wikipedia.org)
  • proteins
  • ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. (wikipedia.org)
  • The third subgroup of ABC proteins do not function as transporters, but are rather involved in translation and DNA repair processes. (wikipedia.org)
  • lipid
  • The study proved that insulin-resistance has an effect on hepatic molecular level and that the topiramate-mediated insulin sensitivity is ensued partly by modulation of hepatic insulin receptor isoforms, activation of tyrosine kinase, induction of GLUT2 and elevation of adiponectin receptors, as well as their ligand, adiponectin, besides its known improving effect on glucose tolerance and lipid homeostasis. (jove.com)
  • blood glucose
  • Since there are no significant differences in blood glucose homeostasis with the two different doses of Empagliflozin, and random blood glucose levels of T1DM mice are significantly improved by 3mg/kg of Empagliflozin, the effect of the lower dose of Empagliflozin (3mg/kg) is investigated on preserving β-cell mass and function [2] . (medchemexpress.com)
  • novel
  • "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (tcdb.org)
  • 2] "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (tcdb.org)
  • In addition, we indicate novel molecular targets, namely microRNAs that might contribute to the observed biological activities of such essential fatty acids. (frontiersin.org)
  • Fatty Acids
  • This review focus on the molecular targets of omega 3 fatty acids and conjugated linoleic acid, as paradigmatic molecules that can be exploited both as nutrients and as pharmacological agents, especially as related to cardioprotection. (frontiersin.org)
  • and infusing glucose and/or Intralipid (a soybean oil emulsion which generates a mixture of approximately 80% unsaturated/20% saturated fatty acids when infused with heparin) for 72 hr. (jove.com)
  • cassette
  • ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study. (semanticscholar.org)
  • Cell
  • The cDNA libraries from single oocytes and pre-implantation buffalo embryos from 2 cell stage to blastocyst were established. (technologynetworks.com)
  • role
  • Recent studies reveal that beta-carotene plays a vital role in supporting the immune system and may prevent certain types of cancer. (medicalnewstoday.com)