Molecular glucose co transporter glucose transporter type 2. Medical search. Frequent questions

Diabetes mellitus type 2 is a disease characterized by chronically elevated blood glucose levels, even when fasting. (wikipedia.org)
The rapidly rising prevalence of type 2 diabetes, along with its strong correlation to heart disease and other health complications has rendered it an area of intense research with an urgent need for treatment options. (wikipedia.org)
Studies monitoring blood glucose levels in rabbits revealed that the activity of G6Pase, and therefore G6PT1, is increased in specimens with diabetes. (wikipedia.org)
citation needed] This strong correlation with diabetes type 2 makes the G6Pase complex, and G6PT1 in particular, an appealing drug target for control of blood glucose levels as its inhibition would directly prevent the release of free glucose into the bloodstream. (wikipedia.org)
The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. (diabetesjournals.org)
None of the variants were associated with type 2 diabetes. (diabetesjournals.org)
These results suggest that variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes in the examined study population. (diabetesjournals.org)
As a quick review, Type 1 diabetes mellitus , which most commonly affects children and adolescents, arises when certain cells of the pancreas known as beta cells are unable to produce enough insulin to maintain normal blood glucose levels . (osmosis.org)
This is in contrast to Type 2 diabetes mellitus where the body is able to produce insulin , but the tissues don't respond as well to it, or in other words, these individuals are insulin resistant. (osmosis.org)
In this video, we'll be focusing specifically on the use of insulin secretagogues like sulfonylurea for the treatment of Type 2 diabetes . (osmosis.org)
In general, diabetes mellitus occurs when your body has trouble moving glucose from your blood into your cells. (osmosis.org)
Now in Type 2 diabetes , the body usually makes insulin , but the tissues don't respond as well to it. (osmosis.org)
Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. (frontiersin.org)
Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
These findings show that CIG can improve the hyperglycemia and hyperlipidemia of HFD-STZ-induced diabetic mice through the PI3K-Akt/PKB signaling pathway, and CIG might be a potential medicine or functional food for type 2 diabetes mellitus remedies. (rsc.org)
Type 2 diabetes mellitus (T2DM) accounts for approximately 90% of the cases of diabetes. (ddw-online.com)
This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
Despite beneficial effects of current glucose-lowering treatments, disease-related morbidity and mortality remain considerable in T2DM patients, galvanising the search for innovative medications that target the multiple metabolic abnormalities as well as inflammatory processes and other pathways predisposing to diabetes-associated disorders. (ddw-online.com)
Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in industrialized countries. (aspetjournals.org)
Our findings suggest that the activation of the AMPK pathway might contribute to the development of novel therapeutic approaches for the treatment of metabolic disorders such as type 2 diabetes and obesity. (aspetjournals.org)
We aimed to determine whether chemerin reduces vascular insulin signaling and whether there is interplay between chemerin/ChemR23, insulin resistance, and vascular complications associated with type 2 diabetes (T2D). (gla.ac.uk)
Impaired glucose metabolism and insulin sensitivity have been linked to the pathogenesis of gestational diabetes mellitus (GDM). (hindawi.com)
GDM is associated with the increased risk of several maternal and neonatal complications, including caesarean section, giant infants, premature delivery, stillbirths, and neonatal hypoglycemia, and it may advance to type 2 diabetes after delivery within 10-15 years [ 2 - 4 ]. (hindawi.com)
Mutation in ZnT8 has been associated with type 2 diabetes. (scirp.org)
In type 1 diabetes, there is a lack of insulin production, in type 2 diabetes, resistance of the effect of insulin is predominant. (scirp.org)
The role of zinc deficiency which could at least potentially exacerbate the cytokinine-induced damage in autoimmune attack which destroys the islet cell in type 1 diabetes is still not clear. (scirp.org)
It has been shown that there appears to be a complex interrelationship between zinc and type 1 and 2 diabetes. (scirp.org)
Sodium/glucose cotransporter 2 (SGLT2) is the predominant mediator of renal glucose reabsorption and is an emerging molecular target for the treatment of diabetes. (aspetjournals.org)
These findings demonstrate that tofogliflozin inhibits SGLT2 in a specific manner, lowers blood glucose levels by increasing renal glucose clearance, and improves pathological conditions of type 2 diabetes with a low hypoglycemic potential. (aspetjournals.org)
Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus. (sciencebiology.org)
cell failure in type 2 diabetes. (sciencebiology.org)
2021). Pedoman Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Dewasa Di Indonesia. (sciencebiology.org)
Mclntyre, E.A. and Walker, M. (2002) Genetics of type 2 diabetes and insulin resistance: Knowledge from human studies. (scirp.org)
Fajans, S.S. and Bell, G.I. (2001) Molecular mechanisms and clinical pathophysiology of maturity onset diabetes of the young. (scirp.org)
1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
Froguel, P. and Velho, G. (1999) Molecular genetics of Maturity-onset Diabetes of the young. (scirp.org)
2001) Single-strand conformation polymorphism analysis of the glucose transporter gene GLUT1 in maturity-onset diabetes of the young. (scirp.org)
We consider how, over the last 20 years, advances in genetic engineering and cell culture techniques have improved the efficiency and efficacy of the transdifferentiation process and brought us closer to a clinically relevant therapy for type 1 diabetes (T1D). (silverchair.com)
If you're managing type 2 diabetes, you'll need to work with your doctor to identify a treatment approach that supports your individual goals. (everydayhealth.com)
Treatment of type 2 diabetes is not limited to the occasional visit to the doctor: It includes important types of self-care in addition to regular medical care from doctors and other healthcare providers, such as dietitians and mental health professionals. (everydayhealth.com)
The latest updates about care for type 2 diabetes can be found in the American Diabetes Association's 2023 Standards of Medical Care , which lists treatment guidelines related to diabetes, complications, new technology, and more. (everydayhealth.com)
Can Berberine Help Prevent or Treat Type 2 Diabetes? (everydayhealth.com)
What Medications Are Used to Treat Type 2 Diabetes? (everydayhealth.com)
Many people with type 2 diabetes start with the oral drug metformin (Glucophage) to help meet their blood sugar level goals. (everydayhealth.com)
Are There Any New Type 2 Diabetes Drugs on the Horizon? (everydayhealth.com)
Sulfonylurea drugs have also been used for many years to help people with type 2 diabetes control their blood sugar. (everydayhealth.com)
These medicines are especially useful among people with type 2 diabetes who are at risk of low blood sugar or lactic acidosis. (everydayhealth.com)
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. (geneticsmr.org)
Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been associated with various diseases, including diabetes mellitus. (geneticsmr.org)
Type 1 diabetes (T1D) is characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells. (geneticsmr.org)
Patients with type 2 diabetes are at increased risk for cardiovascular diseases. (nih.gov)
Sodium-glucose transport 2 inhibitors (SGLT2i) have been shown to enhance cardiovascular health since their debut as a second-line therapy for diabetes. (nih.gov)
Comparisons were made between SGLT2i-treated and control individuals with type 2 diabetes. (nih.gov)
We enrolled 79,504 patients with type 2 diabetes from 43 RCTs. (nih.gov)
Exosomes have previously been associated with a number of endocrine disorders, including obesity, type 2 diabetes mellitus, disorders of the reproductive system and cancer. (spandidos-publications.com)
The quantitative understanding of this dynamic system under normal conditions is essential to the future understanding of the mechanisms underlying insulin resistance and its subsequent progression to Type 2 diabetes. (edu.au)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
XIGDUO XR (dapagliflozin propanediol monohydrate/metformin hydrochloride) modified release tablets contain two oral antihyperglycaemic drugs used in the management of type 2 diabetes: dapagliflozin propanediol monohydrate and metformin hydrochloride. (azurewebsites.net)
Specific molecular events caused by high-fat diets lead to diabetes. (blogspot.com)
A new study led by Jamey D. Marth, Ph.D., director of the Center for Nanomedicine, a collaboration between the University of California, Santa Barbara and Sanford-Burnham Medical Research Institute (Sanford-Burnham), has revealed a pathway that links high-fat diets to a sequence of molecular events responsible for the onset and severity of diabetes. (blogspot.com)
Now that we know more fully how states of over-nutrition can lead to type 2 diabetes, we can see more clearly how to intervene," Dr. Marth said. (blogspot.com)
He and his colleagues are now considering various methods to augment beta cell GnT-4a enzyme activity in humans, as a means to prevent and possibly cure type 2 diabetes. (blogspot.com)
The identification of the molecular players in this pathway to diabetes suggests new therapeutic targets and approaches towards developing an effective preventative or perhaps curative treatment," Dr. Marth continued. (blogspot.com)
is an intermediate, possibly transitional, state between normal glucose metabolism and diabetes mellitus that becomes more common with aging. (msdmanuals.com)
Data-driven subgroups of newly diagnosed type 2 diabetes and the relationship with cardiovascular diseases at genetic and clinical levels in Chinese adults. (cdc.gov)
Association of Met420del Variant of Metformin Transporter Gene SLC22A1 with Metformin Treatment Response in Ethiopian Patients with Type 2 Diabetes. (cdc.gov)
The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome. (cdc.gov)
RS3480 Polymorphism of FNDC5/Irisin Is Associated with Type 2 Diabetes Mellitus in Maya-Mestizo Women. (cdc.gov)

Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro . (hindawi.com)
Although the precise pathogenic mechanism of GDM has not been fully elucidated, it may occur as a result of abnormal glucose regulation and increased IR, inducing the disorders of glucose metabolism. (hindawi.com)
Molecular Metabolism. (wur.nl)
Group 2 innate lymphoid cells (ILC2s) adapt to tissue physiology and contribute to immunity, inflammatory pathology and metabolism. (elifesciences.org)
This important study describes the protective role of group 2 innate lymphoid cells (ILC2s) in tissue physiology and contributes to immunity, inflammatory pathology, and metabolism in maintaining homeostasis during pregnancy. (elifesciences.org)
Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
Glucose-6-phosphate is an intermediate in glycogen synthesis and glucose metabolism. (medscape.com)
Significant impacts of interventions on intestinal bile acid metabolism, farnesoid X receptor (Fxr) signalling in the intestine and liver, and hepatic expression of fatty acid transporters (Fabp4, Vldlr, Cd36) were also evident. (nih.gov)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans. (cdc.gov)

In VSMCs, chemerin, via oxidative stress- and ChemR23-dependent mechanisms, decreased insulin-induced Akt phosphorylation, glucose transporter 4 translocation to the membrane, and glucose uptake. (gla.ac.uk)
Furthermore, no interaction with tofogliflozin was observed in any of a battery of tests examining glucose-related physiological processes, such as glucose uptake, glucose oxidation, glycogen synthesis, hepatic glucose production, glucose-stimulated insulin secretion, and glucosidase reactions. (aspetjournals.org)
insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. (sciencebiology.org)
Stimulation of GLUT4 Glucose Uptake by Anthocyanin-Rich Extract from Black Rice (Oryza sativa L.) via PI3K/Akt and AMPK/p38 MAPK Signaling in C2C12 Cells. (sciencebiology.org)
Mulberry Leaf Extract Stimulates Glucose Uptake and GLUT4 Translocation in Rat Adipocytes. (sciencebiology.org)
Portulaca oleracea L. Extract Enhances Glucose Uptake by Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes. (sciencebiology.org)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
In addition, it reduced glucose uptake, glycogen synthesis and glycolysis, and led to defective TG synthesis and storage in HCs. (helsinki.fi)

Many inhibitors of glucose-6-phosphate translocase of novel, semi-synthetic or natural origin are known and of medical importance. (wikipedia.org)
Inhibitors of G6PT1 are the most studied as this subunit catalyzes the rate limiting step in glucose production through gluconeogenesis or glycogenolysis, and without its function these two processes could not occur. (wikipedia.org)
The selectivity of tofogliflozin toward human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1 was the highest among the tested SGLT2 inhibitors under clinical development. (aspetjournals.org)
Energy substrate utilization and myocardial ion channel regulation have gained research interest especially after the introduction of sodium-glucose co-transporter 2 inhibitors in the treatment of heart failure. (bvsalud.org)

Furthermore, to investigate the molecular mechanism of action, the phosphorylation and protein expression of phosphoinositide 3-kinase (PI3K) and its downstream proteins, such as insulin receptor (INSR), protein kinase B (Akt/PKB) and glucose transporter 4 (GLUT4) have been detected. (rsc.org)
Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels. (sciencebiology.org)
Regulated transport of the glucose transporter GLUT4. (sciencebiology.org)
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. (sciencebiology.org)
Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking: LOCATION! (sciencebiology.org)

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. (ucsf.edu)

RhoA activation triggers a glycolytic burst through the translocation of the glucose transporter SLC2A3/GLUT3 to fuel the cellular contractile machinery, as demonstrated across multiple endothelial cell types. (nature.com)
Consequently, it is critical that we understand the cellular and molecular immune factors that regulate the uterine environment. (elifesciences.org)
Transdifferentiation is a type of cellular reprogramming involving the conversion of one differentiated cell type to another. (silverchair.com)
Reprogramming techniques continue to evolve as we learn more about the developmental and molecular cues which govern cellular differentiation and identity. (silverchair.com)
In healthy people, pancreatic beta cells monitor the bloodstream for glucose using glucose transporters anchored in their cellular membranes. (blogspot.com)
It is very likely that patients with obesity will have to take these antiobesity medications "forever," he said, "until we identify and can repair the cellular and molecular mechanisms that the body uses to regulate body fat mass throughout the life cycle and that are dysfunctional in obesity. (medscape.com)

Dapagliflozin propanediol monohydrate is an orally-active inhibitor of the human renal sodium-glucose co-transporter 2 (SGLT2), the major transporter responsible for renal glucose reabsorption. (azurewebsites.net)

FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
Although the pattern of inheritance that best fits FRG is one of co-dominance, increased glucose excretion was not observed in all individuals with similar or identical mutations. (medscape.com)
Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
GSD type Ib differs from GSD type Ia in that it is not explained by mutations of the phosphohydrolase gene. (medscape.com)
Veiga-da-Cuhna and colleagues provide evidence that all non-1a cases can be explained by mutations of the glucose-6-phosphate translocase gene. (medscape.com)
A newly described form, GSD type Ic, does not appear to be related to mutations within the transporter protein. (medscape.com)
GSD Ia may be explained by mutations of the catalytic unit gene of the G6Pase complex, unlike GSD type Ib and GSD type Ic. (medscape.com)

Das AM, Lücke T, Meyer U, Hartmann H, Illsinger S. Glycogen storage disease type 1: impact of medium-chain triglycerides on metabolic control and growth. (medscape.com)
Schwahn B, Rauch F, Wendel U, Schönau E. Low bone mass in glycogen storage disease type 1 is associated with reduced muscle force and poor metabolic control. (medscape.com)

Further works by [8] have established the fact that Zn transporter (ZnT8) is a key protein for the regulation of insulin secretion from pancreatic Beta-cells. (scirp.org)
Clinical studies of subjects with the different forms of MODY indicate that each is associated with a different defect in the normal pattern of glucose stimulated insulin secretion. (scirp.org)

The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. (diabetesjournals.org)
The recently cloned SLC2A10 gene encodes a 541 amino acid putative facilitative glucose transporter (GLUT10) of the GLUT family class III with between 30 and 34% amino acid homology with the known GLUT proteins ( 1 , 2 ). (diabetesjournals.org)
Two means of glucose transport are noted: facilitative and secondary active transport. (medscape.com)

Fig. 5: RhoA induces glucose transporter SLC2A3 translocation which drives subcellular glycolysis in thrombin-stimulated contractile endothelial cells. (nature.com)

In addition, we describe the molecular mechanisms linking host and the gut microbiota in T2DM, including the host molecules that induce gut microbiota dysbiosis, immune and inflammatory responses, and gut microbial metabolites involved in pathogenesis. (frontiersin.org)
Here, we summarize the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications, as well as the molecular mechanisms linking host and the gut microbiota in T2DM, which may provide new ideas for the treatment of T2DM. (frontiersin.org)
Molecular and vascular mechanisms were probed in mesenteric arteries and cultured vascular smooth muscle cells (VSMCs) from C57BL/6J, nondiabetic lean db/m, and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). (gla.ac.uk)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)

Each of the translocase subunits performs a specific function in the transport of substrates and products, and finally release of glucose (which will eventually reach the bloodstream), as a step in glycogenolysis or gluconeogenesis. (wikipedia.org)
A glycogen storage disease (GSD) is the result of an enzymatic defect among various reactions that produce glucose, either by glycogenolysis or gluconeogenesis. (medscape.com)

As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)
Diagnosis is by measuring plasma glucose. (msdmanuals.com)
Intensive control of plasma glucose can prevent or delay many of these complications but may not reverse them once established. (msdmanuals.com)

Within this framework of glucose regulation, the translocase components are responsible for transporting the substrates and products across the endoplasmic reticulum membrane, resulting in the release of free glucose into the bloodstream. (wikipedia.org)
While the hydrolyzing component of the G6Pase complex is located on the side of the membrane on which it acts, namely facing the lumen, the translocases are all integral membrane proteins in order to perform their function as cross-membrane transporters. (wikipedia.org)
For instance, the Michaelis Constant of the enzyme for glucose-6-phosphate decreases significantly upon membrane disruption. (wikipedia.org)
Insulin reduces the amount of glucose in the blood by binding to insulin receptors embedded in the cell membrane of various insulin -responsive tissues like muscle cells and adipose tissue . (osmosis.org)
When activated, the insulin receptors cause vesicles containing glucose transporter that are inside the cell to fuse with the cell membrane , allowing glucose to be transported into the cell. (osmosis.org)
The exact reason why cells don't "respond" isn't fully understood, but the cells don't move their glucose transporters to their membrane in response, which if you remember, is needed for glucose to get into the cell, these cells are therefore insulin resistant. (osmosis.org)
Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
ORP2 was also found to facilitate cholesterol transport between the late endosomes/lysosomes (LE/LY) and plasma membrane (PM) and to interact with the related LE/LY cholesterol transporter ORP1L. (helsinki.fi)
Proper retention of glucose transporters in the cell membrane depends on this modification, but when FOXA2 and HNF1A aren't working properly, GnT-4a's function is greatly diminished. (blogspot.com)

The G6Pase complex is highly involved in the regulation of homeostasis and blood glucose levels. (wikipedia.org)
Ion transport and regulation in a synaptic vesicle glutamate transporter. (ucsf.edu)
The depletion of ORP2 led to dysregulated transcriptional regulation of lipogenesis in both of the studied cell types. (helsinki.fi)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

Current widespread treatments for T2DM include metformin (suppressor of hepatic glucose production), sulfonylureas (insulin secretagogues), and the thiazolidinedione pioglitazone (PPAR agonist). (ddw-online.com)

It produces glucose by gluconeogenesis. (medscape.com)
The key enzymes of gluconeogenesis are phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase). (medscape.com)
Gluconeogenesis in the kidneys exceeds renal glucose consumption. (medscape.com)
G6Pase hydrolyzes glucose-6-phosphate (G6P), an end-product of both glycogenolysis and gluconeogenesis, into glucose before it can be released into circulation. (medscape.com)

This gene encodes a major glucose transporter in the mammalian blood-brain barrier. (ageing-map.org)

The gene was examined in 61 Danish type 2 diabetic patients, and a total of six variants (−27C→T, Ala206Thr, Ala272Ala, IVS2 + 10G→A, IVS4 + 18T→G, and IVS4 + 26G→A) were identified and investigated in an association study, which included 503 type 2 diabetic patients and 510 glucose-tolerant control subjects. (diabetesjournals.org)
Using serum samples of diabetic patients whose glucose concentrations were above the threshold (10.0 mmol/l), spectroscopic methods were used to determine the concentration of glucose and zinc. (scirp.org)

The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a. (medscape.com)

The results showed that CIG significantly improved oral glucose tolerance in diabetic mice. (rsc.org)
Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. (aspetjournals.org)
In db/db mice, 4-week tofogliflozin treatment reduced glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test 4 days after the final administration. (aspetjournals.org)
While FLAV reduced body (-28-30%), adipose tissue (-45-50%) weights and serum insulin (-22-25%) as observed following an intra-peritoneal glucose tolerance test, n-3 downregulated the expression of Srebf1 and the lipogenic genes (Acaca, Fasn). (nih.gov)

Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K. Molecular background of urate transporter genes in patients with exercise-induced acute kidney injury. (medlineplus.gov)
Placentas exhibit signs of adaptation to stress, including larger maternal blood spaces and increased expression of nutrient transporter genes. (elifesciences.org)

The intracellular glucose intake and glycogen content were measured using a High Sensitivity Glucose Assay Kit and Glycogen Assay Kit, respectively. (hindawi.com)

Most serogroup Y isolates were classified by PFGE as clonal years, and three cases associated with a party in 1999, in group 1 or 2, and most serogroup C isolates were in clonal young adults ages 18, 20, and 21 years (3). (cdc.gov)
1999 Dec. 158 Suppl 2:S43-8. (medscape.com)

To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. (frontiersin.org)
Both types have the same long-term complications. (scirp.org)

CCX832 treatment of db/db mice decreased body weight, insulin, and glucose levels as well as vascular oxidative stress. (gla.ac.uk)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)
So when the researchers fed otherwise normal mice a high-fat diet, they found that the animals' beta cells could not sense and respond to blood glucose. (blogspot.com)

Glucose-6-phosphate translocase is a transmembrane protein providing a selective channel between the endoplasmic reticulum lumen and the cytosol. (wikipedia.org)

Glucose transporters: physiological and pathological roles. (sciencebiology.org)
Bijvoet AG, Van Hirtum H, Vermey M. Pathological features of glycogen storage disease type II highlighted in the knockout mouse model. (medscape.com)

In another study, [3] has shown that malabsorption of zinc results in various types of disorders including the dermal, gastrointestinal, neurological and immunological abnormalities. (scirp.org)
Acute coronary syndrome (ACS), peripheral arterial occlusive disease (PAOD), and ischemic stroke (IS) are types of atherosclerotic cardiovascular disease (ASCVD), although the benefits of treating these disorders have not been shown consistently. (nih.gov)

Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction due to a reduction in the renal tubular reabsorption of glucose. (medscape.com)

However, the recent ACCORD and ADVANCE trials in patients with longstanding T2DM have shown that aggressive glucose control in such patients has no clear benefits, or may even increase CVD events (3). (ddw-online.com)
Renal glucosuria has also been reported in patients with acute pyelonephritis in the presence of a normal blood glucose level. (medscape.com)
Furthermore, to our knowledge, there have been no case reports of the patients of at-risk of HLRCC-associated with kidney cancer who received active surveillance and were treated successfully, and little is known about the relationship between the clinicopathological features and molecular changes associated with targeting therapy in this disease. (biomedcentral.com)
In regard to survival, around 52.9% of patients diagnosed with CRC survive the disease for ten years or more ( 2 ). (frontiersin.org)
Vitamin E supplementation improves neutropenia and reduces the frequency of infections in patients with glycogen storage disease type 1b. (medscape.com)
In a 2-year study of 7 patients with GSD type Ib, Melis et al examined whether the administration of vitamin E could improve or prevent the clinical manifestations of neutropenia and neutrophil dysfunction. (medscape.com)
It is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in patients weighing at least 35 kg. (who.int)

This leads to high levels of glucose in your blood and not enough in your cells, and remember that your cells need glucose as a source of energy. (osmosis.org)

Metformin is a pill that can reduce excess release of glucose from the liver, acting as an "insulin sensitizer," explains Dungan. (everydayhealth.com)

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene. (wikipedia.org)
It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase). (wikipedia.org)
The enzyme is made up of three separate transporting subunits referred to as G6PT1 (subunit 1), G6PT2 (subunit 2) and G6PT3 (subunit 3). (wikipedia.org)
Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease ( GSD type II , acid maltase deficiency), Cori disease ( GSD type III , debranching enzyme deficiency), McArdle disease ( GSD type V , myophosphorylase deficiency), and Tarui disease ( GSD type VII , phosphofructokinase deficiency). (medscape.com)
Glucose-6-phosphatase (G-6-P) is the specific enzyme deficiency in Von Gierke disease. (medscape.com)
Specifically, GSD type Ia is characterized by deficiency in the glucose-6-phosphatase (G6Pase) enzyme. (medscape.com)
GSD type Ib is a similar condition that has active G6Pase enzyme activity but with a defect in the glucose-6-phosphate transporter protein. (medscape.com)
The lac operon of E. coli is but one example of how enzyme and transporter production can be made conditional on the presence of a nutrient to catabolize. (lu.se)

The novel innovation and significance resides within its potential to provide (1) an expanded understanding of the mechanism through which a maternal high fat diet reprograms primate gene expression and (2) a simple intervention (essential nutrient supplementation with neither diet nor behavioral modification) with tremendous potential impact given the current obesity epidemic and the lack of efficacious therapeutics. (nih.gov)

Structure-function study of the glucose-6-phosphate transporter, an eukaryotic antiporter deficient in glycogen storage disease type Ib. (medscape.com)
D'Eufemia P, Finocchiaro R, Celli M, Zambrano A, Tetti M, Ferrucci V. Absence of severe recurrent infections in glycogen storage disease type Ib with neutropenia and neutrophil dysfunction. (medscape.com)
Bone marrow transplantation in glycogen storage disease type 1b. (medscape.com)
Correction of glycogen storage disease type 1a in a mouse model by gene therapy. (medscape.com)

However, the molecular mechanism underlying the selective transport of diverse carbohydrates remains unclear mainly owing to their structural complexity and stereochemistry. (rcsb.org)
Diversity of function and mechanism in a family of organic anion transporters. (ucsf.edu)

However, the codon 206 polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels. (diabetesjournals.org)
In this study, we used PFGE and MLST to England Biolabs, Beverly, MA), 330 µg/mL bovine serum determine whether the genotypes of N. meningitidis , as albumin, and 200 µl NE Buffer #2 at 37°C overnight. (cdc.gov)

The data generated promote the detailed understanding of the molecular basis of common diseases such as cardiovascular diseases and cancers, as well as the development of new treatment modalities. (helsinki.fi)

G6PT1 transports Glucose-6-Phosphate from the cytosol into the lumen of the endoplasmic reticulum, where it is hydrolyzed by the catalytic subunit of G6Pase. (wikipedia.org)
In GSD Ib, G6P transport into the ER is defective and prevents normal G6Pase from converting G6P into glucose. (medscape.com)

P rediabetes is presently defined as moderately elevated fasting blood glucose (FBG), and is estimated to affect 79 million adult Americans, or 35% of the adult population. (ddw-online.com)
A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. (aspetjournals.org)
No blood glucose reduction was observed in normoglycemic SD rats treated with tofogliflozin. (aspetjournals.org)
Medication for T2DM mainly focuses on lowering blood glucose and treating affected organs. (sciencebiology.org)
In health individuals this equates to a blood glucose concentration of approximately 200mg/dL (11mmol/L), which is believed to be threshold for the appearance of glucosuria. (medscape.com)
Exercise was also shown to increase the concentration of blood glucagon like peptide-2(GLP-2), which regulates carbohydrate digestion and absorption in small intestinal epithelium. (preprints.org)
When blood glucose is high, such as after a meal, beta cells take in this additional glucose and respond by secreting insulin in a timed and measured response. (blogspot.com)

The G-6-P transporter protein is found in the liver and kidney. (medscape.com)

Moreover, cardiovascular disease (CVD) is 2-4 times higher in diabetics (2). (ddw-online.com)
This study investigated the relationship of zinc and glucose in diabetics. (scirp.org)

Nature Reviews Molecular Cell Biology, 3(4), 267277. (sciencebiology.org)
Nature Reviews Molecular Cell Biology, 9(3), 193205. (sciencebiology.org)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. (wur.nl)
Cancer biology has significantly benefited from the molecular-level detail provided by these tools, allowing elucidation of many perturbations underlying disease onset and progression. (nih.gov)

The kidneys play an important role in glucose homeostasis. (medscape.com)

We show that mouse uterine ILC2s have a heightened type-2 gene signature and expand during pregnancy. (elifesciences.org)

Anatomy23

Organisms12

Diseases9

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology1

Phenomena and Processes35

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science3

Diabetes74

Metabolism10

Uptake12

Inhibitors4

GLUT45

Glut11

Cellular6

Renal glucose reab1

Mutations7

Metabolic2

Secretion2

Facilitative3

Translocation1

Mechanisms4

Glycogenolysis or gluconeogenesis2

Plasma glucose3

Membrane9

Regulation3

Induces1

Hepatic1

Gluconeogenesis4

Gene encodes1

Diabetic patients2

Translocase gene1

Tolerance4

Genes2

Assay Kit1

19992

Complications2

Mice4

Transmembrane1

Pathological2

Disorders2

Excretion1

Patients7

Levels of glucose1

Release of glucose1

Enzyme8

Obesity1

Glycogen storage4

Mechanism2

Serum2

Cardiovascular diseases1

G6Pase2

Blood7

Protein is found1

Diabetics2

Biology4

Homeostasis1

Mouse uterine1