• Alexandra Preston, a doctoral student from MRC Human Immunology Unit (MRC Weatherall Institute of Molecular Medicine), delivered a plenary talk on 11th December at the ASH Meeting and Exposition in New Orleans, Louisiana. (ox.ac.uk)
  • These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)
  • A better understanding of the mechanisms of ineffective erythropoiesis may be beneficial in the development of therapeutic strategies to prevent severe malarial anaemia. (biomedcentral.com)
  • These include the destruction of parasitized erythrocytes, ineffective erythropoiesis or dyserythropoiesis, and immunity associated with disease. (biomedcentral.com)
  • The intricate interplay of anemia and iron overload under the pathophysiological umbrella of ineffective erythropoiesis in non-transfusion-dependent ß-thalassemia (NTDT) results in a complex variety of clinical phenotypes that are challenging to diagnose and manage. (bvsalud.org)
  • The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described. (cshlpress.com)
  • Research in the Paralkar Lab spans the spectrum from human patient sample studies and mouse models to cutting-edge molecular biology tools, high-throughput sequencing approaches, and novel computational algorithms, all with the goal of gaining insight into how the transcription of coding genes and noncoding ribosomal DNA genes is regulated in hematopoietic stem cells, myeloid progenitors, and in leukemia. (upenn.edu)
  • MNP was trained in molecular and cell biology at the Ecole Normale Supérieure of Lyon and obtained her PhD in molecular and cell biology in 1994 at the Pierre and Marie Curie University. (ijm.fr)
  • Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. (ox.ac.uk)
  • For example, as in all areas of molecular biology, the clinicians are frequently unaware of the contributions to their problems that might be made by the application of more basic knowledge and techniques. (orellfuessli.ch)
  • The current research aims to identify shared molecular gene signatures and pathways that affirm the epidemiological association of T2DM and TB and afford clues on mechanistic basis of their association through integrative systems biology and bioinformatics approaches. (springeropen.com)
  • Lakna, a graduate in Molecular Biology and Biochemistry, is a Molecular Biologist and has a broad and keen interest in the discovery of nature related things. (pediaa.com)
  • Purified erythroid precursor cells have been characterized using "omics" techniques to determine their transcriptional profiles, epigenetic programs, and responses to cell signaling, allowing a better understanding of erythropoiesis in normal conditions and diseased states. (frontiersin.org)
  • He demonstrated the existence of a key physiological and pathological mechanisms of erythropoiesis regulation by caspase-mediated cleavage of erythroid transcription factors. (nfcr.org)
  • In this study, a phosphoproteomic approach was performed to dissect the molecular mechanism of phosphoprotein regulation, which is involved in the inhibitory effect of parasites on erythroid cell development. (biomedcentral.com)
  • 13 Regulation of Erythropoiesis and Possible Implications of the Cell Membrane. (orellfuessli.ch)
  • Gene expression - Other factors such as transcription factors , miRNA , post-translational modification of histones, cytokines , and cofactors are also involved in the regulation of erythropoiesis through the regulation of gene expression. (pediaa.com)
  • Some other factors are also involved in the regulation of gene expression to regulate erythropoiesis. (pediaa.com)
  • From Stem Cell to Red Cell: Regulation of Erythropoiesis at Multiple Levels by Multiple Proteins, RNAs, and Chromatin Modifications. (pediaa.com)
  • The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. (rochester.edu)
  • Next generation sequencing (NGS) technologies have opened up exciting landscapes for diagnosis and study of molecular mechanisms, with unprecedented sensitivity and specificity. (frontiersin.org)
  • The molecular mechanisms underlying the suppression of erythropoiesis by P. vivax are remarkably complex and remain unclear. (biomedcentral.com)
  • The phosphoproteome strategy is alternative proteomic method that allows investigation into the molecular mechanisms of signal transduction pathways [ 23 ]. (biomedcentral.com)
  • Molecular mechanisms of organismal and cell aging remain incompletely understood. (smallrna-bioinformatics.eu)
  • Perhaps, the association between TB and T2DM was the oldest to be identified, but the molecular mechanisms from the immunological point of view behind this comorbidity have only been explored recently [ 5 , 6 ]. (springeropen.com)
  • After cell sorting, the gene expressions of membrane proteins in early and late erythropoiesis precursors and in nonerythroid cells were characterized using microarray analysis. (biomedcentral.com)
  • Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
  • Under supervision of Prof. Stefan Karlsson, Division of Molecular Medicine and Gene Therapy, he led projects discovering novel HSC regulators. (kumamoto-u.ac.jp)
  • The disease is caused by mutations in the GATA1 (Xp11.23) gene encoding GATA1, a transcriptional regulator involved in erythropoiesis and megakaryocytopoiesis. (orpha.net)
  • Finally, using transcription factor binding site analysis, we identified potential transcription factors that may regulate gene expression during terminal erythropoiesis. (ox.ac.uk)
  • Hakobyan S., Loeffler-Wirth H., Arakelyan A., Binder H., Kunz M., A Transcriptome-Wide Isoform Landscape of Melanocytic Nevi and Primary Melanomas Identifies Gene Isoforms Associated with Malignancy, "International Journal of Molecular Sciences", v.22, N13:7165, 2021. (imb.am)
  • This study aimed to examine the tissue-specific contributions of macrophages and extracellular ATP, as a signal of disturbed tissue homeostasis, to erythropoiesis under conditions of repeated psychological stress. (ac.rs)
  • In addition, because patients with dyserythropoiesis generally exhibited a reduced population of APQ0 high cells relative to healthy participants, the analysis results also suggested that the levels of APQ0 high cells in early erythropoiesis serve as a novel biomarker that distinguishes normal from dysregulated erythropoiesis. (biomedcentral.com)
  • The expression levels of AQP0 are downregulated in patients with dyserythropoiesis, indicating a critical role of AQP0 in erythropoiesis. (biomedcentral.com)
  • Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. (wikipedia.org)
  • The objective of this Research Topic is to enhance the application of novel biochemical and molecular methods and techniques in the field of red cell pathophysiology, erythroid maturation, rare hereditary anaemias, transfusion medicine, and red cell production with the specific aim of further improving our understanding of red blood cells and associated disorders. (frontiersin.org)
  • Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (merckmanuals.com)
  • Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)
  • Our team has previously reported that proper control of protein folding is crucial for hematopoietic stem cells (HSC) in order to inhibit elevation of unfolded protein response (UPR) , and bile acid can support protein folding as a molecular chaperone. (kumamoto-u.ac.jp)
  • Therefore this system offers an opportunity to research the molecular system of transcriptional rules as hematopoietic stem cells improvement along the erythroid lineage. (bioerc-iend.org)
  • Learning erythropoiesis in the transcriptional level also needs the capability to over-express or knockdown particular elements in major erythroid cells. (bioerc-iend.org)
  • erythropoiesis of human hematopoietic stem/progenitor cells 1 Isolation of CD34+ human hematopoietic stem/progenitor cells Human CD34+ cell population which contains a mixture of hematopoietic stem cells (HSCs) and early progenitors 8 is usually harvested from umbilical cord blood peripheral blood mobilized with G-CSF (leukapheresis) or bone marrow (Physique 1-Step1). (bioerc-iend.org)
  • During erythropoiesis, mature red blood cells are formed from hematopoietic stem cells. (pediaa.com)
  • Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)
  • Erythropoiesis is a used model program to review cell differentiation commonly. (bioerc-iend.org)
  • TY - JOUR AU - Momčilović, Sanja AU - Bogdanović, Andrija AU - Milošević, Maja AU - Mojsilović, Slavko AU - Marković, Dragana C. AU - Kočović, Dušica M. AU - Vignjević Petrinović, Sanja PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1329 AB - Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
  • article{ author = "Momčilović, Sanja and Bogdanović, Andrija and Milošević, Maja and Mojsilović, Slavko and Marković, Dragana C. and Kočović, Dušica M. and Vignjević Petrinović, Sanja", year = "2023", abstract = "Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
  • They demonstrate enhancer sharing between Nprl3 and ɑ -globin, enabling alignment of metabolism in erythropoiesis to haemoglobin production. (ox.ac.uk)
  • Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
  • Epoetin alfa is a 165- amino acid erythropoiesis-stimulating glycoprotein manufactured by recombinant DNA technology . (rxlist.com)
  • Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)
  • Strikingly, both strains of mice are viable, with only slight alterations in constitutive erythropoiesis or in in vitro assays of red cell lineage function. (elsevierpure.com)
  • Education Teacher - Pathways in Education( PIE) is a pdf erythropoietins and erythropoiesis molecular cellular following Public Non-Profit Charter School who is alongside their ve to achieve scheduled Forex prices. (thecodeworksinc.com)
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  • Overall Project Objective: The experimental study and further mathematical modeling of the microbial heat resistance, as a result of exposure to acids, (extra)cellular metabolites, molecular chaperones and immobilization (in a solid model system). (imperial.ac.uk)
  • 2 Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA. (nih.gov)
  • During these years, he started a strong collaboration with the Department of Hematology, Oncology and Molecular Medicine at the Italian National Institute of Health (NIH), becoming Research Director in 2000 and Chairman in 2008. (nfcr.org)
  • Human molecular genetics 2012 Jun 21 (11): 2610-7. (cdc.gov)
  • Our stringent lists of differentially regulated and continuously expressed transcripts containing many genes with undiscovered functions in erythroblasts are a resource for future functional studies of erythropoiesis. (ox.ac.uk)
  • Because of the many constituent amino acids, many molecular variants are possible. (coem.com)
  • Of considerable interest, we found that expression of elncRNAs, but not plncRNAs, is associated with enhanced expression of neighboring protein-coding genes during erythropoiesis. (biomedcentral.com)
  • IL-11 exerts its biological activities through binding to a specific high-affinity receptor having an apparent molecular mass of 150 kDa. (rndsystems.com)
  • Preferred initial therapy for VTE in patients with cancer is low-molecular-weight heparin (LMWH)-based therapy over warfarin-based therapy or vitamin K antagonists (VKAs), according to guidelines from the American Society of Clinical Oncology (ASCO), the European Society of Medical Oncology (ESMO), the American College of Chest Physicians (ACCP), and the National Cancer Comprehensive Network (NCCN). (oncologynurseadvisor.com)
  • In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
  • Several risk factors for developing venous thrombosis usually coexist in cancer patients including surgery, hospital admissions and immobilization, the presence of an indwelling central catheter, chemotherapy, use of erythropoiesis-stimulating agents (ESAs) and new molecular-targeted therapies such as antiangiogenic agents. (oncologynurseadvisor.com)
  • BACKGROUND: Since 2007 biosimilars of erythropoiesis-stimulating agents (ESAs) are available on the Italian market. (univr.it)
  • We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). (smallrna-bioinformatics.eu)
  • The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin structure interact during normal erythropoiesis. (rochester.edu)
  • Our investigation used a network medicine method to find possible T2DM-TB molecular mediators. (springeropen.com)
  • The immunopathogenesis of many human diseases is characterized at the molecular level. (medscape.com)
  • Thyroid function, pernicious anemia and erythropoiesis: a two-sample Mendelian randomization study. (cdc.gov)
  • Molecular genetic testing can identify GATA1 mutations. (orpha.net)
  • This can be determined using the Revised International Prognostic Scoring System (IPSS-R) in addition to evaluation of a patient's performance status, symptoms, care goals, cytopenias, and molecular genetic testing (eg, for 5q31 deletion or SF3B1 mutations). (medscape.com)