• In conclusion, we recognized the ncRNA pivot (including miR-193b-3p, CRNDE, etc.) and TF pivot (including E2F1, E2F4, etc.) that significantly regulate dysfunction modules. (cellmolbiol.org)
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
  • LIG_RB_pABgroove_1 (LxDLFD), LIG_RB_LxCxE_1 (LxCxE) and LIG_RBL1_LxSxE_2 (LxSxE).The LxDLFD motif binds to a deep groove formed between the A and B subdomains and is present in E2F family transcription factors (E2F1-5). (eu.org)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. (wikipedia.org)
  • Huang Y, Jiang T, Chen J, Yin GY, Fan J. Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1beta and tumor necrosis factor-alpha. (cellmolbiol.org)
  • TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • Cellular reprogramming to iPSCs has uncovered unsuspected links between tumor suppressors and pluripotency factors. (oncotarget.com)
  • Three molecular mechanisms involved in tumor dormancy have been identified: cellular dormancy (quiescence or mitotic arrest), angiogenic dormancy (limited tumor size), and immunologic dormancy (immunosurveillance, balance between clearance and proliferation) (Figure 1 ). (biomedcentral.com)
  • Molecular and Cellular Biology. (wikipedia.org)
  • Cellular and Molecular Biology , 66 (3), 65-71. (cellmolbiol.org)
  • The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. (avivasysbio.com)
  • Much of our research focuses on the cellular and molecular mechanisms that regulate the development and differentiation of skeletal muscle fibers and their respective phenotypes. (rosalindfranklin.edu)
  • Postdoctoral fellows have the opportunity to investigate numerous aspects of the cellular and molecular mechanisms of skeletal and cardiac muscle development. (rosalindfranklin.edu)
  • Molecular and cellular endocrinology , Vol. 415 , pp. 45-55 , ( 2015 ) ( PubMed ). (antibodies-online.cn)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Therefore, this study is based on a modular approach to in-depth analysis and explore the genes of IDD, intended to identify the molecular process of disc degeneration. (cellmolbiol.org)
  • E2F is a group of genes that encodes a family of transcription factors in higher eukaryotes. (fortunepublish.com)
  • Cis-acting DNA sequences which can increase transcription of genes. (lookformedical.com)
  • The mechanisms that regulate myoblast cell proliferation versus differentiation involve extracellular signaling via growth factors, their cognate receptors, intracellular signal transduction cascades, and transcriptional regulation of genes associated with cell proliferation. (rosalindfranklin.edu)
  • Among these genes is the fibroblast growth factor receptor 1 (FGFR1) gene which is expressed in proliferating myoblasts and down-regulated during differentiation. (rosalindfranklin.edu)
  • Put3p activates high level transcription of these genes by binding proline directly. (openrepository.com)
  • The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p. (openrepository.com)
  • Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
  • We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
  • Mycobacterium tuberculosis (MTB) induced tuberculosis has been known as one of the risk factors for lung carcinogenesis. (lidsen.com)
  • Our published findings demonstrate that the FGFR1 gene is positively regulated by the Sp1 transcriptional regulator and negatively regulated by the transcription factor E2F4. (rosalindfranklin.edu)
  • It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)
  • Although both PC-dependent and deuterosome-dependent pathways have been known for decades, the molecular mechanisms that govern the two pathways and their relative contributions to the total complement of centrioles has remained enigmatic. (elifesciences.org)
  • LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74. (nih.gov)
  • The molecular characterisation of cervical cancer by the Cancer Genome Atlas project (TCGA) and others, has provided us with a multi-dimensional understanding of the transcriptomic, genomic, proteomic, and epigenetic landscape of the disease [8-11]. (fortuneonline.org)
  • Therefore, it is imperative to explore the molecular mechanisms underlying the progression in SKCM. (fortunepublish.com)
  • The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • Intervertebral disc degeneration Protein interaction network Enrichment Co-expression analysis Regulatory factors. (cellmolbiol.org)
  • The aim of this research is to identify and characterize the molecular regulatory circuitry that establishes these myogenic cell lineages and which thereby establish fast versus fast/slow muscle fiber types, independent of innervation, and dependent of cell lineage commitment. (rosalindfranklin.edu)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Expert Report of Noriyuki Kasahara, M.D. Ph.D. Expert Witness Statement - Noriyuki Kasahara I, Noriyuki Kasahara, declare the following: As detailed in my Curriculum Vitae, attached herewith as Exhibit B, I am currently an Assistant Professor of Pathology as well as Biochemistry & Molecular Biology, at the Institute for Genetic Medicine of USC/Norris Comprehensive Cancer Center. (healthdrugpdf.com)
  • Two current pieces of investigate recommend that redox is integral for the appetite anorexic mechanism, and integrate this action with all the endocannabinoid program, Via acti vation of AMPK, ghrelin results in elevated mitochon drial oxidation of fatty acids, increased ROS along with a concomitant raise in anti ROS mechanisms, together with transcription of UCP two and improved mitochondrial bio genesis. (wnt-signaling.com)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • The validity of co-IP approaches can quickly deteriorate when forced expression of tagged proteins are used to investigate possible interactions, yet this approach, particularly when endogenous factors are assessed, can provide useful information about potential protein associations. (aacrjournals.org)
  • BACKGROUND/AIM: We analyzed the survival outcomes of patients with epithelial ovarian, peritoneal, or fallopian tube cancer with BRCA1/2 mutations and the clinical factors associated with the prognosis of these cancers. (bvsalud.org)
  • DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)
  • Using computational predictions, we revealed that HPV-positive cervical cancers are regulated by transcription factors including, SOX2, E2F, NANOG, OCT4, and MYC, which control various processes such as the renewal of cancer stem cells, and the proliferation and differentiation of tumour cells. (fortuneonline.org)
  • Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
  • However, mechanistic details are lacking, and recent studies have implicated ALMS1 in several processes including endosomal trafficking, actin organisation, maintenance of centrosome cohesion and transcription. (springer.com)
  • The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. (biomedcentral.com)
  • Despite intense efforts, the molecular mechanisms underlying the persistent inflammation in virologically suppressed people living with HIV (PLWH) remain incompletely characterized [ 10 ]. (biomedcentral.com)
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
  • The number of studies that have used protein interaction discovery approaches for identification of associated factors is overwhelming. (aacrjournals.org)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Molecular Cell. (wikipedia.org)
  • More recently, we have initiated studies to investigate the molecular mechanisms that control the development of distinct myogenic cell lineages during embryonic mygenesis. (rosalindfranklin.edu)
  • Cell-based molecular mechanistic assays are combined with preclinical models coupled to polypectomy. (tamu.edu)
  • Adipogenesis has been extensively studied in mammals [ 7 ] and several cell and animal models have been successfully used to describe the chronology of the molecular events governing this process. (biomedcentral.com)
  • Their growth arrest is reversible and under certain conditions, such as induction by growth factors, cytokines, nutrients, or chemical agents, the cells can re-enter the cell cycle to proliferate again. (biomedcentral.com)
  • Aims: The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced apoptosis. (eurekaselect.com)
  • We do not aim to provide an exhaustive analysis of all available techniques, but instead will highlight some of the most widely used methods for protein-protein assessment and will describe some recent advances in global protein-protein analyses that are enabling non-experts to identify interactomes of their favorite factor. (aacrjournals.org)
  • It has higher identity to E2F4 than to other family members. (wikipedia.org)
  • Understanding the molecular basis of AS is critical for the development of specific therapies. (springer.com)