• The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. (wikipedia.org)
  • Ionotropic glutamate receptors (iGluRs) are the principal excitatory neurotransmitter receptors in the CNS. (jneurosci.org)
  • glutamate receptor, ionotropic, NMDA1. (wikigenes.org)
  • Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity. (libguides.com)
  • Molecular determinants of substrate specificity in sodium-coupled glutamate transporters. (libguides.com)
  • Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter. (mpg.de)
  • 6] "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria. (tcdb.org)
  • Additionally, Klaus Schulten will be honored at the Meeting's Awards Ceremony as a 2012 Society Fellow during the Biophysical Society's on Monday February 27, 2012 for his groundbreaking effort to develop computational molecular biology as an important tool to solve problems in biophysics. (memprotein.org)
  • Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. (wikipedia.org)
  • AMPA receptor variants were identified with a polyclonal antibody recognizing the conserved extracellular loop region of all four AMPA receptor subunits (GluR1-4, both flip and flop ), whereas NMDA receptors were immunolabeled with a polyclonal antibody that binds to an extracellular N-terminal epitope of the NR1 subunit, common to all splice variants. (jneurosci.org)
  • Initially infecting poultry, avian influenza A(H9N2) viruses have been sporadically identified in pigs and humans, which suggests that some of these viruses have adapted to bind mammalian host receptors or have acquired mutations that increase mammalian receptor specificity ( 1 - 3 ). (cdc.gov)
  • Detection of binding sites on SARS-CoV-2 Spike protein receptor-binding domain by molecular dynamics simulations in mixed solvents.IEEE/ACM Transactions on Computational Biology and Bioinformatics, 18: 1281-1289. (medchem.fi)
  • Nature Structural and Molecular Biology [Internet]. (libguides.com)
  • Molecular and Cellular Biology. (westminster.ac.uk)
  • Current Protocols in Molecular Biology (SUPPL). (cshl.edu)
  • Delphine Patin was trained in genetics and molecular biology at the University Paris Diderot, Paris. (degruyter.com)
  • Dominique Mengin-Lecreulx was trained in biochemistry, enzymology, molecular biology and organic chemistry and obtained his PhD degree at the University Paris-Sud in 1987. (degruyter.com)
  • Methods in Molecular Biology Series: "Protein-Ligand Interactions and Drug Design. (medchem.fi)
  • Biochemical characterization of RLC-TS and RLC mutants. (elifesciences.org)
  • Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations. (rhea-db.org)
  • However, recent evidence from biochemical, genetic, and physiologic characterization of their venom suggests that they are two different species as listed above. (medscape.com)
  • The light chains bind to the central neck domain of the myosin heavy chain and have structural and regulatory functions ( Heissler and Sellers, 2014 ). (elifesciences.org)
  • Determining the exact binding site and its structural assessment would help to better understand the interaction between the parasite and the host, which is necessary for the disease progression and thus for the development of a potential therapy. (nusl.cz)
  • Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family. (mpg.de)
  • Structural and Molecular Basis for Coordination in a Viral DNA Packaging Motor. (utmb.edu)
  • This project focused on the molecular and functional characterization of the SCFFBXO38 ubiquitin ligase. (nusl.cz)
  • Characterization of the FBXO7 (PARK15) protein. (hersenbank.nl)
  • Its central postulate is based on the fact that instead of suppressing protein activity with low-molecular inhibitors, we can instead use molecular tools to hijack the host organism's own degradation pathways and force it to degrade chosen proteins by itself. (nusl.cz)
  • This diploma thesis revolves around the preparation of biocompatible polymeric conjugates called "iBodies" that will be used to induce targeted lysosomal degradation of two model enzymes - Fibroblast activation protein α, and Glutamate carboxypeptidase II. (nusl.cz)
  • Tanui R, Tao Z, Silverstein N, Kanner B, Grewer C. Electrogenic steps associated with substrate binding to the neuronal glutamate transporter EAAC1. (libguides.com)
  • Disulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductance. (libguides.com)
  • Con respecto a los modelos animales en TEA, muchos estudios se centran en la expresión génica, la migración y maduración neuronal cortical y los déficits de la red neuronal, pero muy pocos son los estudios que relacionen directamente la comunicación oral animal y la expresión génica en áreas corticales del lenguaje. (bvsalud.org)
  • AMBER-DYES: Characterization of charge fluctuations and force field parameterization of fluorescent dyes for molecular dynamics simulations. (mpg.de)
  • Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity. (rhea-db.org)
  • His main research topics have been the design, synthesis, and study of the binding modes of peptidoglycan biosynthetic pathway inhibitors. (degruyter.com)
  • First, a total of four low-molecular ligands were prepared and fully characterized by standard methods of organic synthesis. (nusl.cz)
  • Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)
  • The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxy-phenylpyruvate, phenylpyruvate and alpha-ketocaproic acid as amino group acceptors. (rhea-db.org)
  • 2] "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues. (tcdb.org)
  • His main research interests concern the identification of genes and enzymes involved in this pathway, the regulation of this metabolism, the mode of action of antibiotics and bacteriocins interfering with this pathway and the corresponding resistance mechanisms, as well as the molecular bases for the recognition of bacterial cell-wall peptidoglycan by host innate immunity mechanisms. (degruyter.com)
  • Identification and Characterization of Novel Small RNAs in Rickettsia prowazekii. (utmb.edu)
  • Molecular analysis showed that multiple mammalian-specific mutations have become fixed in the subtype H9N2 viruses, including changes in the hemagglutinin, matrix, and polymerase proteins. (cdc.gov)
  • Figure 5: Molecular interrogation of dopamine neurons defines a onecut-3-expressing periventricular subtype. (nature.com)
  • Substrate-induced rearrangements in glutamate-transporter homologs. (libguides.com)
  • This finding suggests that constitutively activated GDH enhances oxidation of glutamate, which is intracellularly converted from glutamine to α-ketoglutarate, a tricarboxylic acid cycle substrate, which thereby stimulates insulin secretion. (diabetesjournals.org)
  • Juvonen RO, Jokinen EM , Huuskonen J, Kärkkäinen O, Raunio H, Pentikäinen OT .Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. (medchem.fi)
  • Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. (neurotree.org)
  • The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
  • Here, we describe the isolation and characterization of expressed sequence tags (ESTs) isolated from a chicken pineal gland cDNA library. (westminster.ac.uk)
  • The reaction starts with the fully reduced form of the enzyme, presumably with a water molecule weakly coordinated to the type-2 copper (Cu-T2) ion and no bridging moiety between the two type-3 copper (Cu-T3) ions.17,22 The incoming di- oxygen is immediately reduced, yielding a peroxide-level intermediate (PI),12 with a peroxide ion bound in the centre of the TNC. (lu.se)
  • Lotus Japonicus como Modelo para la Identificaci n de Nuevos Genes Implicados en la Respuesta a Estr s Abi tico y Productividad en Leguminosas. (us.es)
  • El objetivo de nuestro estudio tuvo como objetivo revisar y correlacionar genes involucrados en TEA y aque- llos relacionados con la comunicación ultrasónica en estudios con modelos animales de comportamiento social basado en el lenguaje en la base de datos PubMed. (bvsalud.org)
  • Residence Times of Molecular Complexes in Solution from NMR Data of Intermolecular Hydrogen-Bond Scalar Coupling. (utmb.edu)
  • F-plasmid partition complexes containing ParB F and parS F move by generating and following a local concentration gradient of nucleoid-bound ParA F . However, the process through which ParB F activates ParA F -ATPase has not been defined. (biorxiv.org)
  • Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins. (medchem.fi)
  • Immunocytochemical characterization of the human subthalamic nucleus. (hersenbank.nl)
  • 16] "Initial characterization of the human central proteome. (tcdb.org)
  • GDH is ubiquitously expressed, and its oxidative deamination reaction feeds the tricarboxylic acid (TCA) cycle by converting l -glutamate to α-ketoglutarate, whereas the reductive amination reaction supplies nitrogen for several biosynthetic pathways. (diabetesjournals.org)
  • Supporting Information: LC-MS characterization of GSH-MDI reaction products, Tables of peptides matched to albumin or modified albumin, and MS/MS data on the GSH-MDI modified albumin peptide containing residues 411-428. (cdc.gov)
  • The key step in the reaction mechanism of multicopper oxidases (MCOs)--the cleavage of the O-O bond in O2--has been investigated using combined quantum mechanical and molecular mechanical (QM/MM) methods. (lu.se)
  • In addition to the orthosteric site (the site where the endogenous ligand glutamate binds) at least two distinct allosteric binding sites exist on the mGluR5. (wikipedia.org)
  • Application of molecular and analytical tools to track enrichment of reductive dechlorination cultures from a TCE-contaminated groundwater site. (nih.gov)
  • ParABS partition systems, comprising the centromere-like DNA sequence parS, the parS -binding ParB-CTPase and the nucleoid-binding ParA-ATPase, ensure faithful segregation of bacterial chromosomes and low-copy-number plasmids. (biorxiv.org)
  • Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
  • Journal of Molecular Structure. (medchem.fi)
  • International Journal of Molecular Sciences. (medchem.fi)
  • Most ParABS systems have multiple copies of a ParB dimer binding consensus sequence that collectively constitute a parS site. (biorxiv.org)