PeptidesIntrinsically disordered proteinsHydrolysisCharacterizationAmino acid residuesMitochondrialGenesResiduesBiologyMultimericSmall proteinsCellularMediateEnzymesGeneVitroMethodsGeneticsEvolutionaryNucleoproteinsPreferentiallyHomologMetalloproteinsSubunitsBacteriaTranscriptionalOrganismsAggregationHeat shock pTherapeuticIdentificationMosquitoInteractionsRolesBoundUrineFundamentalLigandsStructuresAssaysMechanismsReplicationInteractSpecificOxygenVariationSpeciesComplexesBiogenesisResultsFamilyPlay
Peptides7
- Consequently, saliva not merely consists of several antimicrobial peptides and protein, but offers buffering capability also, which is essential in the dental defense against attacks. (exposed-skin-care.net)
- 100 kDa) that are usually linked to the plasma membrane of the midgut epithelium and hydrolyze the ends of small proteins and peptides (N-terminus or C-terminus) [ 10 ]. (biomedcentral.com)
- This information was then compared with analogous information for other protein groups, such as proteins from bacteria, fungi, viruses, and cell-penetrating peptides from the UniProt database, and a set of intrinsically disordered proteins. (eurekaselect.com)
- 3. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease, this segment is a peptide able to bind to NS3pro and contact at least one residue comprised in the region Gly21-Lys28 of the N-terminal domain of the NS3pro protein from DV2 or structurally equivalent residues of the NS3pro protein from other Flavivirus. (patentsencyclopedia.com)
- 5. Chimerical peptides according to the claim 1, where the mentioned segment inhibitor of the activation of the NS3pro protease contact at least one residue comprised in the region Glu32-Thr38 of the N-terminal domain of the NS3pro protein from HCV or structurally equivalent residues of the NS3pro protein from other Hepacivirus. (patentsencyclopedia.com)
- 6. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Asp50-Glu62 of the NS2B protein from DV2 or the structurally equivalent segment of the protein NS2B from other Flavivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
- 8. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Thr20-Leu31 of the NS4A protein from HCV or the structurally equivalent segment of the protein NS4A from other Hepacivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
Intrinsically disordered proteins4
- Protein-protein interactions involving intrinsically disordered proteins are important for cellular function and common in all organisms. (elifesciences.org)
- Experiments together with molecular modeling using NMR chemical shifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-affinity complex which is optimized by modulating direct interactions as well as dynamics, while tolerating several potentially disruptive mutations. (elifesciences.org)
- However, a group of proteins called 'intrinsically disordered proteins' are flexible in their shape and lack a stable three-dimensional structure. (elifesciences.org)
- analyzed the amino acid sequences of two specific intrinsically disordered proteins from different organisms to reconstruct the versions of the proteins that were likely found in their common ancestors 450-600 million years ago. (elifesciences.org)
Hydrolysis3
- These are the second stage product of protein hydrolysis obtained by treatment with slightly stronger acids and alkalies. (wikipedia.org)
- Derived proteins or mixtures of cleavage products produced by the partial hydrolysis of a native protein either by an acid or by an enzyme. (uams.edu)
- An enzyme that catalyzes the hydrolysis of proteins, including elastin. (lookformedical.com)
Characterization2
- We performed phylogenetic reconstruction, resurrection and biophysical characterization of two interacting disordered protein domains, CID and NCBD. (elifesciences.org)
- Conclusion: We propose that the "PIM ® profile" of characterization of proteins might be useful for the identification of proteins expressed by arthropod-borne viruses transmitted by Aedes aegypti mosquito. (eurekaselect.com)
Amino acid residues1
- In metalloproteins, metal ions are usually coordinated by nitrogen, oxygen or sulfur centers belonging to amino acid residues of the protein. (wikipedia.org)
Mitochondrial1
- Prof. Travis Beddoe is a multidisciplinary scientist, training initially as a plant biochemist before studying molecular chaperones in mitochondrial targeting as a PhD student (awarded March 2004), and eventually training in biophysical and structural biology in immune receptors as a postdoctoral researcher. (peerj.com)
Genes3
- Based on a comparative analysis of BPH and SBPH after transfer, the genes associated with sugar transporters and heat-shock proteins showed similar variation. (biomedcentral.com)
- Identification of these protein coding genes was achieved by similarity to the A. aegypti genome sequences using Mascot and OMSSA search engines. (biomedcentral.com)
- These results contribute to the gene annotation in this species of unknown genome and represent a small but important step toward the protein-level functional and localization assignment of trypsin-like serine peptidase genes in the Aedes genus. (biomedcentral.com)
Residues2
- The iron atoms are coordinated to the protein through the carboxylate side chains of a glutamate and aspartate and five histidine residues. (wikipedia.org)
- Objective: The objective of the present study was to search for the regularities of the proteins expressed by these five viruses, at residues level, and obtain a "bioinformatic fingerprint" to select them. (eurekaselect.com)
Biology7
- Cancer Cytogenetics: points and Protocols( Methods in Molecular Biology) single Тренинговая тетрадь по математике (задачи на. (private-art.com)
- established in the preferably kinetic materials in Molecular Biology detail information, years support pathways to their Responsible scientists, scientists of the intermolecular values and results, scope, long Turkish question soils, and words on anti-virus and taking given Magnetometers. (private-art.com)
- approaches: Students and Protocols( Methods in Molecular Biology) past EditionCardiac Gene camp: proteins and Protocols( Methods in Molecular Biology) applicable aggregation. (private-art.com)
- cells in Molecular Biology, monoxide 97 by Paul T. sites for correcting us about the apyrase. (private-art.com)
- Nature Reviews Molecular Cell Biology, vol. (private-art.com)
- Progress in Molecular Biology and Translational Science, vol. (private-art.com)
- Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Multimeric3
- Single chains of amino acids that are the units of multimeric PROTEINS. (rush.edu)
- Multimeric proteins can be composed of identical or non-identical subunits. (rush.edu)
- PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). (lookformedical.com)
Small proteins1
- Histatin 5 can be a major element of a small proteins family made by the parotid and submandibular glands [9]. (exposed-skin-care.net)
Cellular5
- By increasing the turnover of cellular structures as well as the clearance of long-lived protein and protein aggregates, the induction of autophagy has been linked to increased tolerance to a range of abiotic stressors in diverse ectothermic organisms. (bvsalud.org)
- Ubiquitins and ubiquitin-like proteins participate in diverse cellular functions, such as protein degradation and HEAT-SHOCK RESPONSE , by conjugation to other proteins. (nih.gov)
- Konstantinides N, Averof M. (2014) A common cellular basis for muscle regeneration in arthropods and vertebrates. (forth.gr)
- Nikoletopoulou V, Kyriakakis E, Tavernarakis N. (2014) Cellular and molecular longevity pathways: the old and the new. (forth.gr)
- A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (jefferson.edu)
Mediate1
- proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and Bleomycin solubility dmso IgG binding to the FcgammaRIIa receptor. (mdm2signals.com)
Enzymes2
- Thus, metalloproteins have many different functions in cells, such as storage and transport of proteins, enzymes and signal transduction proteins, or infectious diseases. (wikipedia.org)
- The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS). (harvard.edu)
Gene7
- Nearly all these proteins are subunits of known or predicted multiprotein complexes, in agreement with the balance hypothesis of evolution of gene copy number. (biomedcentral.com)
- The gene set of the last common ancestor of the crown group consists of 3,413 KOGs and largely includes proteins involved in genome replication and expression, and central metabolism. (biomedcentral.com)
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function. (uchicago.edu)
- Methods】 An antennal binding protein gene was cloned by PCR, and the stage- and tissue-specific expressions of the gene were profiled using real-time quantitative PCR. (insect.org.cn)
- Results】 The antennal binding protein gene cloned was named as PxylOBP31 (GenBank accession no. (insect.org.cn)
- Gene-level and nucleotide-level parallelisms between independently-evolving lineages show the centrality of the DnaJ/DnaK chaperone system in the heat resistance of L. pneumophila. (authorea.com)
- If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. (gephebase.org)
Vitro2
- Recombinant Lon-1 manifested properties of an ATP-dependent chaperone-protease in vitro but did not complement an E. coli Lon mutant, while Lon-2 corrected two characteristic Lon-mutant phenotypes. (researchwithrutgers.com)
- However, we also identified a subset of deletion variants that were synthesized in quantities similar to the WT proteins, secreted under in vitro conditions and bound to the bacterial surface. (mi-rna.com)
Methods2
- Methods】 A yeast two-hybrid system was constructed to screen the interacting proteins of EcR and USP from Spodoptera litura , an important agricultural pest. (insect.org.cn)
- The ancestral proteins were then 'resurrected' by recreating them in test tubes and their characteristics and properties analyzed with experimental and computational biophysical methods. (elifesciences.org)
Genetics2
- Human Molecular Genetics, vol. (private-art.com)
- Human Molecular Genetics, Neolithic pieces of the National Academy of Sciences of the United States of America, vol. (private-art.com)
Evolutionary2
- The abundance of metal binding proteins may be inherent to the amino acids that proteins use, as even artificial proteins without evolutionary history will readily bind metals. (wikipedia.org)
- 2014) E(spl): genetic, developmental, and evolutionary aspects of a group of invertebrate Hes proteins with close ties to Notch signaling. (forth.gr)
Nucleoproteins1
Preferentially1
- Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT. (umassmed.edu)
Homolog1
Metalloproteins1
- For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains although there may be up to 3000 human zinc metalloproteins. (wikipedia.org)
Subunits4
- Protein Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- This graph shows the total number of publications written about "Protein Subunits" by people in this website by year, and whether "Protein Subunits" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "Protein Subunits" by people in Profiles. (rush.edu)
- Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits. (lookformedical.com)
Bacteria1
- The canonical ATP-dependent protease Lon participates in an assortment of biological processes in bacteria, including the catalysis of damaged or senescent proteins and short-lived regulatory proteins. (researchwithrutgers.com)
Transcriptional1
Organisms2
- Proteins synthesized by organisms belonging to the phylum ARTHROPODA . (nih.gov)
- The Hsp90 molecular chaperone has been implicated as a contributor to evolution in several organisms by revealing cryptic variation that can yield dramatic phenotypes when the chaperone is diverted from its normal functions by environmental stress. (bcm.edu)
Aggregation1
- In line with our hypothesis, we report that flies exposed to heat-stress present signs of protein aggregation and appear to trigger an autophagy-related homoeostatic response as a result. (bvsalud.org)
Heat shock p2
- Conclusion】 Our data suggest that heat shock protein chaperone and ubiquitylation may play roles in the regulation of EcR/USP, and this will contribute to the understanding of insect metamorphosis. (insect.org.cn)
- The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. (jefferson.edu)
Therapeutic1
- Additionally, she has a special interest in the therapeutic uses of arthropods venoms, particularly in neurodegenerative diseases and cancer. (peerj.com)
Identification4
- A similar approach could be envisaged for the identification of blood meal source and the detection of insecticide resistance in Anopheles and to other arthropods and pathogens. (nature.com)
- In the present work, we further analyzed the peptidase expression in the midgut of sugar-fed females using 1DE-substrate gel zymography, two-dimensional electrophoresis (2DE), mass spectrometry (MS), and protein identification based on similarity. (biomedcentral.com)
- Our proteomic approach allowed the identification of two different trypsin-like serine peptidases and one chymotrypsin in protein spots of the alkaline region in 2DE map of the A. albopictus female midgut. (biomedcentral.com)
- Recently, the entire genome of this ectoparasitoid wasp was sequenced, enabling the identification of 79 venom proteins. (mdpi.com)
Mosquito1
- Background: The female Aedes aegypti mosquito is a vector of several arthropod-borne viruses, such as Mayaro, Dengue, Chikungunya, Yellow Fever, and Zika. (eurekaselect.com)
Interactions7
- These shared dynamics want home of the most also invited similar molecular filters: experimental proteins for their results, bioengineering Terms for in successful Detection, site for word, such libraries, and relevant interactions. (private-art.com)
- However, it is not clear how such interactions emerge and evolve on a molecular level. (elifesciences.org)
- At multiple time points during evolution, new or modified proteins - and consequently new potential interactions between proteins - have emerged. (elifesciences.org)
- The findings shed light on fundamental principles of how new protein-protein interactions emerge and evolve on a molecular level. (elifesciences.org)
- A next step for the future will be to investigate how other protein-protein interactions have evolved and to identify general underlying patterns. (elifesciences.org)
- A deeper knowledge of how this molecular evolution happened will broaden our understanding of present day protein-protein interactions and might aid the design of drugs that can mimick proteins. (elifesciences.org)
- Interactions between chaperone and energy storage networks during the evolution of Le. (authorea.com)
Roles1
- Yet, these proteins play important roles in many processes that require the protein to interact with a number of other proteins. (elifesciences.org)
Bound3
- Most metals in the human body are bound to proteins. (wikipedia.org)
- Proteins that have one or more tightly bound metal ions forming part of their structure. (bvsalud.org)
- The results showed that the ancestral proteins created weaker bonds between them compared to more 'modern' ones, and were more flexible even when bound together. (elifesciences.org)
Urine1
- A member of the serpin family of proteins that is found in plasma and urine. (lookformedical.com)
Fundamental2
- It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
- Uncovering the functions of ABPs in olfactory recognition of the diamondback moth, Plutella xylostella (L.), is fundamental to revealing the molecular mechanisms of olfaction of the moth. (insect.org.cn)
Ligands1
- Perhaps most famous are the tetradentate N4 macrocyclic ligands incorporated into the heme protein. (wikipedia.org)
Structures1
- Although they take part in the assembly process, molecular chaperones are not components of the final structures. (jefferson.edu)
Assays1
- Then the binding properties of the antennal binding protein to 39 ligand compounds were detected by fluorescence competitive binding assays. (insect.org.cn)
Mechanisms2
- Investigating the potential molecular mechanisms associated with white spot virus resistance in Carcinus maenas. (exeter.ac.uk)
- This study aims to explore the regulation mechanisms of EcR/USP from the aspects of protein interaction. (insect.org.cn)
Replication1
- The residual ability of strains expressing sseBΔ2 or sseBΔ3 to translocate effector proteins appears to be insufficient to confer the ability of intracellular replication. (mi-rna.com)
Interact1
- However, no protein was identified to interact with EcRA. (insect.org.cn)
Specific5
- Mechanism of the small ATP-independent chaperone Spy is substrate specific. (harvard.edu)
- Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. (rush.edu)
- The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. (lookformedical.com)
- Protein domains predicted as putative transmembrane regions or coiled-coil regions were deleted, as well as N- or C-terminal portions, and previously defined binding regions for the specific chaperone SseA [9, 10]. (mi-rna.com)
- The specific order of amino acids in a protein determines its shape and structure, which in turn controls what the protein can do. (elifesciences.org)
Oxygen1
- Hemocyanins carry oxygen in the blood of most mollusks, and some arthropods such as the horseshoe crab. (wikipedia.org)
Variation1
- The capacity of Hsp90 to modulate repeat-tract lengths suggests that the chaperone, in addition to exposing cryptic variation, might facilitate the expression of new phenotypes through induction of novel genetic variation. (bcm.edu)
Species3
- The approximately 40% of KOGs that are represented in six or seven species are enriched in proteins responsible for housekeeping functions, particularly translation and RNA processing. (biomedcentral.com)
- Here we explore the potential role of Hsp90 in modulating the stability of nucleotide repeats, which in a number of species, including humans, exert subtle and quantitative consequences for protein function, morphological and behavioral traits, and disease. (bcm.edu)
- Proteins found in any species of helminth. (bvsalud.org)
Complexes1
- Endopeptidases are relatively small molecules (~25-30 kDa) that can pass through peritrophic membrane pores and endoperitrophic spaces in insects, where they cleave large protein complexes. (biomedcentral.com)
Biogenesis1
- Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis. (harvard.edu)
Results1
- Results: In total, 1736 proteins were identified from the 559228 "reviewed" proteins from the UniProt database, with similar "PIM ® profile" to the 29 mutated proteins that express the five groups of arboviruses. (eurekaselect.com)
Family2
- A family of proteins that are structurally-related to Ubiquitin. (nih.gov)
- A group of seed storage proteins restricted to the POACEAE family. (lookformedical.com)