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  • myosin heavy
  • heart failure Myosin heavy chain 7 cardiac muscle-b (MYH7) Mouse studies suggest a cluster of long noncoding RNAs (lncRNAs) encoded by Myh7 loci. (biocentury.com)
  • Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiomyopathy Myosin heavy chain 7 cardiac muscle-b (MYH7) Mouse studies suggest RNAi that targets a disease-causing mutation in MYH7 could help prevent hypertrophic cardiomyopathy. (biocentury.com)
  • Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Myocardial infarction (MI) Myosin heavy chain 6 cardiac muscle-a (MYH6) Mouse studies suggest blocking autoimmune activity against cardiac myosin could help reduce damage following. (biocentury.com)
  • antibodies
  • To achieve efficient, targeted intracellular delivery of therapeutic agents to mesothelioma cells, we selected a naive human single-chain (scFv) phage antibody display library directly on the surface of live mesothelioma cells to identify internalizing antibodies that target mesothelioma-associated cell surface antigens. (aacrjournals.org)
  • The content of ferritin H and L chains in each layer was determined by western blotting with chain-specific antibodies. (molvis.org)
  • peptide
  • The authors find the monolayer consists of close-packed perfluoroalkanes standing more or less upright and of H-bonded chains of peptide groups. (epfl.ch)
  • polymer chains
  • The conformational relaxation of single polymer chains in uniaxially elongated poly(methyl methacrylate) (PMMA) films were examined by direct observation using scanning near-field optical microscopy ( SNOM ) and excitation polarization modulation microscopy (EPMM). (rsc.org)
  • The permeation was dependent on the molecular weight of PEG and the different conformational preferences of the polymer chains. (ucl.ac.uk)
  • amyloid
  • Eisenberg and his research team found that of the entire tau protein, a small chain of just six amino acids -- abbreviated VQIVYK -- was responsible for the formation of amyloid fibers. (natap.org)
  • Restoration of autophagic flux by pharmacological intervention using rapamycin protected against amyloidogenic light chain protein‐induced pathologies including contractile dysfunction and cell death at the cellular and organ level and also prolonged survival in an in vivo zebrafish model of amyloid cardiotoxicity. (embopress.org)
  • Collectively, these findings detail the downstream molecular mechanisms underlying AL amyloid cardiomyopathy and highlight potential targeting of autophagy and lysosomal dysfunction in patients with amyloid cardiomyopathy. (embopress.org)
  • acids
  • Specific polypeptides investigated include small chains of pure and mixed alanine, glutamate, leucine, lysine and methionine (all amino acids with strong helix-forming propensities), as well as glycine, proline(having a low helix forming propensities), tyrosine, serine and arginine. (aps.org)
  • Imbs AB, Dang LPT, Rybin VG, Nguyen NT, Pham LQ (2015) Distribution of Very-Long-Chain Fatty Acids between Molecular Species of Different Phospholipid Classes of Two Soft Corals. (omicsonline.org)
  • This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. (eurekaselect.com)
  • lysine
  • Following the linkage of the first ubiquitin, additional molecules of ubiquitin are attached to the previously conjugated moiety to form branched polyubiquitin chains employing lysine (K) linkage K29, K48, or K63 ( 45 ). (asm.org)
  • It has been proposed that the fate of a substrate may depend on the length of the chain as well as the lysine linkage (K29, K48, or K63) involved in forming the chain. (asm.org)
  • species
  • The crystalstructure of the p-aminobenzoate species 2 shows the formation of aone-dimensional polymeric chain resulting from the axial binding of thependant p-amino group to one copper center belonging to another dimericunit. (iisc.ernet.in)
  • cell
  • Fiber cell ferritin L chains were 30 kDa (modified from the normal 19 kDa), and were present at the highest level in the outermost layers of both cataractous and non-cataractous lenses. (molvis.org)
  • We have given attention to oligosaccharide chains as the key parti,cipants in cell-cell recognitions of various biological events. (nii.ac.jp)
  • fiber
  • It was determined in an earlier study that ferritin-heavy (H) and -light (L) chains in lens fiber cells are modified in comparison to those in lens epithelial cells. (molvis.org)
  • The purpose of the present study was to determine whether changes in ferritin chain characteristics are developmental, age-related, or associated with cataractogenesis, by analyzing the distribution of modified chains throughout the lens fiber mass. (molvis.org)
  • The amount of modified L chains decreased gradually in the inner layers of the fiber mass, and was undetectable in the inner two layers of cataractous lenses. (molvis.org)
  • However, in these cataractous lenses, the normal-sized ferritin H chains (21 kDA) appear in small quantities in the outer fiber layers, and increase in quantity and size (to 29 kDa) in the inner layers. (molvis.org)
  • Both ferritin H and L chains were modified in lens fiber cells from normal and cataractous canine lenses. (molvis.org)
  • These modifications were not age-related, and most likely occur during the differentiation of epithelial cells to fiber cells, since only normal-sized chains have been found in lens epithelial cells. (molvis.org)
  • In addition, there was a specific and distinct distribution of these modified chains throughout the lens fiber mass. (molvis.org)
  • The most striking differences between normal and cataractous lenses fiber cells were the appearance of normal-sized ferritin H chains and the relatively even distribution of iron binding capacity throughout the fiber mass of the cataractous lenses. (molvis.org)
  • consistent
  • Assuming that the viral phylogeny should be consistent with the "true" transmission history, transmission chains allow assessment of the accuracy and reliability of phylogenetic reconstructions ( 19 ). (pubmedcentralcanada.ca)
  • molecules
  • The coupling of anions and organic molecules rotates the g-tensor out of the molecular plane creating magnetically nonequivalent sites on neighboring chains at domain walls. (hindawi.com)
  • In contrast, parallel aligned and helical PEG 500 chains represented a denser molecular sieve which is only permeable for small molecules 0.3 nm in size. (ucl.ac.uk)
  • towards
  • Interestingly, in cataractous lenses, the modified H chains were found in decreasing amounts towards the interior of the lens, and were undetectable in the nucleus. (molvis.org)
  • structure
  • By describing the relationship between the molecular structure and an important physiochemical property of surface-tethered PEG films, our findings on controllable semipermeable interfaces may be exploited for electrical sensor surfaces. (ucl.ac.uk)
  • The structure of self-assembled monolayers of a long-chain perfluoro mercaptan was studied by using mol. (epfl.ch)
  • different
  • We were able to identify and quantify the molecular footprint of drug-selective pressure in pol using maximum likelihood inference under different codon substitution models. (pubmedcentralcanada.ca)
  • analysis
  • The MINFLUX concept begins a new chapter and opens up unprecedented opportunities in the optical analysis of molecular systems. (mpg.de)
  • short
  • At the early stage of the stress relaxation process, not only the segmental orientation but also the whole chain dimension of the long chain decreased faster in matrices with short chains. (rsc.org)
  • This indicates that the relaxation at the whole chain scale is accelerated by disentanglement, which is caused by the motion of the short surrounding chains. (rsc.org)
  • We present the results of a computational study of the free energy landscapes of short polypeptide chains, as a function of several reaction coordinates meant to distinguish between several known types of helices. (aps.org)
  • DNA polymerases, whether from humans, bacteria, or viruses, cannot copy a chain of DNA without a short sequence of nucleotides to "prime" the process, or get it started. (biocyclopedia.com)
  • heavy
  • Ferritin is a heteromultimeric complex consisting of 24 subunits of two types: light (L)-chain (19 kDa) and heavy (H)-chain (21 kDa). (molvis.org)
  • long chain
  • The fast relaxation in the whole chain dimension cannot be explained by the constraint release picture in the theoretical models, which assumes that the disentanglement only activates the local motion of the long chain. (rsc.org)
  • known
  • More recently, the importance of chains conjugated through the other six lysines in Ub, known as atypical Ub chains, has been revealed. (embopress.org)
  • We show that molecular evolutionary analyses, guided by a known transmission history, can reveal the presence of confounding factors like natural selection and caution should be taken when accurate descriptions of HIV evolution are required. (pubmedcentralcanada.ca)
  • various
  • Oligoacetylacetones and their imine derivatives behave as molecular clay ropes that are convenient to construct various nanostructures. (nature.com)