Molecular carcinoma hepatocellular. Medical search. Frequent questions

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (wikipedia.org)
citation needed] Young adults afflicted by the rare fibrolamellar variant of hepatocellular carcinoma may have none of the typical risk factors, such as cirrhosis and hepatitis. (wikipedia.org)
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver (see the image below) that occurs predominantly in patients with underlying chronic liver disease and cirrhosis . (medscape.com)
Liver fibrosis is a chronic, highly prevalent disease that may progress to cirrhosis and substantially increases the risk for development of hepatocellular carcinoma (HCC). (mdpi.com)
Moreover, HBV/HDV co-infection leads to the most severe form of viral hepatitis with an accelerated progression to liver fibrosis, cirrhosis and hepatocellular carcinoma. (researchsquare.com)
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease worldwide, it causes chronic hepatitis, which leads to cirrhosis and hepatocellular carcinoma. (scirp.org)
The more typical form of hepatocellular carcinoma is often associated with active hepatic inflammation, hepatitis B or C viral infection, alcohol-related liver disease, nonalcoholic fatty liver disease (NAFLD), cirrhosis from any other cause, or dietary aflatoxin B1. (medscape.com)
Viral infections is the cause of liver inflammation, cirrhosis and even liver hepatocellular carcinoma (HCC). (bvsalud.org)
The information retrieved by this causes a silent chronic hepatic illness that can lead to fibrosis, analysis not only has immediate application in local public health cirrhosis and hepatocellular carcinoma [3]. (cdc.gov)
However, infected persons are a source of transmission to others and are at risk for cirrhosis and hepatocellular carcinoma decades after infection. (cdc.gov)
Infection with HBV results in a wide spectrum of acute and chronic liver diseases that may lead to cirrhosis and hepatocellular carcinoma. (cdc.gov)
Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. (who.int)

Javier Camacho , " Molecular Oncology: Principles and Recent Advances ", Bentham Science Publishers (2012). (benthamscience.com)
Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. (cdc.gov)

Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC. (wikipedia.org)
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world with a very poor prognosis. (figshare.com)
Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
In particular, upregulation of the ASPM gene has been studied in brain tumors called gliomas and liver tumors called hepatocellular carcinomas. (medlineplus.gov)
A variant of FLC, known as mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) and characterized by the presence of both FLC and conventional HCC components within the same tumors, has also been reported. (medscape.com)
In general, the tumors in patients with hepatocellular carcinoma (HCC) are discovered either during routine screening or when symptomatic because of their size or location. (medscape.com)

ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)

Another recent study used proteomic profiling of liver biopsies to describe the molecular landscape of hepatocellular carcinoma, the most common type of liver cancer. (cdc.gov)

Although FLC was historically considered to be a histologic variant of hepatocellular carcinoma (HCC), it is currently recognized as a distinct clinical entity with respect to its epidemiology, etiology, and prognosis. (medscape.com)
Fibrolamellar carcinoma is a rare primary hepatic malignancy that was first described as a pathological variant of hepatocellular carcinoma by Edmondson in 1956. (medscape.com)

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma. (nature.com)

A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. (benthambooks.com)
Various mouse models for HCC were developed to study the molecular mechanisms involved in various stages of liver cancer [ 5 ]. (biomedcentral.com)
Therefore, it is imperative to clarify the molecular mechanisms of HCC to discover novel therapeutic targets and improve the treatment options. (hindawi.com)
Hepatocellular carcinoma (HCC) is a major type of death-causing cancer whose pathological mechanisms are not fully understood. (jcancer.org)
In this study, we investigated the functional role of eukaryotic initiation factor 5B (EIF5B) in hepatocellular carcinoma (HCC) and the underlying mechanisms. (techscience.com)
Therefore, a better understanding of the molecular mechanisms underlying HCC growth and progression is necessary to develop more effective treatment strategies for HCC. (techscience.com)
It is generally recognized that exploring the underlying molecular mechanisms of HCC initiation and progression in order to search for functional molecular targets may provide a new approach for HCC treatment. (spandidos-publications.com)
Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma. (nih.gov)
Our group therefore studies several factors in order to understand the molecular mechanisms of disease development. (lu.se)
To investigate the molecular mechanisms that underlie metabolic remodelling, mostly in mouse and cell models. (lu.se)

To determine metabolites that drive the development of human hepatocellular carcinoma (HCC). (lu.se)
sodium dichromate (Na2Cr2O7), cadmium chloride (CdCl2) and nickel chloride (NiCl2) on RAW 264.7 mouse monocyte macrophage cells and HepG2/C3A human hepatocellular carcinoma cells. (cdc.gov)

These molecular alterations are implicated in the development and progression of HCC, and they have been exploited as targets for therapy. (eurekaselect.com)
Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)

Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
Calderaro J, Ziol M, Paradis V and Zucman-Rossi J: Molecular and histological correlations in liver cancer. (spandidos-publications.com)
Sia D, Villanueva A, Friedman S and Llovet J: Liver cancer cell of origin, molecular class, and effects on patient prognosis. (spandidos-publications.com)
Teisseyre A, Gąsiorowska J and Michalak K: Voltage-gated potassium channels Kv1.3-potentially new molecular target in cancer diagnostics and therapy. (spandidos-publications.com)
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide and is the third highest cause of cancer-related death ( Block et al, 2003 ). (nature.com)
We used diethylnitrosamine (DEN) injection to initiate liver cancer in mice and assessed the extent of liver cancer in JDP2-transgenic and wild type control mice by biochemical and molecular biology techniques. (biomedcentral.com)
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer. (biomedcentral.com)
In this chapter, I briefly review these epidemiological findings and the three molecular pathways currently proposed to link body weight gain and cancer risk. (benthamscience.com)
Despite the fact that these molecular pathways, vary and depend on both sex and the type of cancer, I briefly discuss the possible roles of three hormonal systems, the adipose derived hormones, the Insulin-Like Growth Factor (IGF) axis and sex steroids, in linking obesity and cancer risk. (benthamscience.com)
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and N6-methyladenosine (m 6 A) is a predominant internal modification of RNA in various cancers. (hindawi.com)
Hepatocellular carcinoma (HCC), one of the most common malignancies, ranks second among the leading causes of cancer-related death globally [ 1 ]. (hindawi.com)
1 Hepatocellular carcinoma (HCC) has been the fastest rising cause of cancer-related deaths in the United States, increasing by 2% to 3% annually. (ajmc.com)
Hepatocellular carcinoma (HCC), ranking the fourth of cancer-associated mortality, leads to a threat to increasing life expectancy globally [ 1 ]. (jcancer.org)
According to the World Health Organization (WHO), hepatocellular carcinoma (HCC) is the fifth most common cause of cancer worldwide [ 1 ]. (techscience.com)
Molecular heterogeneity is one of the most important concerns in colorectal cancer (CRC), which results in a wide range of therapy responses and patient prognosis. (biomedcentral.com)
Liver hepatocellular carcinoma (LIHC) represents the vast majority of primary liver cancers, which leads to the second most cancer-related mortality worldwide [ 1 ]. (hindawi.com)
Fibrolamellar carcinoma (FLC) is a primary liver cancer that occurs in adolescents and young adults without underlying liver disease. (medscape.com)
Hepatocellular carcinoma (HCC) is the twelfth most common cancer and the fifth leading cause of worldwide cancer related death. (bvsalud.org)
Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey. (cdc.gov)
A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients. (cdc.gov)
A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases. (who.int)

Recently, HCC -a tumor renowned to be refractory to systemic chemotherapy- has attracted wide interest as a result of improved understanding of its molecular biology and pathogenesis. (eurekaselect.com)
Within the last years the detailed characterization of critical molecular pathways implicated in the pathogenesis of HCC has uncovered therapeutic targets that are being explored because of their effectiveness in the prevention and treatment of HCC [3,4]. (exposed-skin-care.net)
Molecular pathogenesis of hepatocellular carcinoma. (medscape.com)

Hepatocellular carcinogenesis typically begins with chronic inflammation of hepatocytes that progressively transform into invasive carcinoma. (eurekaselect.com)

[ 14 ] both of which again highlighted the young age of onset and the relatively good prognosis that continue to distinguish fibrolamellar carcinoma from conventional hepatocellular carcinoma. (medscape.com)
In contrast, the etiology of fibrolamellar carcinoma remains unclear. (medscape.com)
[ 17 ] and no histological precursor lesion to fibrolamellar carcinoma has been identified. (medscape.com)

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. (wjgnet.com)
Here, we demonstrate that hepatitis B virus-positive hepatocellular carcinoma (HCC) could successfully be identified from non-tumor liver tissues by supervised learning analysis of gene expression profiling. (elsevierpure.com)
However, it is still enigmatic about the exact processes in which RBPs-encoding genes and the relevant genes participate in transcriptome level during the biogenesis of secondary tumor in the activity of hepatocellular carcinoma (HCC) cells. (peerj.com)
Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma. (bvsalud.org)
Patient perspectives on molecular tumor profiling: 'Why wouldn't you? (cdc.gov)

Although the therapies of HCC have undergone rapid progress during the past decades, ranging from surgical and local treatment to molecular-targeted therapy and immunotherapy, the prognosis is undesirable [ 2 , 3 ]. (hindawi.com)
miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery. (cdc.gov)

Introduction Hepatocellular carcinoma (HCC) may be the most common primary liver malignancy in adults [1]. (exposed-skin-care.net)

This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. (benthambooks.com)
Cellular and Molecular Biology , 61 (3), 12-16. (cellmolbiol.org)
Cellular and Molecular Biology (CMB) is an international peer-reviewed journal in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology. (cellmolbiol.org)
Background: Molecular biology (MB) is an essential tool for the diagnosis and evaluation of treatment efficacy against viral hepatitis. (bvsalud.org)

Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular carcinoma (HCC). (nature.com)
Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial. (nature.com)
In this study, we aimed at characterizing extracellular transcriptome gene networks of hepatocellular carcinoma patients compared to healthy controls. (frontiersin.org)
Survival in patients with transfusion-dependent thalassemias (TDT) has increased, and complications such as hepatocellular carcinoma (HCC) are emerging. (thalassaemia.org.cy)
Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation. (medscape.com)
Small hepatocellular carcinoma in patients with chronic liver damage: prospective comparison of detection with dynamic MR imaging and helical CT of the whole liver. (medscape.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. (nature.com)
Sorafenib in advanced hepatocellular carcinoma. (nature.com)
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. (nature.com)

Therapeutic Vaccines against Hepatocellular Carcinoma in the Immune Checkpoint Inhibitor Era: Time for Neoantigens? (wjgnet.com)
The absence of NFAT2 and Egr2 in carcinoma tissues reminded us that NFAT2 may be a promising therapeutic target for hepatocellular carcinoma treatment. (researchsquare.com)
Therefore, research on hepatocellular transformations in initiation and development of HCC and identifying effective biomarkers for novel therapeutic option are still emergency challenges. (researchsquare.com)

McGlynn KA, Petrick JL and El-Serag HB: Epidemiology of hepatocellular carcinoma. (spandidos-publications.com)
The In the present work, we performed a molecular survey of the epidemiology of HCV shows some geographic features for the HCV variants that circulate in Mar del Plata and, using sequence different subtypes. (cdc.gov)
Molecular epidemiology of hepatitis C virus in Cambodia during 2016-2017. (who.int)

Neoantigen vaccine: An emerging immunotherapy for hepatocellular carcinoma. (wjgnet.com)

However, alterations in key molecular pathways such as for example WNT/-catenin, hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met), vascular endothelial growth factor (VEGF), insulin like growth factor receptor (IGF1R) and epidermal growth factor receptor (EGFR) are normal to HCC development [4-6]. (exposed-skin-care.net)

Gene disruption studies placed c-Jun as an oncogene at the early stage of a mouse model of hepatocellular carcinoma. (biomedcentral.com)
Our study thus demonstrates the feasibility of performing gene co-expression network analysis from cell-free RNA data and its utility in studying hepatocellular carcinoma. (frontiersin.org)
Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. (nih.gov)
The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. (nih.gov)
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. (medscape.com)

Molecular genetics and targeted therapeutics in biliary tract carcinoma. (bu.edu)

Background & Aims: Chronic hepatitis B viral (HBV) infection still raises a high threat for hepatocellular carcinoma (HCC) worldwide, especially in Asia. (edu.hk)
This review of scientific publications aims to establish the detrimental effects of aflatoxin-contaminated foods and highlights the correlation between aflatoxin and hepatitis B viral-associated hepatocellular carcinoma. (bvsalud.org)
Matching viral hepatitis and HIV surveillance registries, and molecular epidemiologic assessments, can facilitate early detection of social networks of HCV transmission among MSM with HIV infection. (cdc.gov)

Bruix J, Gores GJ and Mazzaferro V: Hepatocellular carcinoma: Clinical frontiers and perspectives. (spandidos-publications.com)

Resistance to chemotherapeutic drugs is a major obstacle in hepatocellular carcinoma (HCC) therapy. (cellmolbiol.org)

Until no far past, advanced hepatocellular carcinoma (HCC) was considered as an "orphan" disease in terms of effective molecules when compared with other highly prevalent cancers worldwide. (eurekaselect.com)
Hepatocellular carcinoma (HCC) has become the leading cause of deaths that are caused by all cancers worldwide [1] and the incidence and mortality of HCC are increasing at a faster pace than other cancers, which trend will continue through at least 2030 in United States [2]. (researchsquare.com)

However, the precise molecular mechanism underlying this phenomenon remains unclear. (bvsalud.org)

Hepatocellular carcinoma (HCC) is a highly lethal disease, therefore effective and tolerable treatment is urgently needed. (eurekaselect.com)
Liver hepatocellular carcinoma (LIHC) remains a lethal disease for humans. (hindawi.com)

In almost all (90%) of cases HCC may be the late complication of the chronic liver disease seen as a sustained liver damage, inflammation and hepatocellular proliferation. (exposed-skin-care.net)

These events are associated with molecular abnormalities and chromosomal alterations. (eurekaselect.com)
Genomic and Molecular Abnormalities in Gynecologic Clear Cell Carcinoma. (bu.edu)

Fujiwara N, Friedman S, Goossens N and Hoshida Y: Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine. (spandidos-publications.com)
The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (wikipedia.org)
A suspected contributor to this increased risk is circulating insulin concentration such that diabetics with poor insulin control or on treatments that elevate their insulin output (both states that contribute to a higher circulating insulin concentration) show far greater risk of hepatocellular carcinoma than diabetics on treatments that reduce circulating insulin concentration. (wikipedia.org)
TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia. (who.int)
Further, non-alcoholic fatty liver disease, a form of ectopic fat deposition as a result of energy imbalance, is associated with increased risk of T2D, CVD and hepatocellular carcinoma. (lu.se)

In the present article, we aimed to critically review experimental evidence regarding the active components and the molecular bases underlying the beneficial role of coffee against chronic liver diseases. (mdpi.com)

The incidence of hepatocellular carcinoma (HCC) is rising in many Western countries, but has always been high in Eastern countries. (benthambooks.com)

In paper 3, we used ML to identify novel molecular features associated with non-alcoholic fatty liver disease (NAFLD). (lu.se)

For example, the TIME of hepatocellular carcinoma (HCC) has been widely studied for its ability to coexist and successfully interact with immune cells to promote its metastatic growth throughout the body. (news-medical.net)
By cataloguing the molecular processes by which cells maintain and modify protein levels, proteomic studies offer another dimension of information that may help advance our understanding of health and disease. (cdc.gov)

Anatomy10

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