AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth Care
Molecular BiologyCell BiologyBiologyModels, BiologicalSystems BiologyDevelopmental BiologySignal TransductionComputational BiologyCell Cycle ProteinsModels, GeneticProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsModels, MolecularHistory, 20th CenturySynthetic BiologyProtein Structure, TertiaryHistory, 21st CenturyNuclear ProteinsApoptosisProtein-Serine-Threonine KinasesDNA-Binding ProteinsDNA RepairDNA DamageSocieties, ScientificCellsNobel PrizePhosphorylationCell Physiological PhenomenaSoftwareGenomicsBiotechnologyMolecular Sequence DataInternetGene Expression ProfilingStem CellsBiochemistryAlgorithmsResearchNeoplasmsDatabases, GeneticDirectories as TopicHistory, 19th CenturyProteinsGeneticsBase SequenceCell DifferentiationDatabases, FactualAmino Acid SequenceSequence Analysis, DNABiological EvolutionGene Expression RegulationHuman Genome ProjectMutationGenetic TechniquesPhylogenyProteomicsComputer SimulationAllergy and ImmunologyPhenotypePolymerase Chain ReactionOligonucleotide Array Sequence AnalysisGenomeInformation Storage and RetrievalGenetic EngineeringUser-Computer InterfaceGene Regulatory NetworksDNACell Physiological ProcessesForensic SciencesScienceDatabase Management SystemsLaboratoriesCytological TechniquesEvolution, MolecularPlantsSequence AlignmentGene ExpressionMicroscopyRegenerative MedicineRegenerationMetabolic Networks and PathwaysStudentsProgramming LanguagesMolecular Targeted TherapyRNA, MessengerCell ProliferationProteomeTeachingBiomedical ResearchRNADatabases, ProteinPlanariansTranscription FactorsTerminology as TopicCloning, MolecularMicrofluidic Analytical TechniquesUniversitiesBiochemical PhenomenaCells, Cultured
BiochemistryGenetics2023MicrobiologyMechanismsLaboratoryTight junctionsStructuralPathwaysBiotechnologyBiolPharmacologyResearchVitroMembranesDifferentiationMitosisLundGeneticInflammationFacultyDepartmentDevelopmentalSearchProcessesGene expressionApoptosisEnzymesMicrobialQuantitativeExcellenceBiochemicalSickle cell anEpigeneticEucaryoticTumorigenesisEpithelial CellsTissuesUniversityNeuroscienceRegulationSequenceDynamicsPlant cellsStemExperimentationReplicationHoffmannPatternsSciencesProteinsCycle progression
Biochemistry10
Genetics4
20234
Microbiology3
Mechanisms8
  • Specifically, our research focuses on unveiling the molecular mechanisms and the modifications of the epigenetic landscape that govern cellular plasticity and determine cell-fate changes that ensure tissue regeneration upon injury and adaptation to environmental changes in disease. (ucl.ac.uk)
  • These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
  • consequently cells have evolved a variety of mechanisms to repair double-strand breaks (DSBs). (brandeis.edu)
  • Dr. Piri's research is aimed toward understanding the molecular mechanisms leading to retinal ganglion cells (RGC) death in glaucoma. (uclahealth.org)
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • Pursue excellence in the following programmatic research areas through strategic hires, grant acquisitions and scholarly publications: Microbial Pathogenesis and Antibiotic Resistance, Structural and Computational Biology Molecular Cell Biology, Molecular basis of gene expression Mechanisms of genomic instability Biology of aging Serve the University, Scientific and greater community by providing intellectual resources and engaging in scholarly activities that are consistent with our education and research missions. (usf.edu)
  • Although he had always had a keen interest in molecular biology, as an undergraduate Tsukita was drawn to histology, and his first interest was to identify axonal transport mechanisms. (rupress.org)
Laboratory9
  • The Scholarship will consist of financial support for a single year of tuition at the Honours level, if taken within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)
  • I am intending to commence Honours (year 4) within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)
  • intend to commence an Honours program within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)
  • The Brohawn laboratory researches the molecular basis of sensory transduction and cellular electrical signaling. (berkeley.edu)
  • These PCR- and qPCR-based mycoplasma assays allow fast (within a few hours), simple, effective and sensitive detection of mycoplasma-contaminated cell cultures in any standard molecular biology laboratory. (cambio.co.uk)
  • The Medical Research Council ( MRC ) Laboratory of Molecular Biology ( LMB ) is a research institute in Cambridge , England , involved in the revolution in molecular biology which occurred in the 1950-60s. (wikipedia.org)
  • Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health. (wikipedia.org)
  • It is an essential laboratory procedure in the molecular cloning of DNA, whereby DNA fragments are joined to create recombinant DNA molecules (such as when a foreign DNA fragment is inserted into a plasmid). (wikipedia.org)
  • The DNA ligase from E. coli cannot ligate blunt-ended DNA except under conditions of molecular crowding, and it is therefore not normally used for ligation in the laboratory. (wikipedia.org)
Tight junctions1
  • Early in his career, Tsukita succeeded in isolating and purifying the adherens junction with his wife Sachiko, an accomplishment that he followed up with an impressive series of discoveries of cell adhesion and cytoskeletal molecules, including what may have been his greatest contribution to the field, the identification of occludin and the claudin family of molecules, which were watershed discoveries in the study of the molecular nature of tight junctions. (rupress.org)
Structural1
  • If you are interested in joining one of the world's leading research intensive universities to deliver significant and transformative advances in a wide range of areas of Structural and Chemical Biology, Cell Proliferation and Differentiation, Regulation of gene expression or Channels, Receptors and Signalling, please see our current vacancies below. (le.ac.uk)
Pathways5
  • These signals are transmitted to specific targets within the cell by intracellular signalling pathways that employ post-translational modifications, particularly phosphorylation. (manchester.ac.uk)
  • This unit will cover how key signalling pathways in cells transduce extracellular signals to regulate gene expression and cellular processes such as growth and apoptosis. (manchester.ac.uk)
  • Intracellular signalling pathways: covering the major pathways in cells (MAPK, PI3K-AKT, mTOR, JAK-STAT, SMAD, IKK-NF- k B, Wnt), their components and key roles of protein kinases and phosphatases. (manchester.ac.uk)
  • Molecular pathways of pulmonary inflammation following aspiration and inhalation of stainless steel welding fume in mice. (cdc.gov)
  • In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026), as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. (cdc.gov)
Biotechnology2
Biol4
Pharmacology1
  • I like to call it 'the Chernobyl effect' -- you've turned the reactor on and now you can't turn it off,' said senior author Bennett Van Houten, Ph.D., professor of pharmacology and chemical biology at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center. (labroots.com)
Research12
  • The teaching and research activities of the Department of Molecular and Cell Biology (MCB) concern the molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms. (berkeley.edu)
  • Research and project orientated acquisition of biomolecular, genetic, biochemical and cell biological techniques in the involved departments in small groups. (uni-goettingen.de)
  • I have been teaching a variety of courses here at Queen's for over 20 years, from introductory biology to the commercialization of biological research at the graduate level. (queensu.ca)
  • As a scientist, I have 30 years of experience conducting research on various molecular problems using a range of organisms, from bacteria to plants. (queensu.ca)
  • Our program emphasizes interdisciplinary training and collaborative research using cutting-edge molecular technologies and experimental systems to address fundamental and innovative biological questions using a range of approaches, from super-resolution imaging to genomic and proteomic analyses. (yale.edu)
  • In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
  • The Department of Molecular Biosciences is a comprehensive research and training department located in the College of Arts and Sciences at the University of South Florida. (usf.edu)
  • Techniques used to research cell signalling. (manchester.ac.uk)
  • Venor®GeM Classic allows fast, reliable and time-saving routine monitoring of mycoplasma contamination in cell culture supernatants, media and biopharmaceuticals in research and industry by conventional PCR. (cambio.co.uk)
  • For students taking BIOL3208 or BIOL3209 as part of this major, the research project must be in the field of cell & molecular biology. (edu.au)
  • It is broadly used in vitro as molecular biology research tool due to its capability of joining as sticky as blunt DNA ends. (wikipedia.org)
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Vitro5
  • We adopt an interdisciplinary approach combining establishment and genetic modifications of 3D organoid cultures, modelling of tissue dynamics upon injury and molecular characterisation of epigenetic, transcriptional and metabolic profiles both in vivo and in vitro, to understand how adult regenerative processes are regulated and explore novel therapeutic strategies for human liver diseases and cancer. (ucl.ac.uk)
  • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
  • 3-D cell culture narrows the gap between in vitro and in vivo. (the-scientist.com)
  • An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
  • Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
Membranes3
  • Emphasis is placed on the structure and function of various cellular organelles and membranes, along with their roles in metabolism, transport, and cell communication. (uiu.edu)
  • But ROS can cause damage to DNA and cell membranes and can promote inflammation. (labroots.com)
  • Ultrastructural and molecular characteristics of crayfish photoreceptor membranes. (rupress.org)
Differentiation1
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
Mitosis1
  • In addition cells have evolved a damage-sensing checkpoint system whereby the cells delay entry into mitosis until the break has been repaired. (brandeis.edu)
Lund1
  • Welcome to the Cell and Gene Therapy Core Facility at Lund University. (lu.se)
Genetic3
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • This major covers the study of life processes at the molecular and cellular levels, including the storage, transfer and regulation of genetic information, the structure and function of prokaryotic and eukaryotic cells and interactions between molecules and cells. (edu.au)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
Inflammation3
  • Failure to execute these regulatory responses causes cell damage and inflammation or senescence, compromising cell survival and the ability to adapt to energetically demanding conditions. (nature.com)
  • The hyphal form, constituted by filamentous cells, has the ability to invade tissue and induce inflammation. (lu.se)
  • Molecular basis of inflammation / editor, Javier Navarro. (who.int)
Faculty1
  • With over 150 faculty participating as trainers in our program, this Track provides a breadth of options to explore, while also creating a challenging intellectual environment that encourages students to take innovative, interdisciplinary approaches to the study of fundamental questions in biology. (yale.edu)
Department3
  • I am a Professor in the Department of Biology at Queen's University. (queensu.ca)
  • To find a publication from the Department of cell and molecular biology search the university publication database DiVA. (uu.se)
  • As a graduate student in the University of Tokyo Medical School Department of Anatomy, Tsukita found an able mentor in Harunori Ishikawa, who himself had earned acclaim for demonstrating the general prevalence of actin in nonmuscle cells while working in Howard Holtzer's lab in the late 1960s. (rupress.org)
Developmental1
  • We develop students to be independent, imaginative and careful scientists, preparing our graduates to be the next generation of molecular cell biologists, geneticists, and developmental biologists in a broad array of science-related careers. (yale.edu)
Search1
Processes4
  • Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. (nature.com)
  • Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
  • The emphasis is on basic principles that underpin the processes unique to living organisms at the molecular and cellular levels. (edu.au)
  • Integrate and extend their conceptual knowledge of the structure and function of prokaryotic and eukaryotic cells, as whole entities and in terms of their subcellular and molecular processes. (edu.au)
Gene expression2
  • These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
Apoptosis4
  • It has been established that RGCs die by apoptosis in glaucoma, but the exact pathway from death stimulus to cell death is not understood. (uclahealth.org)
  • Gene and protein expression studies may lead to a better understanding of the regulatory events involved in RGC apoptosis, and provide molecular targets for the development of new therapeutic agents with neuroprotective effects in order to prevent or delay the loss of ganglion cells in glaucoma. (uclahealth.org)
  • Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. (cdc.gov)
  • Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage. (cdc.gov)
Enzymes1
  • They contain oxidative enzymes, such as catalase and urate oxidase , at such high concentrations that in some cells the peroxisomes stand out in electron micrographs because of the presence of a crystalloid core ( Figure 12-31 ). (nih.gov)
Microbial1
  • High quality but affordable diagnostic kits for the detection of microbial contaminants in cell cultures, biopharmaceutical products, clinical samples and water. (cambio.co.uk)
Quantitative1
  • BIOL2202 is the recommended course from the Quantitative Skills list as it has been designed specifically for students to develop quantitative skills in biology. (edu.au)
Excellence1
  • This scholarship is awarded annually for academic excellence to a student studying Molecular and Cell Biology at the third year level. (edu.au)
Biochemical1
  • This course provides an in-depth overview of the living cell and highlights the molecular and biochemical aspects impacting cell structure and function. (uiu.edu)
Sickle cell an1
  • Also that year, Vernon Ingram discovered that the disease sickle cell anaemia is caused by a single amino acid change in the hemoglobin molecule and Sydney Brenner joined the Unit. (wikipedia.org)
Epigenetic1
  • In our lab, we use and establish both 3D human and mouse adult organoids, which recapitulate the transcriptional and epigenetic landscapes of regenerative cells and mimic disease, and in vivo models. (ucl.ac.uk)
Eucaryotic2
  • Peroxisomes are found in all eucaryotic cells. (nih.gov)
  • One hypothesis is that peroxisomes are a vestige of an ancient organelle that performed all the oxygen metabolism in the primitive ancestors of eucaryotic cells. (nih.gov)
Tumorigenesis1
  • However, which mutations are most important, which events must occur, and if a specific order is involved in molecular tumorigenesis is unclear. (medscape.com)
Epithelial Cells1
  • Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
Tissues2
  • Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
  • Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
University1
Neuroscience1
  • Molecular neuroscience has largely focused on the functions of protein-coding genes, which account for less than 2% of our DNA. (lu.se)
Regulation2
  • We have shown that this regulation involves the action of a small Recombination Enhancer (RE) sequence that enables a donor on the left chromosome arm to recombine preferentially in MATa cells. (brandeis.edu)
  • In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)
Sequence2
  • Using synchronized cells undergoing recombination that is initiated at a specific site on a chromosome by an inducible endonuclease, we use physical monitoring techniques (Southern blots, PCR analysis) to follow the sequence of molecular events that occur in real time. (brandeis.edu)
  • In 1958, Crick's review "On Protein Synthesis" appeared: this laid out, for the first time, the central dogma of molecular biology , the sequence hypothesis and the adaptor hypothesis . (wikipedia.org)
Dynamics2
  • Can molecular dynamics be used to simulate biomolecular recognition? (uu.se)
  • The primary differences in the molecular dynamics (MD) models and those observed in this crystal complex result from small conformational changes in active-site residues on energy minimization. (rcsb.org)
Plant cells1
  • in yeast and plant cells, however, this essential reaction occurs exclusively in peroxisomes. (nih.gov)
Stem1
  • The module will include the importance of cancer stem cells and the tumour microenvironment, the spread of cancer and therapeutic advances. (york.ac.uk)
Experimentation1
  • Explain how biology is an evidence-based discipline involving observation, experimentation and hypothesis testing and how it relates to other scientific disciplines. (edu.au)
Replication1
  • We are interested in understanding at the molecular level how recombination occurs and what roles are played by the many proteins involved in DNA recombination, repair and replication. (brandeis.edu)
Hoffmann1
  • Hoffmann M , Kleine-Weber H , Pöhlmann S . A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells. (cdc.gov)
Patterns3
  • Researchers explore the idea that molecular patterns in individual cells could underlie the development of a left and a right in animals. (the-scientist.com)
  • Beyond the variety of molecular implementations of such patterns, we emphasize the unitary principles associated with them, across scales in space and time, within a general mechanochemical framework. (mpi-cbg.de)
  • So far, as a scientist, I've been on a slow journey to the bottom, to the deepest level of detail, from seeking to explain patterns of evolution spanning the tree of life, to probing how cells react to their environment, to tinkering with the pieces and parts of molecules swarming inside those cells. (designyoutrust.com)
Sciences1
  • The MCBB Program provides students with a strong foundation in several current scientific fields, all focused on molecular sciences. (bu.edu)
Proteins2
  • Study biologically important molecules including DNA, RNA and proteins, as well as the molecular events that govern cell function. (manchester.ac.uk)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Cycle progression1
  • We will discuss the key features of cancer biology, such as deregulated cell cycle progression, growth, invasion and metastasis. (york.ac.uk)