• Human papillomaviruses (HPV), particularly HPV type 16, are the primary etiologic agent of cervical cancer. (johnshopkins.edu)
  • During my first post-doctoral research in the CRUK (Cancer Research UK) Institute for Cancer Sciences at Birmingham, I utilised an organotypic raft model to dissect the interaction between the human papillomavirus (HPV) oncoprotein E6 and host PDZ proteins in cervical cancer. (derby.ac.uk)
  • This work pinpoints E2 as a key protein in the initiation of HPV-induced cervical cancer and identifies the SAC as a target for oncogenic pathogens. (docksci.com)
  • Cervical cancer (CC) kills a 250,000 people annually, frequently affecting young women, and requires persistent infection with high-risk Human Papillomavirus (hrHPV) for its development. (prescriptec.org)
  • HPV OncoPredict is an innovative diagnostic device (IVD) capable of detecting all oncogenic hrHPV genotypes frequently causing cervical infection as well as allowing to accurate identification those 10% of infected women who are truly at risk of developing cervical cancer. (prescriptec.org)
  • The overall aim of SYSTEMCERV is to develop and to validate, a system biology based proto-array for biomarker screening in cervical cancer and pre-cancer to improve clinical diagnosis, and management of disease. (europa.eu)
  • Persistent infection with oncogenic HPV types can cause cervical cancer in women as well as other anogenital and oropharyngeal cancers in women and men. (cdc.gov)
  • Arwa's main research interests are in oncogenic viruses and tumor biology, in particular HPV and its association with cervical cancer progression and she has several publications about the carcinogenic effect of the "high-risk" HPVs. (edu.iq)
  • In recent years, testing for human papillomaviruses (HPVs)-;which cause virtually all cases of cervical cancer-;joined the Pap test as a standard screening tool for cervical cancer. (news-medical.net)
  • While vaccines for preventing cervical cancer-;including Gardasil-9, which protects against nine HPV types-;are safe and effective, several generations of women are above the age for receiving the vaccine. (news-medical.net)
  • Infection with Human Papillomavirus (HPV) "is estimated to cause […] 100% of cervical cancer cases," and contributes to the incidence of other cancers affecting both women and men, including anal cancer, oral and oropharyngeal cancers, and cancers of the genitals (WHO, 2008b). (medscinet.com)
  • The World Health Organization (WHO) has underscored the importance of screening, stating that "the introduction of HPV vaccine should not undermine or divert funding from effective screening programmes for cervical cancer" (WHO, 2009). (medscinet.com)
  • For example, epidemiological evidence suggests that human papillomavirus (HPV) is one of the major risk factors of cervical cancer and contributes to almost all cases [ 5 ]. (jcancer.org)
  • In this review, we summarize some recent findings on HPV-associated carcinogenesis, such as miRNAs in HPV-associated cancers, implication of stem cells in the biology and therapy of HPV-positive cancers, HPV vaccines, targeted therapy of cervical cancer, and drug treatment for HPV-induced intraepithelial neoplasias. (virosin.org)
  • 2011. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. (virosin.org)
  • Human papillomavirus ( HPV ), which causes most cases of cervical cancer, has been found in breast cancer tissue. (foodforbreastcancer.com)
  • Mechanistic insights into the oncogenic partnership of hADA3 and HPVE6-paving ways for improved for improved cervical cancer therapy. (du.ac.in)
  • According to the World Health Organization, human papillomavirus (HPV) causes cervical cancer, which is the fourth most common cancer in women, with an estimated 266,000 deaths and 528,000 new cases in 2012. (phmj.org)
  • His studies included characterizing the viruses' DNA, investigating the tumor-inducing properties of the viruses, and determining the molecular and kinetic parameters of adenovirus infection. (wikipedia.org)
  • These classic studies served to establish adenoviruses as a powerful model system that has since been used to address more global questions about virus replication, human cell molecular biology, infection and immunity, and neoplastic transformation. (wikipedia.org)
  • Objective: To evaluate the efficacy and safety of Nocardia rubra cell wall skeleton (Nr-CWS) in the treatment of persistent cervical high-risk human papillomavirus (HR-HPV) infection. (bvsalud.org)
  • Should they fulfill their promise, these DNA vaccines may prevent HPV infection or control HPV-related cervical lesions. (johnshopkins.edu)
  • My PhD studies utilised molecular and survival analyses to describe immunological gene 'trade-offs' during infection with the bacteria Salmonella Typhimurium and fungal pathogen Cryptococcus neoformans in the model host Caenorhabditis elegans. (derby.ac.uk)
  • Novel laboratory mouse papillomavirus (MusPV) infection. (nature.com)
  • ABSTRACT Studies have suggested a possible link between breast cancer pathogenesis and human papillomavirus (HPV) infection. (who.int)
  • Even though epidemiological studies suggest that tobacco smoking and high-risk human papillomavirus (HR-HPV) infection are mutually exclusive risk factors for developing head and neck cancer (HNC), a portion of subjects who develop this heterogeneous group of cancers are both HPV-positive and smokers. (bvsalud.org)
  • Gardasil, a vaccine which protects against infection by HPV types 16 and 18, was approved by the U.S. Food and Drug Administration (FDA) in 2006. (foodforbreastcancer.com)
  • Cloning, expression and in vitro validation of chimeric multi epitope vaccine candidate against visceral leishmaniasis infection. (du.ac.in)
  • Many of his graduate students and postdoctoral fellows have gone on to successful research careers, making significant contributions to the fields of virology, molecular virology, and tumor biology. (wikipedia.org)
  • DNA methylation is considered a "soft" and potentially reversible change to the genome that can define or adapt to tumor biology and is functionally equivalent to genetic changes like mutation or deletion ( Kulis and Esteller, 2010 ). (frontiersin.org)
  • The Department of Applied Tumor Biology (ATB) at Heidelberg University Hospital's Institute of Pathology is an interdisciplinary, translationally-oriented research laboratory. (atb-heidelberg.de)
  • Molecular epidemiology tools in the management of healthcare-associated infections: towards the definition of recommendations. (cdc.gov)
  • Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae. (cdc.gov)
  • Molecular epidemiology of tuberculosis in Sicily, Italy: what has changed after a decade? (cdc.gov)
  • Molecular epidemiology and evolution of porcine parvoviruses. (cdc.gov)
  • This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines. (cdc.gov)
  • In the 10 years since the outbreak, in addition to the increase in knowledge of the biology and epidemiology of this disease, a major lesson learned is the value of having a national public health institute that is prepared to control disease outbreaks and designed to coordinate a national response and assist localities in their responses. (cdc.gov)
  • The advent of next-generation genetic testing has opened up opportunities for us to more accurately detect oncogenic HPV strains and patterns in the genomes that correspond with the development of AIS and ADC,' said Robert D. Burk, M.D., professor of pediatrics, of microbiology & immunology, of epidemiology and population health, and of obstetrics & gynecology and women's health at Einstein and MECC member, who co-led the study. (news-medical.net)
  • In this review we use influenza vaccine as a model in a discussion of the different mechanisms of action of the available adjuvants. (smw.ch)
  • Hufbauer, M. & Akgül, B. Molecular mechanisms of human papillomavirus induced skin carcinogenesis. (nature.com)
  • The goals of the lab are to provide insight into molecular mechanisms, including epigenomic pathways, that mediate the host-microbiota relationship. (uc.edu)
  • Using a variety of cell culture systems, molecular virology techniques, and patient-derived samples, I investigate the pathogenic and evolutionary mechanisms by which viruses interact with the host and cause disease. (uc.edu)
  • Cellular and molecular mechanisms of normal and cancer hematopoietic stem cells, and transfusion medicine. (uc.edu)
  • The focus of our research is on understanding the molecular mechanisms governing the activity of estrogen receptor (ER), a member of the nuclear receptor transcription factor family that is critical in normal reproduction and is implicated in the pathogenesis of breast cancer. (wisc.edu)
  • We aim to decipher basic molecular mechanisms that contribute to the development of cancer. (atb-heidelberg.de)
  • The aim of the ATB's team is to identify and understand molecular mechanisms that turn normal somatic cells into cancer cells and to derive novel concepts for the development of diagnostic markers as well as therapeutic targets from that research. (atb-heidelberg.de)
  • Its cancer assays provide information to healthcare providers to identify oncogenic alterations that qualify a subset of cancer patients for targeted therapy at diagnosis, progression, and monitoring to identify resistance mechanisms. (finder.com)
  • Using a combination of chromatin biochemistry, computational modelling, atomic force microscopy (AFM), genetics, genomics and cell biology, Dr. Dalal and colleagues are investigating whether chromatin adopts alternate structural conformations in cancer cells, the functional consequences of large-scale chromosomal alterations upon the cancer epigenome, and identifying small molecules which can target these structures or processes. (elifesciences.org)
  • Our research focuses on the molecular genetics of neural development with a focus on development of the basal ganglia and surrounding ventral telencephalic regions. (uc.edu)
  • Our studies integrate molecular genetics, genomics, biochemistry and cell biology to address fundamental questions in virus replication and virus-cell interactions. (wisc.edu)
  • His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
  • Human papillomaviruses (HPVs) cause virtually all cervical cancers, the second leading cause of death by cancer among women, as well as other anogenital cancers and a subset of head and neck cancers. (virosin.org)
  • Here we show that T cell immunity against commensal papillomaviruses suppresses skin cancer in immunocompetent hosts, and the loss of this immunity-rather than the oncogenic effect of HPVs-causes the markedly increased risk of skin cancer in immunosuppressed patients. (nature.com)
  • Research over the past 30 years revealed that the oncogenic activity of HPVs is mediated by two oncogenes (E6 and E7) that are required to induce and maintain their carcinogenic function. (atb-heidelberg.de)
  • The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. (who.int)
  • Green founded the Institute of Molecular Virology at St. Louis University School of Medicine in the late 1950s, and later served as its chairman. (wikipedia.org)
  • He played a critical role in developing adenovirus as an experimental system and made many contributions to virology and molecular biology, leading to over 300 authored/co-authored publications and one U.S. patent (No. 61/509,891). (wikipedia.org)
  • He first coined the term molecular virology, later founding an institute bearing that name. (wikipedia.org)
  • She granted six months from the Iraqi Ministry of Higher Education as visiting Scholar at Molecular Virology Laboratory, Department of Pathology, Microbiology, & Immunology, USC School of Medicine, South Carolina-United State of America. (edu.iq)
  • She has extensive practical experience in Tumor Virology and Molecular Virology. (edu.iq)
  • 2- Molecular Virology (Hepatitis C Virus Genotyping). (edu.iq)
  • Quadrivalent HPV vaccine (HPV4) contains four HPV type-specific VLPs prepared from the L1 proteins of HPV 6, 11, 16, and 18. (cdc.gov)
  • Two HPV vaccines, bivalent HPV vaccine (HPV2) and quadrivalent HPV vaccine (HPV4) are licensed for use in the United States ( 10 , 11 ). (cdc.gov)
  • Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination. (who.int)
  • Describe about the biology and the replicative cycle of viruses associated with cancers. (fun-mooc.fr)
  • Epstein-Barr virus, papillomaviruses, hepatitis B virus, human herpesvirus-8 and Merkel cell polyomavirus are the five DNA viruses that are capable of causing the development of human cancers. (fun-mooc.fr)
  • The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. (gesundheitsindustrie-bw.de)
  • Influenza vaccine immunology. (smw.ch)
  • Both vaccines protect against HPV types 16 and 18, which cause 70% of cervical cancers. (cdc.gov)
  • There is also emerging evidence that human papillomavirus (HPV) is responsible for inconsistencies in HNSCC trends, with oncogenic HPV DNA found in approximately half of oropharyngeal cancers and in a high proportion of oropharyngeal cancers in nonsmokers and nondrinkers. (cancernetwork.com)
  • Clinical activity of TIL therapy has also been reported in other cancer types, including human papillomavirus-associated cancers, cholangiocarcinoma, non-small-cell lung cancer (NSCLC), and triple-negative breast cancer (TNBC). (biomedcentral.com)
  • Wnt signaling is highly oncogenic to mammalian epithelia, and indeed comprises one of the main sources of human tumor initiation identified to date. (wisc.edu)
  • Moreover, several strains have been the subject of intensive research and are used as tools in mammalian molecular biology. (biologydiscussion.com)
  • RÉSUMÉ Des études ont suggéré qu'un lien était possible entre la pathogénèse du cancer du sein et l'infection à papillomavirus humain. (who.int)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • Seuls trois échantillons de tissu mammaire tumoral bénin (12,5 %) étaient positifs pour l'ADN de papillomavirus humain tandis qu'aucun échantillon de tissu mammaire sain ne l'était. (who.int)
  • La détection de génotypes du papillomavirus humain hautement oncogènes chez les patientes atteintes de cancer du sein vient appuyer l'hypothèse du rôle étiologique du virus dans l'apparition d'un cancer du sein. (who.int)
  • Vaccination is also recommended for persons at increased risk of severe vaccine-preventable disease. (smw.ch)
  • Systems biology of vaccination for seasonal influenza in humans. (smw.ch)
  • Preventive screening programmes and vaccination against human papillomavirus (HPV) result in reduced cancer incidence and mortality. (prescriptec.org)
  • As a compendium of all current recommendations for use of HPV vaccines, information in this report is intended for use by clinicians, vaccination providers, public health officials, and immunization program personnel as a resource. (cdc.gov)
  • Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions. (malaimare.ro)
  • Human papillomavirus genotyping using next generation sequencing (NGS) in cervical lesions: Genotypes by histologic grade and their relative proportion in multiple infections. (who.int)
  • Natural History of Incident and Persistent Cutaneous Human Papillomavirus and Human Polyomavirus Infections. (who.int)
  • She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
  • During the course of their studies, members of the Audhya laboratory demonstrated that two oncogenic fusion proteins, TFG-NTRK1 and TFG-ALK, created by distinct chromosomal translocation events, localize to subdomains of the endoplasmic reticulum (sites of COPII vesicle formation) and dramatically upregulate ERK activity. (wisc.edu)
  • We are also part of the Molecular Medicine Partnership Unit (MMPU) of the European Molecular Biology Laboratory ( EMBL ) in Heidelberg. (atb-heidelberg.de)
  • Biocept, Inc. , a molecular oncology diagnostics company, develops and commercializes proprietary clinical diagnostic laboratory assays designed to identify rare tumor cells and cell-free tumor DNA from blood and cerebrospinal fluid, or CSF in the United States. (finder.com)
  • Furthermore, HPV oncogenic proteins such as E6 and E7 proteins are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. (johnshopkins.edu)
  • Vaccines targeting these proteins may provide an opportunity to control HPV-associated malignancies. (johnshopkins.edu)
  • Plasmid DNA encoding antigen of interest, such as capsid protein L1 and L2 (for preventive vaccines) and non-structural proteins E6 and E7 (for therapeutic vaccines) enters the host and stimulates an antigen-specific humoral and cellular immune response. (johnshopkins.edu)
  • These vaccines alert the patient's immune system to proteins that are harbouring cancer-typical alterations. (gesundheitsindustrie-bw.de)
  • The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
  • Papillomaviruses: Viral evolution, cancer and evolutionary medicine. (virosin.org)
  • While originally trained in engineering, he completed a 5 year "re-training" in cell biology via an NIH K25 award which transitioned his lab to more biology and medically focused work. (wisc.edu)
  • They represent ideal targets for the development of therapeutic vaccines against HPV infections and HPV-associated neoplasia. (johnshopkins.edu)
  • This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
  • Thesis: A Study on Human Papillomavirus: High-Risk HPV E6, p53 and p16INK4Proteins Expression and Their Role in Cervical Carcinogenesis. (edu.iq)
  • Elise addressed the clinically and scientifically important question of why the skin lesions in individuals with neurofibromatosis and other inherited disorders of RAS signaling tolerate a surprisingly high burden of oncogenic mutations and thereby resist malignant transformation. (washington.edu)
  • This finding was not only of scientific interest, but it also raised concerns because the military was using live adenoviruses as vaccines against adenovirus-induced acute respiratory disease. (wikipedia.org)
  • Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. (scirp.org)
  • Despite the optimism that has accompanied the introduction of prophylactic vaccines to prevent some HPV infections, the relatively modest uptake of the vaccine, especially in the developing world, and the very high fraction of men and women who are already infected, means that HPV-associated disease will remain as a significant public health problem for decades. (virosin.org)
  • Candidates developed in collaboration with GSK within broad infectious disease vaccine program encode for antigens covering four WHO-recommended flu strains. (gesundheitsindustrie-bw.de)
  • Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
  • However, which mutations are most important, which events must occur, and if a specific order is involved in molecular tumorigenesis is unclear. (medscape.com)
  • Physicians and cancer researchers from Heidelberg and Mannheim have now treated adult patients with advanced midline gliomas, difficult-to-treat brain tumors, with a peptide vaccine for the first time. (gesundheitsindustrie-bw.de)
  • We are studying aspects of mammary gland biology and neoplasia using transgenic mouse models. (wisc.edu)
  • To investigate the effects of papillomavirus on carcinogen-driven skin cancer, we colonized several strains of immunocompetent mice with mouse papillomavirus type 1 (MmuPV1) 5 . (nature.com)
  • I was appointed as a Lecturer in Molecular and Cellular Biology at the University of Derby in 2017 and promoted to Senior Lecturer in September 2019. (derby.ac.uk)
  • The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
  • Elise Cai performed her dissertation research in the Molecular and Cellular Biology Program under the mentorship of Dr. Slobodan Beronja at the Fred Hutchinson Cancer Research Center. (washington.edu)
  • Different human papillomavirus types share early natural history transitions in immunocompetent women. (who.int)
  • Jeffrey Townsend is a Professor of Organismic and Evolutionary Biology at Yale University. (notedsource.io)
  • SYSTEMCERV, Systems biology approaches to cervical pre-cancer and cancer, is a SME targeted collaborative research project funded through the European Union Seventh Framework Programme Health programme [Grant number 306037]. (europa.eu)
  • The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
  • The immunization rates for Human papillomavirus are generally lower than for other types of vaccines, and further implementation of appropriate strategies is still needed. (malaimare.ro)
  • Translational and molecular studies to identify new therapeutic targeted drugs for developmental vascular anomalies. (uc.edu)
  • For his PhD at the UW, Chris engineered new photochemically controllable biomaterials that he used in conjunction with induced pluripotent stem cells and organoids to model renal and cardiovascular biology. (washington.edu)
  • Vaccines offer the potential to prime a pathogen-specific immune response and subsequently reduce disease burden. (smw.ch)
  • The vaccine-induced immune response is influenced by: (i.) vaccine factors i.e., type and composition of the antigen(s), (ii. (smw.ch)
  • In the late 1950s and early 1960s, Green was among the first scientists in the world to study biochemical features of virus replication in cell culture and to develop and apply the emerging concepts of molecular biology. (wikipedia.org)
  • S V40 is an oncogenic virus. (biologydiscussion.com)
  • For this, we set out to find out the results of applying the molecular biology techniques for the determination and typification of the human papilloma virus (HPV), together with colposcopic (with 5% acetic acid) and cytologic (conventional exfoliative Pap smear) studies, by means of a sample that is representative of our reference menopause consult for the central district of Malaga, Western Costa del Sol and Guadalhorce Valley. (scirp.org)
  • Moreover, the way a healthcare provider presents and recommends a vaccine can be decisive in the choice wart virus how long a person to immunize or not. (malaimare.ro)
  • The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. (virosin.org)
  • Genetic immunization with naked DNA has emerged as an important strategy for vaccine development. (johnshopkins.edu)
  • RV can be grown in a wide variety of cell culture systems, andthis has been the cornerstone of vaccine development. (vdocuments.net)
  • Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. (virosin.org)