Molecular biology cellular junctions cell cycle. Medical search. Frequent questions

Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, neuronal transmission and the signal transduction pathways that integrate them. (sfu.ca)
In addition, flow cytometry analysis and the MTT assay were conducted to detect the effects of miR‑125b on apoptosis and cell viability. (spandidos-publications.com)
Additionally, transfection with 50 nM miR‑125b mimics markedly reduced the mRNA and protein expression levels of TP53 in the cultured lens epithelial cells, and miR‑125b significantly induced apoptosis in the epithelial cells compared with negative control cells. (spandidos-publications.com)
CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. (thermofisher.com)
Organic solvent-induced proximal tubular cell apoptosis via caspase-9 activation. (cdc.gov)

Somatic Cell and Molecular Genetics. (wikipedia.org)
To address our goals we use several model systems such as giant reticular spinal axon in lamprey, Drosophila neuromuscular junction, and mammalian neurons, in combination with molecular biology, genetics, cellular imaging techniques, and intracellular recordings. (ki.se)
To accomplish this aim, we blend expertise from bacterial genetics, cellular microbiology, cellular biology and advance imaging techniques. (tamu.edu)
To dissect the basis underlying exosporium assembly we use molecular biology, bacterial genetics, biochemical and structural analysis, omics and single cell imaging techniques to understand the mechanisms through which key morphogenetic proteins drive exosporium assembly and interplay with other spore-coat and exosporium constituents. (tamu.edu)

Investigating the cellular architecture of the developing cortex, we observed a loss of the radial orientation of radial glial cells, likely due to the disruption of the apical band of adherens junctions, which is the first effect observed after loss of the protein, and the consequent formation of rosette like structures in the brain parenchyma. (uni-muenchen.de)
Since F-actin stabilizes adherens junctions, RhoA's regulation of actin levels might indeed be at the origin "double-cortex" phenotype. (uni-muenchen.de)
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions. (tamu.edu)

Ruehle MD, Li S, Agard DA, Pearson CG (2023) Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. (ciliate.org)

Our Biochemistry degree is recognised by the Royal Society of Biology (RSB). (kent.ac.uk)
In your first year, your modules give you an insight into various biological and chemical disciplines, including biochemistry, cell and molecular biology, microbiology and physiology. (kent.ac.uk)
Dr. Mukhopadhyay did his doctoral studies in Biochemistry at the Department of Biochemistry from Calcutta University and received the postdoctoral training in the Department of Cell Biology, Cleveland Clinic Foundation, USA. (jnu.ac.in)

He joined the 'Special Centre for Molecular Medicine' in 2001. (jnu.ac.in)
Prior to joining the 'Special Centre for Molecular Medicine' in April 2001 he was working in an NIH sponsored research scheme at the University of Texas Health Science Centre, USA. (jnu.ac.in)

Accordingly, the group is positioned to work at the interface of systems biology, RNA biology and molecular neuroscience. (ed.ac.uk)
You also choose two optional modules from a range that covers areas such as the biology of ageing, cancer biology and neuroscience. (kent.ac.uk)

ZO-1 may be involved in signal transduction at cell-cell junctions. (thermofisher.com)

Finally, in situ hybridization analyses revealed the presence of RP11-295G20.2 in the nuclei of corneal epithelial cells, but not in the stromal cells of the human cornea, while RP11-322M19.1 was present in epithelial and non-epithelial cells. (molvis.org)
Estrogens stimulate the proliferation and the differentiation of breast epithelial cells through the activation of downstream mitogenic signaling pathways, namely via the estrogen receptors ERα and ERβ. (scirp.org)
The links between epithelial cells are initiated and maintained by cell adhesion molecules (ie. (ubc.ca)
We are now modulating the expression and function of cell adhesion molecules in these cultures to determine how architectural disruption allows epithelial cells to break away from the original tumor and begin invading surrounding tissues. (ubc.ca)
Cataracts are the leading cause of blindness worldwide and are characterized by progressive aggregation and precipitation of lens proteins, and the development of age‑related cataracts is associated with dysregulated cellular activities of lens epithelial cells. (spandidos-publications.com)
A luciferase assay demonstrated that transfection of lens epithelial cells with wild type TP53 3'‑UTR significantly reduced the luciferase activity of the miR‑125b overexpressing cells compared with scramble controls. (spandidos-publications.com)
Furthermore, it was demonstrated that the expression level of miR‑125 was comparable in epithelial cells from patients with age‑associated cataracts and controls, whereas the expression level of TP53 was significantly higher in the cataract group compared with controls. (spandidos-publications.com)

Das Cells in Motion Interfaculty Centre organisiert die Veranstaltung in Kooperation mit Verbundforschungsprojekten unserer Universität. (uni-muenster.de)
Since the Centre for Cellular Imaging opened in 2004 our users have produced many high-quality articles in scientific journals and several of our users have finished their doctoral studies and defended their Ph.D. thesis. (gu.se)

In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cell-intrinsic program during neuronal differentiation. (uiowa.edu)

A diverse range of wet and dry-lab techniques are used to achieve this, whilst the translational research is principled upon core concepts of basic mammalian RNA biology. (ed.ac.uk)
Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells ). (wikipedia.org)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)

New imaging technologies have revolutionized the study of developmental biology. (cshlpress.com)
Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press Imaging series, presents a comprehensive set of essential visualization methods. (cshlpress.com)
Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques. (cshlpress.com)
Developmental biology 366.2 (2012 Jun 15): 204-17. (uiowa.edu)
Developmental biology 356.2 (2011 Aug 15): 553-65. (uiowa.edu)
Frontiers in cell and developmental biology. (lu.se)

However, previous studies of Ca 2+ handling in auditory hair cells have often been conducted in immature hair cells, with elevated extracellular Ca 2+ concentration, or through steady-state stimulation that may not be physiologically relevant. (jneurosci.org)
For invasion to occur, cells that have been released from the original tumor mass must be able to migrate through the extracellular matrix (ECM) which acts as a scaffold between and within tissues. (ubc.ca)
elevation, while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators, and removal of the cell wall inhibit this reaction. (deepdyve.com)

Preformed Ω-profile closure and kiss-and-run mediate endocytosis and diverse endocytic modes in neuroendocrine chromaffin cells. (ki.se)

This group focuses on the cell biology of normal and tumor cells and how these differences can explain tumor progression and possibly identify potential targets for therapeutic intervention. (actrec.gov.in)
The objectives of these studies are to provide novel insights into how the cell regulates organelle size and number, how these mechanisms are altered in tumor cells and the subsequent consequences for tumor progression. (actrec.gov.in)
The laboratories of Dr. Teni and Dr. Dalal study therapy resistance in oral, cervical and colorectal cancers with an emphasis on how tumor cells acquire resistance to radiation and commonly used chemotherapeutic agents and determining whether these can serve as targets for therapeutic intervention or prognostic markers that can predict the choice of therapy. (actrec.gov.in)
Metastatic lesions are thought to originate from disseminated tumor cells (DTCs) shed from a primary tumor. (jefferson.edu)
In parallel, 2) research in Dr. Bussard's laboratory intends to elucidate the molecular basis of crosstalk between tumor cells and the host stroma, with a focus on understanding alterations in bone osteoblasts, that create a permissible environment for metastatic cancer cell colonization and survival. (jefferson.edu)
We are determining the specific molecules that are involved in regulating this migratory switch in breast and ovarian tumor cells. (ubc.ca)
Both processes are the result of a complex interaction between tumor cells and their microenvironment. (ibecbarcelona.eu)

Liquid-liquid phase separation in cells has emerged as a common principle for the organization of membrane-less compartments. (ki.se)
Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy . (wikipedia.org)
ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
Membrane proteins from cultured embryonic Drosophila neuronal cells. (uiowa.edu)
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. (springer.com)
CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (thermofisher.com)
The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane. (leibniz-fmp.de)

The Rho family of small GTPases is known for its many cell biological functions such as regulation of the cytoskeleton, gene expression, cell migration, adhesion, cell polarity and the cell cycle. (uni-muenchen.de)
Your second year builds on this knowledge and covers areas such as gene regulation, cell biology and metabolism. (kent.ac.uk)
Das D, Tapryal N, Goswami S.K., Fox P.L, and Mukhopadhyay C.K. Regulation of Ceruloplasmin in human hepatic cells by redox active copper: Identification of a novel AP-1 site in ceruloplasmin gene. (jnu.ac.in)
Professor Dna Replication Cell Cycle Regulation Parasitology. (irins.org)
Assistant Professor Regulation of Epithelial Tight Junctions, Modulati. (irins.org)

The laboratories of Dr. Bhattacharyya and Dr. Dalal study the biogenesis and size and copy control mechanisms of organelles such as the Golgi complex, the endoplasmic reticulum, the nucleus, the centrosome and the cell-cell adhesion junction the desmosome. (actrec.gov.in)
Specialized adhesion molecules that link cells to the ECM (ie. (ubc.ca)

While the mechanism for directional metastasis is unknown, the bone microenvironment provides a fertile soil for breast cancer cells to colonize and grow. (jefferson.edu)
One of our main lines of research is to study how tumours exploit the functions of non-cancer cells in their microenvironment to invade and metastasize. (ibecbarcelona.eu)

We study the molecular and biophysical mechanisms underlying and regulating vesicle trafficking in neurons and in particular in their axons and presynaptic nerve terminals. (ki.se)
Finally, by using in-utero electroporation to delete RhoA in individual cells, we found out that the misplacements of neurons in the heterotopic cortex was not due to an inability of RhoA-neg. (uni-muenchen.de)
One hallmark embodying the auditory temporal precision is phase-locking, a phenomenon that the timing of spikes fired by single auditory neurons is synchronized and therefore phase-locked to acoustic cycles ( Heil and Peterson, 2017 ). (jneurosci.org)
Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. (plos.org)

Mechanistic follow-up of key events is then carried out within hiPSC models using established molecular biology, functional genomics and systems biology methods in order to determine both their cause and consequence. (ed.ac.uk)

We are aiming at characterizing the signaling mechanisms that regulate the liquid-liquid phase transitions in the synaptic vesicle cycle, mitochondrial functions, and degradation pathways at nerve terminals to clarify how do they become affected at the early stages of neurodegenerative diseases and which molecular steps lead to protein aggregate formation. (ki.se)
Looking for molecular pathways that may be at the start of these defects, we could observe a decrease of F-actin levels in RhoA-neg. (uni-muenchen.de)
Further studies are required to clarify the intra cel lular molecular pathways affecting NDRG1 function in human prostate cancer. (scirp.org)

1) identify microRNA, proteins, and novel mediators that facilitate cancer cell dissemination to bone, including mediators of cancer cell arrival and localization, as well as delineate conditions that orchestrate proliferative quiescence and cancer cell re-activation in bone. (jefferson.edu)
Dr. Bussard has found that breast cancer cells cause osteoblasts to alter their production of matrix proteins, and increase their production of a set of inflammatory cytokines: IL-6, IL-8, MCP-1, and VEGF that mediate breast cancer cell maintenance and survival. (jefferson.edu)
In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
Here we identified Nup2 in a pool of enriched proteins that co-purify with tagged Ndj1 from meiotic cell extracts. (biorxiv.org)
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)

New evidence in mice suggests that cells expressing the transcription factor FOXC2 may form a reservoir of quiescent stem cells that contributes to sperm formation. (elifesciences.org)
This involves spermatogonial stem cells (SSCs) dividing to form undifferentiated spermatogonia (uSPGs), which then progress through the meiotic and haploid phases of spermatogenesis to form mature sperm ( de Rooij, 1998 ). (elifesciences.org)
My lab integrates traditional and single-nuclei RNA sequencing to elucidate transcriptome-wide changes to RNA metabolism in clinically relevant post-mortem brain tissue and human induced pluripotent stem cell (hiPSC) models of neurological disease including ALS and autism. (ed.ac.uk)
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. (nih.gov)
Of particular interest is their contribution to Developmental Neurotoxicity (DNT) as well as their potential impact on stem cells. (plos.org)
Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)
Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development. (uiowa.edu)
A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. (nature.com)
Since then they were systematically cultured as tumorospheres in defined stem cell culture conditions, allowing them to keep their GSC properties including their capacity to generate intracerebral tumors in immunodeficient mice (Supplementary Fig. S1 A). (nature.com)
Organoids from many organs have now been obtained from embryonic stem cells, induced pluripotent stem cells and organ progenitors. (ibecbarcelona.eu)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)

Our current interest is in the molecular mechanisms, which link the synaptic vesicle cycle with the onset of neurodegenerative diseases and primerily under conditions that lead to α-synuclein-related pathologies observed in Parkinson's disease, as well as in several diseases referred to as synucleinopathies. (ki.se)
Thus, there is a critical need for elucidating the molecular mechanisms facilitating breast cancer dormancy and reactivation in the bone such that preventative therapeutics can be developed. (jefferson.edu)
This allowed us to reveal the Ca 2+ extrusion mechanisms that are required for phase-locking at auditory hair cell ribbon synapses. (jneurosci.org)
The co-evolution of CifA-CifB pairs may account in part for the incompatibility patterns documented in insects infected with different Wolbachia strains, but the molecular mechanisms remain elusive. (bvsalud.org)

[10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
The FHA cycle is active inside the cell, detoxifying superoxide anion radicals (O2·-), which are mainly generated as a result of so-called 'electron leakage' to triplet oxygen (O2) in photosynthetic, mitochondrial, peroxisomal, and probably other electron transport chains (Ozyigit et al. (deepdyve.com)

Towle KM, Chaytor JL, Liu H, Austin P, Roberge M, Roskelley CD , Vederas JC (2013) Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion . (ubc.ca)
We aim at understanding how physical forces and molecular control modules cooperate to drive biological function. (ibecbarcelona.eu)
1974. Biological handbooks: Biology data book. (cdc.gov)
Currently, with the application of molecular biology resources in human identification, it became possible to identify a person even without physical ante-mortem data or with deteriorated biological material in negligible amounts, which are actually relatively common conditions in forensic analyses 7,12,16,19 . (bvsalud.org)

This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)

Research in Dr. Bussard's laboratory utilizes both 2D and 3D in-vitro cell culture models, high-end fluorescence microscopy, novel humanized mouse models of tumor development, and implantable hydrogel biomaterial scaffolds to examine interactions between cancer cells and the host stroma, with a focus on bone metastatic breast cancer. (jefferson.edu)
The materials we make are niche polymers with tailor-made sites that facilitate selective molecular interactions. (lu.se)
The MIPs are produced by various polymerization methods but in all cases specifi c interactions, molecular partitioning and polymer structure are key properties that we focus on. (lu.se)

An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction. (ki.se)
Consistently, phase-locking of synaptic vesicle releases from hair cells was also significantly reduced by blocking PMCA, MCU, or SERCA, but not NCX. (jneurosci.org)

International Journal of Molecular Sciences. (lu.se)

Among the top ten genes preferentially enriched in these cells, Foxc2 was the only one to code for a protein exclusively present in the nucleus of uSPGs that also expressed ZBTB16, a protein important for SSCs to self-renew. (elifesciences.org)
The role of the protein Mcl-1 in regulating the cellular response to DNA damage has resulted in the determination that drugs targeting Mcl-1 might serve as therapeutics in oral cancer. (actrec.gov.in)
Associate Professor Biology of Plasmodium Falciparum Infection Protein. (irins.org)
We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). (nature.com)
We show that radiation-induced migration/invasion occurs through the stabilization and nuclear accumulation of the transcription factor hypoxia-inducible factor 1 alpha (HIF1α), which drives the transcription of Junction-mediating and regulatory protein (JMY) 27 that stimulates GSC migration through its actin nucleation-promoting activity. (nature.com)

integrins) generate signals within cells that cause them to either remain stationary or become migratory. (ubc.ca)

Define RNA metabolism changes in direct context of human neuropathology: Molecules and networks are characterised at region, cell and pseudotemporal resolution. (ed.ac.uk)
Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert chemical energy from oxygen molecules or nutrients into adenosine triphosphate atp and then release waste products. (pages.dev)
The energy released is in the form of ATP molecules that are used to carry out various functions of the cell. (pages.dev)

He pursued his research work in the area of 'Molecular Endocrinology' as a Feinberg Research Fellow at the Weizmann Institute of Science, Israel and later as INSERM international fellow in France. (jnu.ac.in)
Professor Molecular and Cellular Endocrinology. (irins.org)

The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

The cell nuleus is shown in blue, actin filaments in red and keratin filaments in green. (ibecbarcelona.eu)
The actin cytoskeleton can be seen in green, coated with active myosin (ppMLC) in red, and the cell-cell junctions (E-cadherin) in blue. (ibecbarcelona.eu)

Nature Structural & Molecular Biology. (wikipedia.org)

Mechanistically dissect key RNA metabolism changes causing neural cell dysfunction: Our priorities are to understand the cause and consequence of dysregulated splicing events, and to identify intrinsic master regulators driving transcriptome-wide signatures of neurological disease. (ed.ac.uk)
LKB1 is a serine/threonine kinase mutated in Peutz-Jeghers syndrome (PJS), implicated in many cellular processes including energy metabolism, cell polarization and cell cycle arrest and has also been shown to play an essential role as a tumor suppressor gene by negatively regulating the mTOR pathway. (scirp.org)
2016). AA also takes part in the regeneration of α-tocopherol (vitamin E) in photosynthetic membranes and participates in chloroplast metabolism as a cofactor for violaxanthin de-epoxidase, an enzyme involved in xanthophyll cycle-mediated photoprotection (Smirnoff and Wheeler, 2000). (deepdyve.com)

Data generated in Dr. Bussard's laboratory suggest that osteoblasts form gap junctions with metastasis-suppressed breast cancer cells, which may contribute to cellular crosstalk between the two cell types. (jefferson.edu)
Tumor cell invasion is a prerequisite for metastasis. (ubc.ca)
Cancer cell invasion and metastasis remain the leading cause of death in patients with cancer. (ibecbarcelona.eu)

In particular, sound-evoked spikes in auditory afferent fibers in vivo are phase-locked to sound frequencies up to 5 kHz, but it is not clear how hair cells can handle intracellular Ca 2+ changes with such high speed and efficiency. (jneurosci.org)
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)

In this study, we combined patch-clamp recording and two-photon Ca 2+ imaging to examine Ca 2+ dynamics in hair cell ribbon synapses in the bullfrog amphibian papilla of both sexes. (jneurosci.org)
To study cell and tissue dynamics we develop new technologies to measure physical forces at the cell-cell and cell-matrix interface. (ibecbarcelona.eu)
By combining these technologies with computational analysis of cell shape and velocity we obtain a full experimental characterization of epithelial dynamics during tissue growth, wound healing and cancer cell invasion. (ibecbarcelona.eu)
Here, we target an important enzyme in the Wolbachia heme biosynthetic pathway (ferrochelatase), using high-throughput virtual screening and molecular dynamics with MM-PBSA calculations. (bvsalud.org)

The laboratories of Dr. Dalal, Dr. Hasan and Dr. Teni study cell cycle progression and checkpoint control. (actrec.gov.in)
However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)

thus, Pnn may affect crucial alternative splicing (AS) decisions and, in turn, impact cell-type specific gene expression. (molvis.org)
This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
Nuclear Receptors (NRs), that include steroid hormone receptors, are intra-cellular transcription factors that regulate gene expression in response to their cognate ligands. (jnu.ac.in)

Breast cancers can be classified into several subtypes based on their epidemiological risk factors, molecular markers and response to systemic and local therapies. (scirp.org)
presented an overview of the intrinsic molecular subtypes of breast cancer, as well as their prognostic and therapeutic implications [16] summarized in the Table 1 . (scirp.org)
CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. (thermofisher.com)

Transplantation experiments have revealed that most cells which can perform the hallmark feature of SSCs (that is, re-establishing full spermatogenesis in testes lacking germ cells) are found within the single uSPG population, but may also be present among paired and aligned progenitors ( Kubota and Brinster, 2018 ). (elifesciences.org)
transplanted a population of uSPGs enriched in these cells into the testes of mice treated with busulfan, a toxic compound that kills endogenous germ cells. (elifesciences.org)
Depletion of SMC5/6 sensitizes male germ cells to DNA damage. (nih.gov)

Cold Spring Harbor Laboratory Press (CSHLP) announced the release of T-Cell Memory, available on its website in hardcover and eBook formats. (cshlpress.com)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
Medical Biology - Cell Biology has theoretical (lecture) and laboratory (practice) parts. (semmelweis.hu)

Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)

Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). (wikipedia.org)
Although most of a eukaryotic cell's DNA is contained in the cell nucleus , the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes. (wikipedia.org)
[20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)
Furthermore, human cDNA of NDRG1 from normal placenta was cloned into a eukaryotic expression vector and transfected into the three cancer cell lines. (scirp.org)

Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)
Architecturally, the epithelial tissues affected are made up of tightly linked cells that line ducts (ie. (ubc.ca)
We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. (ibecbarcelona.eu)
By combining this physical information with systematic molecular perturbations and computational models we explore the principles that govern the interplay between chemical and physical cues in living tissues. (ibecbarcelona.eu)
CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. (thermofisher.com)

iCLIP of spliceosome components reveals that PRPF8 depletion decreases RNP complex formation at most splice sites in exon-intron junctions throughout the genome. (biomedcentral.com)

The quiz asks you about formulas and products related to cellular respiration. (pages.dev)
It is evident that a linear-quadratic formula has no place in describing DNA damage caused by low dose radiation, but it is less clear that we should try to develop formulas rooted in molecular and cellular biology instead. (cdc.gov)

This theory would deal with the way an organism spontaneously grows from a single cell to a complete and complex organism, introducing organization at the different development stages and homeostasis for a mature organism. (nature.com)
An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)

James Miller introduced the living systems theory 4 , where each system must include a number of critical subsystems, dealing with their structure, interaction, behavior and development, that can be applied from simple cells to full organisms. (nature.com)
Loss of sensitivity to p21 cell cycle control may be associated with prostatic cancer behavior. (scirp.org)

38. Do Schwann cells or Oligodendrocytes assist in regeneration? (fsu.edu)

Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)

This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals. (plos.org)

By stimulating hair cells with sinusoidal voltage commands that mimic pure sound tones, we recapitulated the phase-locking of hair cell exocytosis with an in vitro approach. (jneurosci.org)

This finding is consistent with the fact that many FOXC2-regulated genes are involved in cell cycle arrest. (elifesciences.org)
For good reason, much of modern cancer research has focused on genes whose products regulate cell growth and survival. (ubc.ca)
K. Kokame, H. Kato and T. Miyata, "Homocysteine-Respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis. (scirp.org)

In fact, scientists still lack genetic markers that clearly allow them to distinguish these cells from the rest of the uSPG pool. (elifesciences.org)
However, FOXC2-producing uSPGs were also capable of self-renewal, forming cells which feature genetic markers associated with SSCs. (elifesciences.org)
They also focus on the monitoring of minimal residual disease (MRD) in AML using molecular markers. (actrec.gov.in)

J Cell Sci, 2016 Apr 15. (nih.gov)

The team started by screening the expression profile of individual cells in a population of mouse uSPGs containing both SSCs and progenitors. (elifesciences.org)

Mol Biol Cell, 2001 Jun. (nih.gov)

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