• The products in this section are designed for molecular cloning of cDNA, gene, PCR fragments (up to 15kb) and also the construction of libraries for much larger fragments (up to 40kb) such as fosmids. (cambio.co.uk)
  • A cDNA clone coding for a membrane proteoglycan core protein was isolated from a neonatal rat Schwann cell cDNA library by screening with an oligonucleotide based on a conserved sequence in cDNAs coding for previously described proteoglycan core proteins. (rupress.org)
  • On Northern blots the cDNA hybridized to a single 5.6-kb mRNA that was present in Schwann cells, neonatal rat brain, rat heart, and rat smooth muscle cells. (rupress.org)
  • Protein chemistry and cDNA sequencing were used to identify an Aedes albopictus mosquito lysozyme secreted after treatment of cultured cells with heat-killed bacteria. (umn.edu)
  • albopictus lysozyme cDNA was cloned using PCR-based approaches. (umn.edu)
  • Hernandez, VP , Higgins, L & Fallon, AM 2003, ' Characterization and cDNA cloning of an immune-induced lysozyme from cultured Aedes albopictus mosquito cells ', Developmental and Comparative Immunology , vol. 27, no. 1, pp. 11-20. (umn.edu)
  • A 31-kDa protein was detected in eukaryotic cells transfected with an expression vector containing the TEF-1delta cDNA. (cdc.gov)
  • The process known as "DNA cloning," "molecular cloning" or "gene cloning" has been used widely since the 1970s. (wtnnews.com)
  • The molecular mechanisms involved in the specific regulation of PDGF alpha R expression are unknown, but transcriptional regulation of the PDGF alpha R gene is most likely to be involved. (nih.gov)
  • This study describes the molecular cloning of the non-coding exon 1 and approximately 2 kb of 5' flanking region of the human PDGF alpha R gene. (nih.gov)
  • In addition, the morphogen retinoic acid, alone or in combination with dibutyryl cAMP, gives a 22-fold induction of PDGF alpha R gene promoter activity in human teratocarcinoma cells. (nih.gov)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
  • Differential display analysis of gene expression revealed consistent and reproducible overexpression of a transcript in the transformed cells compared with the nontransformed cells. (cdc.gov)
  • As the sequencing and gene annotation projects of entire genomes of many species are headed towards completion (see, e.g. [13] ), massive mapping efforts in biology are now focused on how the genes interact. (lu.se)
  • The molecular interactions of genes and gene products underlie fundamental questions of biology. (lu.se)
  • Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)
  • However, as expected, the knowledge that resulted from these candidate gene studies has been limited to understanding molecular mechanisms related to known disease pathobiologic processes. (medscape.com)
  • As a senior scientist in the Hi-TIDe , I'm currently responsible for the high-throughput discovery and characterization of cellular immune responses directed against unknown, shared and private tumor epitopes and participate in the development of new adoptive cell therapy strategies. (unil.ch)
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
  • β-Cells possess inherent mechanisms to adapt to overnutrition and the prevailing concentrations of glucose, fatty acids, and other fuels to maintain glucose homeostasis. (diabetesjournals.org)
  • The molecular mechanisms potentially responsible for cadmium -induced cell transformation and tumorigenesis were investigated using Balb/c-3T3 cells transformed with cadmium chloride. (cdc.gov)
  • prevention by elucidating the molecular etiology and prevention), using in vitro mechanisms by which genetic and models and state-of-the-art approaches The expected outcome of these studies epigenetic alterations alter critical including (epi)genome-wide screens is the opening up of an opportunity molecular pathways and promote cancer and functional genomics. (who.int)
  • First, MCA studies are of specific cancers and surrogate the Epigenetics Group (EGE) and the aimed at providing critical insights into tissues and to identify signatures of Molecular Mechanisms and Biomarkers mechanisms of carcinogenesis through cancer risk and exposures. (who.int)
  • While use of therapeutic cloning to produce "replacement" body parts is possible, the grand opening of "Body Parts 'R Us" is years and probably decades away. (wtnnews.com)
  • But cloning for therapeutic reasons - meaning, carefully regulated research into disease using human embryonic embryos - is an entirely different matter. (wtnnews.com)
  • What's new is therapeutic cloning of human stem cells. (wtnnews.com)
  • Therapeutic cloning isn't being done in Wisconsin today, but Doyle wisely refused to cut off the possibility it might someday happen. (wtnnews.com)
  • Certainly, it's being done in South Korea and the United Kingdom, where therapeutic cloning was protected four years ago. (wtnnews.com)
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
  • understand the theoretical basis for laboratory work (cloning, recombinant expression of proteins, protein purification, etc. (tum.de)
  • The genetic material, in the form of deoxyribonucleic acid (DNA), continues to shorten with each cell division, and cells eventually stop dividing when they sense that their DNA is critically shortened. (wikipedia.org)
  • Since then, the South Korean scientists have reported creating nearly a dozen new lines of human embryonic stem cells that for the first time carry the genetic signature of diseased or injured patients. (wtnnews.com)
  • A clone is an organism that is a genetic copy of an existing one. (who.int)
  • In recent years, understanding of the genetic and molecular components of cystinuria has advanced. (medscape.com)
  • Through the cloning of Dolly, we learned that the cell nucleus contains all the genetic information needed for the cell to develop into any type of cell. (lu.se)
  • Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow fever immunization - the model for acute infection in humans - showing their large diversity. (elifesciences.org)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • Various authors have studied amino acid transport in cell membranes obtained from the proximal renal tubule of humans, rats, and rabbits. (medscape.com)
  • Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
  • Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
  • Its pharmacology and cell biology are largely unknown, and no known natural cell lines or tissues possess sufficient numbers of fBB 4 -R's to allow either of these to be determined. (acs.org)
  • Nonetheless, what has recently emerged is that insulin resistance alone (in the non-β-cell target tissues of the hormone) cannot cause diabetes without β-cell failure ( 10 ). (diabetesjournals.org)
  • DAMPs, damage-associated tissues and the molecular target structures and pathways. (cdc.gov)
  • C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)
  • As a technician within the Hi-TIDe , I closely interact with different scientists, analyse and discuss data aiming at the development of new assays with a special focus on TCR cloning. (unil.ch)
  • Since joining the Department of oncology UNIL CHUV in 2013, I performed, validated and implemented cellular and molecular assays to interrogate T cells from clinical samples for research and in the context of clinical trials (immunological monitoring). (unil.ch)
  • Other than a tiny number of weird scientists, it's hard to find anyone who likes the idea of implanting a cloned embryo into a woman's womb, risking not only the health of the "mother" but almost certainly producing babies with birth defects. (wtnnews.com)
  • In many animals, the germ cells originate near the gut of an embryo and migrate to the developing gonads. (absoluteastronomy.com)
  • The resulting diverse naïve repertoire contains T-cell clones that recognize epitopes of yet unseen pathogens, and can participate in the immune response to infection or vaccination. (elifesciences.org)
  • Memory B cells generated under these long priming conditions had higher levels of antibody somatic hypermutation, and both memory B cells and antibodies were more likely to recognize non-immunodominant epitopes. (bvsalud.org)
  • The specificity of T-cells is determined by the T-cell receptor (TCR), a heterodimer of alpha and beta protein chains. (elifesciences.org)
  • The lab uses a wide range of approaches in our projects: molecular biology, protein biochemistry, in vitro cell culture models, xenograft and syngeneic mouse models, genetically engineered mouse models, various CRISPR-based techniques, and genomic/transcriptomic/proteomic omics techniques. (postdocjobs.com)
  • Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)
  • Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period without further immunization, we demonstrate germinal centre B (BGC) cells that last for at least 6 months. (bvsalud.org)
  • Overexpression of the TEF-1delta protein by transfection was oncogenic in NIH3T3 cells as evidenced by the appearance of transformed foci exhibiting anchorage-independent growth and the potential to grow as tumors in nude mice. (cdc.gov)
  • In 1993, Lee et al cloned a human complementary DNA, rBAT (renal basic amino acid transporter) in chromosome 2, encoding a transport protein for cystine and dibasic amino acids. (medscape.com)
  • An in-depth study on the political impact of modern biology and biotechnology, and their influence on how we understand ourselves as human beings and citizens. (rit.edu)
  • After obtaining my Master's in Medical Biotechnology in Padua and Molecular Biology, in Bologna, I undertook a PhD in Oncology at the University of Padua, which is where my first interest in T cell engineering, and clinically oriented immunotherapy protocols developed. (unil.ch)
  • The book is separated into three chapters covering biotechnology, animal cloning and human cloning. (progress.org.uk)
  • Whilst it is targeted at 14-18 year olds, 'Biotechnology and Cloning' assumes a high level of knowledge on an ambitious range of hard to grasp topics, none of which are directly explained in the book. (progress.org.uk)
  • Buy Biotechnology and Cloning from Amazon UK . (progress.org.uk)
  • AID and Polη function during B-cell affinity maturation by catalyzing somatic hypermutation (SHM) of immunoglobulin variable genes (IgV) to generate high-affinity Abs. (bvsalud.org)
  • The thesis work would focus on identification of genes that are essential for the optimal functioning of the ubiquitin-proteasomal system in leukemic cells. (lu.se)
  • These studies focus on genes thought to contribute to the pathobiology of a disease and are therefore unlikely to identify novel biology. (medscape.com)
  • [ 1 ] These genes are involved in a variety of biologic processes: Th2 inflammation, T-reg cell function, the HLA locus/immunity, and IgE response of B cells. (medscape.com)
  • The many exciting recent advances in the field include: 1) the first description of AID's molecular structure, 2) remarkable advances in high throughput approaches that precisely track AID targeting genome-wide, and 3) the discovery that the cohesion-mediate loop extrusion mechanism [initially discovered in V(D)J recombination studies] also governs AID-medicated CSR. (bvsalud.org)
  • Sheared DNA can be repaired and then ligated for blunt-end cloning, genomic DNA cloning and subcloning. (cambio.co.uk)
  • Two decades of intensive research has greatly expanded our knowledge of how AID functions in peripheral B cells to optimize antibody responses against infections, while maintaining tight regulation of AID to restrain its activity to protect B cell genomic integrity. (bvsalud.org)
  • The B cells in the body have two important phenotypes (functional forms)-the antibody secreting, terminally differentiated (that is, they cannot divide further) plasma cells, and the memory and the naive cells-both of which retain their proliferative potential. (wikipedia.org)
  • I am involved in developing a high-throughput platform to interrogate patients' immunity against private antigens and to identify highly functional T cells (and TCRs) for adoptive cell therapy (ACT). (unil.ch)
  • After obtaining my Master's in Biochemistry at the University of Geneva in 1994, I worked for Glaxo and Serono Pharmaceutical Research Institute in the Chemokines and Functional Genomics fields where I acquired a variety of techniques in molecular and cellular biology. (unil.ch)
  • He has succeeded in converting human skin cells into blood stem cells, which is a first step towards creating fully functional blood stem cells in test tubes. (lu.se)
  • All the granulosa cells in a Graafian follicle are in fact clones. (wikipedia.org)
  • Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
  • The Cell Culture Facility (CCF) located in the Life Science Laboratories supports research by providing space, equipment, cell cultures (plant and mammalian), media, supplies and training on a recharge basis for both academic labs and corporate partners. (umass.edu)
  • Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. (lu.se)
  • Control of muscle differentiation in BC3H1 cells by fibroblast growth factor and vanadate. (wustl.edu)
  • However, stable fBB 4 -R cell lines were obtained in CHO-K1 cells which were shown to faithfully demonstrate the correct pharmacology of the related Bn receptor, the GRP receptor, when expressed in these cells. (acs.org)
  • Improving the knowledge of mech- the identification of molecular alterations focus is on cancers of the breast, anisms of carcinogenesis related to and molecular pathways deregulated urinary tract, and liver and childhood environmental exposures provides a by specific cancer risk factors. (who.int)
  • Major emphasis is placed is involved in identifying molecular molecular events and pathways that on discerning events that precede or biomarkers of exposure and cancer underpin carcinogenesis, thereby elu- drive tumour initiation and progression risk. (who.int)
  • Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. (lu.se)
  • Using mosaic analysis and RNAi in the model organism Drosophila melanogaster, we show that Dystroglycan is required cell-autonomously for cellular polarity in two different cell types, the epithelial cells (apicobasal polarity) and the oocyte (anteroposterior polarity). (lu.se)
  • Those were side effects during the process that led to the cloning of Dolly the sheep. (wtnnews.com)
  • He was in high school when he heard about Dolly, one of the world's most extreme examples of cell reprogramming. (lu.se)
  • Filipe Pereira, professor of molecular medicine at Lund University, is awarded this year's Fernström prize for young, exceptionally promising, and successful researchers. (lu.se)
  • Today, he is a professor of molecular medicine at Lund University, and in recent years, his research successes and prestigious research grants have followed one another. (lu.se)
  • Antibody somatic hypermutation of BGC cells continued to accumulate throughout the 29-week priming period, with evidence of selective pressure. (bvsalud.org)
  • It is worth mentioning that many of the electron-affinic radiosensitizers of hypoxic cells also have the property of preferential or selective toxicity directed against hypoxic cells even in the absence of radiation [1,2]. (who.int)
  • In 2008, I joined the the Department of oncology UNIL CHUV in the laboratory of Pr Immanuel Luescher where I started to study CD8 T-cells and their receptor (TCR). (unil.ch)
  • fBB 4 -R expression in cells widely used for other Bn receptor subtypes was unsuccessful as was expression in two frog cell lines. (acs.org)
  • diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)
  • The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. (elifesciences.org)
  • Many of the tumors derive from one (sufficiently) mutated cell, so they are technically a single clone of cells. (wikipedia.org)
  • However, this view of cancer onset has been challenged in recent years and many tumors have been argued to have polyclonal origin, i.e. derived from two or more cells or clones, including malignant mesothelioma. (wikipedia.org)
  • Her work was fundamental to the understanding of tertiary lymphoid organs, accumulations of lymphoid cells that are damaging in autoimmunity, but can be key to defense against microorganisms and tumors. (ctcase.org)
  • In cancer patients dendritic cells may become dysfunctional or excluded from tumors. (lu.se)
  • The reprogrammed cancer cells thereby lose their ability to become tumors, and instead activate the immune system to respond to mutated proteins in the tumor. (lu.se)
  • 13 Genome Plasticity and B Cell, University of Paris-Sud, Centre National de la Recherche Scientifique, Cancer Institute Gustave Roussy, Villejuif, France. (jci.org)
  • Single-cell transcriptional profiling showed that both light- and dark-zone germinal centre states were sustained. (bvsalud.org)
  • Numerous BGC cell lineage phylogenies spanning more than the 6-month germinal centre period were identified, demonstrating continuous germinal centre activity and selection for at least 191 days with no further antigen exposure. (bvsalud.org)
  • Before the tools of molecular biology were available, she developed T cell clones and realized that the cytotoxic factor she discovered was a combination of the cytokines lymphotoxin and tumor necrosis factor (TNF). (ctcase.org)
  • Blocking the translation of TEF-1delta with antisense TEF-1delta mRNA resulted in a significant reversal of the oncogenic potential of cadmium -transformed Balb/c-3T3 cells as evidenced from suppression in anchorage-independent growth and tumorigenesis in nude mice. (cdc.gov)
  • Our findings demonstrate, for the first time, that the cell transformation and tumorigenesis induced by cadmium are due, at least in part, to the overexpression of TEF-1delta, a novel cadmium -responsive proto-oncogene. (cdc.gov)
  • Pereira's research also involves reprogramming skin cells into dendritic cells, which are the sentinels of the immune system. (lu.se)
  • Therefore, new ways are needed to reprogram other cells into immune cells with the same capacity as the "natural" dendritic cells. (lu.se)
  • By using skin cells as the starting cell-type, he managed to identify the three molecules needed to "program" dendritic cells in just nine days. (lu.se)
  • In the next step, he used the same molecules to reprogram cancer cells into dendritic cells. (lu.se)
  • In time series experiments, which for many experimental systems are confined to laboratory cell culture experiments (cell lines), each slide corresponds to a measured time point. (lu.se)
  • A postdoctoral position is available in Dr. Lixin Wan's group at Moffitt Cancer Center Department of Molecular Oncology. (postdocjobs.com)
  • We hypothesized that only a small fraction of cells within the AMBI-1 clone are activated to produce virus particles during cell division while the majority remain latent despite division, ensuring their survival. (frontiersin.org)
  • The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
  • I am an Engineer in Life Sciences of the EPFL, the Swiss Federal Institute of Technology in Lausanne, specialized in molecular medicine and systems biology. (unil.ch)
  • s refers to those that are manufactured by the cell, as opposed to cloned transcription factors. (absoluteastronomy.com)
  • Little is known about the fraction of infected cells persisting on ART that are latently-infected versus transcriptionally active or about the factors that influence proviral transcription. (frontiersin.org)
  • Chronic high glucose dramatically influences β-cell lipid metabolism via substrate availability, changes in the activity and expression of enzymes of glucose and lipid metabolism, and modifications in the expression level of key transcription factors. (diabetesjournals.org)
  • Using a molecular biology technique called cloning, Nattalie created two new stable cell lines that express TRPC4 and TRPC6, two ion channels very closely related to TRPC5. (broadinstitute.org)
  • After Gov. Jim Doyle vetoed a bill that would have banned cloning of human embryonic stem cells for research purposes, the legislative director of Wisconsin's Right to Life movement made a remark that seemed straight out of a science fiction movie. (wtnnews.com)
  • Had the Legislature passed a bill that only banned human reproductive cloning, Doyle would have signed it in a nanosecond. (wtnnews.com)
  • First or all, scientists have been cloning human cells or their components for years. (wtnnews.com)
  • Not even the South Korean scientists claim they're close to transplanting cells into a human, however. (wtnnews.com)
  • That is why he vetoed the so-called "human cloning bill," not because he or any Wisconsin scientist wants to create Frankenstein's monster or a body parts shopping mall. (wtnnews.com)
  • Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour). (progress.org.uk)
  • 2. Over the years, the international community has tried without success to build a consensus on an international convention against the reproductive cloning of human beings. (who.int)
  • WHA50.37 of 1997 argues that human cloning is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • General Assembly the adoption of a declaration on human cloning by which Member States were called upon to prohibit all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life. (who.int)
  • 3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)
  • 7. The WHO Regional Committee for Africa is invited to review this document for information and guidance concerning reproductive cloning of human beings. (who.int)
  • 3. Media reports on nuclear transfer are usually about one form, reproductive nuclear transfer, also known as reproductive cloning of human beings . (who.int)
  • WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • Human CMV grows only in human cells and replicates best in human fibroblasts. (medscape.com)
  • I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)
  • This sparked Filipe Pereira's curiosity about the human body, and he put aside his plans to study architecture, choosing instead biology and later pursue a doctorate in epigenetics. (lu.se)
  • We are interested in understanding how these modifications are misregulated in tumor cells, tumor-infiltrating immune cells, and tumor-interacting stroma cells. (postdocjobs.com)
  • Both the structure of the PGs and the GAG chains, and the expression of the enzymes involved in their biosynthesis and degradation, vary between normal cells and tumor cells. (lu.se)
  • Frontiers in Molecular Neuroscience. (lu.se)
  • During my PhD, I have worked on the development of NeoTIL, a novel strategy to generate adoptive cell transfer products for next-generation cellular immunotherapies. (unil.ch)
  • These findings show that the vast majority of HIV-1 proviruses within expanded T cell clones, including intact proviruses, may be transcriptionally silent at any given time, implying that infected T cells may be able to be activated to proliferate without inducing the expression of the integrated provirus or, alternatelively, may be able to proliferate without cellular activation. (frontiersin.org)
  • Filipe Pereira has found his niche at the interface of cellular reprogramming and blood cell identity. (lu.se)
  • A provirus is a virus genome that is integrated into the DNA of a host cell.This state can be a stage of virus replication, or a state that persists over longer periods of time as either inactive viral infections or an endogenous retrovirus. (absoluteastronomy.com)
  • To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common. (frontiersin.org)
  • was also a source of persistent viremia on ART, begging the question of how the AMBI-1 clone can survive despite infection with a replication-competent, actively-expressing provirus. (frontiersin.org)
  • Whereas, the cells of clones dealt with here are specialized cells of a multicellular organism (usually vertebrates), and reside at quite distant places. (wikipedia.org)
  • Endogenous substances are those that originate from within an organism, tissue, or cell. (absoluteastronomy.com)
  • A germ cell is any biological cell that gives rise to the gametes of an organism that reproduces sexually. (absoluteastronomy.com)
  • Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing an enzyme telomerase. (wikipedia.org)
  • However, this enzyme in "youthful" cells replaces these lost bits (nucleotides) of DNA, thus making almost unlimited cycles of cell division possible. (wikipedia.org)
  • We also offer solutions for automation, site-directed mutagenesis, as well as your favorite restriction enzyme, ligase or competent cell products. (neb.com)
  • To determine the structural requirements for beta 4GalT7 activity, we have cloned and expressed the enzyme and designed a focused library of 2-naphthyl beta-D-xylopyranosides with modifications of the xylose moiety. (lu.se)
  • More to the point, it's not happening in Wisconsin, where opponents of stem cell research and related work recently persuaded the Legislature to pass a bill that would make criminals out of potential Nobel laureates. (wtnnews.com)
  • Doyle and a significant number of legislators from both parties simply want to hold open the possibility of continuing all forms of stem cell research in Wisconsin, the state that pioneered the process less than 10 years ago. (wtnnews.com)
  • The debate over stem cell research is complicated enough without "sci-fi" claims that mislead policymakers and the public. (wtnnews.com)
  • and stem cell research, written about by the Irish Council for Bioethics and the Telegraph among others. (progress.org.uk)
  • At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)
  • T-cells play a crucial role in the immune response to pathogens by mediating antibody formation and clearance of infected cells, and by defining an overall response strategy. (elifesciences.org)
  • Our current projects include the multifaceted roles of ITCH in melanoma and the melanoma immune microenvironment, the context-dependent functions of master cell cycle regulator APC/C in breast cancer and ovarian cancer, the crosstalk between tumor cell aneuploidy and innate immunity, and several others. (postdocjobs.com)
  • They play a key role in orchestrating the immune response by "informing" other immune cells about the threat from foreign substances in the body. (lu.se)
  • In other words, using the molecules as a trojan horse to "force" cancer cells to develop into immune cells. (lu.se)
  • 1. Cloning is an umbrella term traditionally used to describe different processes for duplicating biological material. (who.int)
  • The dramatic increase in efficiency - more than one cell line for every 20 attempts - could pave the way for treating conditions such as diabetes and spinal cord injury with stem cell transplants. (wtnnews.com)
  • A 186-fold increase in BGC cells was present by week 10 compared with conventional immunization. (bvsalud.org)
  • This concept of clone assumes importance as all the cells that form a clone share common ancestry, which has a very significant consequence: shared genotype. (wikipedia.org)
  • We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)
  • Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)
  • Molecular Therapy - Methods and Clinical Development. (lu.se)
  • He receives the award for his work on reprogramming blood cells and the development of immunotherapies based on this technology. (lu.se)
  • Beyond the variety of molecular implementations of such patterns, we emphasize the unitary principles associated with them, across scales in space and time, within a general mechanochemical framework. (mpi-cbg.de)
  • Reprogramming skin cells to blood stem cells could potentially provide an unlimited source of cells for transplantation to patients with blood disorders. (lu.se)
  • Highest levels of HIV-1 RNA were found in the effector memory (EM) T cell subset. (frontiersin.org)