• Our second COVID-19 test leverages the same proprietary Aptima chemistry and Panther instrumentation that have made Hologic a leader in molecular diagnostics for other infectious diseases," said Steve MacMillan, the Company's Chairman, President and CEO. (hologic.com)
  • Bruker Molecular Diagnostics (MDx) is focused on MDx products within Bruker´s Microbiology & Diagnostics Business Area. (bruker.com)
  • Three different assays are approved by the US Food and Drug Administration (FDA) for clinical use, Abbott HCV enzyme immunoassay (EIA) 2.0 (Abbott laboratories), ORTHO HCV version 3.0 enzyme-linked immunoassay (ELISA) (Ortho-Clinical Diagnostics) and VITROS Anti-HCV assay (Ortho-Clinical Diagnostics). (medscape.com)
  • SYPRO Orange has an excitation/emission wavelength profile compatible with qPCR machines which are almost ubiquitous in institutions that perform molecular biology research. (wikipedia.org)
  • In conclusion, this study demonstrated that HMGB1 is involved in NIHL pathogenesis and its molecular biology has essential and subtle influences, preserving a translational potential for pharmacological intervention. (frontiersin.org)
  • Tris is an established basimetric standard and buffer used in biochemistry and molecular biology. (sigmaaldrich.com)
  • The molecular biology qualities are also tested for absence of nucleases and the luminescence quality spectroscopic tests are performed. (sigmaaldrich.com)
  • Tris buffer solutions are widely used in cell and molecular biology for processes such as protein and nucleic acid extraction and purification. (sigmaaldrich.com)
  • Retrieved on December 10, 2023 from https://www.news-medical.net/news/20210407/Canopy-Biosciences-introduces-high-plex-spatial-biology-assay-for-quantitative-immune-cell-profiling.aspx. (news-medical.net)
  • In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology. (bruker.com)
  • Some reagents for the anti-Xa assay use a patient's own antithrombin, and other reagents add antithrombin exogenously to make a complex of heparin and antithrombin. (medscape.com)
  • Estrogen Assay Laboratories manufactures the estradiol assays reagents distributed by Genprice. (smbe2019.org)
  • Two of 3M's Molecular Detection Assays -- Listeria monocytogenes and Listeria species--have been approved for First Action Official Method of Analysis distinction by AOAC International. (food-safety.com)
  • Constant monitoring of genetic changes in the circulating influenza A(H1N1)pdm09 viruses is important for maintaining the sensitivity of molecular detection assays. (who.int)
  • To complement its current Tropical Disease microorganism offerings, ZeptoMetrix has added 3 strains of Zika Virus for the development and verification of molecular diagnostic assays. (prweb.com)
  • This digital PCR assay kit co-quantifies respiratory pathogens SARS-CoV-2, influenza A, influenza B, and RSV, as well as an internal process control all within a single reaction well. (wreg.com)
  • GT-Digital Wastewater Surveillance Respiratory Pathogen Assay Kit for the Roche Digital LightCycler® System detects and quantifies influenza A/B, SARS-CoV-2, Respiratory Syncytial Virus (RSV) A/B, including an internal process control and a fecal indicator. (wreg.com)
  • Using the Roche Digital LightCycler®, GT Molecular developed a multiplex assay kit targeting influenza A, influenza B, RSV A/B, SARS-CoV-2, along with all necessary controls. (wreg.com)
  • The Panther Fusion system, an add-on module to the base Panther platform, uses polymerase chain reaction (PCR) chemistry to perform Hologic's suite of respiratory assays such as influenza. (hologic.com)
  • The gold standard assay for influenza diagnosis is the reverse transcription polymerase chain reaction (RT-PCR) assay. (who.int)
  • Both conventional RT-PCR and real-time RT-PCR assays are rapid, sensitive methods for detecting the genetic material of influenza viruses. (who.int)
  • FORT COLLINS, Colo. , Sept. 19, 2023 /PRNewswire/ -- GT Molecular, Inc., a company providing ultrasensitive PCR assays for wastewater-based epidemiology testing, pathogen detection, and cancer research is pleased to announce an agreement with Roche to provide a highly multiplexed respiratory panel for wastewater surveillance on the new Roche Digital LightCycler® System. (wreg.com)
  • The global glycated albumin assay market is projected to reach USD 0.3 billion by 2028 from USD 0.2 billion in 2023, at a CAGR of 8.9% during the forecast period. (marketsandmarkets.com)
  • The Spatial Immune Cell Profiling Assay can be customized with the addition of researcher-selected antibodies for detecting additional biomarkers. (news-medical.net)
  • The new targeted proteomics assay is run on Canopy's ZellScanner instrument, which enables precise spatial multiplexing with greater than single-cell resolution, and quantification with high dynamic range over eight orders of magnitude of protein abundance. (news-medical.net)
  • The Solana HSV 1+2/VZV Assay is a multiplex in vitro diagnostic test for the detection and differentiation of Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), and Varicella-zoster virus (VZV) nucleic acids isolated and purified from cutaneous or mucocutaneous swab specimens obtained from symptomatic patients. (quidel.com)
  • CONCLUSIONS: Molecular classification of NSCLC using an objective quantitative test can be highly accurate and could be translated into a diagnostic platform for broad clinical application. (johnshopkins.edu)
  • Molecular assays: These detect viral nucleic acid and can be qualitative or quantitative. (medscape.com)
  • Qualitative tests only detect the presence of HCV RNA (specificity, approximately 98%) whereas the quantitative assays detect the viral load in IU/mL (specificity, approximately 98-99%) and provide adequate information that guides clinicians to manage and monitor treatment outcome. (medscape.com)
  • We therefore developed and validated a mass spectrometry-based probe extension assay with a series of internal controls to detect the insertion event using 24 previously characterized positive samples from patients with mucin-1 kidney disease and 24 control samples known to be wild type for the variant. (mit.edu)
  • MARLBOROUGH, Mass.--(BUSINESS WIRE)-- Hologic, Inc. (Nasdaq: HOLX) announced today that it plans to launch a new Aptima® molecular assay to detect the SARS-CoV-2 virus that will run on its market-leading Panther® system. (hologic.com)
  • Moreover, Bruker is pleased to confirm that their full range of other FluoroType ® SARS-CoV-2 assays are also expected to reliably detect the Omicron variant (B.1.1.529). (bruker.com)
  • Molecular tests were used to detect pathogens. (who.int)
  • Validation results indicate an accurate and reliable test for clinically establishing the molecular diagnosis of mucin-1 kidney disease with 100% sensitivity and specificity across 275 tests called. (mit.edu)
  • For clinical laboratory use, ZeptoMetrix has treated Zika Virus with its proprietary NATtrol™ inactivation process to manufacture non-infectious, molecular testing controls and an assay range validation panel. (prweb.com)
  • Mimicking a true, infected clinical specimen, these ready-to-use non-infectious products are safe to use and refrigerator stable while controlling for all steps in molecular testing including: centrifugation, extraction, amplification and nucleic acid detection. (prweb.com)
  • These labs may use the assay for clinical testing on Hologic's Panther system after completing performance verification testing. (hologic.com)
  • Comprehensive development, validation & delivery service for research and clinical use assays from our global clinical laboratories in USA, Europe and APAC. (almacgroup.com)
  • Here, we report the clinical validation of the specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay using the enzyme Cas13a from Leptotrichia wadei for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-the virus that causes coronavirus disease 2019 (COVID-19)-in 154 nasopharyngeal and throat swab samples collected at Siriraj Hospital, Thailand. (nature.com)
  • The assay was developed specifically for FFPE tissue samples, one of the most widely used sample types in clinical and biomedical sciences. (news-medical.net)
  • There's been a tremendous need in the clinical research community for immune cell profiling assays in FFPE tissues that can spatially resolve as well as quantify individual cells. (news-medical.net)
  • Both types of assays in association with the clinical presentation (jaundice, ALT elevation) have been used to adequate identify acute or chronic HCV infections. (medscape.com)
  • We believe that the QBT Fatty Acid Uptake Assay Kit will enable high-throughput screening of these drug targets and enhance fatty acid metabolism research. (news-medical.net)
  • The 3M™ Molecular Detection System, first introduced to food processors, third-party reference laboratories and other customers in 2011, is based on unique isothermal DNA amplification and bioluminescence detection technologies. (food-safety.com)
  • The major players in glycated albumin assay market are Asahi Kasei Corporation (Japan), Beijing Strong Biotechnologies, Inc. (China), Diazyme Laboratories, Inc. (US), DxGen Corp. (South Korea), Weldon Biotech (India), and Hzymes Biotech (China). (marketsandmarkets.com)
  • Conventional assays using radioisotopes are expensive and time-consuming and have limited the ability of drug researchers to identify potential new drugs via high-throughput screening. (news-medical.net)
  • Since this assay uses a fluorescence-based readout rather than a radioactivity-based one, it eliminates the safety risks associated with conventional radiolabel assays, in addition to being faster and easier to perform. (news-medical.net)
  • The FLIPR® Potassium Assay Kit uses a novel thallium-sensitive indicator dye and a masking agent to significantly widen the conventional assay window, enabling studies of channels with low conductance or low expression levels. (the-scientist.com)
  • Growth in the glycated albumin assay market is mainly driven by factors such as the rising prevalence of diabetes and increasing government focus on disease diagnosis. (marketsandmarkets.com)
  • Diagnostic kits/assays tested for the molecular diagnosis of SARS-CoV-2 infection in São Paulo, Brazil. (bvsalud.org)
  • This assay used Roche Linear Array HPV Genotyping test that is based on HPV L1 consensus polymerase chain reaction (PCR) with biotinylated PGMY09/11 primer sets. (cdc.gov)
  • With its GT-Plex™ patented assay technology, GT Molecular is a leader in providing ultrasensitive, multiplexed digital PCR and qPCR tests for cancer research and wastewater-based epidemiology. (wreg.com)
  • The primer and probe sets in the HA gene were checked for mismatches, and phylogenetic analyses were performed to determine the molecular epidemiology of these viruses. (who.int)
  • The ZeptoMetrix NATtrol treatment blocks surface protein receptors on highly purified microorganisms rendering them non-infectious while allowing the internal nucleic acids to remain intact for molecular detection. (prweb.com)
  • A rapid assay for affinity and kinetics of molecular interactions with nucleic acids. (bvsalud.org)
  • Therefore, any molecular interactions involving nucleic acids can be tested. (bvsalud.org)
  • Canopy Biosciences, a Bruker Company, today announced the launch of its Spatial Immune Cell Profiling Assay for formalin-fixed paraffin-embedded (FFPE) tissue samples. (news-medical.net)
  • Molecular Devices Corporation announced the launch of its QBT Fatty Acid Uptake Assay Kit, the first assay kit that addresses the need for a single-step, homogenous in vitro assay for fatty acid uptake for use in high- throughput screening and metabolic disease research. (news-medical.net)
  • The assay can be adapted for use in microplates, tubes or cuvettes. (mobitec.com)
  • The iQuant™ dsDNA HS Assay Kit is designed specifically for an easy and accurate quantitation of dsDNA. (mobitec.com)
  • The NIH Molecular Libraries Roadmap Initiative wishes to solicit HTS assay applications from the scientific community from investigators who have the interest and capability to work with the Molecular Libraries Probe Production Centers Network (MLPCN) in support of chemical probe development. (nih.gov)
  • The Solana HSV 1+2/VZV Assay consists of two major steps: (1) specimen preparation, and (2) amplification and detection of target sequence specific to HSV-1, HSV-2 and/or VZV using isothermal Helicase-Dependent Amplification (HDA) in the presence of target-specific fluorescence probe. (quidel.com)
  • Buffalo, NY (PRWEB) February 03, 2016 -- ZeptoMetrix™ Corporation (ZMC), announced today the release of several new products to aid in the rapid development and ongoing quality control of molecular assays targeting the Zika Virus. (prweb.com)
  • ZeptoMetrix NATtrol Molecular Diagnostic Products are an essential part of today's fast growing market and are designed provide the safest, most accurate and cost effective support for critical microorganism detection. (prweb.com)
  • The market players are focusing on the research of the glycated albumin assays and including new products in the market. (marketsandmarkets.com)
  • A thermal shift assay (TSA) measures changes in the thermal denaturation temperature and hence stability of a protein under varying conditions such as variations in drug concentration, buffer pH or ionic strength, redox potential, or sequence mutation. (wikipedia.org)
  • The binding of low molecular weight ligands can increase the thermal stability of a protein, as described by Daniel Koshland (1958) and Kaj Ulrik Linderstrøm-Lang and Schellman (1959). (wikipedia.org)
  • Biochemical assays require a catalytic activity of the protein in question as well as a specific assay. (wikipedia.org)
  • Each method has its strengths and weaknesses but they all struggle with intrinsically disordered proteins without any clearly defined tertiary structure as the essence of a thermal shift assay is measuring the temperature at which a protein goes from well-defined structure to disorder. (wikipedia.org)
  • The new assay panel includes 16 protein biomarkers that can be used to identify and quantify 23 different immune cell populations, including T-cell , B-cell, and dendritic cell subtyping. (news-medical.net)
  • The Differential Radial Capillary Action of Ligand Assay (DRaCALA) allows detection of protein interactions with low- molecular weight ligands based on separation of the protein - ligand complex by differential capillary action . (bvsalud.org)
  • Current thallium-based potassium ion channel assays require multiple buffer or media replacements, making them slow and cumbersome, and prone to well-to-well variation. (the-scientist.com)
  • An IC50 value and the detection range for TCS in assay buffer were 1.19 and 0.21-6.71 µg/L, respectively. (cdc.gov)
  • The assays provide rapid results after as little as 24 hours of enrichment--days faster than the standard methods. (food-safety.com)
  • The AOAC Official Methods of Analysis carry a reputation for the highest standards of excellence and rigorous analysis, and we are proud that our assays are recognized by this globally-recognized agency," said John David, global marketing supervisor with 3M Food Safety. (food-safety.com)
  • For its 3M Molecular Detection System, 3M also has AOAC International First Action Official Methods of Analysis status for its 3M Molecular Detection Assay Salmonella and both AOAC PTM and NF Validation by AFNOR Certification for its 3M Molecular Detection Assay Salmonella and 3M Molecular Detection Assay E.coli O157 (including H7), in addition to certifications from government and regulatory organizations in other countries around the world. (food-safety.com)
  • The thermofluor assay was the first high-throughput thermal shift assay and its utility and limitations has spurred the invention of a plethora of alternate methods. (wikipedia.org)
  • In addition, the assay simultaneously detects the S-gene mutations Del69-70 and N501Y, which are expected to be clear indications that the variant is Omicron (B.1.1.529). (bruker.com)
  • Bruker Corporation (Nasdaq: BRKR) today announced that its established CE-IVD marked FluoroType ® SARS-CoV-2 varID Q real-time multiplexed PCR assay reliably detects all SARS-CoV-2 variants, and in addition is expected to also provide a clear indication of Omicron (B.1.1.529), recently declared a 'variant of concern' by the WHO. (bruker.com)
  • These molecular based assays are without a doubt the most sensitive and specific ways to identify and monitor a Zika Virus infection. (prweb.com)
  • The FLIPR Potassium Assay Kit directly measures potassium channel function using a thallium-sensitive indicator dye that passively diffuses into cells as an acetoxymethyl ester. (the-scientist.com)
  • Polyclonal rabbit antisera were screened against the coating antigen library to identify combinations of immunoreagents resulting in the most sensitive assays. (cdc.gov)
  • The most sensitive assay identified was one utilizing antiserum no. 1155 and a heterologous competitive hapten, where the 2'-OH group was substituted with a Cl atom. (cdc.gov)
  • In 2022, Asahi Kasei Corporation (Japan) led the glycated albumin assay market. (marketsandmarkets.com)
  • In 2022, Beijing Strong Biotechnologies, Inc. (China) was the second-largest market player in the glycated albumin assay ecosystem. (marketsandmarkets.com)
  • Hymes Biotech, a prominent player in the global glycated albumin assay market, secured a significant market share in the glycated albumin assay market in 2022. (marketsandmarkets.com)
  • Similar to Molecular Devices' FLIPR Assay Kits, the QBT Fatty Acid Uptake Assay eliminates the need for cell washing steps, resulting in a faster, more streamlined route to drug discovery. (news-medical.net)
  • The development of fatty acid uptake regulators as potential drugs is dependent upon having a rapid assay that can be used in high-throughput screening. (news-medical.net)
  • The QBT Fatty Acid Uptake Assay removes these limitations by providing a rapid, reproducible, inexpensive method for laboratory screening. (news-medical.net)
  • Susan Williams-Clark, Director of Marketing at Molecular Devices stated, "Working together with researchers at the Palo Alto Medical Foundation's Research Division, we have applied our proprietary quench technology to develop the first single-step homogenous assay for fatty acid uptake. (news-medical.net)
  • Williams-Clark continued, "Prior to the development of this assay, it was extremely difficult for drug discovery researchers to study fatty acid uptake processes and identify new regulators. (news-medical.net)
  • In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
  • The most commonly used methodology is the chromogenic assay, which uses a chromophore-linked substrate of factor Xa. (medscape.com)
  • High-mobility group box 1 (HMGB1), a representative damage-associated molecular pattern (DAMP), acts as a mediator of inflammation or an intercellular messenger according to its cellular localization. (frontiersin.org)
  • Specifically, damage-associated molecular patterns (DAMPs), the cellular byproducts of damage, are known to play an essential role in this inflammation. (frontiersin.org)
  • More specifically, DAMPs include pathogen-associated molecular patterns (PAMPs) and "alarmins," endogenous molecules that signal tissue and cellular damage. (frontiersin.org)
  • Bruker's high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. (bruker.com)
  • The data suggests that the AADx assay interacts with RAS mutation and may define RAS wild-type mCRC patients that respond differently to cetuximab or bevacizumab in combination with FOLFIRI. (almacgroup.com)
  • The anti-factor Xa assay is designed to measure plasma heparin (unfractionated heparin [UH] and low-molecular weight heparin [LMWH]) levels and to monitor anticoagulant therapy. (medscape.com)
  • however, this depends on the proportion of higher molecular weight components. (medscape.com)
  • We therefore investigated whether Pentaisomaltose (PIM), a low-molecular-weight carbohydrate (1 kDa), can be used for cryopreservation of peripheral blood stem cells, more specifically hematopoietic progenitor cell apheresis (HPC(A)) product. (lu.se)
  • This whitepaper describes assay and system compatibility with various workflows, wastewater inhibition, longitudinal studies for monitoring atypical seasonal behavior. (wreg.com)
  • Approximately 750 U.S. hospital, public health and reference labs use the Panther system and its suite of proprietary Aptima technologies - including transcription-mediated amplification (TMA) - to perform tens of millions of molecular tests annually for sexually transmitted infections, cervical cancer screening and viral load monitoring in people with HIV and hepatitis. (hologic.com)
  • For monitoring LMWH, the anti-Xa assay plays an essential role since it is the only assay offered for this purpose, since LMWH has minimal effect on PTT. (medscape.com)
  • Provided online is a simple cGMP assay protocol, with no need for co-factors, cell lysis, or complex liquid handling. (montanamolecular.com)
  • The Spatial Immune Cell Profiling Assay is initially available as a service, with researchers sending their samples to Canopy for analysis. (news-medical.net)
  • The Spatial Immune Cell Profiling Assay addresses those needs, finally giving researchers the spatial context, single-cell resolution, and high dynamic range quantification needed to fully understand immune responses. (news-medical.net)
  • MMC also induced phosphorylation of the nuclear histone marker of DNA damage, γH2AX (a member of the H2A histone family), without induction of cell cycle entry or immediate DNA repair measured by Comet assay. (molvis.org)
  • The Estradiol Assays reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (smbe2019.org)
  • The number of live RGCs was then counted using a cell viability assay. (molvis.org)
  • Molecular Devices, at SLAS 2015, launched a homogeneous, no-wash assay to measure ligand- and voltage-gated potassium channel activity. (the-scientist.com)
  • BGI said it has scaled up production of the assay and donated 20,000 kits to support the response to the 2019-nCoV outbreak in Wuhan and Hubei Province. (genomeweb.com)
  • Hain Lifescience GmbH is the legal manufacturer of the FluoroCycler ® XT, MTBDR 2.0 assay, GXT nucleic acid preparation kits and of the FluoroType ® SARS-CoV-2 assays. (bruker.com)
  • Through its funding of the MLPCN, NIH will support the costs of assay automation, screening and optimization chemistry. (nih.gov)
  • The company focuses on research and development as well as expanding the manufacturing of the glycated albumin assay market. (marketsandmarkets.com)
  • Molecular Devices is one of the world's leading providers of high-performance bioanalytical measurement systems, software and consumables for life science research, and pharmaceutical and biotherapeutic development. (the-scientist.com)
  • Molecular Devices is committed to the continual development of innovative solutions for life science applications. (the-scientist.com)
  • This initiative is one of the integrated components of the NIH Molecular Libraries Roadmap initiative that offers biomedical researchers access to large-scale automated high throughput screening (HTS) centers in the MLPCN, diverse compound libraries in the Small Molecule Repository (MLSMR) and information on biological activities of small molecules in the PubChem BioAssay public database. (nih.gov)
  • The Aptima SARS-CoV-2 assay runs on the Panther system, a fully automated, high-throughput molecular diagnostic platform that is widely used around the world, with more than 1,800 systems installed in 60 countries. (hologic.com)
  • In these scenarios, comprehensive genomic profiling via a validated NGS assay may be used to identify above- mentioned mutations and amplification. (medscape.com)
  • Panels: The anti-Xa assay is usually ordered separately. (medscape.com)
  • NGS: When limited tissue is available for testing or if the patient cannot undergo traditional biopsy, the use of limited molecular diagnostic panels may quickly exhaust the sample. (medscape.com)
  • Thermal stability of proteins has traditionally been investigated using biochemical assays, circular dichroism, or differential scanning calorimetry. (wikipedia.org)
  • Elevated excitability and its ac- and the molecular mechanisms of memory. (lu.se)