• Its relevance in maintaining brain tissue homeostasis from development to aging and neurodegenerative diseases is undisputed but, nonetheless, many fundamental questions about the biology of the process remain open: How is phagocytosis efficiency regulated at the cellular and molecular levels? (frontiersin.org)
  • Our focus is on further understanding (via cryoEM, with Prof Alex Cameron) the structural biology of how CO 2 causes conformational change in these connexins and elucidating further physiological functions of connexin mediated CO 2- signalling such as hypercapnic arousal reflexes (with Prof Mark Wall). (warwick.ac.uk)
  • However, we are now pursuing a new approach: using molecular biology to modify natural receptors to create fluorescent reporters for molecules of interest. (warwick.ac.uk)
  • Core themes will include biochemistry, molecular biology, chemistry and bioinformatics. (mdx.ac.uk)
  • This course covers the field of biochemistry with a focus on human biology and medicine and includes core themes from a wide range of science subjects including molecular biology, immunology and chemistry. (mdx.ac.uk)
  • The molecular biology of the hepatic viruses and various aspects of colonic neoplasia will also be considered. (mcgill.ca)
  • American Journal of Molecular Biology , 3 , 187-197. (scirp.org)
  • Plant Molecular Biology, 12, 51-58. (scirp.org)
  • There are multiple other putative mechanisms for accelerated CVD in CKD patients, identified by phenotyping using state of the art imaging, physiological studies and molecular biology, although these are yet to translate to clinical practice. (medscape.com)
  • Handbook of mouse auditory research: from behavior to molecular biology. (cdc.gov)
  • On a molecular level, proposed mechanisms for toxicity involve fundamental biochemical processes. (cdc.gov)
  • In this project we will use a combined approach using computer-based methods including virtual screening of molecular databases and biochemical/biophysical techniques as well as X-ray crystallography to develop cofactor-specific inhibitors. (uni-wuerzburg.de)
  • To present and discuss a literature review regarding the mechanisms of physiological and inflammatory pathological root resorption in primary teeth, emphasizing their biochemical and cellular events. (bvsalud.org)
  • On the other hand, a class of photoreceptors known as phytochromes is involved in the biochemical mechanisms driving photoperiodic responses in plants. (who.int)
  • The main goals of the research described in this thesis were to evaluate mechanisms responsible for drought tolerance in turfgrasses by evaluating whole-plant, cellular, proteomic, metabolomic, genetic, and genomic regions associated with drought defense responses. (rutgers.edu)
  • Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)
  • Dodd I, Ryan A (2016) Whole-Plant Physiological Responses to Water-Deficit Stress. (springer.com)
  • Thus, plastic responses were combined with a physiological syndrome linking SMR and TEWL. (wiley.com)
  • Within this branch of research, I am studying: 1) the physiological and genomic responses of vertebrates to crude oil and its chemical derivatives, and 2) the influence of biotic and abiotic factors on metal bioavailability and toxicity in fish. (lsu.edu)
  • Due to its significant role in regulating a variety of physiological responses, p97 has emerged as a potential therapeutic target. (uni-wuerzburg.de)
  • Phytochromes play a key role in how plants perceive the day in the complex network of proteins and signalling channels that make up the molecular mechanisms behind photoperiodic responses in plants. (who.int)
  • To unravel the molecular mechanisms that underlie the interactions between enteroviruses, pancreatic beta cells, and the host immune responses in T1D pathogenesis. (lu.se)
  • To reveal the neuron- and plasticity-type specificity, the identified molecular pathways will be analysed in different types of neurons in culture and acute brain slices. (europa.eu)
  • One possible explanation for patients' improvement due to exercise is that lung progenitors regain their physiological stretching from healthy conditions and activate molecular pathways favouring lung regeneration. (lu.se)
  • In this project, we aim to study the molecular pathways in lung regeneration induced by stretching on lung progenitors in COPD. (lu.se)
  • These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
  • Ion channels are membrane protein complexes that translocate ions across cell or organelle membranes, underlying a broad range of the most basic physiological processes from nerve and muscle excitability, to membrane potential setting, pH/cell volume regulation, secretion and absorption. (mdanderson.org)
  • For instance, to optimise the response to variations in day length, the photoperiodic pathway interacts with the circadian clock, which controls numerous physiological processes in plants. (who.int)
  • Fate conversion of liver to pancreas is conceivable for numerous physiological and developmental reasons, and, possibly, suitable for future clinical applications. (europa.eu)
  • We use a combination of genetics, advanced microscopy and computational image analysis to unravel the mechanisms underlying epithelial tube formation. (lsu.edu)
  • We use a combination of electrophysiology, live cell imaging and molecular methods to unravel the complexities of amacrine cell synapses. (lsu.edu)
  • These inhibitors will be important to dissect the molecular and cellular functions of p97, thus helping to unravel their specific role in controlling p97 activity and may be potential alternatives to existing anti-cancer drug candidate molecules. (uni-wuerzburg.de)
  • Since then, scientists have advanced our understanding of neuronal interactions tremendously, evaluating synaptic plasticity with ever-increasing temporal and spatial resolution and, in some cases, even correlating electrophysiological and molecular changes with organism behaviour. (europa.eu)
  • The EU-funded project PreSynPlast is using a variety of in vitro preparations and electrophysiological and molecular studies to provide an unprecedented window onto presynaptic plasticity. (europa.eu)
  • The ambitious goal of this project is to reveal the molecular mechanisms of presynaptic plasticity in the vertebrate brain. (europa.eu)
  • My ambitious aim is therefore to uncover the molecular and biophysical mechanisms of presynaptic plasticity. (europa.eu)
  • Building on these unique abilities, I will also investigate physiological and pathophysiological modulations of presynaptic plasticity. (europa.eu)
  • How plasticity interacts with physiological syndromes through lifetime in long-lived species is currently unknown. (wiley.com)
  • My ERC-funded project (ERC Starting Grant "HEPATOPANCREATIC") is focused on the molecular mechanisms underlying cellular plasticity between liver and pancreatic cells. (europa.eu)
  • Chaves MM, Flexas J, Pinheiro C (2009) Photosynthesis under drought and salt stress: regulation mechanisms from whole plant to cell. (springer.com)
  • These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
  • Mechanisms and Regulation of Photosynthetic. (hhmi.org)
  • We are also determining the structure of other class III RNRs which have overall activity regulation (the T4 enzyme does not), as well as of mutants of the T4 RNR which affect the catalytic mechanism and the allosteric regulation. (lu.se)
  • Namely, the environment, population behavior, and even the evolution of cellular and molecular systems. (bbva.com)
  • It is very likely that patients with obesity will have to take these antiobesity medications "forever," he said, "until we identify and can repair the cellular and molecular mechanisms that the body uses to regulate body fat mass throughout the life cycle and that are dysfunctional in obesity. (medscape.com)
  • Such timekeeping may actually be a core mechanism of the circadian clock in both insects and mammals. (eurekalert.org)
  • 2] A. Patke, M. W. Young, S. Axelrod, Molecular mechanisms and physiological importance of circadian rhythms. (eurekalert.org)
  • The plant uses this physiological response to time-critical developmental events like flowering. (who.int)
  • Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications. (bvsalud.org)
  • The other part of my research program is focused on the functional characterization of homeostatic mechanisms that allow animals to survive exposure to diverse aquatic environments. (lsu.edu)
  • Understanding the mechanisms involved in guiding at least under homeostatic or physiological conditions. (lu.se)
  • 14. Uptake of toxic elements, mechanism of their accumulation, hyperaccumulation. (elte.hu)
  • Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)
  • Heavy Metal Toxicity in Plants: Physiological and Molecular Perspectives highlights the various metal induced impacts on plants and adaptation strategies employed to avoid these stressful conditions. (routledge.com)
  • A combined analysis of physiological and iTRAQ (isobaric tags for relative and absolute quantification)-based proteomic approach was performed in tuber development in vitro under exogenous JA treatments (0, 0.5, 5 and 50 μΜ). (biomedcentral.com)
  • This study is the first to integrate physiological and proteomic data to provide useful information about the JA-signaling response mechanism of potato tuber development in vitro . (biomedcentral.com)
  • We have demonstrated that lung stromal cells stretched in vitro with physiological lung motions actively sense the mechanical stimuli from their environment. (lu.se)
  • Here we elucidate the molecular mechanism of these drugs by combining experiments and simulations. (rsc.org)
  • been conducted to elucidate the mechanisms responsible for the prothrombotic state. (who.int)
  • Fig. 6: GFP- and RFP-based biosensor structures provide insight into the mechanism of the fluorescence response. (nature.com)
  • We are thus able to identify the mechanism of fibril formation of the tau 304-380 fragment at physiological pH using fluorescence. (lu.se)
  • The researchers found that the cellular survival mechanism provided by Hsp12 functioned under several different kinds of assault, including heat shock, oxidative stress, and osmotic stress -- a sudden change in the solution surrounding a cell that challenges its ability to regulate the flow of water through the membrane. (mytum.de)
  • The knowledge regarding molecular mechanisms and factors that regulate the process of root resorption is still meager. (bvsalud.org)
  • The body is able to regulate fat mass at multiple stages during development," Kaplan, from Massachusetts General Hospital and Harvard Medical School, Boston, explained, "and when it doesn't do it appropriately, that becomes the physiological basis of obesity. (medscape.com)
  • QTL are large genomic regions that are associated with molecular markers and specific plant phenotypes that can be used in plant breeding strategies. (rutgers.edu)
  • Fig. 1 Overview of viral entry mechanism. (rsc.org)
  • Viral molecular analysis showed identity between isolates from cases with acute and chronic hepatitis C. (cdc.gov)
  • Molecular analysis of HCV has permitted comparison of different viral sequences to confirm transmission. (cdc.gov)
  • We have a major interest in identifying the genes and molecular polymorphisms that underpin variation in fitness components (so-called life-history traits), such as body size, reproduction and lifespan, and in determining how they contribute to adaptation. (unifr.ch)
  • Obtaining a comprehensive understanding of the triggers and mechanisms responsible for beta cell loss in T1D is crucial for establishing therapeutic approaches that can either slow down or prevent the disease. (lu.se)
  • Molecular, physiological, and quantitative real-time analyses showed high expression of AtCBF3 in three selected transgenic lines. (springer.com)
  • Fang Y, Xiong L (2015) General mechanisms of drought response and their application in drought resistance improvement in plants. (springer.com)
  • The physiological response of plants to the length of day or night is known as photoperiodism. (who.int)
  • In this essay, I will cover the current understanding of how plants respond to photoperiod and the molecular mechanisms underpinning this response. (who.int)
  • The plant response to biotic and abiotic stress has been studied for many years, but the molecular mechanism controlling touch-signalling in plants is not well understood. (lu.se)
  • My group investigates fundamental mechanisms of signalling and communication in the nervous system and how these contribute to neural function and behaviour. (warwick.ac.uk)
  • Defining the molecular basis by which VRAC and other volume-sensitive channels detect cell volume changes is a fundamental and longstanding physiological problem. (elifesciences.org)
  • The odontoclasts cells are responsible for resorption of dental tissues, and they are influenced by several stimuli and molecular signals derived from cytokines, neuropeptides, hormones and degradation products released when tissue is injured. (bvsalud.org)
  • The principal focus is on the recent literature pertaining to cell and molecular mechanisms underlying the motility secretory process, absorption and secretion. (mcgill.ca)
  • We identified two novel cytoplasmin siforms of CD59, which are required for insulin secretion and we are now studying the mechanism underlying this phenomenon as well as physiological importance using mouse models. (lu.se)
  • Diisocyanates are reactive compounds, MDI can react under physiological conditions with various functional groups found on biological molecules resulting in conjugate formation or undergo non-enzymatic hydrolysis to form 4,4'-methylenedianiline (MDA). (cdc.gov)
  • The current paper in Molecular Cell also presents evidence that Hsp12 enhances the health of yeast cells under normal physiological conditions. (mytum.de)
  • Activity is regulated on two levels: overall activity and substrate specificity (as only one RNR catalyses the reduction of all four ribonucleotides under given physiological conditions). (lu.se)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • Genetics and live-cell imaging revealed core CME spatiodynamic similarities between the two yeasts, though two-zone actin assembly is a fission yeast-specific mechanism, which is not essential for CME. (biorxiv.org)
  • Progress in understanding of PC and PS levels have been noted in the the disease was initially slow, but molecular steady state [8-11], although some studies research has led to advances in understand- have reported no significant difference be- ing the genetics, evolution and history of tween steady state and vaso-occlusive crisis the disease. (who.int)
  • Ion channels have long been key therapeutic targets in disease intervention and pharmaceutical drug development because of their direct involvement in diverse diseases, vulnerability to small molecular modulation, and accessibility for direct activity measurement on cell membranes by patch-clamp recording from whole cell to single molecule levels. (mdanderson.org)
  • This evidence that Hsp12 must have a protective function, together with its small molecular mass, led to its classification with other heat shock proteins (HSPs). (mytum.de)
  • Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
  • The mechanism of MN induction from these potential MDI metabolites/reaction products was explored in the present study using immunofluorescent staining of kinetochore in MN of cytokinesis-blocked V79 cells. (cdc.gov)
  • Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. (plos.org)
  • In the second part, we will compare the mechanisms that mediate recognition and engulfment and their epigenetic, transcriptional, metabolic, and immunological consequences. (frontiersin.org)
  • The gross anatomy (peripheral and central nervous system) of taste, microscopic and ultrastructural morphology of taste buds, physiology of taste (modalities, distribution of taste sensations, electrophysiology of the receptors, mechanism and intensity of stimulation, and taste contrasts), as well as a few clinical applications, are discussed in this article. (medscape.com)
  • These studies identified conserved CME mechanisms and species-specific adaptations and have broad implications that extend from yeast to humans. (biorxiv.org)
  • It is believed that mechanisms of noise -induced hearing loss cross species, but exceptions will be noted. (cdc.gov)
  • The evidence supporting the physiological relevance of the heptameric assembly and the hypothesized role of lipids is incomplete and will be addressed in future studies. (elifesciences.org)
  • Understanding certain key scientific concepts behind the battle against COVID-19 and how SARS-CoV-2's biological mechanisms actually work will allow us to navigate in the sea of information to better gauge the scope of the problem and the prospects concerning the development of potential treatments. (bbva.com)
  • To achieve these objectives, our research methodology integrates cutting-edge technologies with both state of the art and traditional physiological, virological, immunological, and molecular biological techniques. (lu.se)
  • mechanisms of carcinogenesis chapter 15. (who.int)
  • This book is an attempt to bring together researchers who have been engaged in the area of stress signaling, crosstalk and mechanisms of heavy metal stress and share their research findings. (routledge.com)
  • For additional background information, the reader is referred a review of the literature on physiological effects of noise -induced hearing loss by Borg, Canlon, and Engstrom (1995). (cdc.gov)
  • Analysis of the mutual genotypic relationships among twenty four genotypes of P. tetragonolobus through Mantel test found a significant correlation ( r = 0.839) between similarity matrices of the results obtained from the use of the RAPD and ISSR molecular markers. (scirp.org)
  • Of the many reasons why this has been the case, a critical one has been a general black-box view of biosensor structure and mechanism. (nature.com)
  • With this Perspective, we aim to summarize what is known about biosensor structure and mechanisms and, based on this foundation, provide guidelines to accelerate the development of a broader range of biosensors with performance comparable to that of the GCaMP series. (nature.com)
  • Detailed molecular understanding of this important problem requires accurate channel structural information. (elifesciences.org)
  • Fig. 4: Post-translational mechanisms governing respiratory control and the role of mitochondrial membrane dynamics. (nature.com)
  • Specific consideration will be given to eating environments and physiological changes that influence access, preparation, and consumption of food by older adults living in the community and in facilities. (uoguelph.ca)
  • is the science that studies organisms' physiological response mechanisms against microorganism, toxin or antigen attacks. (bbva.com)
  • Molecular Studies of Bioenergetics in Health and. (hhmi.org)
  • viscosity, reduced red cell deformability, The main objectives of this study were abnormal red cell adhesive properties, en- to assess platelet aggregation patterns and dothelial intimal proliferation, bone marrow levels of PC, PS and AT III in SCA patients or fat embolism and a chronic hypercoagula- in the steady state and in vaso-occlusive ble state [6]. (who.int)
  • We wish to identify the neurons that release it, the key molecular components involved in its release and what function L-Asp may be serving in the brain. (warwick.ac.uk)
  • The antioxidant properties of rottlerin have been demonstrated but it is unclear whether the effects are because of BKCa++ channel opening or an additional mechanism of rottlerin. (wikipedia.org)
  • However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
  • Abiotic stressors such as drought and salinity adversely affect physiological citrus performance and survival. (springer.com)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)