Molecular adhesins escherichia coli. Medical search. Frequent questions

We describe two serogroup O157 Escherichia coli strains from Brazilian infants with diarrhea. (cdc.gov)
These strains possess a novel bfpA allele encoding the type IV pilin characteristic of typical enteropathogenic E. coli strains. (cdc.gov)
EHEC strains share with enteropathogenic E. coli (EPEC), a leading cause of infant diarrhea in developing countries, the ability to induce the attaching and effacing effect on host cells. (cdc.gov)
Here we describe two strains of the O157 serogroup identified as part of an ongoing epidemiologic survey of pathogenic E. coli in Brazil ( 3 ). (cdc.gov)
Clonal phylogeny of Escherichia coli strains of various pathotypes inferred from distances at synonymous sites in sequences of 13 concatenated loci ( mutS was not included) by using the neighbor-joining algorithm. (cdc.gov)
E. coli strains that are eae + and stx- are by definition, EPEC ( 2 ). (cdc.gov)
Pathogenic Escherichia coli strains on raw or insufficiently cooked foods are of public health concern as serious disease may result from their ingestion. (nih.gov)
The presence of fecal organisms in beef products suggests a failure of sanitary controls during processing and the more prevalent relatives of E. coli O157, Shiga toxin-producing Escherichia coli, enteropathogenic E. coli, and enterohemorrhagic E. coli, serve as more sensitive indicators of contamination than O157 strains alone. (nih.gov)
While very elegant work has been done to describe the genes which are responsible for encoding the AAF/1 fimbriae in some EAggEc strains, it is not possible at present to implicate AAF/1 as the fimbrial adhesin which is present in all or even the majority of EAggEc strains. (usda.gov)
Strains from these two groups of patients will be compared, using molecular techniques. (usda.gov)
The second project is focused on identification of the 'selection footprints' of nucleotide polymorphisms that affect various types of genes encoding different adhesins of E. coli, Shigella and Salmonella strains. (washington.edu)
Due to the appearance of the highly virulent strain of E. coli of serotype O157:H7 in the US and Canada in the 1980's, and subsequently in other Latin American countries, there is an increase need for accurate testing for this and other pathogenic E. coli strains, substantially enhancing detection of virulent strains and, therefore, facilitating identification of sporadic E. coli infections and outbreaks. (eurekaselect.com)
The emergence and evolution of pathogenic Escherichia coli strains associated with diarrheal diseases have become a topic of active investigation in recent years due to the emergence of more virulent strains and the association of new serotypes with disease. (eurekaselect.com)
The relative contribution of recombination events in the generation of new categories of pathogenic E. coli varies among the E. coli population, and it is represented by the wide variety of mobile elements found in different diarrheal strains (e.g. pathogenicity islands, phages, transposons, pathoadaptive mutations, etc). (eurekaselect.com)
In addition, factors underlying the emergence of enteroaggregative and atypical enteropathogenic E. coli strains associated with persistent diarrhea are unknown. (eurekaselect.com)
Horizontal transfer of genetic elements that affect virulence of diarrheagenic E. coli strains and changes in global agricultural processes, as well as movement of humans and animals, may contribute to the complex natural history of diarrheagenic E. coli. (eurekaselect.com)
The residues in the FimH mannose-binding pocket were sequenced and found to be invariant in over 200 uropathogenic strains of E. coli. (rcsb.org)
The detection of APEC strains towards 31 Escherichia coli isolates were done by using polymerase chain reaction (PCR) with vt1 and vt2 specific primer. (ugm.ac.id)
They are characterized as E. coli strains that do not secrete enterotoxins LT or ST and adhere to HEp-2 cells in an AA pattern. (microbiologynote.com)
The genes encoding adhesins, toxins (including Shiga toxin), and other virulence proteins vary significantly among EAEC strains. (microbiologynote.com)
In this study, we characterised the genes encoding type 3 fimbriae from CAUTI strains of Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca , Citrobacter koseri and Citrobacter freundii . (biomedcentral.com)
All of the strains examined caused type 3 fimbriae mediated agglutination of tannic acid treated human erythrocytes despite sequence variation in the mrkD -encoding adhesin gene. (biomedcentral.com)
Biochemical characteristic of biofilm of uropathogenic Escherichia coli Dr+ strains. (mostwiedzy.pl)
PEB 1 is a superficial antigen that appears to be a major adhesin and is conserved among C jejuni strains. (medscape.com)

These studies are devoted to the structure/functional analysis of allelic variations of the E. coli type 1 fimbrial adhesin, FimH protein. (washington.edu)
We also employ site-directed mutagenesis and Steered Molecular Dynamics simulations (in collaboration with the Center for Nanotechnology, UW, Seattle) to understand the functional effect of structural changes in FimH that are induced by mechanical force under various flow conditions. (washington.edu)
The clade members uniformly contained allele 41 of fimH (type 1 fimbrial adhesin) and a narrow range of alleles of gyrA and parC (fluoroquinolone target genes). (umn.edu)
The first subunit to be engaged is FimH, the adhesin at the very tip of the pilus, and subsequent subunits are added one at a time from the base up. (esrf.fr)
The adhesin subunit FimH is in green (FimH L and FimH p stand for the lectin and the pilin domains respectively) and the periplasmic chaperone FimC is in yellow. (esrf.fr)
The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. (ox.ac.uk)
In some cases, the mast cell TNF-alpha response was triggered when these cells directly bound FimH on the surface of Escherichia coli. (ox.ac.uk)
The first step in the colonization of the human urinary tract by pathogenic Escherichia coli is the mannose-sensitive binding of FimH, the adhesin present at the tip of type 1 pili, to the bladder epithelium. (rcsb.org)
Our structure/function analysis demonstrated that the binding of the monosaccharide alpha-D-mannose is the primary bladder cell receptor for uropathogenic E. coli and that this event requires a highly conserved FimH binding pocket. (rcsb.org)
Only enterohaemorrhagic E. coli (EHEC) possess a sequence variation within the mannose-binding pocket of FimH, suggesting a naturally occurring mechanism of attenuation in EHEC bacteria that would prevent them from being targeted to the urinary tract. (rcsb.org)
n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, a virulence factor of E. coli. (univ-lille.fr)
Animal models of UTI have revealed that the mannose-binding FimH adhesin of type 1 pili is critical for the colonization of and invasion into the bladder epithelium by UPEC, as well as other uropathogenic members of the Enterobacteriaceae family, such as Klebsiella, Enterobacter , and Citrobacter species. (justia.com)
The distal FimH adhesin protein is connected to the the pilus rod by the flexible tip fibrillum, which is composed of one copy each of FimF and FimG. (justia.com)
The adhesin tip protein FimH is a two-domain protein comprised of a pilin domain (FimHp), which allows it to incorporate into the pilus, and a lectin domain (FimHL) that contains a conserved mannose binding pocket. (justia.com)
In all of these models the adhesin FimH has been shown to play an integral role in pathogenesis, highlighting it as an excellent therapeutic target. (justia.com)
These infections are initiated by adhesion of uropathogenic E. coli to uroplakin receptors in the uroepithelium via the FimH adhesin located at the tips of type 1 pili. (wustl.edu)
Here, we provide for the first time binding data of the molecular events underlying type 1 fimbrial adherence, by crystallographic analyses of the FimH receptor binding domains from a uropathogenic and a K-12 strain, and affinity measurements with mannose, common mono- and disaccharides, and a series of alkyl and aryl mannosides. (wustl.edu)
Our results illustrate that the lectin domain of the FimH adhesin is a stable and functional entity and that an exogenous butyl α-D-mannoside, bound in the crystal structures, exhibits a significantly better affinity for FimH (K d = 0.15 μM) than mannose (K d = 2.3 μM). (wustl.edu)
Taken together, these relative FimH affinities correlate exceptionally well with the relative concentrations of the same glycans needed for the inhibition of adherence of type 1 piliated E. coli. (wustl.edu)

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is the serotype most commonly associated with hemorrhagic colitis and the hemolytic uremic syndrome ( 1 ). (cdc.gov)
In this study, the molecular basis of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium flagella binding to epithelial cell cultures was investigated. (ed.ac.uk)
Motor mutants of E. coli O157:H7 and S. Typhimurium caused reduced haemolysis compared to wild-type, indicating that membrane disruption was in part due to flagella rotation. (ed.ac.uk)
Flagella from E. coli O157 (H7), EPEC O127 (H6) and S. Typhimurium (P1 and P2 flagella) were shown to bind to purified intracellular components of the actin cytoskeleton and directly increase in vitro actin polymerization rates. (ed.ac.uk)
We propose that flagella interactions with host cell membranes and cytoskeletal components may help prime intimate attachment and invasion for E. coli O157:H7 and S. Typhimurium, respectively. (ed.ac.uk)
Therefore, many commercial producers of beef products screen for E. coli O157:H7 before shipment. (nih.gov)
Of the E. coli O157-positive samples, 14% were also Salmonella positive. (nih.gov)
However, a significant risk exists that infections caused by highly virulent E. coli isolates, such as the enterohemorrhagic E. coli O157:H7, develop into serious and potentially lifethreatening complications, such as hemolytic uremic syndrome. (eurekaselect.com)

This issue will be addressed by undertaking molecular characterization of EAggEc isolates from patients in whom 'host factors' which may be related to EAggEc pathogenesis can be measured. (usda.gov)
An analysis of recent clinical E coli collections showed that the O16 ST131 clade is globally distributed, accounts for 1 to 5% of E coli isolates overall, and, when compared with other ST131 isolates, it is associated with resistance to ampicillin, gentamicin, and trimethoprim-sulfamethoxazole and with susceptibility to fluoroquinolones and extendedspectrum cephalosporins. (umn.edu)
The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)

Molecular Microbiology. (northwestern.edu)
f) Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine (USA). (esrf.fr)
Our findings reveal how bacteria have evolved a mechanism to colonize the bladder in order to persist and cause UTIs, and our vaccination study suggests that inhibiting this mechanism could be part of a viable approach to treating or preventing these infections," said Scott Hultgren, PhD, the Helen L. Stoever Professor of Molecular Microbiology and one of the study's senior authors. (wustl.edu)
Molecular Microbiology , 55 (2), 441-455. (wustl.edu)

Our results emphasize the pitfalls of classifying pathogenic E. coli by serogroup. (cdc.gov)
Alfredo G. Torres , " Pathogenic Escherichia coli in Latin America ", Bentham Science Publishers (2010). (eurekaselect.com)
At least six different categories of pathogenic E. coli causing enteric infections have been identified and further characterized. (eurekaselect.com)
Understanding the population structure of pathogenic E. coli is important, since it impacts the effectiveness of molecular epidemiological studies. (eurekaselect.com)
Avian Pathogenic Escherichia coli (APEC) is a pathogen that causes colibacillosis in poultry, including salpingitis, omphalitis, cellulitis, swollen head syndrome, coligranuloma yolk sac inflammation, and air sacs inflammation. (ugm.ac.id)
Thechicken as anatural model for extra intestinal infections caused by avian pathogenic Escherichia coli (APEC). (ugm.ac.id)

2012. Identification of Coli Surface Antigen 23, a Novel Adhesin of Enterotoxigenic Escherichia coli . (umd.edu)

The first project is directed towards understanding the mechanism of bacterial adhesion to host cells mediated by the most common kind of bacterial adhesins known - type 1, or mannose-sensitive, fimbriae. (washington.edu)
The effect of D-mannose and D-glucose on bacteriuria due to Escherichia coli with mannose-sensitive adhesins was investigated in adult male Sprague-Dawley rats undergoing diuresis. (dmanna.com)

Uropathogenic Escherichia coli (UPEC) attach specifically to human bladder cells using surface structures known as type 1 pili. (esrf.fr)
To avoid being swept away during urination, E. coli attaches to the bladder with long, hairlike projections called pili. (wustl.edu)
Mannose-binding type 1 pili are important virulence factors for the establishment of Escherichia coli urinary tract infections (UTIs). (wustl.edu)

The most prevalent bacteria were Escherichia coli (39.0%), Proteus vulgaris (12.2%), Klebsiella spp. (scielo.br)
Escherichia coli are Gram-negative bacteria found as normal commensal flora in the gastrointestinal tract. (eurekaselect.com)
The exact prevalence of EAEC-related diseases is unclear due to the lack of a specific molecular marker for these bacteria. (microbiologynote.com)
The bacteria also produce multiple adhesins. (medscape.com)
Bacteria are able to compete effectively for iron bound to host proteins because of the secretion of high-affinity, low molecular weight iron chelators known as siderophores. (medscape.com)
The researchers removed the gene for FmlH from E. coli and then infected the urinary tracts of mice with bacteria with and without the gene. (wustl.edu)
They found that E. coli lacking FmlH were less likely to establish chronic infections in mice than bacteria with the protein. (wustl.edu)
Then, they infected both groups with E. coli and measured the amount of bacteria in their bladders and kidneys one, two and three days after infection. (wustl.edu)
Enterotoxigenic Escherichia coli (ETEC) are the most common bacteria causing diarrhea. (illinois.edu)
Recent studies indicated that FUT1 gene was important in the synthesis of the structure that was beneficial to the adhesion between E. coli F18 fimbriated bacteria and the small intestinal wall [6]. (symbiosisonlinepublishing.com)
Therefore, FUT1 gene was regarded as a good candidate for gene controlling the expression of the receptor for E. coli F18 bacteria. (symbiosisonlinepublishing.com)
Surveillance and molecular epidemiology of antibiotics resistant bacteria are urgently needed in the study area. (bvsalud.org)

The human urinary tract is one of the most common sites of bacterial infection and most of them are caused by uropathogenic Escherichia coli (UPEC). (esrf.fr)
Greater than 85% of UTI are caused by uropathogenic Escherichia coli (UPEC). (justia.com)

EPEC are defined by this attaching and effacing phenotype or, at a molecular level, by the presence of the eae gene and the absence of the genes for Shiga toxins ( 2 ). (cdc.gov)
During 2005-2008, about 971,389 samples from several commercial beef production plants were tested using a rapid screening method based on the polymerase chain reaction to determine if they were presumptively positive for bacterial cells carrying Salmonella or Shiga toxin-producing E. coli-specific genes. (nih.gov)
Serotypes, virulence genes, and intimin types of Shiga toxin-producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) isolated from calves in Sao Paulo, Brazil. (ugm.ac.id)
The outbreak was caused by an EAEC O104:H4 strain that was infected with a Shiga toxin-encoding phage, typically associated with Shiga toxin-producing E. coli. (microbiologynote.com)
Choice of library preparation affects sequence quality, genome assembly, and precise in silico prediction of virulence genes in shiga toxin-producing Escherichia coli. (cdc.gov)

Outbreak studies indicate that most patients with an intestinal E. coli infection develop mild, uncomplicated diarrhea. (eurekaselect.com)
Researchers have identified a potential way to prevent chronic urinary tract infections, a common infection primarily caused by E. coli (shown above). (wustl.edu)
To elucidate the molecular details of UPEC pathogenesis, several murine models of infection have been established which recapitulate many of the clinical manifestations often seen in humans. (justia.com)
In this study, we established a dynamic micromodel of urinary tract infection to analyze the impact of UT-segment-specific urinary outflow on the persistence of E. coli colonization. (mostwiedzy.pl)
Besides, Meishan piglets may have its characteristic immune system for the infection of E. coli F18. (symbiosisonlinepublishing.com)

In molecular biology, YadA is a protein domain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly at their C-terminal end. (wikipedia.org)
The Eib immunoglobulin-binding proteins from Escherichia coli were third, followed by the DsrA proteins of Haemophilus ducreyi, amongst others. (wikipedia.org)
Treponemal proteins ranging in molecular weight from 37,000 daltons to 120,000 daltons were identified by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and immunoblotting of phage lysate proteins. (bmj.com)
The mrk gene cluster is similar to other fimbrial operons of the chaperone-usher class in that it contains genes encoding major ( mrkA ) and minor ( mrkF ) subunit proteins as well as chaperone- ( mrkB ), usher- ( mrkC ) and adhesin- ( mrkD ) encoding genes [ 37 , 38 ]. (biomedcentral.com)
The high-affinity interaction of LF with pore-forming outer-membrane proteins (OMPs) of Gram-negative enterics, including Escherichia coli , is critical for the antimicrobial outcome of LF (Gado et al. (ift.org)

Influência da biossegurança na colonização intestinal por Escherichia coli em psitacídeos. (scielo.br)
On a valency-corrected basis, HM-based glycopolymers are, respectively, 10(2) and 10(6) times more potent than HM and d-mannose for their capacity to disrupt the binding of adherent-invasive E. coli to T84 intestinal epithelial cells. (univ-lille.fr)
The presence of E. coli F18 receptor on small intestinal villi is the essential requirement for the adhesion and colonization. (symbiosisonlinepublishing.com)

Such studies are needed to understand the increasingly recognized diversity of enterotoxigenic E. coli, a leading cause of pediatric and travelers' diarrhea. (eurekaselect.com)
EAEC is considered an emerging enteric pathogen, and it is the second most common cause of traveler's diarrhea, following Enterotoxigenic E. coli. (microbiologynote.com)

The Enteroaggregative Escherichia coli (EAggEc) are a complex group of bacterial organisms which have a distinctive phenotype and a strong association with persistent diarrheal disease in children in the developing world and in patients infected with the Human Immunodeficiency Virus (HIV). (usda.gov)
Not all patients colonized with Enteroaggregative Escherichia coli are symptomatic. (usda.gov)
Enteroaggregative Escherichia coli (EAEC or EAggEC) is a pathotype of Escherichia coli that is responsible for both acute and chronic diarrhea in both developed and developing countries. (microbiologynote.com)
Disease caused by Enteroaggregative Escherichia coli (EAEC) can have significant impacts, particularly in children. (microbiologynote.com)

Intracellular events, such as blocking of microbial attachment factors such as fimbriae (hairlike structures) and other adhesins (putative receptors), have been observed (Naidu and Bidlack, 1998). (ift.org)
Considering that the biological processes and pathways FUT1 gene involved in was related to glycosphingolipid biosynthesis, we can speculate that higher expression of FUT1 in jejunum and duodenum is beneficial to the formation of receptors to E. coli F18. (symbiosisonlinepublishing.com)

Research in Sokurenko's laboratory is focused on understanding mechanisms of molecular adaptive evolution of genes in bacterial pathogens. (washington.edu)
These studies employ methods of both evolutionary genetics and molecular biology to discover pathogenicity-adaptive variation of the genes. (washington.edu)
Thus, a single gene encoding a mesophilic variant of citramalate synthase from Methanococcus jannaschii, CimA3.7, was expressed in E. coli to convert acetyl-CoA and pyruvate to citramalate, and the ldhA and pflB genes were deleted. (microbiologyresearch.org)

Some of these variations result in adaptive changes of the receptor-specificity of type 1 fimbriae that lead to an increased tissue tropism and, consecutively, virulence of uropathogenic and meningitis-associated E. coli. (washington.edu)

This property is specified by a pathogenicity island that includes the eae gene encoding the outer membrane adhesin intimin. (cdc.gov)
The gene was cloned and overexpressed in Escherichia coli. (microbiologyresearch.org)
The E. coli and K. pneumoniae mrkABCD gene sequences clustered together in two distinct clades, supporting previous evidence for the occurrence of inter-genera lateral gene transfer. (biomedcentral.com)
A gene discovery approach is being used to identify global changes in protein expression that occur when adhesin P1 is engaged with a physiological binding partner. (ufl.edu)
So the M307 of FUT1 gene has been proposed as a genetic marker to distinguish the E. coli F18 resistant from susceptible phenotypes in some imported pigs. (symbiosisonlinepublishing.com)
7] estimated that the FUT1 gene polymorphism was less than 1 centimorgan from the S and E. coli F18 receptor loci. (symbiosisonlinepublishing.com)

SpyCatcher002 was fused to an intimin derived from enterohemorrhagic Escherichia coli. (ox.ac.uk)

The YadA protein domain, is a form of trimeric autotransporter adhesins (TAAs). (wikipedia.org)
The recombinant protein in Escherichia coli lysates was labelled P2 (P2 star) to differentiate it from the comigrating adhesin protein called P2. (bmj.com)
This protein superglue is a broadly useful tool for molecular assembly, locking together biological building blocks efficiently and irreversibly in diverse architectures. (ox.ac.uk)
and studies of intra- and inter-molecular protein-protein interactions relevant for bacterial protein stability, function and adhesive interactions with host constituents. (ufl.edu)
Also, in collaboration with Dr. Champion Deivanayagam of the Center for Biophysical Sciences and Engineering at the University of Alabama we are utilizing X-ray crystallography in conjunction with protein interaction methodologies to define the structure of P1 and to identify the binding motif responsible for its interaction with the high molecular weight gp340 salivary agglutinin ligand. (ufl.edu)
Vaccinating mice against a key protein that E. coli use to latch onto the bladder and cause UTIs reduces severe disease, according to researchers at Washington University School of Medicine in St. Louis. (wustl.edu)

As a pathogen, E. coli are the most frequent causes of bacterial infections, including urinary tract infections, diarrheal disease, and other clinical infections such as neonatal meningitis, pneumonia and bacteremia. (eurekaselect.com)

We developed an engineered E. coli strain and a fed-batch bioprocess to produce citramalate at concentrations in excess of 80 g l −1 in only 65 h. (microbiologyresearch.org)

Adhesins mediate bacterial attachment and colonization, and enterotoxins including heat-labile (LT) and heat-stable type Ib toxin (STa) disrupt fluid homeostasis in host cells that leads to fluid hyper-secretion and diarrhea. (illinois.edu)
Investigating the role of epithelial surface architecture, we showed that the presence of budding cells-a model microarchitectural obstacle-promotes colonization of the urinary tract by E. coli. (mostwiedzy.pl)
We report a previously undescribed phenomenon of epithelial cell "rolling-shedding" colonization, in which the detached epithelial cells reattach to the underlying cell line through a layer of adherent Dr+ E. coli. (mostwiedzy.pl)

We found that the adherence of Dr+ E. coli to bladder T24 transitional cells and type IV collagen is maximal at lowest shear stress and is reduced by any increase in flow velocity. (mostwiedzy.pl)

To date, however, there are very few hard data about EAggEc that permit speculation about the molecular basis for pathogenesis or development of additional diagnostic methodologies. (usda.gov)

In this research, the isolation and the identification of Escherichia coli were done by using selective media MacConkey, Kligger Iron Agar, and Gram staining. (ugm.ac.id)
Structure-function analysis of decay-accelerating factor: identification of residues important for binding of the Escherichia coli Dr adhesin and complement regulation. (childrensmercy.org)
Serological and Molecular Identification of Brucella spp. (mdpi.com)

Heptyl α-d-mannose prevents binding of type 1-piliated E. coli to the human bladder cell line 5637 and reduces both adhesion and invasion of the UTI89 cystitis isolate instilled in mouse bladder via catheterization. (dmanna.com)

Afroz H., Sultana F., Fakruddin M., Khan Z.U.M. and Datta S. (2013) Isolation of Escherichia coli and Staphylococcus aureus from Full Cream Powder Milk Sold Under Market Conditions at Dhaka, Bangladesh and Their Antibiotic Susceptibility. (ugm.ac.id)

About 80 percent of UTIs are caused by Escherichia coli (E. coli) . (wustl.edu)

It also has two molecular regulators: an activator, VirF and a repressor, YmoA. (wikipedia.org)

This new breakthrough provides new insights into the molecular details of pilus assembly. (esrf.fr)
Over the last two decades, some of the molecular details of pilus biogenesis through the CU pathway have been provided [1] . (esrf.fr)
The filaments are anchored to a molecular machinery in the cell envelope [ 13 ], where the ATPase PilB drives pilus polymerzation while pilus retraction is driven by the AT-Pases PilT and PilU. (biorxiv.org)
Many of these infections are initiated by a critical interaction between host ligands (frequently polysaccharide moieties) and bacterial adhesins (frequently expressed at the distal tip of polymeric pilus fibers assembled by the chaperone-usher pathway). (justia.com)

Escherichia coli sequence type 131(ST131), a widely disseminated multidrug-resistant extraintestinal pathogen, typically exhibits serotype O25b:H4. (umn.edu)

Adhesins and enterotoxins are the virulence determinants in ETEC diarrhea. (illinois.edu)
F18-fimbriated Escherichia coli are associated with porcine post weaning diarrhea and edema disease. (symbiosisonlinepublishing.com)

Herein we report on the construction of multivalent HM-based glycopolymers as potent antiadhesives of type 1 piliated E. coli. (univ-lille.fr)
2] found that F18-fimbriated E. coli selectively interact with glycosphingolipids having blood group ABH determinants on type 1 core, and blood group A type 4 heptaglycosylceramide. (symbiosisonlinepublishing.com)

However, the molecular mechanisms underlying how cells use this adhesin (a hypothetical fusogen) to recognize kin and transition towards a multicellular lifestyle remain largely unexplored. (nature.com)
Once Dr+ E. coli bound to host cells or collagen, they did not detach even in the presence of elevated shear stress or of chloramphenicol, a competitive inhibitor of binding. (mostwiedzy.pl)

Thus, adhesins and enterotoxins have been primarily targeted in ETEC vaccine development. (illinois.edu)

At present, there are a lot of researches on the receptor of E. coli F18, and the genetic locus for this receptor has been mapped to porcine chromosome 6 (SSC6), based on its close linkage to the S locus and other loci of the halothane (HAL) linkage group [1]. (symbiosisonlinepublishing.com)

Anatomy10

Organisms26

Diseases7

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes82

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Health Care4

Strains24

FimH19

O1578

Isolates3

Microbiology4

Pathogenic6

Antigen1

Mannose-sensitive2

Pili3

Bacteria12

Uropathogenic Escherichia coli2

Shiga5

Infection5

Proteins5

Intestinal3

Enterotoxigenic2

Enteroaggregative Escherichia4

Receptors2

Genes3

Fimbriae1

Gene6

Enterohemorrhagic1

Protein6

Including urinary tract infe1

Strain1

Colonization3

Adherence1

Pathogenesis1

Identification3

Bladder1

Susceptibility1

UTIs1

Repressor1

Pilus4

Sequence1

Diarrhea2

Type2

Cells2

Enterotoxins1

Receptor1