• American Journal of Biochemistry and Molecular Biology is a peer-reviewed international journal dedicated to provide an active forum to the global scientific community for publishing and disseminating high quality research work in the field of biochemistry and molecular biology. (scialert.net)
  • Statistical analysis revealed that BRAF and KRAS mutations were the best predictors of the combinatorial activity, and were significantly associated with synergistic effect with a p value of 0.01 compared with cetuximab alone. (aacrjournals.org)
  • This preliminary report forms as a foundation for functional studies to be performed to reveal their roles in EC activation and pathophysiological events associated with the vasculature including tumor growth. (biomedcentral.com)
  • Preclinical models using antibody treatment to block LAG-3 for cancer treatment show enhanced activation of antigen-specific T cells at the tumor site and disruption of tumor growth ( 25 ). (aacrjournals.org)
  • However, there is no clear understanding of the effect of distance on activation in S. cerevisiae in vivo and no knowledge concerning factors that might play a role in controlling this effect. (asm.org)
  • In this study, we set out to reevaluate previous suggestions that LAG-3 −/− mice had no T cell defect ( 16 , 17 ), and to determine whether there was a role for LAG-3 in T cell activation and expansion in vivo or in the generation of a memory T cell response. (jimmunol.org)
  • Integrative analysis of the expanded RPPA data set revealed five major clusters of cell lines and five principal proteomic signatures. (aacrjournals.org)
  • The initial analysis of LAG-3 −/− mice did not reveal a defect in T cell function ( 16 , 17 ). (jimmunol.org)
  • Egg activation, the transition of mature oocytes into developing embryos, is initiated by different external signals in different animals. (cornell.edu)
  • By naïvely characterizing comprehensive molecular profiles for each patient, the authors were able to identify a coherent signature of macrophage activity that was otherwise obscured by conventional staging criteria. (sciencemag.org)
  • To study the potential for long-distance activation in S. cerevisiae , we constructed and analyzed reporters in which the UAS-TATA distance varied. (asm.org)
  • A number of in vitro model systems have thus been developed to study EC activation that employs either one or more combinations of ECM molecules including fibrin, fibronectin, collagens, laminins, and Matrigel ® matrices together with PMA and FGF [ 7 - 9 ]. (biomedcentral.com)
  • In S. cerevisiae , upstream activation sequences (UASs) are generally located within a few hundred base pairs of a target gene, while in Drosophila and mammals, enhancers are often several kilobases away. (asm.org)
  • Confocal and Western blot analyses showed that both phosphorylated and non-phosphorylated forms of AKT are present in melanoma cells nuclei. (bioscirep.org)
  • Western blot verified activation of SREBP2 in these cells, and apoptosis was enhanced by pretreatment with simvastatin, an activator of SREBP2, and by overexpression of the N-terminal fragment of SREBP2. (sigmaaldrich.com)
  • In the case of CTLA-4, absence of this molecule results in a striking lymphoproliferative disorder, mediated by the costimulation dependent activation of CD4 + T cells ( 2 , 3 , 4 ). (jimmunol.org)
  • In part because of the extensive pharmacological characterization of NCI60, they have frequently been used as test samples for emerging technologies and methods of analysis ( 2 - 8 ). (aacrjournals.org)
  • Cuomo CA, Oettinger MA (1994) Analysis of regions of RAG-2 important for V(D)J recombination. (springer.com)
  • Global gene analysis indicated that functions related to cell survival and invasion were influenced by combined treatment. (mdpi.com)
  • Microarray experiments followed by principal component analysis (PCA) mapping showed distinct gene clustering after treatment, and cell cycle checkpoint regulators were affected. (mdpi.com)
  • Dr. Esserman has recently launched a University of California-wide breast cancer initiative called the Athena Breast Health Network, a project designed to follow 400,000 women from screening through treatment and outcomes, incorporating the latest in molecular testing and web-based tools into the course of care. (ucsf.edu)