Moiety transferases other substituted phosphate groups. Medical search. Frequent questions

Deoxyribose 5-phosphate is a a metabolite in the pentose phosphate pathway. (hmdb.ca)
Alternately Deoxyribose 5-phosphate can be converted to D-glyceraldehyde-3 phosphate that can then feed into the pentose phosphate pathway. (hmdb.ca)
It has been shown in a number of organisms that deoxynucleosides or deoxyriboses cause the induction of aldolases (such as DERA) involved in their catabolism, leading to the utilisation of the pentose moiety as carbon and energy source. (hmdb.ca)
Belongs to the class of organic compounds known as pentose phosphates. (hmdb.ca)
These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. (hmdb.ca)
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. (easyomics.org)

In enzymology and molecular biology, a holo-[acyl-carrier-protein] synthase (ACPS, EC 2.7.8.7) is an enzyme that catalyzes the chemical reaction: CoA-[4'-phosphopantetheine] + apo-acyl carrier protein ⇌ {\displaystyle \rightleftharpoons } adenosine 3',5'-bisphosphate + holo-acyl carrier protein This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. (wikipedia.org)
The protein part is called apo-enzyme and the non-protein part is a prosthetic group. (studyread.com)
Firstly Ins-P is conjugated with UDP-GlcNAc to yield N -acetyl glucosamine myo -inositol-1-phosphate (GlcNAc-Ins-P) via enzyme glycosyltransferase MshA. (encyclopedia.pub)
Here, we report a noncanonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycinothricin to form the antibiotic BD-12. (hokudai.ac.jp)
It can be generated from D-glyceraldehdye-3 phosphate via the enzyme 2-Deoxyribose 5-phosphate aldolase (DERA). (hmdb.ca)
Deoxyribose 5-phosphate can also be generated from 2-Deoxy-D-ribose via the enzyme Ribokinase (EC 2.7.1.15). (hmdb.ca)
The first, ubiquitous, enzyme of the pathway, MtnA (methylthioribose-1-phosphate isomerase), belongs to a family of proteins related to eukaryotic intiation factor 2B alpha. (biomedcentral.com)
Ketomethylthiobutyrate is finally transaminated by an aminotransferase that exists usually as a broad specificity enzyme (often able to transaminate aromatic aminoacid keto-acid precursors or histidinol-phosphate). (biomedcentral.com)

It transfers a 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to an invariant serine in an acyl carrier protein (ACP), a small protein responsible for acyl group activation in fatty acid biosynthesis. (wikipedia.org)
Other names in common use, disregarding the synthetase/synthase spelling difference, include acyl carrier protein holoprotein synthetase, holo-ACP synthetase, coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine, acyl carrier protein synthetase (ACPS), PPTase, acyl carrier protein synthase, P-pant transferase, and CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase. (wikipedia.org)
These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. (ymdb.ca)

Glycosylation refers to a sequence of events that take place in the Golgi body and the endoplasmic reticulum of the cells of the expression system (predominantly mammalian) that lead to post-translational addition and processing of carbohydrate or glycan moieties to the protein backbone (usually serine- or threonineâ linked glycosylation for O-linked glycans and asparagineâ linked glycosylation for N-linked glycans) (6). (chromatographyonline.com)

But unlike systemic enzymes, they can be substituted externally in case of deficiency. (studyread.com)
The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. (hindawi.com)
Actinomycetes lack the enzymes for GSH biosynthesis, but as a substitute, they utilize alternative low molecular weight thiols (LMW), such as bacillithiol (BSH) and MSH, ergothioneine (ESH) [ 1 ] . (encyclopedia.pub)
MSH biosynthesis involves five enzymes, and the substrates myo -inositol-1-phosphate (Ins-P), UDP- N -acetyl glucosamine (UDP-GlcNAc), and Cysteine (Cys) represented in Figure 1 . (encyclopedia.pub)
A cooperative and competitive interaction between multiple enzymes, cell lines, and cell culture conditions causes processing of the oligosaccharide structure during which some of the already attached moieties like mannose are trimmed to yield a fiveâ residue core (Man3GlcNAc2), to which N-acetylglucosamine (GlcNAc), fucose, galactose, and N-acetylneuraminic acid (sialic acid or Neu5Ac) residues get added in a probabilistic fashion. (chromatographyonline.com)
The synthesis of the peptide stem of bacterial peptidoglycan involves four enzymes, the Mur ligases (MurC, D, E and F). Among them, MurD is responsible for the ATP-dependent addition of d -glutamic acid to UDP-MurNAc- l -Ala, a reaction which involves acyl-phosphate and tetrahedral intermediates. (degruyter.com)
The citric acid cycle is a complex of many enzymes that convert the by-products of glucose, protein, and fat degradation as pyruvate (glucose and some amino acids) and acetate (fatty acids and some amino acids) into covalently bound CoA moieties to make acetyl CoA, the major entry point substrate for the citric acid cycle ( Figure 4.1 ). (veteriankey.com)

The latter molecule has to be recycled or further metabolized, either after excision of the adenine moiety by hydrolysis or phosphorolysis, or by direct hydrolysis into adenosine and homocysteine. (biomedcentral.com)

It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. (lookformedical.com)
These readily undergo iron-catalyzed secondary free radical reactions leading to truncated products which retain the signature PE headgroup and which can readily react with nucleophilic moieties in proteins via their truncated electrophilic acyl chains. (cdc.gov)

The structure in complex with a substrate analogue suggests a catalytic mechanism that is distinct from those of known NADases, ADP-ribosyl cyclases and transferases. (nature.com)

Amino and amide groups from these 2 substances are freely transferred to other carbon skeletons by transamination and transamidation reactions. (medmuv.com)
Serious skin/hypersensitivity reactions such as Stevens-Johnson Syndrome, toxic epidermal necrolysis and erythema multiforme: Discontinue oseltamivir phosphate capsules and initiate appropriate treatment if allergic-like reactions occur or are suspected. (nih.gov)
Furthermore, other still unknown reactions might exist, transferring the aminopropyl-group to yet unrecognized acceptors (most likely to be nitrogen atoms). (biomedcentral.com)

The prosthetic group can be an inorganic part like Zn, Cu, etc., which is called a co-factor. (studyread.com)
The generation of ATP is a universal process in all cells that occurs through the enzymatic machinery of the mitochondrial electron transport chain (ETC). In short, the ETC utilizes free hydrogen to create an electrochemical gradient between the inner and outer mitochondrial membrane that generates a covalent bond between ADP and inorganic phosphate to make ATP as the storage form of energy. (veteriankey.com)

Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids (2022) Bioorganic and Medicinal Chemistry Letters, 77, статья № 129019. (org.ua)

This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP. This superfamily consists of two subtypes: the trimeric ACPS type such as E. coli ACPS and the monomeric Sfp (PCP-synthesizing) type such as B. subtilis SFP. (wikipedia.org)

These moieties are critical in terms of their role in in-vivo safety and efficacy (pharmacodynamics and pharmacokinetics), protein folding, protein targeting and trafficking, ligand binding, stability, protein halfâ life regulation, and immunogenicity (8). (chromatographyonline.com)
4'-Phosphopantetheinyl transferases (PPTases) play an essential role in activating the carrier protein domains of mega-synthases involved in primary and secondary metabolism and have been validated as promising drug targets in multiple pathogens. (bvsalud.org)
For anticoagulation potency, the formation of the SP/protease protein complex and the associated non-specific polar interaction between the negatively and positively charged groups in the polysaccharide and protein is responsible for anticoagulant activity. (springer.com)

The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. (easyomics.org)

increase in mature neurons was unlikely due to suppressed apoptosis, because terminal deoxynucleotidyl transferase dUTP nick-end labeling analysis showed no difference in DNA terminal labeling between vehicle and 8-OH-DPAT-infused mice. (thetechnoant.info)

This group of polysaccharides has a backbone of alternating 3-linked β- d -galactose and 4-linked α- d -galactose residues (Tuvikene et al. (springer.com)

Obviously, compared with the blank group, ADC had a significant inhibitory effect on the growth of 293 cells. (genemedi.com)

The addition of a precursor 13-residue oligosaccharide moiety GlcNAc2Man8Gluc3 to the nascent polypeptide chain occurs in the endoplasmic reticulum, following which the assembly folds and acquires its secondary, tertiary, and quaternary structure. (chromatographyonline.com)

In this batch, we selected 5.4 equivalent TCEP and 10.8 equivalent VCMMAE groups for DAR detection. (genemedi.com)

The α -glucosidase (EC 3.2.1.20) Agl2 produced by Xanthomonas campestris shows high α -glucosyl transfer activity toward alcoholic and phenolic hydroxyl groups. (researchsquare.com)
This group transfer results in the synthesis of S-adenosyl homocysteine (AdoHcy). (biomedcentral.com)

Following 6 mu g/kg, the mean AUC was 5.01 ngh/mL for the 12-16-year-old group, a 1.8-fold increase. (pdgfrsignals.com)

The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures. (lookformedical.com)

These highlights do not include all the information needed to use OSELTAMIVIR PHOSPHATE CAPSULES safely and effectively. (nih.gov)
See full prescribing information for OSELTAMIVIR PHOSPHATE CAPSULES. (nih.gov)
Serious skin/hypersensitivity reactions such as Stevens-Johnson Syndrome, toxic epidermal necrolysis and erythema multiforme: Discontinue oseltamivir phosphate and initiate appropriate treatment if allergic-like reactions occur or are suspected. (nih.gov)
Neuropsychiatric events: Patients with influenza, including those receiving oseltamivir phosphate, particularly pediatric patients, may be at an increased risk of confusion or abnormal behavior early in their illness. (nih.gov)
Avoid administration of LAIV within 2 weeks before or 48 hours after oseltamivir phosphate capsules use, unless medically indicated. (nih.gov)
Oseltamivir phosphate capsules are indicated for the treatment of acute, uncomplicated illness due to influenza A and B infection in patients 2 weeks of age and older who have been symptomatic for no more than 48 hours. (nih.gov)
Oseltamivir phosphate capsules are indicated for the prophylaxis of influenza A and B in patients 1 year and older. (nih.gov)

and A is a substituted oxazole, thiazole, oxadiazole or thiadiazole substituted with at least one C 1-6 alkyl, C 3-7 cycloalkyl or C 1-6 haloalkyl. (justia.com)

HN - 2024 BX - Angucycline Aglycons BX - Angucycline and Angucyclinone Derivatives BX - Angucycline Antibiotics BX - Angucyclines BX - Angucyclinone Antibiotics BX - Angucyclinones FX - Anthraquinones MH - Anthrones UI - D000095322 MN - D2.455.426.559.847.117.380 MN - D4.615.125.380 MS - Anthracenes with one ketone group, typically 9,10-dihydroanthracene carrying an oxo group at C-9. (nih.gov)
These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. (ecmdb.ca)
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids . (lookformedical.com)

It is also known as 4'-phosphopantetheinyl transferase after the group it transfers. (wikipedia.org)
A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis . (nih.gov)

A group of uridine ribonucleotides in which the phosphate residues of each uridine ribonucleotide act as bridges in forming diester linkages between the ribose moieties. (lookformedical.com)
In addition to the free base forms, cytokinins can also be present in the plant as a riboside (in which a ribose sugar is attached to the 9 nitrogen of the purine ring) or a ribotide (in which the ribose moiety contains a phosphate group). (bioone.org)

[ 34 ] Since the mAGP complex serves as a rigid barrier against chemical injury and bactericidal substances, the four Rml enzymes encoded by rml genes, including glucose-1-phosphate thymidyltransferase (RmlA), dTDP-glucose dehydratase (RmlB), dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC) and dTDP-4-dehydrorhamnose reductase (RmlD), that form dTDP-rhamnose from dTDP and glucose-1-phosphate, are attractive targets for the development of new TB therapeutics. (medscape.com)
Summary Bovine galactosyl transferase was found to utilize UDPgiucose as a substrate and elicit disaccharide biosynthesis with glucose and N-acetylglucosamine as acceptors. (docksci.com)
Introduction Galactosyl transferase (uridine diphosphate-D-galactose : D-glucose-l-galactosyltransferase, EC 2.4.1.22) of bovine milk catalyzes the two basic reactions below: UDPGal + GIcNAc Me(I! (docksci.com)
We have been quite interested in how the enzyme imparts its specificity towards galactose as the donor saccharide moiety and apparently not glucose, which differs only by its equatorial (rather than axial) 4'-hydroxyl group. (docksci.com)
Either the UDPGal binding site is sterically restricted at the equatorial 4' position for any group larger than a proton, or the formation of a specific hydrogen bond with an axial 4'-hydroxyl group conformationally "signals" the active site to catalyze the scission at the 1' position and subsequent transfer to the carbohydrate acceptor (glucose or GlcNAc). (docksci.com)
First, phosphorylase removes glucose moieties (linked to their neighbors via alpha1,4 glucosidic bonds and depicted as the 7 black circles) from the unbranched outer portions of the glycogen molecule until only 4 glucosyl units (depicted as the 3 green circles and the 1 red circle) remain before an alpha1,6 branch point. (medscape.com)
The transferase component of debranching enzyme then transfers the 3 (green) glucose residues from the short branch to the end of an adjacent branch of the glycogen molecule. (medscape.com)
The glucosidase component of debranching enzyme then removes the glucose moiety (depicted as the red circle) remaining at the alpha1,6 branch point. (medscape.com)
In the process, the branch point formed by the alpha1,6 glucosidic bond is removed, hence the name debrancher.Unlike phosphorylase, which removes glucose moieties from glycogen in the form of glucose-1-phosphate, debrancher releases 1 free glucose moiety from each branch point. (medscape.com)
Eventually, large portions of the glycogen molecule are degraded to free glucose by the action of the amylo-alpha1,6-glucosidase activity of debranching enzyme and to glucose-1-phosphate by the action of phosphorylase. (medscape.com)

In MTB, the major cell wall-associated components containing lipid moieties are lipoarabinomannan (LAM), the phthiocerol dimycoserosate (PDIM) family of complex lipids and 6,6'-trehalose dimycolate (TDM). (medscape.com)
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). (lookformedical.com)

It is a glycerophospholipid in which a cytidine diphosphate moiety occupies a glycerol substitution site. (hmdb.ca)

Therefore, glycolipids contain a carbohydrate moiety, while there are no carbohydrate moieties in phospholipids. (trnds.co)
The key difference between glycolipids and phospholipids is that glycolipids contain a carbohydrate group attached to the lipid residue, whereas phospholipids contain a phosphate group attached to the lipid residue. (trnds.co)

A phospholipid molecule is constructed from four components: fatty acids, a platform to which the fatty acids are attached, a phosphate, and an alcohol attached to the phosphate. (trnds.co)
Our in vitro and in vivo analyses indicate that the MECR G165Q variant allows synthesis of octanoyl groups but not long chain fatty acids, confirming the validity of our computational approach to engineer substrate length specificity. (nature.com)
A group of fatty acids , often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. (lookformedical.com)
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon. (lookformedical.com)
A group of 16-carbon fatty acids that contain no double bonds. (lookformedical.com)

Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. (lookformedical.com)

Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds. (nih.gov)
belongs to the class of organic compounds known as hexose phosphates. (ecmdb.ca)

An L-rhamnosyl residue plays an essential structural role in the cell wall of MTB, since arabinogalactan, to which mycolic acids are esterified, thereby forming an outer lipid layer, is connected via a linker disaccharide containing a rhamnosyl residue to a muramic acid moiety of the peptidoglycan. (medscape.com)
The lipid residue contains two parts: polar head group and nonpolar tail group. (trnds.co)

Isoprenoids play essential roles in the growth of MTB as follows: polyprenyl phosphate acts as a carrier of activated sugar in the biosynthesis of the arabinan portion of arabinogalactan, arabinomannan and LAM, thereby supporting cell wall synthesis [ 38 ] . (medscape.com)
After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (blogspot.com)

Glucosyl transferase activity of bovine galactosyl transferase. (docksci.com)
The present study demonstrates a marginal, yet real, glucosyl transferase activity of galactosyl transferase in the presence and absence of a-lactalbumin. (docksci.com)
Increasingly, this class of natural products is becoming the subject of anti-infective research, and many groups have isolated and identified the structures of flavonoids possessing antifungal, antiviral and antibacterial activity. (propoleo.cl)

We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP. (embl.de)

Due to decreased pH in tumor sites, the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor cells. (blogspot.com)

HN - 2024 BX - Amphidinolide BX - Iriomoteolide BX - Iriomoteolides MH - Amphidinols UI - D000095722 MN - D2.355.291.933.63 MN - D2.540.576.625.63 MN - D4.345.241.654.63 MN - D4.345.674.625.63 MN - D23.946.580.80 MS - Long linear polyketides with polyol groups and polyolefins and core motifs of two tetrahydropyran rings produced by marine dinoflagellates such as AMPHIDINIUM. (nih.gov)

The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. (easyomics.org)

The degree of oxidative DNA damages was studied in a group consisted of thirty patients with diagnosed chronic venous insufficiency (CVI) in the 2nd and 3rd degree, according to clinical state, etiology, anatomy and pathophysiology (CEAP), and qualified to surgical procedure. (opencardiovascularmedicinejournal.com)

In addition, numerous research groups have sought to elucidate the antibacterial mechanisms of action of selected flavonoids. (propoleo.cl)

Anatomy5

Organisms5

Diseases1

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes49

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science4

Health Care1

Pentose6

Enzyme8

Coenzyme3

Linked glycosylation1

Enzymes7

Adenine1

Proteins2

Substrate1

Reactions3

Inorganic2

Inhibition1

Acyl1

Protein3

Acetyl1

Terminal1

Backbone1

Inhibitory1

Secondary1

Detection1

Transfer2

Increase1

Level1

Oseltamivir phosphate7

Alkyl1

Derivatives3

Phosphopantetheinyl2

Ribose2

Glucose10

Lipids2

Glycerol1

Phospholipids2

Fatty acids5

Methyl1

Compounds2

Residue2

Synthesis2

Activity3

Oxygen1

Active1

Long1

Form1

Patients1

Addition1