• A process for the synthesis of quinazolinone containing compounds which may be useful for the treatment of cancer, is hereby disclosed. (justia.com)
  • The ideal synthesis of a target compound is most often described in terms of the number of synthetic operations required to reach said product-with ideality lying as close to one single step as possible 1 . (nature.com)
  • These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
  • A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. (lookformedical.com)
  • 1.6 What do standard heats of formation tell us about chemical bonding and ground-state properties of organic compounds? (dattanibookagency.in)
  • The review is summarized and systematized the published data on the multicomponent reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and nucleophilic reagents. (researchgate.net)
  • The synthesized compounds were screened for their antimicrobial activity. (eurjchem.com)
  • All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
  • In addition, compound intermediates relating to these processes are also disclosed. (justia.com)
  • The increased stability of the intermediates (such as compounds of formula (III)) against competing hydrolysis reactions, removes the need to work under anhydrous conditions. (allindianpatents.com)
  • Many aldehydes are volatile compounds with distinct and characteristic olfactory properties. (tuwien.ac.at)
  • The heterogeneous catalysts are often prepared by in-situ activation of a metal halide (MClx) using organoaluminium or organotin compounds, e.g. combining MClx-EtAlCl2. (wikipedia.org)
  • The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
  • 1-Acylbenzimidazoles undergo 1,3-dipolar cycloaddition with nitrileimine to produce derivatives of the 1 H ,9 H -1,2,4-triazolo[4,3-a]benzimidazole system, followed by a rapid in situ substitution at 9a-position by the benzhydrazidoyl moiety. (heterocycles.jp)
  • All the synthesized compounds were evaluated for their in vitro antimicrobial activity against two bacterial strains, Escherichia coli and Staphylococcus aureus and two fungal strains, Penicillium italicum and Fusarium oxysporum using the well-diffusion method. (rjptonline.org)
  • The structures of these compounds are closely related both to each other and to the TlSe-structure. (degruyter.com)
  • Structures of the new compounds were established by elemental analyses and spectral data. (eurjchem.com)
  • The geometrical parameters of the title compound are in agreement with the values of similar structures. (eurjchem.com)
  • The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. (justia.com)
  • Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue. (justia.com)
  • The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. (justia.com)
  • Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. (justia.com)
  • Both tungsten compounds are formed by reaction of water and oxygen with the acetylene complex PPh 4 [WCl 5 (Ph - C ≡ C - C (Br) = C(Br) -Ph)] in CH 2 Cl 2 solutions, and in the presence of PPh 4 Cl. (degruyter.com)
  • The crystal structure of C 12 H 13 NOS, which was obtained in a base-catalysed condensation reaction of thiophene-3-carboxaldehyde with 1-aza-bicyclo[2.2.2]octan-3-one, is presented. (uky.edu)
  • In spite of inefficient hydrolysis of 1-(2-aminophenyl)-2,2,3,3,4,4,4-heptafluorobutan-1-one diethyl acetal ( 2 ), this compound undergoes readily the acid-catalyzed Friedländer reaction with enolizable ketones to give the corresponding quinolines ( 4 - 6 ). (heterocycles.jp)
  • In the preparation of fluticasone propionate, the introduction of the CH2F-moiety has been accomplished by the reaction of the carbothioic metal salt with a dihalomethane derivative, preferably a fluorohalomethane. (allindianpatents.com)
  • A new three dimensional proton transfer compound, (tataH) 2 (citH).2H 2 O (I) was synthesized from the reaction of citric acid (citH 3 ), and 2,4,6-triamino-1,3,5-triazine (tata). (eurjchem.com)
  • The compounds according to the present invention are useful as inhibitors of PERK. (justia.com)
  • A series of arylketo-containing P1-P3 linked macrocyclic BACE-1 inhibitors were designed, synthesized, and compared with compounds with a previously known and extensively studied corresponding P2 isophthalamide moiety with the aim to improve on permeability whilst retaining the enzyme- and cell-based activities. (openmedicinalchemistryjournal.com)
  • Earlier studies in our laboratory [ 9 ] led to the development of a series of macrocyclic BACE-1 inhibitors, e.g. compound 1a (Fig. 1 ), where both promising enzymatic and cell-based activities were observed. (openmedicinalchemistryjournal.com)
  • The title compound, which contains a double bond connecting an azabicyclic ring system to a thiophen-3-ylmethylene moiety, crystallizes from solution in methanol and has a thienyl ringflip disorder. (uky.edu)
  • Compound 3 crystallizes in space group P2 1 /n with lattice parameters a = 8.552(6) Å, b= 16.953(2) Å, c- 12.157(9) Å and β= 103.46(2)° with four formula units in the unit cell. (degruyter.com)
  • Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
  • The antimicrobial studies revealed that compounds 3a, 3b, 3c and 3d showed promising antibacterial activity against both the bacterial strains, while compound 3c and 3d exhibited good antifungal activity against both the fungal strains. (rjptonline.org)
  • In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal alpha,beta-unsaturated-gamma-lactone moiety. (kib.ac.cn)
  • It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group. (lookformedical.com)
  • Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 mu M. (kib.ac.cn)
  • Subbarajuc V. Kuttana R. Anticancer and Antioxidant Activity of Synthetic Chalcones and Related Compounds. (rjptonline.org)
  • The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
  • Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)
  • Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
  • Cysteine engineered anti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. (justia.com)
  • The structural relations to the variants of the W-structure type of compounds in the system Li-Sn and Na-Sn are shown. (degruyter.com)
  • The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and disorders and for preparing pharmaceuticals for this purpose. (justia.com)
  • Putrescine N-methyltransferase is a key JA-regulated step in the biosynthesis of nicotine, an alkaloidal compound highly accumulated in Nicotiana spp. (bvsalud.org)
  • Lipins are a group of compounds comprising fats and lipoids which are soluble in ether. (justia.com)
  • A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. (lookformedical.com)
  • Fungal bicyclo[2.2.2]diazaoctane indole alkaloids demonstrate intriguing structures and a wide spectrum of biological activities. (chemrxiv.org)
  • Biological assays of these compounds revealed that 2 potently inhibits HIV-1 integrase without cytotoxicity. (nih.gov)
  • Natural products and relevant compounds with biological and pharmaceutical activity are often characterized by complex molecular structures. (frontiersin.org)
  • Well-defined organometallic compounds have mainly been investigated for small-scale reactions or in academic research. (wikipedia.org)
  • Their work, first published in 1937, was intended as a preliminary progress report of thermochemical studies of energy changes during addition reactions of various unsaturated and cyclic compounds. (cloudfront.net)
  • Neither conventional NMR analyses nor DFT (density functional theory)-based computationally assisted chemical shift discussions were sufficient to elucidate the relative configuration of the 1,4-epoxydiol moiety. (nih.gov)
  • Chemical compounds derived from acids by the elimination of a molecule of water. (lookformedical.com)
  • Benzene derivatives are chemical compounds derived from benzene, a common organic chemical, that have medical applications. (lookformedical.com)
  • Compounds that include a single 1-phenyl-2-propene moiety in their structure. (nih.gov)
  • Comparing the Electronic Structure of Iron, Cobalt, and Nickel Compounds That Feature a Phosphine-Substituted Bis(imino)pyridine Chelate. (academictree.org)
  • Maleates are a class of organic compounds that are used in various medical applications, including as a preservative in injectable medications and as a chelating agent to remove heavy metals from the body. (lookformedical.com)
  • Mercaptoethylamines are a class of compounds containing a thiol (-SH) group attached to an ethylamine (-NH2) group, with potential applications in medicine as antioxidants, anti-inflammatory agents, and treatments for neurological disorders. (lookformedical.com)
  • Compounds of general formula (I) are CD80 antagonists. (justia.com)
  • The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. (justia.com)
  • Putrescine N-methyltransferase is a key JA-regulated step in the biosynthesis of nicotine, an alkaloidal compound highly accumulated in Nicotiana spp. (bvsalud.org)