Molecular weight1
- Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Signal3
- BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
- Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
- Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)
Cell1
- Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Found1
- We identified a total of 102 OM proteins, 52 are found in the two red coral biominerals with scleritin being the most abundant protein in each fraction. (biomedcentral.com)
Function1
- The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)
MRNA expression2
- Alterations in the mRNA expression, protein levels and proteolytic activity of matrix metalloproteinases (MMPs) have been detected in VVs and VLU. (oaepublish.com)
- MMP mRNA expression, protein levels and proteolytic activity can be modulated by numerous factors including venous hydrostatic pressure, hypoxia, tissue metabolites and the inflammatory response. (oaepublish.com)
Dopamine7
- AB - Using computer-aided molecular modeling techniques to analyze models recently proposed for the receptor binding sites of dopaminergic agonists, we superimposed the chemical structures of various compounds that mimic the pharmacological behavior of dopamine, as well as inactive enantiomers, on a postulated three dimensional frame of reference. (nih.gov)
- AB - A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. (nih.gov)
- Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. (niigata-u.ac.jp)
- Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. (niigata-u.ac.jp)
- Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages. (niigata-u.ac.jp)
- Dopamine signal is transduced through the dopamine receptor gene family. (niigata-u.ac.jp)
- The dopamine D1 receptor (D1R) is highly expressed in the striatum, and is responsible for regulating the motor function. (niigata-u.ac.jp)
Extracellular matrix4
- Mesenchymal stromal cells and macrophages release tolerogenic cytokines and favor anti-apoptotic signaling pathway activation, while the urokinase plasminogen activator receptor (uPAR) system contributes to migration through an extracellular matrix. (bvsalud.org)
- MMPs in turn increase proteolysis of different protein substrates in the extracellular matrix particularly collagen and elastin, leading to weakening of the vein wall. (oaepublish.com)
- MMPs are Zn 2+ -dependent endopeptidases that cause degradation of different protein substrates in the extracellular matrix (ECM). (oaepublish.com)
- Vascular homeostasis is maintained by the extracellular matrix (ECM) and related cell surface receptors, such as integrins, characterised by collagen deposition, collagen crosslinking, and elastin degradation within the vascular ECM. (biomedcentral.com)
Residues2
- Molecular cloning and complete sequencing of cDNA corresponding to the full-length open reading frame of this 1.2-kb mRNA unexpectedly show it to contain all the partial cDNA sequence encoding 135 amino acid residues previously reported for a human laminin receptor. (nih.gov)
- This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Conformational1
- Binding of STa to the extracellular domain of GC-C has been suggested to induce a conformational change in the protein kinase-like domain, resulting in an uncontrolled increase of GC-C activity. (medscape.com)
Amino2
- In the case of STa, the secreted protein encompasses 18-19 amino acids, including six cysteines and is capable of forming three disulfide bridges to create a highly stable molecule. (medscape.com)
- Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Intracellular1
- Elevation of intracellular cGMP activates protein kinase II (cGKII, also referred as protein kinase G) and protein kinase A, which, in turn, phosphorylate and stimulate the cystic fibrosis transmembrane conductance regulator (CFTR) Cl − channels. (medscape.com)
Formation3
- When bound to the receptor, toxins can act at the cell membrane by interfering with signal transduction pathways, pore formation or enzymatic activities on membrane compounds. (medscape.com)
- The regression analysis of log KD with respect to the distances of the vectors of the acidic hydrogen support the hypothesis that these compounds bind to the receptor as donors in hydrogen bond formation. (nih.gov)
- We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. (niigata-u.ac.jp)
Specific1
- The first step of toxin activity is the recognition of a specific receptor on the target cell surface. (medscape.com)
Active1
- Escherichia coli thermostable toxin (STa), a hormone-like enterotoxin, recognizes the extracellular domain of GC-C and blocks the enzyme in its active form, leading to accumulation of cGMP, activation of protein kinase II (or PK-G), reduction of Na + absorption by inhibition of the Na/H exchanger (NHE-3), opening of CFTR channels and secretion of water and electrolytes. (medscape.com)
Activation1
- Additionally, we underscore the significance of an ECM protein imbalance, which can lead to increased ECM stiffness and activation of the YAP pathway, resulting in vascular remodelling. (biomedcentral.com)
Role1
- Bassoon is a 420 kDa protein that localizes at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. (enzolifesciences.com)
Activity2
Functions1
- Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)