Modulation immune tolerance. Medical search. Frequent questions

Thus, therapeutics that induce, restore, and maintain immune tolerance toward these autoantigens represent the "Holy Grail" of treatments for autoimmune diseases. (frontiersin.org)
Other tools are available to further help predict if a therapeutic will induce an immune response. (pegsummit.com)
It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
A tolerized and de-immunized version of factor VIII would allow patients and their families to experience the benefits of FVIII treatment, which does not induce a reaction of the immune system (no immunogenicity) without the fear of developing inhibitory antibodies ("inhibitors") against the therapeutic factor VIII. (epivax.com)
We conclude that, although the effect was less obvious, vaccination with VLDL to induce neonatal tolerance had an effect on modulating immune response, protecting endothelial cells, and reducing blood lipids. (bvsalud.org)
Our treatments aim at harnessing a patient's immune system to induce tolerance or to achieve the ultimate anti-tumor immune response. (regimmune.com)
Treg and DCreg induce mechanisms only peripheral tolerance. (genescells.ru)

The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
The mammalian immune system evolved to protect our bodies from foreign pathogens and intrinsic aberrant malignancies while concurrently preventing deleterious immune responses toward self ( 1 ). (frontiersin.org)
In situ immunization aims at generating antitumor immune responses through manipulating the tumor microenvironment. (aacrjournals.org)
In mice, this three-step therapy induced CD4- and CD8-dependent systemic immune responses that enhanced T-cell infiltration into distant tumors, leading to their eradication and significantly improving survival. (aacrjournals.org)
Complement activates as soon as a pathogen enters the body and serves to neutralise the threat via lysis or opsonisation (where the pathogen is tagged for destruction by host phagocytic cells) and prepare the body against further assault by stimulating and directing inflammatory and adaptive immune responses. (le.ac.uk)
In the current collaboration, EpiVax and Biotest scientists will use Tregitopes to selectively dampening unwanted immune responses to factor VIII, the primary therapeutic used to control bleeding for individuals who have hemophilia A. For more information about Tregitopes visit https://www.epivax.com/pipeline/immune-modulation/ . (epivax.com)
Spleen tissues were extracted for fluorescence-activated cell sorting (FACS) analysis to analyze the effect of BJIKT on immune responses. (biomedcentral.com)
BJIKT can regulate AhR activation and may help reduce inflammation in AD by regulating the expression of skin barrier genes and immune responses. (biomedcentral.com)
The aryl hydrocarbon receptor (AhR) signaling pathway plays a critical role in various physiological processes, including immune responses and skin homeostasis [ 1 ]. (biomedcentral.com)
The section will disseminate translational, clinical and mechanistic research related to the modulation of immune responses by foods, dietary ingredients and natural products. (frontiersin.org)
Mechanisms of action of food ingredients and natural products on the innate and adaptive immune responses. (frontiersin.org)
Modulation of immune responses by dietary components in inflammatory bowel disease, celiac disease, diabetes and obesity. (frontiersin.org)
Computational modeling of the modulation of immune responses by dietary components, natural products and oral drugs. (frontiersin.org)
Medical foods, functional foods and nutritional supplements that modulate immune responses. (frontiersin.org)
The Transplant Immunology section of the laboratory is devoted to pushing the boundaries of transplant research by improving our understanding of the complex mechanisms of transplant rejection as well as devising novel strategies to exploit mechanisms underlying the regulation of immune responses. (tts.guide)
Ideal treatment for rheumatoid arthritis should include restoration of normal immune function and prompt suppression of inflammatory responses and symptoms," the team noted. (justmclasscars.com)
In the immune system, the TLE1/3/4 complex promotes CD8 lineage specification and identity consolidation by repressing transcription of CD4 signature genes 12 , while TLE4 inhibits inflammatory responses in macrophages by repressing transcription of interleukin ( Il ) 6 and Il12p40 13 . (tsinghua.edu.cn)
Transforming growth factor-beta (TGF-β), a multifunctional cytokine, is involved in a plethora of immunological processes, such as immune cell development, modulation of inflammatory responses, and maintenance of immune tolerance [16] , [17] . (tsinghua.edu.cn)
The gut virome can interact with the immune system and influence immune responses. (peptiko.gr)

These results advanced our knowledge regarding the intricate crosstalk between the intestinal innate and adaptive immune compartments. (tsinghua.edu.cn)
Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) have critical effects on interfaces of the immune and reproductive systems, and the spleen plays a key role in both innate and adaptive immune functions. (animal-reproduction.org)

Several evidences show that an altered composition of the intestinal microbiota (dysbiosis) could play a key role in the pathogenesis of CD, through the modulation of intestinal permeability and the regulation of the immune system. (preprints.org)
Dietary modulation of microbiota composition, function and metabolism and immune effects. (frontiersin.org)
Recent research has shown that gut microbiota, including some commensal bacteria, is capable of interacting with the host immune system and remarkably influencing the development and outcome of experimental autoimmune encephalomyelitis, a classic animal model of MS. In addition, gut dysbiosis, presented with a significantly altered composition of commensal bacteria, is linked to the immune response and inflammation, such as Th17 activation and B cell function. (accscience.com)
Moreover, it has been observed that microbiota impacts the immune system by regulating the metabolites in the gut. (accscience.com)
2016, Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls. (accscience.com)
A diverse and balanced gut microbiota helps promote immune tolerance, regulate inflammation, and defend against harmful pathogens. (peptiko.gr)
The gut microbiota interacts with the immune system in various ways, influencing immune cell development, activation, and response. (peptiko.gr)
They help regulate the composition and diversity of the gut microbiota, which in turn affects various aspects of gut health, such as digestion, nutrient metabolism, and immune function. (peptiko.gr)
microbiota intestinal, en especial con el uso de Lactobacilli y Bifidobacterium spp. (bvsalud.org)

modulation of the immune system by cytokines and drug delivery systems. (biomedcentral.com)
Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
The disease leads to a combination of disturbing symptoms and mechanisms, such as arthritis, production of harmful cytokines, and immune system imbalance, which work together to create a relentless cycle of worsening symptoms. (justmclasscars.com)
Our goal was to break the vicious cycle of RA by creating a treatment that is immune to complications caused by synovial inflammation, harmful cytokines, and immune tolerance," they wrote. (justmclasscars.com)
Class III MHC molecules include several proteins with other immune functions, such as cytokines, heat shock proteins, and parts of complement system. (medscape.com)
Once triggered, SLE's autoimmune reaction affects many sites through multiple mechanisms such as deposition of immune complexes, effects of cytokines and other chemical neuromodulators, direct attack by autoantibodies or activated leukocytes, and others. (medscape.com)

There are two mechanisms that maintain immunological tolerance denominated central and peripheral tolerance. (frontiersin.org)
Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
Effects and mechanisms of food ingredients and immune imprinting. (frontiersin.org)
The understanding of main mechanisms that determine the ability of immune privilege related to Sertoli cells (SCs) will provide clues for promoting a local tolerogenic environment. (johnshopkins.edu)
This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. (nshealth.ca)
It was given supposition that at using BM cells the forming of steady transplant tolerance state is a result of successive entering of central (thymical induction of temporary mixed chimer-ism) and peripheral tolerance mechanisms. (genescells.ru)

Effects of food, natural products and nutrients on tolerance, autoimmunity and cancer. (frontiersin.org)

Some of the strategies for regulating retinal dehydrogenases are only now becoming more clear after in vivo regulation remained mysterious for some time, though much of the current research on regulation has focused on the modulation of gene expression rather than direct protein regulation. (wikipedia.org)
Therefore, our study aimed to investigate the impact of a low AhR ligand diet on impaired skin barrier function and immune regulation in AD mice. (biomedcentral.com)
It is hypothesized that NLR family participates in maternal splenic immune regulation during early pregnancy in sheep. (animal-reproduction.org)

Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)
One of the key changes in the immune system of an expectant mum is the switch from immune surveillance to immune tolerance. (parentsguidecordblood.org)
In healthy full-term pregnancies, this switch prevents the rejection of the fetus, which is essentially foreign to the mother's immune system. (parentsguidecordblood.org)
The switch in a mother's immune system during pregnancy is largely mediated by regulatory T cells in the maternal bloodstream. (parentsguidecordblood.org)
The role of the microbiome, immune system and neuroglia in dementia. (uschirodirectory.com)
However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. (mdpi.com)
This leads to the hypothesis of a disease-specific alteration of vitamin D metabolism and reinforces the role of vitamin D in maintaining a healthy immune system. (mdpi.com)
The coagulation factor VIII used for Hemophilia therapy will be altered in such a way that the immune system of the patients may not respond by developing inhibitory antibodies. (epivax.com)
Tregitopes are linear sequences of amino acids contained within the framework of a very common serum protein known as immunoglobulin G. Tregitopes act as a natural immune system 'off switch" and have been shown in standard preclinical models, to "reset" the immune response away from immunogenicity and towards tolerance. (epivax.com)
The aryl hydrocarbon receptor (AhR) is a transcription factor that plays a crucial role in regulating the immune system and maintaining skin barrier function. (biomedcentral.com)
The complex interactions occurring in the interface of nutritional and metabolic processes, the immune system and immune response are incompletely characterized. (frontiersin.org)
It is primarily characterized by abnormal activation of the innate immune system and vascular cells, significantly increasing the risk of thrombosis in blood vessels of varying sizes. (debuglies.com)
Multiple sclerosis (MS) is a severe central nervous system autoimmune inflammatory disease featured by the presence of infiltrated immune cells, demyelination, and degeneration. (accscience.com)
IMPORTANCE The immune system must be able to tailor its response to different types of pathogens in order to eliminate them and protect the host. (biomed.news)
When confronted with bacterial pathogens, macrophages, frontline defenders in the immune system, switch to a glycolysis-driven metabolism to carry out their antibacterial functions. (biomed.news)
In essence, the ideal treatment for rheumatoid arthritis should not only provide immediate relief from inflammation and symptoms, but also address the root cause by returning the immune system to its normal, balanced state. (justmclasscars.com)
The ability to restore the immune system to a healthy state remains one of the major hurdles in treating rheumatoid arthritis. (justmclasscars.com)
ATG can exert various effects on the immune system, including T-cell depletion in the blood and peripheral tissues, down-modulation of adhesion molecules and chemokine receptors, 7 and possibly a direct effect on hematopoietic stem cells. (haematologica.org)
Cluster of differentiation 4 T helper (CD4 + T) cells represent an essential arm of the intestinal adaptive immune system, specializing in providing antigen-specific protective immunity. (tsinghua.edu.cn)
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. (metabolon.com)
This group of genes code for proteins found on the surfaces of cells that help the immune system recognize foreign substances. (medscape.com)
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. (nshealth.ca)
Maintaining a healthy immune system is essential for overall well-being and defense against illness. (peptiko.gr)
Emerging research has highlighted the significant connection between gut health and the immune system. (peptiko.gr)
In this article, we will explore the intricate relationship between the gut and the immune system, understanding how a healthy gut contributes to a robust immune response, and practical steps to support gut health for optimal immune function. (peptiko.gr)
How does gut health affect immune system? (peptiko.gr)
The ability of tumors to evade destruction by the IMMUNE SYSTEM. (bvsalud.org)
In type 1 diabetes, the immune system destroys insulin-producing pancreatic beta cells. (medscape.com)
as well as testing in the humans showing that there didn't appear to be significant immune system modulation. (medscape.com)
So, we can envision giving DFMO in addition to something that targets the immune system, as a combination therapy," said Sims, who also worked on the pivotal study of teplizumab. (medscape.com)

Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
Pregnancy-related immune weakness does not seem to affect the course of acute hepatitis C but can affect the progression of chronic hepatitis C. In fact, postpartum immune restoration can exacerbate hepatic inflammation, thereby worsening the liver disease, particularly in patients with liver cirrhosis. (wjgnet.com)
A compromised gut barrier, commonly referred to as "leaky gut," can lead to increased immune activation and inflammation, potentially contributing to autoimmune conditions and other health issues. (peptiko.gr)

They also play key roles in stimulating and directing fundamental immunological processes including phagocytosis cell adhesion modulation of immune cell function and maintenance of immune tolerance as well as providing important bridges between innate and adaptive immunity. (le.ac.uk)

An important consideration when developing a new protein therapeutic is the potential and consequences of the therapeutic inducing an immune response. (pegsummit.com)
The possible consequences of an immune response are also evaluated when completing a risk assessment. (pegsummit.com)
Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially. (pasteur.fr)
In response to the undertreatment of pain, the American Pain Society (APS) issued a 1997 statement encouraging judicious use of opioids and even suggesting that tolerance was rare [7]. (ama-assn.org)
Induction of immune tolerance to ox-LDL could reduce atherosclerosis by modulation immune response. (bvsalud.org)
Through a comprehensive analysis of these aspects, our study aimed to provide valuable insights into the effects of BJIKT on the skin barrier, modulation of AhR signaling, and immune response in AD mice subjected to a low AhR ligand diet. (biomedcentral.com)
In this study, we evaluated the property of humoral and cellular immune response modulation provided by porcine SCs. (johnshopkins.edu)
These include beneficial bacteria, viruses, fungi, and other microorganisms that play a crucial role in maintaining gut health and modulating the immune response. (peptiko.gr)
It helps regulate the delicate balance between an appropriate immune response to pathogens and tolerance to harmless substances, preventing unnecessary immune reactions and allergies. (peptiko.gr)
CD), wheat allergy (WA), and non-celiac tion and the immune response it presents gluten sensitivity (NCGS)2. (bvsalud.org)

Innovators in the field of immunogenicity are constantly furthering our understanding of factors that contribute to immunogenicity and developing new and advanced approaches for predicting immunogenicity, for reducing immunogenicity, and for tolerance induction. (pegsummit.com)
These might open optimistic perspectives for the use of porcine SCs in tolerance induction eliminating the need for chronic immunosuppressive drugs. (johnshopkins.edu)
Sachs D.H., Kawai T., Sykes M. Induction of tolerance through mixed chimerism. (genescells.ru)

Modulation of immunometabolic processes by dietary ingredients and foods. (frontiersin.org)

They may promote tolerance leading to virus and tumor immune escape. (pasteur.fr)

Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)

Both immune dependent and independent factors have been shown to contribute to the pathogenesis of CAV. (lidsen.com)

Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)

Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
They are responsible for triggering cellular events such as activating the maternal regulatory T cells that maintain tolerance and promoting their proliferation, while concurrently inducing the death of activated T cells that could compromise the pregnancy. (parentsguidecordblood.org)
The HLA-G molecule plays a major role in immune tolerance during pregnancy, particularly at the maternal-fetal interface, where HLA-G inhibits the migration and proliferation of maternal immune cells. (parentsguidecordblood.org)
The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
It is mainly expressed in immune cells such as T cells, B cells and monocytes. (jcancer.org)
Moreover, blocking antibody against PD-1 promotes tumor growth both in SW480 cells and mice CRC xenografts in an adaptive immune-independent manner. (jcancer.org)
Regulatory T cells (Tregs) regulate not only immune tolerance but also tissue repair and angiogenesis. (iiarjournals.org)
Furthermore, AhR target pathway genes were negatively correlated with immune cell subtypes, including CD4 + and CD8 + T cells and macrophages (CD11b + F4/80 +) at the systemic level. (biomedcentral.com)
Immune cells must be able to adjust their metabolic programs to effectively carry out their effector functions. (biomed.news)
This generates regulatory T cells for long-term immune tolerance. (justmclasscars.com)
The authors further explained, "These two main components (Ce NPs and MSCNVs) of Ce-MSCNV work individually and synergistically to create synergy, providing rapid treatment of damaged joints, modulating immune cells and restoring disturbed T balance. (justmclasscars.com)
6 In addition, rATG may selectively promote the expansion of regulatory T cells, 11 possibly inducing in vivo immune tolerance through this mechanism. (haematologica.org)
In non-immune cells, TLE3 favors white adipocyte differentiation by repressing transcription of brown adipocyte-related genes [9] , [10] , and it supports pancreatic β cell development by repressing transcription of the hepatic program 11 . (tsinghua.edu.cn)
This review presents analysis of the modern state of transplant tolerance forming problem in recipient organism by using stem/ progenitory cells of bone marrow (BM) and differentiated immunoregulatory (tolerogenic) subsets of blood cells-regulatory B- and T-lymphocytes (Treg), and regulatory dendritic cells (DCreg). (genescells.ru)
It is pointed out that protocols based on the using BM cells, permit to work out the tolerance state and now they are estimate at clinical kidney transplantation, during multicentre investigations. (genescells.ru)
Combined application of BM cells and Treg permits to increase the terms for maintaining of donor chimerism into all cell lines (incuding Tcells) and transplant tolerance in recipient organism. (genescells.ru)
The gastrointestinal tract, often referred to as the gut, is not only responsible for digestion but also houses a vast network of immune cells. (peptiko.gr)
Approximately 70-80% of the body's immune cells reside in the gut, making it a vital hub for immune activity. (peptiko.gr)

Immunogenicity suppression will be also achieved through integration of EpiVax' proprietary Tregitope, an immune-modulating technology, with the FVIII treatment. (epivax.com)

In genetically susceptible individuals, this antigenic stimulation may ultimately result in the expression of overt rheumatoid arthritis (RA) via molecular mimicry, a process whereby foreign peptides, similar in structure to endogenous peptides, may cause antibodies or T-lymphocytes to cross-react with both foreign and endogenous peptides and thereby break immunological tolerance. (cambridge.org)

First, tolerogenic vaccines aiming at robust, lasting autoantigen-specific immune tolerance. (frontiersin.org)
The combination of both parts in Ce-MSCNV nanoparticles aims to bridge both innate and adaptive immunity to achieve short-term pain relief, as well as shifting the tissue environment to a tolerogenic immune state to prevent recurrence of symptoms. (justmclasscars.com)

A correlation analysis was conducted to analyze the correlation between immune markers and skin barrier genes and AhR target genes. (biomedcentral.com)
The pathophysiology of SLE has not been defined fully, although many genes that affect immune function, particularly the human leukocyte antigen (HLA), may augment susceptibility to clinical disease. (medscape.com)

It may provide a new idea and mechanism for answering why the immune monoclonal antibody treatment is ineffective in cancer patients. (jcancer.org)

This network, known as gut-associated lymphoid tissue (GALT), plays a pivotal role in immune function. (peptiko.gr)

While most people understand the importance of a balanced diet, regular exercise, and sufficient sleep for immune function, there is another crucial factor that often goes overlooked: gut health. (peptiko.gr)

Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
Gut epithelial cell stress and innate immune activation are responsible for breaking oral tolerance to gliadin, the gluten component. (preprints.org)
Following a mixed-meal tolerance test at 6 months, the C-peptide area under the curve ― a measure of beta-cell function ― was significantly higher with the three highest DFMO doses compared to placebo ( P = .02, .03, and .02 for 125 mg/m 2 , 750 mg/m 2 , and 1000 mg/m 2 , respectively). (medscape.com)

Modulation of tissue trace metal concentrations in weanling rats fed different levels of zinc and exposed to oral lead and cadmium. (cdc.gov)

These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. (mdpi.com)
Here the immune function of non-pathological lipoproteins is addressed by analysing their impact on human DC maturation triggered by TLR ligands. (bvsalud.org)
This interaction helps shape the immune system's development, function, and tolerance to both commensal and pathogenic microorganisms. (peptiko.gr)

disbiosis en pacientes con enfermedad celíaca y sensibilidad al gluten no celíaca. (bvsalud.org)

Bacteriophages, for example, can trigger immune activation through the release of bacterial components during infection. (peptiko.gr)

The Tregitope technology is an additional immune-modulating tool that is expected to improve tolerance of protein drugs such as replacement enzymes, blood factors, and monoclonal antibodies. (epivax.com)

As one of the crucial immune checkpoint molecules, PD-1 belongs to the CD28/CTLA-4 family [ 6 ]. (jcancer.org)

Lupus is a well-known systemic autoimmune disease characterized by autoantibodies targeting nuclear components, leading to the formation of immune complexes that deposit in organs, causing damage. (debuglies.com)

To bring a fresh perspective to the field, the advanced skillset of rodent models of skin, heart, and the unique model of hind limb transplantation, is paired with multidisciplinary approaches that range from bio-engineering approaches of drug delivery (for effective immune-modulation) to mathematical modeling of the dynamics of transplant rejection. (tts.guide)

Anatomy40

Organisms17

Diseases18

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes66

Disciplines and Occupations1

Information Science3

Health Care4

Induce7

Responses19

Innate and adaptive immune2

Microbiota9

Cytokines6

Mechanisms6

Autoimmunity1

Regulation3

System30

Inflammation3

Immunological processes1

Response10

Induction3

Processes1

Tumor immune1

Pathogens1

Pathogenesis1

Tissues1

Cells20

Suppression1

Rheumatoid arthritis1

Tolerogenic2

Genes2

Mechanism1

Role in immune1

Diet1

Cell3

Tissue1

Function3

Gluten1

Activation1

Monoclonal1

Molecules1

Complexes1

Transplant1