Proliferation and differentiationHuman pluripotent stemNeuronal differentiationPathwaysRegulatesMesenchymal stemApoptosisProteinsHealthy cell differentiationProgenitor cellErythroid differentiationInductionCellularCardiomyocyteDifferentiateEmbryonicInhibitionEpithelial cellLineageMaturationExtracellularPathwayBehaviorProgenitorsMetabolismInducesGenesEpidermalCerebral cortexStem cellNeuroblastoma cellsFunctionalMechanismsProgressionTumor-cellImmune functionHead and Neck Squamous Cell CarcDepletionEffectorSubtypeBiologyReduced in culturedTumourMyogenicFateInhibitsAdhesionBone marrowMyoblastsPhenotypeNeuronsTumorigenesis
Proliferation and differentiation4
- Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
- Accordingly, in various biological contexts, EVs are reported to engage in immune modulation, senescence, and cell proliferation and differentiation. (wjgnet.com)
- Enhancer of zeste homolog 2 (EZH2) belongs to poly-sulfur protein family and can mediate cell proliferation and differentiation via the modulation of various genes expressions. (medscimonit.com)
- The mechanisms of action of natural vitamin A metabolites on human skin are based on the time- and dose-dependent influence of morphogenesis, epithelial cell proliferation and differentiation, epithelial and mesenchymal synthetic performance, immune modulation, stimulation of angiogenesis and inhibition of carcinogenesis. (nih.gov)
Human pluripotent stem5
- Differentiation of human pluripotent stem cells (hPSCs) into functional cell types is a crucial step in cell therapy. (ashpublications.org)
- Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. (rndsystems.com)
- Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. (rndsystems.com)
- Little has been studied regarding EVs derived from human pluripotent stem cells (hPSC-EVs), even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative ability. (wjgnet.com)
- Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)
Neuronal differentiation5
- The regulations of NPCs' differentiation and proliferation by the Ras-ERK pathway were also shown by the rescues of the effects of bFGF depletion, neuronal differentiation, and antiproliferation by epidermal growth factor. (elsevierpure.com)
- Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation. (lu.se)
- The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)
- We have examined NGF-induced signal transduction events and neuronal differentiation in MAH cells, a neuronal progenitor cell line, in which the expression of the two NGF receptors, p140^(trk) (Trk) and p75^(LNGFR) (p75), has been independently manipulated. (caltech.edu)
- These data provide evidence that p75 can modulate signal transduction through Trk in a neuronal progenitor cell context and that such modulation has functional consequences for the neuronal differentiation pathway induced by NGF. (caltech.edu)
Pathways11
- Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis. (nature.com)
- Caspases, while dispensable for cell death during mitochondrial apoptosis, inhibit activation of pro-inflammatory pathways after MOMP. (nature.com)
- For instance, mtDNA and bacterial DNA are highly similar thereby activating similar cell autonomous immune signalling pathways. (nature.com)
- Therefore, this 3-year research proposal is intended to study the action of mechanisms of VPA in modulating DC differentiation and maturation, CD1 isoform molecules, adhesion molecules expression, possible signaling pathways, and the possible mechanisms underlied. (tmu.edu.tw)
- In the present study, we demonstrate that functional CD34 + progenitor cells can be efficiently produced from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) by combined modulation of 2 signaling pathways. (ashpublications.org)
- Our results suggest that combined modulation of signaling pathways may be an efficient means of differentiating hPSCs into functional CD34 + progenitor cells. (ashpublications.org)
- Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
- With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
- Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
- Noted for activating Smad signaling cascades through interactions with a conserved family of cell surface serine/threonine-specific protein kinase receptors, the complexity of TGF-β signaling has been demonstrated through the additional regulation of physiological processes by TGF-β Superfamily Ligand through non-canonical pathways, and the activation of signaling molecules other than Smad proteins. (peprotech.com)
- The major mechanisms of gene induction by cadmium known so far are modulation of cellular signal transduction pathways by enhancement of protein phosphorylation and activation of transcription and translation factors. (cdc.gov)
Regulates5
- Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis. (rndsystems.com)
- HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling. (harvard.edu)
- An anti-nucleolin DNA aptamer, iSN04, regulates cardiomyogenesis of murine pluripotent stem cells. (shinshu-u.ac.jp)
- In keratinocytes and other cell types, 1,25(OH) (2)D (3) regulates growth and differentiation. (nih.gov)
- Another pathway involved in embryogenesis, the Hedgehog pathway also regulates normal stem cell activity. (beforeitsnews.com)
Mesenchymal stem5
- Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
- Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
- Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
- In order to find optimal material parameters, the models were fitted to the experimental data available for mesenchymal stem cells. (hindawi.com)
- Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
Apoptosis5
- The Notch signaling pathway, also involved in embryogenesis, plays a key role in regulating cell differentiation, proliferation and programmed cell death (apoptosis), as well as the functioning of normal stem cells. (beforeitsnews.com)
- Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
- Considered vital to the modulation of cell proliferation, differentiation, matrix synthesis, and apoptosis, members of the TGF-β Superfamily are fundamental to prenatal development and the postnatal growth, remodeling, and maintenance of various tissues and organs. (peprotech.com)
- Cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. (cdc.gov)
- In this review multiple mechanisms are discussed, such as modulation of gene expression and signal transduction, interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species (ROS), inhibition of DNA repair and DNA methylation, role in apoptosis and disruption of E-cadherin-mediated cell-cell adhesion. (cdc.gov)
Proteins12
- SAHA treatment caused an accumulation of acetylated histones (H2B, H3, and H4), an increase of p21(WAF1) and bax proteins, a decrease of Stat6 and phospho-Stat6 proteins, and activation of caspase-3 in CTCL cells. (lymphomation.org)
- We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)
- Aptamers are single-stranded pieces of DNA that bind to target proteins and are able to modulate signaling cascades during cell differentiation when a stem cell commits to a specific functional role or phenotype. (shinshu-u.ac.jp)
- CXCR1 and CXCR2 are proteins expressed on cells, including CSCs, which respond to the aforementioned cytokines in a deleterious manner. (beforeitsnews.com)
- Proposed mechanisms of action in cancer prevention include inhibition of cancer growth, induction of differentiation by modulation of cell-cycle regulatory proteins, alterations in insulin-like growth factor-1 or vascular endothelial growth factor levels, prevention of oxidative DNA damage, and possible enhancement of carcinogen-metabolizing enzymes. (cancernetwork.com)
- Encompassing a plethora of growth, differentiation and morphogenic factors, the Transforming Growth Factor-β (TGF-β) Superfamily is comprised of signaling proteins that have been universally conserved throughout the animal kingdom and presently consists of over forty members, the likes of which include: TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins, and inhibins. (peprotech.com)
- Given the intricacies and significance associated with the activities of TGF-β Superfamily proteins, the impairment of proper signaling has been understandably connected to a variety of clinical indications, such as tumor cell growth, fibrosis, skeletal defects, and autoimmune disease. (peprotech.com)
- The selected candidate will become an integral part of a research project focused on exploring the non-canonical functions of two complement proteins, C3 and CD59, in the pathophysiology of pancreatic β-cells, particularly in their connection to diabetes development. (lu.se)
- Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
- Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
- Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)
- Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
Healthy cell differentiation1
- Supports healthy cell differentiation. (blueskyvitamin.com)
Progenitor cell2
- In this study, Sur8 was severely repressed in the course of neural progenitor cell (NPC) differentiation in the cerebral cortex of developing rat embryos. (elsevierpure.com)
- The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. (sdbonline.org)
Erythroid differentiation2
- Assembly of protein 4.1 during chicken erythroid differentiation. (rupress.org)
- All protein 4.1 variants exhibit a similar kinetic behavior irrespective of the stage of erythroid differentiation. (rupress.org)
Induction4
- So, when inhibition of differentiation of stem cell is desired, inhibition of differentiation is achieved through induction of increased NR2F6 activity. (wikipedia.org)
- Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
- ST3GAL5 is known to play a part in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. (prospecbio.com)
- We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Cellular3
- On a cellular level, osmotic pressure influences cell fate decisions of mesenchymal stroma cells (MSCs). (charite.de)
- Initial analysis of Collier/Early B Cell Factor function in the lymph gland revealed the role of the Posterior Signaling Center (PSC) in mounting a dedicated cellular immune response to wasp parasitism. (sdbonline.org)
- This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)
Cardiomyocyte1
- Ultimately, terminal cell differentiation commits to the cardiomyocyte lineage. (shinshu-u.ac.jp)
Differentiate6
- Human embryonic stem cells (hESCs) derived from an early embryo can self-renew indefinitely and differentiate into a variety of cell types. (ashpublications.org)
- The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
- We had previously found that iSN04 promoted myogenic precursor cells (myoblasts) to differentiate into skeletal muscle cells and had hypothesized that the aptamer also enhanced differentiation of pluripotent stem cells. (shinshu-u.ac.jp)
- Strikingly, upon the removal of self-renewing cues Sox2-low nPSCs differentiate into both embryonic and extraembryonic cell fates in vitro and in vivo. (cam.ac.uk)
- This differs from previous studies which only identified conditions that allowed cells to differentiate to one fate or the other. (cam.ac.uk)
- We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
Embryonic4
- Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (shinshu-u.ac.jp)
- The team, led by Associate Professor Tomohide Takaya from the Department of Agricultural and Life Sciences at Shinshu University, recently discovered that an anti-nucleolin aptamer, myogenetic oligodeoxynucleotide iSN04, induced myocardial differentiation in embryonic stem cells (ESCs). (shinshu-u.ac.jp)
- A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
- These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
Inhibition3
- Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-γ-producing iNKT cells (NKT1 cells), suggesting that NKT1 cells may require a lower TCR signal threshold. (nih.gov)
- In situations where differentiation of stem cells into a cell of increased maturity is desired, inhibition of NR2F6 activity must be performed. (wikipedia.org)
- A higher proportion of CD34 + cells (∼ 20%) could be derived from hPSCs by inhibition of mitogen-activated protein kinase (MAPK) extracellular signal-regulated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling and activation of bone morphogenic protein-4 (BMP4) signaling. (ashpublications.org)
Epithelial cell2
- After 24-30 hours, mitosis begins to restore epithelial cell population. (medscape.com)
- A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
Lineage6
- Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch. (harvard.edu)
- an anti-nucleolin DNA aptamer, iSN04, can determine a cell's lineage during differentiation. (shinshu-u.ac.jp)
- Self-renewal and pluripotency-the capacity to form any cell lineage-are inherent characteristics of induced pluripotent stem cells (iPSCs). (shinshu-u.ac.jp)
- iSN04 treatment under differentiating conditions inhibited stem cell commitment to the cardiac lineage. (shinshu-u.ac.jp)
- This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
- Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
Maturation2
- Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells. (rndsystems.com)
- As cells become postmitotic and undergo the final steps of maturation the membrane skeleton may be gradually stabilized by the assembly of protein 4.1. (rupress.org)
Extracellular3
- How does osmotic modulation of the extracellular matrix affect the osteogenic differentiation of mesenchymal stroma cells (MSCs)? (charite.de)
- Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. (wjgnet.com)
- Furthermore, different assumptions of compressibility and viscoelastic properties for the cells will lead to different patterns and magnitudes of stress and strain fields within the cell and cytosol when studying the coupling of external forces in cell-extracellular matrix (ECM) interaction. (hindawi.com)
Pathway6
- The Ras-ERK pathway is involved in Sur8-mediated regulations of differentiation, as the treatment of ERK kinase (MEK) inhibitors blocks the effects of Sur8. (elsevierpure.com)
- In summary, Sur8 is an antidifferentiation factor that stimulates proliferation for maintenance of self-renewal in NPCs via modulation of the Ras-ERK pathway. (elsevierpure.com)
- Using various assays like RNA sequencing, cell staining and imaging, and molecular interaction and pathway analysis, the researchers investigated iSN04's effect on murine ESCs and iPSCs. (shinshu-u.ac.jp)
- Second, it results in the modulation of the Wnt signaling pathway that governs cell differentiation. (shinshu-u.ac.jp)
- Curcumin has been found to suppress tumor cells along the Notch pathway. (beforeitsnews.com)
- This pathway plays a key role in regulating normal stem cells, with aberrant signaling stimulating CSCs, resulting once again in tumor recurrence and resistance to chemotherapy. (beforeitsnews.com)
Behavior8
- However, such cell behavior was investigated mainly in 2D cell culture experiments so far. (charite.de)
- Neo-Hookean viscohyperelastic (NHVH) incompressible and compressible models were used to simulate the creep behavior of cells in MA, particularly accounting for the effect of compressibility, bulk relaxation, and hardening phenomena under large strain. (hindawi.com)
- Based on the results, we suggest that the compressibility and bulk relaxation/fluid flow play a significant role in the deformation behavior of single cells and should be taken into account in the analysis of the mechanics of cells. (hindawi.com)
- Mechanobiology of tissues and cell biosynthesis are related to the mechanical signals experienced by cells, and the deformation behavior of cells within a tissue is affected by the mechanical environment and mechanical properties of cells. (hindawi.com)
- The time-dependent deformation behavior of the cell cannot be modeled with an elastic model. (hindawi.com)
- Additionally, in MA cells undergo very large strains and cells exhibit a strain hardening behavior [ 10 , 11 ], which are not included in this analytical solution. (hindawi.com)
- Hyperelastic models are able to account for nonlinear behavior of cells under large strains. (hindawi.com)
- The time-dependent deformation behavior of different cell types has been modeled using viscoelastic, poroelastic and poroviscoelastic material models [ 8 , 12 - 22 ]. (hindawi.com)
Progenitors8
- Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
- In the lymph gland , an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). (sdbonline.org)
- In contrast with this model, this study shows that genetic ablation of the PSC does not cause an increase in blood cell differentiation or a loss of blood cell progenitors. (sdbonline.org)
- Collier is expressed in a core population of lymph gland progenitors and cell autonomously maintains this population. (sdbonline.org)
- The PSC contributes to lymph gland homeostasis by regulating blood cell differentiation, rather than by maintaining core progenitors. (sdbonline.org)
- Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
- Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
- Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
Metabolism3
- Vitamins A and D are the first group of substances that have been reported to exhibit properties of skin hormones, such as organized metabolism, activation, inactivation, and elimination in specialized cells of the tissue, exertion of biological activity, and release in the circulation. (nih.gov)
- Recent studies have shown that the mechanical factors play an important role in cell metabolism, differentiation, and function [ 1 , 2 ]. (hindawi.com)
- Abteilung NMR-Spektroskopie, Weinbergweg 22, DE- and differentiation and in lipid metabolism. (lu.se)
Induces2
- It was found that expression of NR2F6 was consistently upregulated in neoplastic tissues in leukemic, ovarian cancer and endometrial cancer as compared to non-malignant tissues, while the silencing of NR2F6 induces a reduction of cancer cell proliferation, inhibiting clonogenicity and self-renewal of proliferating cancer cells, and induces differentiation. (wikipedia.org)
- Induces differentiation of cardiomyocytes from human ESCs and iPSCs. (rndsystems.com)
Genes8
- However, when these pluripotent stem cells were treated after experiencing differentiating conditions for five days, specific marker genes were upregulated, and the cells committed to forming beating cardiomyocytes. (shinshu-u.ac.jp)
- Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
- This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
- Polaris consists of measurement of mRNA levels of 46 genes, comprising 31 genes involved in cell cycle progression and 15 housekeeping genes by reverse transcription polymerase chain reaction (RT-PCR), that is scored on a 10-point scale and gives the score percentile within the patient's NCCN risk profile. (medscape.com)
- The score is based on the microarray-based expression of 22 genes involved in androgen receptor signaling, cell proliferation, differentiation, motility, and immune modulation. (medscape.com)
- After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
- Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
- Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Epidermal1
- Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. (rndsystems.com)
Cerebral cortex2
- TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. (thermofisher.com)
- 2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)
Stem cell5
- Modulation of Hematopoietic Stem Cell Differentiation. (wikipedia.org)
- Dr. Price's research interests include stem cell therapeutics . (marshall.edu)
- Dr. Spitzer's research interests include modulation of neural stem cell differentiation . (marshall.edu)
- Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (rndsystems.com)
- These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
Neuroblastoma cells1
- In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)
Functional3
- Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The Importance of Neuronal Subtype, Cell Source and Connectivity for Functional Recovery. (lu.se)
- The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
- Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
Mechanisms2
- Therefore, we attempt to elucidate in more depth the possible molecular action of mechanisms underlying VPA-induced DC's immuno-modulation. (tmu.edu.tw)
- Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). (cam.ac.uk)
Progression2
- We show that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme. (elifesciences.org)
- Moreover, evaluation of the mechanical properties of cells improves the understanding of the onset and progression of tissue pathologies. (hindawi.com)
Tumor-cell2
- IL-8, another cytokine, is released after tumor cell death, subsequently stimulating CSCs to regrow the tumor and resist chemotherapy. (beforeitsnews.com)
- The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
Immune function1
- Supports modulation of immune function. (blueskyvitamin.com)
Head and Neck Squamous Cell Carc3
- [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
- Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
- Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran. (who.int)
Depletion1
- Depletion of oMAP4 impairs cell elongation and cell-cell fusion. (elifesciences.org)
Effector5
- Herein, we show that mTOR complex 1 (mTORC1) and mTORC2 have distinct roles in the generation of CD8 + T cell effector and memory populations. (jci.org)
- however, due to constitutive mTORC1 activation, these cells retained a terminally differentiated effector phenotype and were incapable of transitioning into a memory state. (jci.org)
- In the immune system, Eomes controls the differentiation of effector and memory CD8+ T cells, as well as natural killer (NK) cells. (thermofisher.com)
- We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. (cdc.gov)
- Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. (cdc.gov)
Subtype1
- Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
Biology3
- As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
- The candidate must hold a PhD preferentially in the field of diabetes research, cell biology or related discipline, and must have completed their PhD within 3 years from the start of the appointment. (lu.se)
- Having prior expertise in the following areas can be highly advantageous for this role: cell biology, diabetes research, beta-cell differentiation, proficiency in microscopy techniques, hands-on experience with mouse models, and a strong background in bioinformatic analysis, particularly in RNA sequencing and ChIP sequencing. (lu.se)
Reduced in cultured1
- Similarly, Sur8 was also critically reduced in cultured NPCs, which were induced differentiation by removal of basic fibroblast growth factor (bFGF). (elsevierpure.com)
Tumour2
Myogenic1
- They also showed that cross-regulation between col and eya in muscle progenitor cells is required for specification of muscle identity, revealing a new parallel between the myogenic regulatory networks operating in Drosophila and vertebrates. (sdbonline.org)
Fate5
- Together, this study shows that the PSC is dispensable for blood cell progenitor maintenance and reveals the key role of the conserved transcription factor Col as an intrinsic regulator of hematopoietic progenitor fate. (sdbonline.org)
- This raises a pertinent question: Can regulating the fate of stem cells in clinical settings and at scale be made more economical? (shinshu-u.ac.jp)
- Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
- Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
- Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
Inhibits1
- Apoptotic caspase activity inhibits cell death-associated inflammation. (nature.com)
Adhesion1
- The disruption of E-cadherin-mediated cell-cell adhesion by cadmium probably further stimulates the development of tumors. (cdc.gov)
Bone marrow5
- NR2F6 impairs the formation of mature red blood cells in animals that over-express NR2F6 in their bone marrow. (wikipedia.org)
- Mice that over expression of NR2F6 in their bone marrow cells have a block at the pro-erythroblast stage of blood cell development both in the bone marrow and in the spleen of animals that have excessive expression of NR2F6. (wikipedia.org)
- Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
- Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
- Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
Myoblasts3
- Cells called myoblasts elongate and fuse together at their tips to make the muscle cells. (elifesciences.org)
- The experiments show that the filaments progressively become more ordered as the myoblasts develop into muscle cells. (elifesciences.org)
- Upon differentiation, mono-nucleated myoblasts withdraw from the cell cycle and fuse to form syncytial myotubes ( Wakelam, 1985 ). (elifesciences.org)
Phenotype1
Neurons7
- CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
- This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
- Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
- First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
- Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
- This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
- The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
Tumorigenesis3
- This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells. (medscimonit.com)
- The effect on tumorigenesis potency of glioma stem cells was determined by mouse transplantation assay. (medscimonit.com)
- Our data demonstrated that in brain glioma cells, the decrease of EZH2 level could suppress cell proliferation and tumorigenesis potency, and meanwhile inhibit the expressions of oncogenes including c-myc and Akt. (medscimonit.com)