Epithelial cellsCytokineDendritic cellsMacrophagesApoptosis1982SubsetsImmuneMucosalMurineActivationAntibodyInflammatoryPopulationsUndergoProliferationMigrationVitroPeripheralResponsesPreventionMolecularPathogenesisSerumAccumulationTissueInteractionsReactionHumansResponseCellInsightsDiseaseModelSuggestActivityPatientsEffort
Epithelial cells4
- Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. (wikipedia.org)
- Extensive lymphocyte severe infections is a massive loss of lymphocytes, den- apoptosis has also occurred in humans and animals infect- dritic cells, gastrointestial epithelial cells, and other cell ed with several exotic agents, including Bacillus anthracis , types through apoptosis, or programmed cell death. (cdc.gov)
- A monolayer of intestinal epithelial cells forms the interface between the intestinal content and the underlying mucosal immune system and may play a pivotal role in mucosal immune modulation via dietary components. (uu.nl)
- Therefore a transwell co-culture model of human intestinal epithelial cells (IEC) and mixed lymphocytes was developed to study the cross-talk between these cells (see http://www.uu.nl/organisatie/3rs-centre-uls/3vs/3v-interviews ). (uu.nl)
Cytokine6
- Zinc possesses anti‑inflammatory activity by inhibiting NF‑κB signaling and modulation of regulatory T‑cell functions that may limit the cytokine storm in COVID‑19. (spandidos-publications.com)
- Current goals include elucidation of signal transduction events initiated through as well as independently of cannabinoid receptors, including the peroxisome proliferator activated receptor (PPARy), leading to aberrant cytokine gene expression by T lymphocytes. (msu.edu)
- We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
- Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
- exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
- matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
Dendritic cells4
- In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
- Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
- The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
- CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. (thermofisher.com)
Macrophages3
- Inflammatory cell infiltration (macrophages and T lymphocytes and subsequently B lymphocytes) is followed by tissue fibrosis which is present in all ruptured IA [ 16 ]. (biomedcentral.com)
- however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
- Exposure to GO reduced eosinophil accumulation, but increased alveolar macrophages and lymphocytes in BAL fluid, as compared to those in OVA-only treated animals. (cdc.gov)
Apoptosis5
- In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)
- Lymphocytes, in particular, undergo massive and infection, potentially improving outcomes for patients in a apparently unregulated apoptosis in human patients and variety of disease states. (cdc.gov)
- Prevention of lymphocyte apoptosis, same process by which these cell populations are regulat- through either genetic modification of the host or treatment ed during normal health ( 1 , 2 ). (cdc.gov)
- Flow cytometry was used for the analysis of apoptotic cells and proteins involved in the modulation of apoptosis. (iiarjournals.org)
- 1 The genetic and molecular mechanisms involved in the development of the disease are not well known, but recent observations suggest that the modulation of survival signals interfering with apoptosis may be a pivotal tool in the pathogenesis of CLL. (haematologica.org)
19822
- Bardos P, Bach JF (1982) Modulation of mouse natural killer cell activity by serum thymic factor. (springer.com)
- Maluish AE, Ortaldo JR, Herberman RB (1982) Modulation of NK activity by recombinant leucocyte interferon in advanced cancer patients. (springer.com)
Subsets1
- The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
Immune3
- These findings suggest that inter- the apoptotic destruction of lymphocytes and dendritic ventions aimed at reducing the extent of immune cell apop- tosis could improve outcomes for a variety of severe cells could have a particularly adverse effect on disease human infections, including those caused by emerging outcome. (cdc.gov)
- One major research focus is to characterize the mechanism for immune modulation by cannabinoid compounds. (msu.edu)
- Induction of sustained T-cell responses may require additional immune modulation later in therapy. (ox.ac.uk)
Mucosal1
- Chin YH, Cai JP, Hieselaar T. Lymphocyte migration into mucosal lymphoid tissues: mechanism and modulation. (medscape.com)
Murine1
- Here we investigated the modulation of allergic response in a murine model of ovalbumin (OVA)-induced asthma by pulmonary exposure to GO. (cdc.gov)
Activation6
- Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (nature.com)
- Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. (rochester.edu)
- Accumulating data indicate that BM of RA patients participates in the pathogenesis of this disease as a site of proinflammatory cytokines overproduction and lymphocytes activation. (nih.gov)
- It is also known that an effective response against Pb depends on both TCD4 and TCD8 lymphocyte activation in the presence of ideal concentrations of Th1 inflammatory cytokines [ 12 - 14 ]. (hindawi.com)
- My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
- A major emphasis of all of the projects is the elucidation of the molecular mechanisms for impairment of signal transduction cascades and gene expression during lymphocyte activation by drugs and chemicals. (msu.edu)
Antibody2
- It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. (karger.com)
- And then following transport to the cell's surface, the CD4 T cell can perform various functions, for example can help a B lymphocyte to differentiate and become an antibody producing cell. (hstalks.com)
Inflammatory2
- Glial cells, especially microglia, get locally activated in the damaged brain areas and are able to induce the recruitment of scavenger blood cells, such as monocytes and lymphocytes to injured sites, contributing to the inflammatory reaction [ 3 , 4 ]. (hindawi.com)
- Zinc plays a signaling role involved in the modulation of inflammatory responses ( 3 ). (spandidos-publications.com)
Populations1
- A study of patient AAA tissue showed a reduction of VSMC markers, macrophage infiltration, and increased CD4+ and CD8+ T lymphocyte populations compared to healthy aorta. (biomedcentral.com)
Undergo1
- B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
Proliferation2
- bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
- CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)
Migration1
- Modulation of lymphocyte migration by human lymphokines. (wikipedia.org)
Vitro1
- Kaiserlian D, Bardos P, Bach JF (1983) In vitro modulation of mouse natural killer (NK) cell activity by the serum thymic factor (FTS). (springer.com)
Peripheral1
- Following consumption of 1.2 litres of cows' milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fcγ-receptors). (karger.com)
Responses1
- The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. (ox.ac.uk)
Prevention2
- Lymphocytes are key contributors to IA pathogenesis and provide a novel target for the prevention of IA progression and rupture in patients. (biomedcentral.com)
- Therefore, Zn may possess protective effect as preventive and adjuvant therapy of COVID‑19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator‑induced lung injury, modulation of antiviral and antibacterial immunity. (spandidos-publications.com)
Molecular1
- This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
Pathogenesis1
- Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Serum1
- In man it was found that Fcγ-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. (karger.com)
Accumulation1
- Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of CD5CD23 B-cell lymphocytes. (haematologica.org)
Tissue3
- Histological analysis of unruptured IA tissue showed robust B and T lymphocyte infiltration in the WT group, while there were no differences in macrophage infiltration, IA diameter, and wall thickness. (biomedcentral.com)
- Many of these changes are influenced by the infiltration of leukocytes into the vessel wall which can act to degrade the extracellular matrix (ECM) through the secretion of MMPs and promote VSMC phenotypic modulation via secretion of cytokines such as tissue necrosis factor (TNF), interleukin-1 beta, and interleukin-6 (IL-6) [ 13 ]. (biomedcentral.com)
- We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
Interactions4
- Modulation of macrophage/lymphocyte interactions by L. infantum. (unl.pt)
- http://www.ncbi.nlm.nih.gov/pubmed/?term=Canine+leishmaniosis.+Modulation+of+macrophage%2Flymphocyte+interactions+by+L.+infantum. (unl.pt)
- Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
- This increase is shown to result from vinculin's modulation of paxillin-FAK interactions. (rupress.org)
Reaction1
- RPA-T4 blocks HIV binding and mixed lymphocyte reaction. (thermofisher.com)
Humans1
- IL-16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). (wikipedia.org)
Response2
- There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
- Chemokine signaling is essential for T lymphocyte trafficking during homeostasis and in response to inflammation. (duke.edu)
Cell1
- Here, we investigated the functionality of TLR9 and its role in the modulation of RA BM B-cell functions. (nih.gov)
Insights1
- Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ + and TCRαβ + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). (nature.com)
Disease1
- Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. (uc.edu)
Model1
- However, no study has systematically examined the contribution of lymphocytes in a model of IA. (biomedcentral.com)
Suggest1
- Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID‑19. (spandidos-publications.com)
Activity1
- PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
Patients1
- et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
Effort1
- This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)