Endothelial Progenitor CellsMouse bone marrowEPCsMultipotent progenitor cellsMSCsDifferentiationVascularMigrate to the peripheralStromal cellsProliferationAdultEnter the thymusPeripheral bloodThymusHaematopoieticInflammationHematopoietic cellsThymicPopulationsDerived tumorNeutrophilsInduceMyeloidTransplantsTransplantationVivoMigrationTissueTissuesDental pulpMediateImmature bloodStem cellNeovascularizationInducesMiceLungsRegenerationProteinsMetabolismProcessesGene expressionFunctionalSymptomsTreatment
Endothelial Progenitor Cells11
- OBJECTIVE-: Both matrix metalloproteinases (MMPs) and endothelial progenitor cells (EPCs) have been implicated in the process of neovascularization. (tmu.edu.tw)
- The existence of endothelial progenitor cells has been posited since the mid-twentieth century, however their existence was not confirmed until the 1990s when Asahara et al. (wikipedia.org)
- Endothelial progenitor cells are likely important in tumour growth and are thought to be critical for metastasis and the angiogenesis. (wikipedia.org)
- Ablation of the endothelial progenitor cells in the bone marrow lead to a significant decrease in tumour growth and vasculature development. (wikipedia.org)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
- Diabetes is known to impair the number and function of endothelial progenitor cells in the circulation, causing structural and functional alterations in the micro- and macro-vasculature. (biomedcentral.com)
- Based on review of current literature, this study examined the expression level of 35 genes that are known to be involved in endothelial progenitor cell migration and function in magnetically sorted Lin - /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early stages of diabetes (18 weeks) using RT-PCR and Western blotting. (biomedcentral.com)
- We observed a significant increase in the number of Lin - /VEGF-R2 + endothelial progenitor cells within the bone marrow in diabetic mice compared with non-diabetic mice. (biomedcentral.com)
- Two genes, SDF-1 and SELE, were significantly differentially expressed in diabetic Lin - /VEGF-R2 + endothelial progenitor cells and six other genes, CAV1, eNOS, CLDN5, NANOG, OCLN and BDNF, showed very low levels of expression in diabetic Lin - /VEGF-R2 + progenitor cells. (biomedcentral.com)
- Low SDF-1 expression may contribute to the dysfunctional mobilization of bone marrow Lin - /VEGF-R2 + endothelial progenitor cells, which may contribute to microvascular injury in early diabetes. (biomedcentral.com)
Mouse bone marrow3
- Here, we visualised the sequential phases of intravascular MK protrusions and fragments in living mouse bone marrow (BM), using intravital microscopy, and examined their ultrastructure. (nih.gov)
- Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
- Here we have determined the expression of a network of 18 key haematopoietic transcription factors in 597 single primary blood stem and progenitor cells isolated from mouse bone marrow. (ox.ac.uk)
EPCs2
- Certain developmental cells may be similar to or the same as other endothelial progenitors, though not typically referred to as EPCs. (wikipedia.org)
- A large amount of research has been done on CFU-Hill bone marrow-derived putative EPCs. (wikipedia.org)
Multipotent progenitor cells2
- Bone marrow - derived stromal cells or mesenchymal stromal cells (BMSCs or MSCs, as we will call them in this work) are multipotent progenitor cells that can differentiate into osteoblasts, adipocytes and chondrocytes. (terraintherapy.com)
- The development of practical T lymphocytes happens in the thymus and is maintained from the periodic immigration of multipotent progenitor cells (MPPs) from either the embryonic liver or the adult bone marrow (1). (bio-biz-navi.com)
MSCs6
- In addition, MSCs have been shown to modulate the function of a variety of immune cells. (terraintherapy.com)
- Young MSCs double more quickly and differentiate into bone and fat cells more efficiently than those from older donors. (terraintherapy.com)
- Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
- Despite this imperfect knowledge, sufficient medical encounter offers been accumulated from the several medical tests using numerous adult come cell populations, including bone tissue marrow-derived mononuclear cells (BMMNCs), mesenchymal come cells (MSCs), and come cells separated from cardiac cells (Number 1). (bioinf.org)
- The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues. (tamu.edu)
- Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
Differentiation10
- We examined the influence of variable hemodynamic conditions on progenitor cell localization and differentiation in experimental AAAs.Murine AAAs were created via porcine pancreatic elastase (PPE) infusion. (stanfordhealthcare.org)
- Modulating cell lineage differentiation of mature progenitor cells may represent a novel therapeutic strategy to maintain medial cellularity and extracellular matrix integrity in AAA disease. (stanfordhealthcare.org)
- M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. (m-csf.com)
- These secreted factors may stimulate vascular growth and redesigning, attenuate fibrosis, modulate swelling, regulate cell differentiation and survival, and sponsor resident come or progenitor cells.12,13 Activation of these pathways may blunt reperfusion injury or attenuate adverse remodeling in individuals suffering from acute myocardial infarction (AMI) or HF, respectively. (bioinf.org)
- In adult animals MPPs enter the thymus through venules in the cortical medullary junction (CMJ) rapidly loose B cell differentiation potential and give rise to early thymic progenitors (ETPs) (2). (bio-biz-navi.com)
- Differentiation from ETPs is definitely associated with migration of progenitors through the Picroside III cortex away from the CMJ where DN2 (CD4?CD8? (bio-biz-navi.com)
- Several targets of the ICN/CSL/MAML complex have been recognized in T cell progenitors and many of these possess critical functions that contribute to T cell differentiation and transformation (18). (bio-biz-navi.com)
- An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
- They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
- Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
Vascular1
- Bone marrow-derived vascular progenitor cells (CD34+) are present in human and animal models of abdominal aortic aneurysm (AAA) disease. (stanfordhealthcare.org)
Migrate to the peripheral1
- These cells are derived from mast cell progenitors (MCps) that migrate to the peripheral tissues via the blood in response to allergic or non-allergic stimuli. (avhandlingar.se)
Stromal cells3
- Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
- These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
- Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
Proliferation3
- By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. (m-csf.com)
- In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
- Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
Adult3
- Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. (scirp.org)
- Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
- This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
Enter the thymus1
- In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)
Peripheral blood1
- Examination of peripheral blood smear and bone marrow is diagnostic. (msdmanuals.com)
Thymus4
- Numerous studies from our laboratory and others have demonstrated that noradrenergic (NA) and peptidergic nerve fibers are present in various compartments of primary (bone marrow, thymus) and secondary (spleen, lymph nodes) lymphoid organs and that these nerve fibers can modulate immune functions [5-10]. (brainimmune.com)
- The chemokine receptor CCR9 controls the immigration of multipotent hematopoietic progenitor cells into the thymus to sustain T cell development. (bio-biz-navi.com)
- Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)
- thymus from marrow-derived progenitors circulating in the blood. (lu.se)
Haematopoietic3
- According to data from the Spanish Register of Tumours in Infants (RETI), ours it the Department that treats the most children in Spain, and is the leading centre for the transplant of haematopoietic progenitors or stem cells (better known as "bone marrow transplants"), having performed more than 1200 such operations. (vallhebron.com)
- Transplant of haematopoietic progenitors (autologous, allogeneic relatives and unrelated donors). (vallhebron.com)
- VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. (southernbiotech.com)
Inflammation1
- We have discovered that sleep helps to regulate the production in the bone marrow of inflammatory cells and the health of blood vessels and that, conversely, sleep disruption breaks down control of inflammatory cell production, leading to more inflammation and more heart disease," says Filip Swirski, PhD, of the MGH Center for Systems Biology, senior author of the Nature paper. (sciencedaily.com)
Hematopoietic cells1
- Unfortunately, there are no unique markers for endothelial progenitors that are not shared with other endothelial or hematopoietic cells, which has contributed to the historical controversy surrounding the field. (wikipedia.org)
Thymic1
- Downloaded from periodic thymic colonization by progenitor cells guarantees stage. (lu.se)
Populations2
- Molecular genetic analysis of early outgrowth putative EPC populations suggests they do indeed have monocyte-like expression patterns, and support the existence of a separate population of progenitors, the late outgrowth, or endothelial colony forming cell (ECFC). (wikipedia.org)
- We demonstrate that different stem/progenitor populations are characterized by distinctive transcription factor expression states, and through comprehensive bioinformatic analysis reveal positively and negatively correlated transcription factor pairings, including previously unrecognized relationships between Gata2, Gfi1 and Gfi1b. (ox.ac.uk)
Derived tumor1
- SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice. (southernbiotech.com)
Neutrophils1
- G-CSF also modulates multiple differentiated functions of human neutrophils, including enhanced oxidative metabolism in response to f- Met-Leu-Phe (f-MLP), increased antibody-dependent cell-mediated cytotoxicity (ADCC), and augmented arachidonic acid release in response to ionophore and chemotactic agents. (ashpublications.org)
Induce1
- Among these focuses on are itself is definitely a transcriptional target of the E proteins (38 39 The E proteins can also synergize with ICN1 to induce manifestation in T cell progenitors (39). (bio-biz-navi.com)
Myeloid1
- In this report, we show that biosynthetic (recombinant) human G-CSF enhances colony formation by normal human bone marrow and the human myeloid leukemic cell lines, HL-60 and KG-1, as well as nonhematopoietic small cell lung cancer lines, H128 and H69. (ashpublications.org)
Transplants1
- Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
Transplantation2
- Transplantation of bone marrow cells from wild-type mice restored collateral flow formation in MMP-9 mice. (tmu.edu.tw)
- The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
Vivo3
- These results strongly suggested that BM MKs form and release two types of platelet progenitors via distinct intravascular protrusions, and that platelet demand modulates the type of intravascular protrusion that is formed in vivo. (nih.gov)
- We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
- Human granulocyte colony-stimulating factor (G-CSF) is a regulatory glycoprotein that stimulates the production of neutrophilic granulocytes from committed hematopoietic progenitor cells both in vitro and in vivo. (ashpublications.org)
Migration4
- C-kit positive bone marrow cells of MMP-9 mice have attenuated adhesion and migration than those isolated from wild-type mice. (tmu.edu.tw)
- The aim of this study was to identify early diabetes-related changes in the expression of genes that have been reported to be closely involved in endothelial progenitor cell migration and function. (biomedcentral.com)
- Since all these processes depend on the recruitment of cells with the potential to be committed to the osteoblastic lineage, we studied possible effects of IGF-I and -II on migration of human mesenchymal progenitor cells (MPC) using a modified Boyden chamber assay. (neuroprobe.com)
- In conclusion, our results show that IGF-I and -II are chemotactic factors for MPC and indicate that IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells. (neuroprobe.com)
Tissue5
- Plasma levels and bone marrow concentrations of soluble Kit-ligand (sKitL) were significantly elevated in wild-type mice in response to tissue ischemia, but not in MMP-9 mice. (tmu.edu.tw)
- ECFCs are now known to be tissue-resident progenitor cells in adults that maintain some vasculogenic ability. (wikipedia.org)
- In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
- She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
- However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
Tissues1
- The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
Dental pulp1
- Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
Mediate1
- In hematological malignancies, tumor-derived EVs might reprogram the bone marrow environment, suppress antileukemic immunity, mediate drug resistance and interfere with immunotherapies. (nature.com)
Immature blood1
- Validation using transcriptional and transgenic assays confirmed direct regulatory interactions consistent with a regulatory triad in immature blood stem cells, where Gata2 may function to modulate cross-inhibition between Gfi1 and Gfi1b. (ox.ac.uk)
Stem cell1
- Angioblasts are believed to be a form of early progenitor or stem cell which gives rise to the endothelium alone. (wikipedia.org)
Neovascularization1
- Bone marrow-derived progenitor cell (BMPC) therapy has been shown to promote neovascularization, decrease infarct area and attenuate left ventricular (LV) dysfunction after MI. (indexindex.com)
Induces1
- Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
Mice2
- Age-related loss of bone marrow pre-B- and immature B-lymphocytes in the autoimmune-prone flaky skin mutant mice. (southernbiotech.com)
- Further experiments revealed that the sleep-deprived mice had a nearly two-fold increase in the production in their bone marrow of stem cells that give rise to white blood cells. (sciencedaily.com)
Lungs1
- Mast cell progenitors originate from the bone marrow and migrate to the lungs via the blood. (avhandlingar.se)
Regeneration2
- Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the regeneration of the endothelial lining of blood vessels. (wikipedia.org)
- Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
Proteins1
- While Notch signaling modestly modulates the binding of E proteins to one of the Picroside III two enhancers we found Picroside III that Notch signaling represses in T cell lymphoma lines in which transcription is self-employed of E protein function. (bio-biz-navi.com)
Metabolism1
- Prof. Elisabeth Engel got her PhD in 2003 in bone metabolism diseases in medical school. (ibecbarcelona.eu)
Processes1
- We also have identified how a hormone in the brain known to control wakefulness controls processes in the bone marrow and protects against cardiovascular disease. (sciencedaily.com)
Gene expression1
- Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. (ox.ac.uk)
Functional1
- Although bone marrow-derived cells do appear to localize to injured vessels and promote an angiogenic switch, other studies have suggested these cells do not contribute directly to the functional endothelium, instead acting via paracrine methods to provide support for the resident endothelial cells. (wikipedia.org)
Symptoms1
- Disseminated rhabdomyoblasts in the bone marrow may mimic the symptoms and light microscopic findings of leukemia. (medscape.com)
Treatment1
- Importance Come cell therapy is a promising treatment strategy for individuals with heart failure, which accounts for over 10% of deaths in the U. marrow mononuclear cells, have found only a humble benefit in individuals receiving come cell therapy. (bioinf.org)