Modulate the expression. Medical search. Frequent questions

Gene expression analysis revealed that cholesterol exposure significantly increased the expression of ER stress-response genes, including XBP1. (aacrjournals.org)
No cure for HHT has been found, so identification of drugs able to increase the expression of these genes is essential when proposing new therapies. (aspetjournals.org)
The effect of CTGF silencing on the TGF-β2-modulated expression of these genes was investigated by transfection of CTGF small interfering (si)RNA before TGF-β2 treatment. (arvojournals.org)
Pathway analysis revealed substantial modulation of gene expression in defence and immune responses and in particular modulation of genes in the Fcγ-receptor-mediated phagocytosis pathway. (biomedcentral.com)
The ability of curcumin to mitigate the expression levels of age-associated genes in young flies suggests that the action of curcumin on these genes is a cause, rather than an effect, of its life span-extending effects. (escholarship.org)
Modulating the expression of disease genes with RNA-based therapy. (ox.ac.uk)
4-HPR resulted in an up-regulation of expression of proapoptotic genes and mitochondrial uncoupling protein in OVCA433 cells and modulation of the RXR receptors in IOSE cells, and down-regulation of mutant BRCA genes in both IOSE and OVCA433 cells. (arizona.edu)
Despite low or absent protein coding polymorphism, the Drosophila Y chromosome has been associated with natural phenotypic variation, including variation in the expression of hundreds to thousands of genes located on autosomes and on the X chromosome. (jgenomics.com)
signaling and regulates the expression of pro-inflammatory cytokine genes encoding interleukin (IL)-6 and -8. (kyobobook.co.kr)

Chronic helminth infection causes immune hyporesponsiveness and stimulates anti-inflammatory cytokine production, which in turn modulates the host immune response to malaria. (biomedcentral.com)
However, it is unclear that dexmedetomidine modulates histamine-induced signaling and pro-inflammatory cytokine expression. (kyobobook.co.kr)

To determine whether ischemic AMPK activation-modulated by the Sesn2-AMPK complex in the heart-is impaired in aging that sensitizes the heart to ischemic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-26 mo) were subjected to left anterior descending coronary artery occlusion for in vivo regional ischemia. (nih.gov)

Here we show that at neocortical synapses in slices from rat visual cortex, adenosine modulates the weight dependence of heterosynaptic plasticity: blockade of adenosine A 1 receptors abolished weight dependence, while increased adenosine level strengthened it. (jneurosci.org)
This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2). (scienceopen.com)

The current study used event-related potentials (ERPs) technique to investigate the impact of monetary reward on the discrimination of emotional facial expressions. (psych.ac.cn)
Early P1, N170 and VPP amplitudes were not affected by emotional facial expressions. (psych.ac.cn)
These results suggested an impact of reward anticipation on the processing of upcoming emotional facial expressions. (psych.ac.cn)
The effect of opponent's emotional facial expressions on individuals' cooperation and underlying mechanism in prisoner's dilemma game [J]. Acta Psychologica Sinica, 2021, 53(8): 919-932. (psych.ac.cn)
Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. (bvsalud.org)

Sialyltransferase 8Sia IV(-/-) mice, which lacked polySia expression in the immune compartment, demonstrated an increased contact hypersensitivity response and decreased control of tumor growth as compared with wild-type animals. (ca.gov)
Lactate modulates cardiac gene expression in mice during acute physical exercise. (bvsalud.org)

The results suggest that quercetin was able to efficiently potentiate the effect of γδ T cells and modulate Wnt/β-catenin signalling pathway. (banglajol.info)

Is the Subject Area "Facial expressions" applicable to this article? (plos.org)
By recording from densely distributed locations across the surfaces of the cortical region that controls speech production and related facial expression, they can analytically define what the patient is trying to say, even while the disconnected outputs of the patient's brain hit a dead end. (medscape.com)
By recording facial expression dynamics, it can also modulate the speech to further express the patient's conveyed emotions. (medscape.com)
In parallel, Chang's team is further training patients to deploy inherent brain plasticity to improve the accuracy and speed of their speech production, facial expressions, and emotion-modulated voicing still further. (medscape.com)

PolySia is best known for its proposed role in modulating neuronal development. (ca.gov)
Here, we report that neuronal activity enhances Nr4a2 expression and function in cultured mouse hippocampal neurons (both sexes) by an ionotropic glutamate receptor/Ca2+/cAMP response element-binding protein/CREB-regulated transcription factor 1 (iGluR/Ca2+/CREB/CRTC1) pathway. (uab.cat)

Endogenous extracellular adenosine level fluctuates in an activity-dependent manner and with sleep-wake cycle, modulating synaptic transmission and short-term plasticity. (jneurosci.org)
Altogether, our results indicate that the iGluR/Ca2+/CREB/CRTC1 pathway mediates activity-dependent expression of Nr4a2 which is involved in glutamatergic synaptic plasticity by increasing BDNF and synaptic GluA1-AMPARs. (uab.cat)

Cholesterol increases expression of exhaustion markers in tumor-infiltrating CD8 + T cells. (aacrjournals.org)
Tumor microenvironment-induced T-cell exhaustion can be overcome by modulating cholesterol levels. (aacrjournals.org)
XBP1 knockdown or treatment with an ER stress inhibitor decreased PD-1 and 2B4 expression on tumor-infiltrating CD8 + T cells and also significantly decreased tumor burden, suggesting that cholesterol-induced ER stress affected T-cell antitumor functionality. (aacrjournals.org)
Herein we show the expression of polySia on hematopoietic progenitor cells, and demonstrate a role for this glycan in immune response using both acute inflammatory and tumor models. (ca.gov)
and Heikinheimo, Markku, "FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. (wustl.edu)
In the CAM xenograft model, DOX and PEMF exposure also synergistically reduced tumor size as well as reduced Transient Receptor Potential Canonical 1 (TRPC1) channel expression. (pemfprofessionals.com)

ChIP profiling and transcriptional reporter assays revealed that cholesterol increases PD-1 expression in part by increasing XBP1 occupancy at the Pdcd1 promoter. (aacrjournals.org)
SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. (musc.edu)

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. (alzforum.org)
Here, we find that the immunosuppressor FK506 increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells and enhances the TGF-β1/ALK1 signaling pathway and endothelial cell functions like tubulogenesis and migration. (aspetjournals.org)
signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect. (kyobobook.co.kr)
A third mechanism of action involves retrograde signaling and the modulation of gene expression. (truthseekerforum.com)

Emerging evidence suggests that lncRNA MALAT1 is abnormally expressed in diabetic nephropathy (DN) and can attenuate renal fibrosis by modulating podocyte epithelial-mesenchymal transition (EMT). (harvard.edu)
CONCLUSION: Conclusively, our study revealed that QHYS significantly reduced proteinuria, alleviated renal fibrosis, and attenuated the podocyte EMT in DN rats, which may be associated with the downregulation of lncRNA MALAT1 expression and inhibition of the Wnt/ β -catenin pathway. (harvard.edu)

Small interfering RNAs were used to inhibit PTPN2, STAT1, Bim, and Jun NH 2 -terminal kinase 1 (JNK1) expression. (diabetesjournals.org)

We evaluated the impact of curcumin on life span, fecundity, feeding rate, oxidative stress, locomotion, and gene expression in two different wild-type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. (escholarship.org)

In this study, we elucidated the potential role of STAT3 in the skin barrier and its effect on kallikrein-related peptidase 5 (KLK5) and serine protease inhibitor Kazal-type 5 (SPINK5) expression using a mouse model with keratinocyte-specific ablation of STAT3. (korea.ac.kr)
These results suggest that the expression of SPINK5 and KLK5 in keratinocytes could be dependent on STAT3 and that STAT3 might play an essential role in the maintenance of skin barrier homeostasis. (korea.ac.kr)

Therefore, we investigated the in vitro effect of DHEA on the expression pattern of adhesion molecules of human endothelial cells and neutrophils. (biomedcentral.com)
Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)

Top microRNA clusters that significantly modulate reporter expression. (figshare.com)
Quercetin exposure significantly increased γδ T cell proliferation and also raised the expressions of granzyme B (Gra B), perforin (PFP), and interferon- γ (IFN-γ) in γδ T cells. (banglajol.info)
Along with these modulations, curcumin significantly decreased the populations of macrophages and alpha smooth muscle actin-expressing myofibroblasts, which were accompanied by reduced expression of transforming growth factor beta 1 and phosphorylated-Smad2/3. (scienceopen.com)
Importantly, QHYS significantly downregulated the expression level of lncRNA MALAT1, upregulated the expression of nephrin, the podocyte marker protein, downregulated the expression of desmin and FSP-1, and mesenchymal cell markers. (harvard.edu)
Furthermore, QHYS significantly downregulated the expression levels of Wnt1, β -catenin, and active β -catenin. (harvard.edu)
In addition, cardiac lactate levels were significantly correlated to both PGC-1α and COX-IV cardiac gene expression . (bvsalud.org)

Hha, along with the chromatin-associated protein H-NS, is involved in the regulation of expression of the toxin alpha-haemolysin in response to osmolarity and temperature. (wikipedia.org)
This is the first demonstration of polySia expression and regulation on myeloid cells, and the results in animal models suggest a role for polySia in immune regulation. (ca.gov)
Thus, we conclude that one mechanism by which DHEA may exert its protection in animal models is via the differential regulation of adhesion molecule expression. (biomedcentral.com)

Because TNF-alpha expression is upregulated in hepatic inflammation, the data suggest TNF-alpha-mediated increases in tTG expression may play an important role in the process of hepatic fibrogenesis. (nih.gov)

Histamine stimulated IL-6 mRNA expression not IL-8 mRNA within 2 hrs, however this effect was attenuated by dexmedetomidine. (kyobobook.co.kr)

Treatment with an ER stress inhibitor or XBP1 knockdown blocked the exhaustion effects of cholesterol exposure and inhibited cholesterol-induced increased PD-1 and 2B4 expression. (aacrjournals.org)
Reduced β-catenin expression with increased expressions of phosphorylated- β-catenin, axin1 and 2 were observed in HT55 and HCT116 cells on exposure to quercetin. (banglajol.info)
We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
Chronic exposure to DOX depressed TRPC1 expression, proliferation, and responses to both PEMF exposure and DOX in a manner that was reversible upon removal of DOX. (pemfprofessionals.com)
Finally, PEMF exposure was shown to attenuate the invasiveness of MCF-7 cells in correlation with TRPC1 expression. (pemfprofessionals.com)
Exposure to perfluorooctanesulfonic acid (PFOS) during 2,4,6-trinitro-benzene sulfonic acid (TNBS)-induced inflammation enhanced the expression of proinflammatory cytokines as. (lu.se)

In molecular biology, the haemolysin expression modulating protein family is a family of proteins. (wikipedia.org)
CIBERNED_Patología molecular en la enfermedad de Alzheimer. (uab.cat)
Because the molecular mechanisms regulating the expression of the transgene are well understood, this model provides a useful tool for investigating cellular and molecular effects of opioids on the hypothalamus. (huji.ac.il)

While the positive emotion processing effect was not modulated by reward anticipation, the negative emotion processing effect and negative bias effect for the N300 component were larger in incentive condition than in non-incentive condition. (psych.ac.cn)
Motivational factors may modulate the distribution of attentional resources, which then bias the processing of negative emotion. (psych.ac.cn)
Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)

Aldosterone stimulates Na + ,K + -ATPase activity and may modulate α 1 /β 1 expression. (pucv.cl)
Aldosterone stimulates Na+,K+-ATPase activity and may modulate α1/β1 expression. (pucv.cl)

To examine HDE-induced effects on PARs surface expression, epithelial cells were challenged with 5% HDE for 30' to 18h, and were then immunostained for PAR1 and PAR2 for cytology and flow cytometry. (cdc.gov)

We investigated the modulation of gene expression by 4-HPR in immortalized ovarian surface epithelial (IOSE) cells and ovarian cancer (OVCA433) cells with DNA microarray. (arizona.edu)
Here we describe use of this transgenic model to study modulation of stress-regulated gene expression in the PVN by opiates. (huji.ac.il)

abstract = "Stressful stimuli strongly induce proenkephalin gene expression within the paraventricular nucleus (PVN) of the hypothalamus. (huji.ac.il)

this model provides high sensitivity, cellular resolution, and ready quantification of levels of proenkephalin gene expression. (huji.ac.il)

OBJECTIVE: In the present study, we aimed to explore whether QHYS could modulate lncRNA MALAT1 expression and attenuate the podocyte EMT as well as the potential mechanism related to the Wnt/ β -catenin signal pathway. (harvard.edu)

There was also no difference in gene expression profile between healthy controls and coinfected children. (biomedcentral.com)
An ERh gene expression profile was identified and was markedly different from the ERa signature. (lu.se)

Nr4a2 activation mediates Brain-derived neurotrophic factor (BDNF) production and increases expression of iGluRs, thereby affecting long-term depression (LTD) at CA3-CA1 synapses in acute mouse hippocampal slices (both sexes). (uab.cat)
Acute or subacute morphine administration prior to a hypertonic saline stress produced marked superinduction of transgene expression compared with hypertonic saline stress alone. (huji.ac.il)

Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
In addition, the expression levels of podocyte EMT protein markers and Wnt/ β -catenin pathway proteins in renal tissues were evaluated by Western blotting and immunohistochemistry. (harvard.edu)
We thus demonstrate that the expression levels of TRPC1 consistently predicted breast cancer sensitivity to DOX and PEMF interventions and positively correlated to EMT status, providing an initial rationale for the use of PEMF-based therapies as an adjuvant to DOX chemotherapy for the treatment of breast cancers characterized by elevated TRPC1 expression levels. (pemfprofessionals.com)
[ 1 ] Antibodies are positive in 90% of patients, but 10% patients have no detectable levels of binding/blocking/modulating antibodies. (medscape.com)

These initial observations were confirmed in human patient samples, as cholesterol content in CD8 + T cells isolated from primary colon tumors or myeloma samples correlated with increased PD-1 and 2B4 expression. (aacrjournals.org)
Specifically, we found that human NK cells modulate expression of NCAM and the degree of polymerization of its polySia glycans according to activation state. (ca.gov)
This contrasts with the mouse, where polySia and NCAM expression are restricted to multipotent hematopoietic progenitors and cells developing along a myeloid lineage. (ca.gov)
We hypothesized that the β 3 isoform of the Na + ,K + -ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. (pucv.cl)
Results: miR-206 mimic repressed mRNA and protein expression of OATP1B1 in Huh-7 cells. (amsterdamumc.org)

Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

In the present study, we were able to demonstrate effects of DHEA on the expression of every adhesion molecule investigated. (biomedcentral.com)
Social value orientation modulates the processing of social rewards for self： Evidence from ERPs study [J]. Acta Psychologica Sinica, 2020, 52(6): 786-800. (psych.ac.cn)

Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached to the protein scaffold neural cell adhesion molecule (NCAM). (ca.gov)

The effect of STAT3 on KLK5 expression in keratinocytes was not only substantiated by the increase in KLK5 expression following treatment with STAT3 siRNA but also by its decreased expression following STAT3 overexpression. (korea.ac.kr)
A workhorse of a modulating delay, the Adventure Audio Again produces an intuitive delay effect experience that only expands outward once you dig into it. (russomusic.com)
Conclusions: miR-206 exerts a suppressive effect on OATP1B1 expression by an epigenetic mechanism. (amsterdamumc.org)

Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. (ca.gov)
However β-actin expression was found to be not much altered. (banglajol.info)
We found that β 3 is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of β 3 . (pucv.cl)
The researchers also found that the degree of expression of the ADAM10 gene, which converts RAGE into sRAGE, plays a role in colorectal cancer development. (who.int)

Furthermore, curcumin increased protein level of ACE2 and enhanced its expression in the intermyocardium relative to the Ang II group. (scienceopen.com)

microRNA-206 (miR-206) expression in human liver tissues was measured by real-time RT-PCR. (amsterdamumc.org)
OATP1B1 expression in Huh-7 and in human liver tissues was assessed by real-time RT-PCR, Western blotting and immunostaining. (amsterdamumc.org)

In contrast, chronic morphine administration decreased basal expression of the transgene, and inhibited stress-induced expression of the transgene. (huji.ac.il)

Six controls allow you to dial expressive modulated delay tones that can vary from quick slapbacks to drawn out repeat trails. (russomusic.com)

Genes9

Cytokine2

Ischemic1

Receptors2

Emotional facial expressions5

Mice2

Signalling pathway1

Facial4

Neuronal2

Synaptic2

Tumor6

Transcriptional2

Signaling4

Fibrosis2

Kinase1

Oxidative1

Barrier2

Endothelial cells2

Significantly6

Regulation3

Hepatic1

MRNA expression1

Exposure6

Molecular3

Negative3

Stimulates2

Epithelial Cells1

Modulation2

Abstract1

Cellular1

Explore1

Gene expression profile2

Acute2

Levels4

Cells5

Protein expression1

Study2

Neural1

Effect3

Found4

Curcumin1

Human2

Stress1

Controls1