NeuronsDopamineOscillationsCircuitsCognitiveNeural2018AcetylcholineCurrentsPathwaysProcessesDifferentiationHippocampusGABAExcitatoryInhibitPhysiologicalVivoExcitabilityGlialPopulationsSensorimotorDecreasesMechanismsBrainSynapticSignaling pathwayCultured neuronalHumanDynamicsCalciumTemporalNetwork activityMarkerResponsesEffectsDemonstrateFunctionsSpecificSignalsRole
Neurons12
- Our findings reveal a novel type of activity-dependent plasticity acting on the timing of neuronal maturation and functional integration of newly generated neurons along the longitudinal axis of the adult hippocampus. (jneurosci.org)
- We found that tension in neurons modulates active transport of vesicles by increasing the probability of active motion, effective diffusivity and induces a retrograde bias. (nature.com)
- We show that mechanical tension modulates active transport processes in neurons and that external forces can couple to internal (subcellular) forces and change the overall transport dynamics. (nature.com)
- Exploring underlying neuronal processes, we found that the activity of neurons in OFC represented the conflict between behavioral options independent from the other aspects of the task. (jneurosci.org)
- With whole-cell recording from single neurons, we found that ACh inhibited excitatory postsynaptic currents (EPSCs) while elevating neuronal firing in a dose-dependent manner. (springer.com)
- D3 activity in the neurons modulated these effects. (jci.org)
- We use an approach informed by an understanding of neuronal microcircuit dynamics, macrocircuit connectivity and organism-level behavior to connect between the level of single neurons, networks of those neurons and animal behavior. (google.com)
- Taken together, these results suggest that K ATP channel activation mediates the response of hippocampal neurons to hyperglycemia by coupling metabolism with neuronal activity and ISF Aβ levels. (jci.org)
- Gamma-aminobutyric acid (GABA)-releasing interneurons modulate neuronal network activity in the brain by inhibiting other neurons. (lu.se)
- These results provide a proof-of-concept that hESC-derived neurons can integrate and modulate the activity of a human host neuronal network. (lu.se)
- Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
- Prof. Lindvall and Dr. Kokaia were the first in the world to show that the brain produces new neurons in response to stroke which opened new possibilities for cell therapy by developing the way to modulate and direct brains this self-repair mechanisms. (lu.se)
Dopamine3
- Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of neuronal dopamine production in the brain, causing motor and non-motor symptoms. (medscape.com)
- NBI-98854 is a novel, highly selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) protein that modulates neuronal dopamine levels. (medscape.com)
- Modulation of neuronal dopamine levels in diseases such as tardive dyskinesia, Tourette syndrome , Huntington's chorea , schizophrenia , and tardive dystonia , which are characterized, in part, by a hyperdopaminergic state, should provide symptomatic benefits for patients with these diseases," they say. (medscape.com)
Oscillations2
- 2013 ). Due to its sinusoidal current, tACS has been demonstrated to modulate endogenous brain oscillations (e.g. (springer.com)
- How field potential oscillations and neuronal firing rates are correlated time in the frontal cortex in rodent recordings. (google.com)
Circuits3
- However, understanding exactly how such molecular and cellular actions of ACh translate into modulation of the network activity of neuronal ensembles in vivo has been challenging, in part due to the vast complexity of native circuits. (springer.com)
- NE, DA, and 5-HT principally modulate this brain region, and dysregulation or imbalance in their levels affect neuronal circuits involved in cognitive processing. (cdc.gov)
- Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connections. (lu.se)
Cognitive4
- This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load. (mit.edu)
- How minimal variations in neuronal cytoskeletal integrity modulate cognitive control. (tu-dresden.de)
- Listening to music represents a complex cognitive function of the human brain, which is known to induce several neuronal and physiological changes. (sciencedaily.com)
- Specifically, the investigators point out that tDCS can "positively modulate neuronal activity in prefrontal structures central for affective and cognitive processes" including emotion regulation, cognitive control working memory, and learning. (medscape.com)
Neural5
- Adult neurogenesis is a complex process whereby neural progenitor cells adopt a neuronal fate, migrate, and mature over several weeks. (jneurosci.org)
- These results show that mutant huntingtin precludes normal neuronal fate acquisition and highlights a possible connection between mutant huntingtin and abnormal neural development in HD. (unipv.it)
- Las neuropilinas son receptores de la superficie celular de los vertebrados, de 140 kD, que se unen a moléculas de guía neuronal durante el desarrollo neural y el crecimiento axónico y modulan la angiogénesis mediada por VEGF. (bvsalud.org)
- Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. (bvsalud.org)
- Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. (lu.se)
20181
Acetylcholine2
- Pretreatment of differentiating P19 cells with HOE-140 on day 5 resulted in a reduction of the calcium response induced by the cholinergic agonist carbamoylcholine and decreased expression levels of M1-M3 muscarinic acetylcholine receptors, indicating crucial functions of the B2BKR during neuronal differentiation. (unifesp.br)
- We have studied if Pm affects nicotinic acetylcholine receptors (nAChRs), since they play broad functional roles, both in the nervous system and non-neuronal tissues. (mdpi.com)
Currents1
- Antidromic and orthodromic depolarization currents may modulate neuronal activity at sites distant from the stimulation target. (medscape.com)
Pathways1
- Thus, ACh modulates network dynamics in a biphasic fashion, probably by inhibiting excitatory synaptic transmission and facilitating neuronal excitability through muscarinic signaling pathways. (springer.com)
Processes2
- Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
- The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests that some localized mRNAs have not yet undergone the "very first translation," which contribute to the spatio-temporal regulation of gene expression. (frontiersin.org)
Differentiation3
- Here we show that the kinin-B2 receptor (B2BKR) is differentially expressed during in vitro neuronal differentiation of P19 cells. (unifesp.br)
- Following induction by retinoic acid, cells form embryonic bodies and then undergo neuronal differentiation, which is complete after 8 and 9 days. (unifesp.br)
- Immunochemical staining revealed that B2BKR protein expression was below detection limits in nondifferentiated P19 cells but increased during the course of neuronal differentiation and peaked on days 8 and 9. (unifesp.br)
Hippocampus2
- Isoflurane anesthesia decreases neuronal activity in the hippocampus. (elifesciences.org)
- Inward rectifying, ATP-sensitive potassium (K ATP ) channels mediated the response to elevated glucose levels, as pharmacological manipulation of K ATP channels in the hippocampus altered both ISF Aβ levels and neuronal activity. (jci.org)
GABA1
- Those previous works involving a pathological condition or a specific alteration in GABA signaling showed that neuronal development is sensitive to altered activity. (jneurosci.org)
Excitatory1
- The interaction of a variety of excitatory and inhibitory neuronal systems influence the activity of the PMC, which by default attempts to trigger the voiding reflex. (medscape.com)
Inhibit2
- DBS may inhibit the neuronal networks in the target. (medscape.com)
- The other neuronal population releases the anorexigenic cocaine- and amphetamine-regulated transcript and pro-opiomelanocortin neurotransmitters, both of which inhibit feeding. (medscape.com)
Physiological1
- However, whether the timing of maturation of newborn DGCs can be regulated by changes that occur within a physiological range of neuronal activity remains unknown. (jneurosci.org)
Vivo2
- Our results demonstrate that OPCs are directly modulated by norepinephrine in vivo to enhance Ca 2+ dynamics and promote population homeostasis. (nature.com)
- Here, we combined two techniques - glucose clamps and in vivo microdialysis - as a means to dynamically modulate blood glucose levels in awake, freely moving mice while measuring real-time changes in amyloid-β (Aβ), glucose, and lactate within the hippocampal interstitial fluid (ISF). (jci.org)
Excitability2
- With computational modeling, we found that simulated changes in EPSCs and the excitability of single cells mimicking the effects of ACh indeed modulated the evoked network reverberation similar to experimental observations. (springer.com)
- Kainate receptors (KARs) are glutamate receptors that modulate neurotransmission and neuronal excitability. (helsinki.fi)
Glial1
Populations1
- Both neuronal populations innervate the paraventricular nucleus, which, in turn, sends signals to other areas of the brain. (medscape.com)
Sensorimotor1
- We conclude that neuronal circuitry subserving sensorimotor function after stroke is depressed by a mGluR5-dependent maladaptive plasticity mechanism that can be restored by mGluR5 inhibition. (lu.se)
Decreases1
- Hypoxia decreases astrocyte-mediated thyroid hormone signaling in neuronal SK-N-AS cells. (jci.org)
Mechanisms1
- Investigating the mechanisms of neuronal transport is critical in understanding neuronal function. (nature.com)
Brain6
- In this study PEG-coated and anti-Aβ antibody-conjugated antioxidant nanoparticles (Aβ-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. (researchportal.be)
- Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. (elifesciences.org)
- This inhibits repetitive neuronal firing and propagation of nerve impulses to other parts of the brain. (medicinenet.com)
- The balance of energy intake and expenditure by the brain relies on the complex integration of signals originating in the periphery with those from diffuse neuronal networks within the brain itself. (medscape.com)
- The type-5 metabotropic glutamate receptor (mGluR5) has been shown to modulate brain plasticity and function, and is a therapeutic target in neurological diseases outside of stroke. (lu.se)
- Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
Synaptic2
- Proper transport of vesicles and their cargo to specific locations in the cell is critical in building and maintaining synaptic machinery as well as modulating synaptic plasticity 8 . (nature.com)
- Our data suggest that all three synucleins affect synapse function, but only αSyn mediates the downstream function of vesicle clustering and SNARE-complex assembly, while βSyn and γSyn modulate the activity of αSyn through regulating its binding to synaptic vesicles. (biorxiv.org)
Signaling pathway1
- Aβ-CNPs-PEG specifically targets the Aβ aggregates, and concomitant rescue of neuronal survival better than Aβ-CNPs, by modulating the BDNF signaling pathway. (researchportal.be)
Cultured neuronal1
- Here, we investigated how ACh influences reverberatory activity in cultured neuronal networks. (springer.com)
Human3
- Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. (ca.gov)
- Specifically, we found that human NK cells modulate expression of NCAM and the degree of polymerization of its polySia glycans according to activation state. (ca.gov)
- For gene therapy, a combinatorial approach with multiple target genes, as well as more complex optogenetic approaches are studied, while for cell-therapy human induced pluripotent stem cells and human induced neuronal cells are investigated. (lu.se)
Dynamics1
- Mechanical strain is applied to modulate tension along neurite length and vesicle dynamics are tracked. (nature.com)
Calcium1
- Oxcarbazepine also enhances potassium conductance and modulates the activity of calcium channels. (medicinenet.com)
Temporal1
- Voluntary exercise enhanced network activity only in the temporal region and, in turn, accelerated neuronal development. (jneurosci.org)
Network activity1
- A microscale soft ionic power source modulates neuronal network activity. (bvsalud.org)
Marker2
- In a murine model of AD, induction of acute hyperglycemia in young animals increased ISF Aβ production and ISF lactate, which serves as a marker of neuronal activity. (jci.org)
- S100 as personality changes, memory disorders, levels sometimes rise in the absence of disorientation, flapping tremor, shortened neuronal damage, suggesting that S100 attention span, lack of muscle coordination, is a marker of BBB rather than neuronal bradykinesia, somnolence and changes in damage, although in a variety of neurologi- sleep patterns [2]. (who.int)
Responses1
Effects1
- It may suppress pathological rhythms and involve neuronal networks with widespread connections, resulting in beneficial effects. (medscape.com)
Demonstrate1
- Results: Here we show that the zebrafish screen is a robust system that can be used to rapidly screen thousands ofcompounds and also demonstrate that riluzole is capable of reducing neuronal stress in this model system. (whiterose.ac.uk)
Functions1
- Astrocytic functions modulate neu- served in patients with liver failure and/or ronal ammonia toxicity because ammonia is portal-systemic bypass. (who.int)
Specific1
- however, elevated serum levels specific, and their presence in the serum have been detected in a number of neu- is a specific indicator for neuronal and ropathological conditions [8]. (who.int)
Signals1
- It accesses the short- and long-term hormonal and nutrient signals from the periphery via semi-permeable capillaries in the underlying median eminence and receives neuronal feedback from the NTS. (medscape.com)
Role1
- PolySia is best known for its proposed role in modulating neuronal development. (ca.gov)