Modulate gene family encode. Medical search. Frequent questions

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. (antibodies-online.com)

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. (wikipedia.org)
NCS1 is part of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed primarily in neurons. (prospecbio.com)
Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. (antikoerper-online.de)
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. (origene.com)
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. (thermofisher.com)
FUNCTION: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. (utsouthwestern.edu)
The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. (antibodypedia.com)
Six new antimicrobial peptides (AMPs) with sequence homology to the Nk-lysin (Nkl) family of proteins have been characterized and their patterns of gene expression in rainbow trout (Oncorhynchus mykiss) described. (usda.gov)
Phylogenetic analysis revealed a conserved structure of Nkls among the teleosts and further protein sequence analyses suggests that all six nkl genes fall within the Nkl sub-family of the Saposin family of proteins. (usda.gov)
The finding that yeast Rab GAPs share homology with proteins in other species, such as Caenorhabditis elegans and human, suggests the existence of a conserved Rab GAP family. (embl.de)
In addition, it has recently been observed that other channel-proteins encoded by genes of the SLC26 family interact with CFTR thereby increasing the gating activity. (unina.it)
Polycomb Group (PcG) proteins are a family of protein complex that regulate gene expression, especially repressing gene transcription [ 1 ]. (hindawi.com)
Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. (dimabio.com)
Description: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (postgenomeconsortium.com)
1993). CALM1 is the archetype of the calmodulin (calcium-modulated proteins) family of which nearly 20 members have been identified. (preventiongenetics.com)
FUNCTION: The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. (utsouthwestern.edu)

Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
PURPOSE: Biallelic variants in TBC1D24, which encodes a protein that regulates vesicular transport, are frequently identified in patients with DOORS (deafness, onychodystrophy, osteodystrophy, intellectual disability [previously referred to as mental retardation], and seizures) syndrome. (bvsalud.org)
This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. (utsouthwestern.edu)
The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. (chinaagrisci.com)
Since identification of EZH2 in the research of protooncogene product Vav [ 3 ], studies have shown that EZH2 is highly expressed in tumorigenesis, which regulates the expression of tumor suppressor genes, such as in breast cancer, prostate cancer, and lung cancer [ 4 - 6 ]. (hindawi.com)
fd3F regulates genes required for specialized aspects of chordotonal dendrite physiology. (tcd.ie)
In addition to these intermediate transcriptional regulators, we show that atonal directly regulates a novel gene, dilatory, that is directly associated with ciliogenesis during neuronal differentiation. (tcd.ie)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)
CONCLUSION: We expand the phenotype associated with ATP6V1B2 and propose another causal gene for DOORS syndrome. (bvsalud.org)
PHENOTYPE: Homozygous mutation of this gene results in increased bone density. (utsouthwestern.edu)
Gene variants in these genes may act as causative mutations for CF or may contribute to modulate the clinical phenotype of CF patients. (unina.it)
Upon detection of environmental alterations, bacteria adjust their gene expression in order to obtain a phenotype that is suitable for the environment to which they are exposed ( Federle, 2012 ). (frontiersin.org)
PHENOTYPE: Homozygous null mutants are indistinguishable from normal littermates, but increased levels of protein from other Birc gene family members suggest a compensatory mechanism in the absence of the Birc4 gene's product. (utsouthwestern.edu)

Yet, the simultaneous knockdown of KAT2B and ADD3 synergistically impaired kidney and heart function in flies as well as the adhesion and migration capacity of cultured human podocytes, indicating that mutations in both genes may be required for the full clinical manifestation. (nih.gov)
Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
Thus far, 2,000 mutations have been identified but the scanning of the whole coding region of the CFTR gene reveals mutations in about 95% of alleles. (unina.it)
We speculate that CF causative mutations or gene variants that may influence the clinical expression of the disease may occur in the non-coding regions of CFTR (intron regions, etc). (unina.it)
In addition, the effects of gene knockdown can be assessed using various loss-of-function mutants, and researchers recently developed a new method of generating loss-of-function mutations in targeted genes in C. elegans [ 2 ]. (biomedcentral.com)
In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). (utsouthwestern.edu)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)

The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
The protein encoded by this gene is an S-type lectin. (thermofisher.com)
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. (ebiocell.com)

MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. (cshlpress.com)
This book is essential reading for all cancer biologists, as well as researchers studying the regulation of gene expression. (cshlpress.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Expression varies depending on the nature of the gene. (origene.com)
Reactive oxygen species (ROS) are known as mediators of intracellular signaling pathways, playing an important role in the activation of transcription factors, modulating the expression of genes related to pathogen defense and plant development. (ufrgs.br)
It was observed that the expression of genes was induced during the stages of flowering and grain filling. (ufrgs.br)
Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
There was an age-related upregulation in expression of genes involved in synaptogenesis, axonogenesis and neuroprotection suggesting preservation of neuronal processes with age. (nature.com)
This unique age-related gene expression profile in the red sea urchin nervous system may play a role in mitigating the detrimental effects of aging in this long-lived animal. (nature.com)
Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)
Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)
Gene expression stability during aging was also observed in tissues of the long-lived giant mole-rat ( Fukomys mechowii ) with a maximum lifespan of more than 20 years 14 . (nature.com)
Accumulation expression levels of 326 co-up regulated genes in both tomato lines at 6 DPI might be involved in basal defense, while the specific and strongly induced genes at 6 DPI might be correlated with the resistance in PI 114490. (frontiersin.org)
We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
Quantitative reverse transcription-PCR was done to evaluate the gene expression of E2F1, TS , and Survivin . (aacrjournals.org)
0.0001), although no correlation was observed between E2F1 gene expression and the apoptotic index. (aacrjournals.org)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. (utsouthwestern.edu)
Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)
In this study, we identified six genes with sequence homology to Nkl and characterized their patterns of mRNA expression and abundances in rainbow trout (Oncorhynchus mykiss). (usda.gov)
In this study, the expression patterns of the two Halloween genes AhCYP307A2 and AhCYP314A1 were determined by quantitative PCR (qPCR) at different developmental stages. (chinaagrisci.com)
To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
Other genes, inherited irrespective of CFTR, may modulate the clinical expression of the disease (Castaldo et al. (unina.it)
Here, we identified the coding sequence of the EZH2 gene and characterized its expression pattern in fetal tissues of Duroc pigs at 65- and 90-day postcoitus (dpc). (hindawi.com)
Furthermore, the decreased expression of the EZH2 gene is crucial for stem cell differentiation into specific cell lineages involved in myogenesis, adipogenesis, osteogenesis, neurogenesis, and haematopoiesis [ 9 ]. (hindawi.com)
Thus, the appropriate expression level of the EZH2 gene is important for embryonic development. (hindawi.com)
However, the transcript and expression status of the EZH2 gene during porcine embryonic development remains unknown. (hindawi.com)
In this organism, various cell-specific promoters can be utilized for cell-specific expression to determine the function of a gene in a specific cell. (biomedcentral.com)
In contrast to cell-specific promoters, heat shock promoters drive the expression of genes at arbitrary timing via heat shock [ 4 ]. (biomedcentral.com)
However, heat shock promoters drive global expression, meaning that the knockdown is performed in the majority of cells, thereby removing vital cellular functions and thus inducing lethality when essential genes are knocked down by this method. (biomedcentral.com)
Our data revealed that TprA expression is modulated by a complex regulatory network, where the master regulators CcpA and GlnR are involved in a sugar dependent manner. (frontiersin.org)
Transcriptional regulators enable the microbes to sense and respond to environmental stimuli, by altering gene expression. (frontiersin.org)
Community level coordination of gene expression is known as quorum sensing (QS). (frontiersin.org)
Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. (affbiotech.cn)
Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. (affbiotech.cn)
High-resolution temporal profiling of gene expression reveals the events downstream of atonal proneural gene function during the development of Drosophila chordotonal (mechanosensory) neurons. (tcd.ie)
Among other findings, this reveals the onset of expression of genes required for construction of the ciliary dendrite, a key specialisation of mechanosensory neurons. (tcd.ie)
When compared with historic strains, recent isolates showed increased expression of flagellar genes and genes involved in lipopolysaccharide biosynthesis and decreased expression of polysaccharide capsule genes. (cdc.gov)
Furthermore, a previous study indicated that gene order rearrangements associated with IS elements can alter gene expression profiles in B. pertussis ( 20 ). (cdc.gov)
Recently, we have shown that, besides their effect on genome structure and stability, ISs can affect expression profiles of neighboring genes by IS element-specific promoters ( 21 ). (cdc.gov)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). (postgenomeconsortium.com)
negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages. (genscript.com)

Methods: Here, we overexpressed STK32B RNA in human cerebellar DAOY cells and used an RNA-Seq approach to identify differentially expressed genes (DEGs) by comparing the transcriptome profile of these cells to one of the control DAOY cells. (bvsalud.org)
Overall, the numbers of differentially expressed genes (DEGs) were higher in the resistant tomato line PI 114490 than in the susceptible line OH 88119, and the numbers of DEGs were higher at 6 DPI than at 6 HPI. (frontiersin.org)

Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. (nih.gov)
The gene encoding this protein is localized on human chromosome 3p21.31. (sigmaaldrich.com)
Chromosomal locations of these peptides show that nkl1 was located on chromosome arm 25q, whereas the other five nkl genes were clustered on chromosome arm 19q. (usda.gov)
A pseudogene of this gene is found on chromosome 7. (utsouthwestern.edu)
In 2001, a deletion mutation in the gene (now known as VPS13A) localized to chromosome band 9q21 was identified as the site for the defect generating the autosomal recessive form of NA. (medscape.com)
Of family members in this research who presented with epilepsy, 70-80% had large deletions in the NA gene, now known as VPS13A , on chromosome 9. (medscape.com)

Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). (antibodies-online.com)
Multiple alternatively spliced transcript variants have been found for this gene. (thermofisher.com)
Alternatively spliced transcript variants have been found for this gene. (antibodypedia.com)
Moreover, of the 2000 identified gene variants, the disease-causing effect remains unproven for most of these variants, especially for missense ones. (unina.it)

Members of this family show sequence homology with estrogen receptors but are incapable of being bound by estrogen. (nature.com)
IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. (antibodies-online.com)
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). (dimabio.com)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

In addition, it provides a paradigm for how transcriptional regulation may modulate the ciliogenesis pathway to give rise to structurally and functionally specialised ciliary dendrites. (tcd.ie)

in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
The CF Transmembrane Conductance Regulator (CFTR) gene, which causes CF, was cloned in 1989. (unina.it)
Prominent among these is the RRNPP (Rap, Rgg, NprR, PlcR, PrgX) family of transcriptional regulators, which are characterized at the structural level by the presence of tetratricopeptide repeats that mediate regulator-peptide interactions ( Cook and Federle, 2014 ). (frontiersin.org)

It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. (antikoerper-online.de)
Therefore, for detailed analysis of multifunctional genes, such as the components of the Ras-MAPK pathway described below, simultaneous time-specific and cell-specific knockdown is necessary. (biomedcentral.com)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
Spontaneous foraging is regulated by a neural circuit composed of three classes of neurons: IL1, OLQ, and RMD, and we found that Ras functions in this neural circuit to modulate the direction of locomotion. (biomedcentral.com)
CHGA is a member of the granin family of neuroendocrine secretory protein, It is located in secretory vesicles of neurons and endocrine cells. (postgenomeconsortium.com)
In contrast, fd3F encodes a novel forkhead family transcription factor that is exclusively expressed in differentiating chordotonal neurons. (tcd.ie)

Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (nih.gov)

This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

The following GMFG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. (antikoerper-online.de)
Nutritional supplementation in athletes may potentiate tissue repair, support the immune system, and modulate oxidative stress and inflammation. (healthvoice360.com)
It also modulates activation of immune cells during inflammation. (sigmaaldrich.com)
Computational analysis unveiled a hitherto unknown role for ACVRL1 in relation to genes modulating the functionality of the immune cell compartment. (lu.se)

Fewer genes (78 in PI 114490 and 15 in OH 88119) were up-regulated and most DEGs were down-regulated, suggesting that the inducible defense response might not be fully activated at 6 HPI. (frontiersin.org)
Most DEGs were involved in plant hormone signal transduction, plant-pathogen interaction and phenylalanine metabolism, and the genes significantly up-regulated in PI 114490 at 6 DPI were associated with defense response pathways. (frontiersin.org)

As one of the two distinct complexes, namely, Polycomb Repressive Complex 1 (PRC1) and PRC2, PRC2 mediates gene silencing by modulating chromatin structure [ 2 ]. (hindawi.com)

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Gene symbols, accession ids and various other target identifiers. (nih.gov)

While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
NCS1 is related with secretory granules and modulates synaptic transmission and synaptic plasticity. (prospecbio.com)

Identification and characterization of the host resistance as well as regulatory genes can provide insights into understanding the mechanisms of host resistance and the use of host resistance to develop new cultivars with durable resistance. (frontiersin.org)
Characterization of cytochrome P450 genes involving in ecdysteroidogenesis in silkworm (Bombyx mori). (chinaagrisci.com)

E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene. (wikipedia.org)
Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. (rockland.com)
In humans, CHGA protein is encoded by the CHGA gene, and it is mapped to 14q32.12. (postgenomeconsortium.com)

This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
Appears to modulate insulin sensitivity and function. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
The nematode worm Caenorhabditis elegans , in which loss-of-function mutants and RNA interference (RNAi) models are available, is a model organism useful for analyzing effects of genes on various life phenomena, including behavior. (biomedcentral.com)

Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)

While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. (utsouthwestern.edu)

It functions to modulate E2F-regulated transcription and stimulate proliferation. (wikipedia.org)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
The cDNA sequences for the six Nkls encoded precursor peptides of 128-133 aa in length, and mature peptides of 109-111 aa in length. (usda.gov)
These sequences represent the protein coding region of the GMFG cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)

Altogether, our studies describe the expansion of the phenotypic spectrum in ADD3 deficiency associated with a homozygous likely pathogenic KAT2B variant and thereby identify KAT2B as a susceptibility gene for kidney and heart disease in ADD3-associated disorders. (nih.gov)
Development of asthma is multifactorial and depends on the interactions among multiple susceptibility genes and environmental factors. (msdmanuals.com)

Our results showed that the coding sequence of EZH2 was 2241 bp, encoding 746 amino acids. (hindawi.com)
CALM1 encodes a 149 amino acid protein, spans around 10 kb and is located at Chr 14p32.11 (Berchtold et al. (preventiongenetics.com)

Overall, these newly characterized AMPs may contribute to host innate immunity as they are modulated following challenge with aquaculture-relevant pathogens as well as by physiological stressors. (usda.gov)

Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. (utsouthwestern.edu)
Deletion of the GYP1 gene or overexpression of Gyp1p did not alter the growth rate of yeast. (embl.de)

CHGA gene product is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. (postgenomeconsortium.com)

In 2005, based upon research involving several large French-Canadian families that presented with temporal lobe epilepsy, an expanded conceptualization of the molecular genetics of the autosomal recessive form NA was attained. (medscape.com)

This gene encodes distinct protein isoforms that may be similarly proteolytically processed. (utsouthwestern.edu)

The aim of the study was to identify a genetic cause in families with DOORS syndrome and without a TBC1D24 variant. (bvsalud.org)
A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes. (bvsalud.org)
The nematode Caenorhabditis elegans is useful for studying the effects of a gene on behavior through facilitated behavioral analyses and well-developed genetic analyses. (biomedcentral.com)

However, conventional RNAi is insufficient for investigating pleiotropic genes with various sites of action and life stage-dependent functions. (biomedcentral.com)
RNAi is one of the most powerful tools for gene knockdown. (biomedcentral.com)

Anatomy20

Organisms56

Diseases1

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes98

Disciplines and Occupations2

Technology, Industry, Agriculture8

Information Science8

Health Care2

Binding protein2

Proteins17

Regulates7

Phenotype7

Mutations7

Involved in mitochondrial4

Protein encoded3

Expression46

Negatively2

Differentially expressed2

Chromosome6

Variants4

Receptors4

Transcriptional regulation1

Regulator3

Pathway2

Neurons4

Homolog1

Tumor2

RefSeq1

Immune4

DEGs2

Chromatin1

Accession2

Synaptic2

Characterization2

Humans3

Function5

Ontology1

Apoptosis1

Proliferation1

Sequences3

Susceptibility2

Amino2

Innate1

Overexpression2

Precursor1

Autosomal1

Distinct1

Genetic3

RNAi2