Modulate expression of genes. Medical search. Frequent questions

A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)
Alternative approaches targeting RNA have the potential to circumvent some of these difficulties, particularly as the active therapeutic molecules are usually short oligonucleotides and the target gene transcript is under endogenous regulation. (ox.ac.uk)
4-HPR resulted in an up-regulation of expression of proapoptotic genes and mitochondrial uncoupling protein in OVCA433 cells and modulation of the RXR receptors in IOSE cells, and down-regulation of mutant BRCA genes in both IOSE and OVCA433 cells. (arizona.edu)
In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
Hha, along with the chromatin-associated protein H-NS, is involved in the regulation of expression of the toxin alpha-haemolysin in response to osmolarity and temperature. (wikipedia.org)
Co-ordinate down-regulation of smooth muscle-specific genes and acquisition of unregulated proliferative characteristics have been proposed as hallmarks of the atherosclerotic process. (houstonmethodist.org)
These results demonstrate that c-Ha-ras(EJ) transfection is associated with alterations in the expression of genes associated with muscle-specific functions in vascular SMCs and implicate c-Ha-ras in the regulation of phenotypic expression in SMCs. (houstonmethodist.org)
By cross-referencing these data against chromatin activity and gene expression regulation, we were able to narrow down the genes involved in immune disease from thousands to less than a hundred. (sanger.ac.uk)
For information on therapeutic regulation of gene expression, see therapeutic gene modulation.Regulation of gene expression includes the processes that cells and viruses use to regulate the way that the information in genes is turned into gene products. (absoluteastronomy.com)
Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down- regulation of specific genes. (cdc.gov)

Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
Vitamin D is obviously the most well-known one that regulates over 2,000 genes related to immune health, musculoskeletal health and many other things. (truthseekerforum.com)
Bone morphogenetic protein signaling regulates size of hair follicles and modulates the expression of cell cycle-associated genes. (brad.ac.uk)
Alternatively, activation of BMP signaling in HaCaT KC induces growth arrest, stimulates p27(Kip1) expression, and positively regulates p27(Kip1) promoter activity, thus further supporting a role of p27(Kip1) in mediating the effects of BMP signaling on HF size. (brad.ac.uk)
GTF2IRD1 binds to enhancer and promoter regions in the mouse rhodopsin, M- and S-opsin genes, but regulates their expression differentially. (wustl.edu)
GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. (bmj.com)

Pathway analysis revealed substantial modulation of gene expression in defence and immune responses and in particular modulation of genes in the Fcγ-receptor-mediated phagocytosis pathway. (biomedcentral.com)
We investigated the modulation of gene expression by 4-HPR in immortalized ovarian surface epithelial (IOSE) cells and ovarian cancer (OVCA433) cells with DNA microarray. (arizona.edu)
A third mechanism of action involves retrograde signaling and the modulation of gene expression. (truthseekerforum.com)
Here we describe use of this transgenic model to study modulation of stress-regulated gene expression in the PVN by opiates. (huji.ac.il)
It lays the groundwork for understanding the modulation of gene expression in these cells, providing valuable data on which to build future studies and pursue new treatments. (sanger.ac.uk)
Gene modulation redirects here. (absoluteastronomy.com)

Francisco FO, Lemos B. How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. (jgenomics.com)
Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. (europa.eu)

this model provides high sensitivity, cellular resolution, and ready quantification of levels of proenkephalin gene expression. (huji.ac.il)
Because the molecular mechanisms regulating the expression of the transgene are well understood, this model provides a useful tool for investigating cellular and molecular effects of opioids on the hypothalamus. (huji.ac.il)
Gene Ontology classification showed that a majority of the predicted targets were related to cellular components and cellular processes and performed a certain function. (ppjonline.org)
Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. (cdc.gov)
These genetic, molecular, and cellular findings suggest that MS4A4A modulates sTREM2. (lu.se)

SRF controls gene transcription of various actin isoforms (e.g. (jneurosci.org)
Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
The present study provides evidence that cardiac lactate levels are associated to gene transcription during an acute bout of high intensity running exercise . (bvsalud.org)
All target genes were down-regulated with different degree by vsiRNAs as shown by real-time reverse transcription polymerase chain reaction. (ppjonline.org)
Rediscovery of a microbiologic phenomenon, first described by van Leeuwenhoek, that microorganisms attach to and grow universally on exposed surfaces led to studies that revealed surface-associated microorganisms (biofilms) exhibited a distinct phenotype with respect to gene transcription and growth rate. (cdc.gov)

Susceptibility to T1D is linked to genetic factors, but T1D-predisposing genes have low penetrance and only a small proportion of individuals genetically at risk will develop the disease. (diabetesjournals.org)
Well-known susceptibility genes include HLA-DR , CTLA-4 , IFIH1 ( MDA5 ), and PTPN22 ( 2 ). (diabetesjournals.org)
For example, the fat mass and obesity-associated (FTO) gene polymorphism affects the susceptibility to obesity but accounts for less than 0.5% of the overall variance in body mass index (BMI). (medscape.com)

We evaluated the impact of curcumin on life span, fecundity, feeding rate, oxidative stress, locomotion, and gene expression in two different wild-type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. (escholarship.org)
The Y chromosomes of Drosophila melanogaster and D. simulans contain only a handful of protein-coding genes, which are related to sperm mobility and reproductive fitness. (jgenomics.com)
Despite low or absent protein coding polymorphism, the Drosophila Y chromosome has been associated with natural phenotypic variation, including variation in the expression of hundreds to thousands of genes located on autosomes and on the X chromosome. (jgenomics.com)

The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
In this review, we discuss the role of 3' regulatory regions in gene expression, and the superior potential that plant 3' regulatory regions have compared to NOS, OCS and 35S 3' regulatory regions. (frontiersin.org)
The study, published in Cell Genomics , identified 91 unique genes that play an important role in immune diseases, such as asthma and Crohn's disease, by influencing how regulatory T cells function. (sanger.ac.uk)
2022). Immune disease variants modulate gene expression in regulatory CD4+ T cells. (sanger.ac.uk)
A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

However, between malaria infected and coinfected children there were 240 differentially expressed genes with 180 genes upregulated and 60 downregulated in the coinfected group. (biomedcentral.com)
The expression of the following genes was salient: (a) Cd163, an anti-inflammatory stroke-associated gene, was the most differentially expressed gene by NPD1+RvD1, displaying more than a 123-fold upregulation in the ipsilesional penumbra (Lisi et al. (springer.com)

We have focused on how the gene networks in the nervous system can modulate animal lifespan in response to food and other environmental cues. (kcl.ac.uk)
These effects are attributed not only to genetic changes but to epi genetic changes (ie, post-DNA modifications that occur throughout the lifespan) that modulate gene expression. (medscape.com)

Genes (Basel), 2021 May 29. (nih.gov)

These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA. (absoluteastronomy.com)

The two strains mediate adhesion by different mechanisms and, when combined, synergically induce the expression of Caco-2 tight junction proteins. (frontiersin.org)
Stressful stimuli strongly induce proenkephalin gene expression within the paraventricular nucleus (PVN) of the hypothalamus. (huji.ac.il)
Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. (elifesciences.org)
We found that glial cell D2 activity resulted in increased T3 production, which acted in a paracrine fashion to induce T3-responsive genes, including ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), in the cocultured neurons. (jci.org)

Here we report that CBD modulates type I interferon responses in human macrophages. (thctotalhealthcare.com)

This evidence suggests that identifying how genetic variants modulate Treg function could have important clinical implications. (sanger.ac.uk)
For this study, researchers at the Wellcome Sanger Institute isolated Tregs from 124 healthy individuals to map how genetic variants regulated the expression of genes and function of the cells. (sanger.ac.uk)
These data were then cross-referenced against variants associated with increased risk of developing immune diseases 1 , in order to hone in on the genes that play pivotal roles in disease pathogenesis. (sanger.ac.uk)
Genetic variants predisposing individuals to immune diseases were linked to a total of 91 genes, 31 of which were specifically impaired in Tregs but not in other immune cell types investigated by the researchers. (sanger.ac.uk)
This research lays a foundation upon which to build our understanding of how the interplay between genetic variants and gene expression causes immune diseases to develop. (sanger.ac.uk)

We present a hitherto unappreciated cross talk of actin signaling with gene expression governing neuronal motility. (jneurosci.org)
Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)
Con respecto a los modelos animales en TEA, muchos estudios se centran en la expresión génica, la migración y maduración neuronal cortical y los déficits de la red neuronal, pero muy pocos son los estudios que relacionen directamente la comunicación oral animal y la expresión génica en áreas corticales del lenguaje. (bvsalud.org)

Overexpressing these mutant actins in mouse hippocampal neurons not only modulated growth-cone function but also neurite elongation, which was ambiguous by traditional pharmacological interference. (jneurosci.org)
D3 activity in the neurons modulated these effects. (jci.org)

Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)

Because TNF-alpha expression is upregulated in hepatic inflammation, the data suggest TNF-alpha-mediated increases in tTG expression may play an important role in the process of hepatic fibrogenesis. (nih.gov)
Inflammation is a prime target to modulate because it can be both detrimental and beneficial after stroke (Marcheselli et al. (springer.com)

RNA-based strategies offer a series of novel therapeutic applications, including altered processing of the target pre-mRNA transcript, reprogramming of genetic defects through mRNA repair, and the targeted silencing of allele- or isoform-specific gene transcripts. (ox.ac.uk)
We compared the mRNA levels of osteoblast expressed genes in control cultures of subcultivated cells where nodule formation is diminished, to cells continuously (35 days) exposed to 10 ‐7 M dexamethasone, a synthetic glucocorticoid, which promotes nodule formation to levels usually the extent observed in primary cultures. (nyu.edu)
Cyclical stretch of randomly cycling cells, seeded on a flexible elastin substrate at a rate of 100 cycles/min for 72 h, did not significantly influence the pattern of α-SM or β/γ-actin mRNA expression in neo-LF-1 or ras-LF-1 cells. (houstonmethodist.org)

To determine whether ischemic AMPK activation-modulated by the Sesn2-AMPK complex in the heart-is impaired in aging that sensitizes the heart to ischemic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-26 mo) were subjected to left anterior descending coronary artery occlusion for in vivo regional ischemia. (nih.gov)
Microarray and real-time PCR analyses of the laser-captured hair matrix cells show a strong decrease in expression of Cdk inhibitor p27(Kip1) and increased expression of selected cyclins in TG vs. WT mice. (brad.ac.uk)
Primary epidermal keratinocytes (KC) from TG mice exhibit significantly increased proliferation and decreased p27(Kip1) expression, compared with WT KC. (brad.ac.uk)
Lactate modulates cardiac gene expression in mice during acute physical exercise. (bvsalud.org)

abstract = "To understand the mechanisms by which glucocorticoids promote differentiation of fetal rat calvaria derived osteoblasts to produce bone‐like mineralized nodules in vitro, a panel of osteoblast growth and differentiation related genes that characterize development of the osteoblast phenotype has been quantitated in glucocorticoid‐treated cultures. (nyu.edu)

How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)

Chronic helminth infection causes immune hyporesponsiveness and stimulates anti-inflammatory cytokine production, which in turn modulates the host immune response to malaria. (biomedcentral.com)
Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes. (cdc.gov)

However, the mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)
However, these genes only account for part of interindividual differences in disease predisposition or phenotypic diversity, and the pathophysiologic mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)

and Heikinheimo, Markku, "FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. (wustl.edu)
We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. (nature.com)
These data suggest that BMP signaling plays an important role in regulating cell proliferation and controls the size of anagen HFs by modulating the expression of cell-cycle-associated genes in hair matrix KC. (brad.ac.uk)
Incubation of ras- and neo-LF-1 SMGs in a restrictive serum concentration (0.1%) for 72 h inhibited DNA synthesis in both cell types, but differentially influenced the pattern of α-actin gene expression. (houstonmethodist.org)
In an apparent paradox, although GTF2IRD1 is widely expressed in multiple cell types across the retina, knock-out of GTF2IRD1 alters the retinal expression of only a limited number of annotated genes. (wustl.edu)
We are using state-of-the-art next generation sequencing combined with bioinformatic strategies, and developing stem cell-based approaches for gene therapy and drug discovery. (nih.gov)
Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. (rcsb.org)
Two major thrusts in the last decade have dramatically impacted our understanding of biofilms: the utilization of the confocal laser scanning microscope to characterize biofilm ultrastructure, and an investigation of the genes involved in cell adhesion and biofilm formation. (cdc.gov)
These findings were associated with reduced tracheal epithelial cell PKCa and PKCe activity and whole lung TLR2 and TLR4 gene expression. (cdc.gov)
Computational analysis unveiled a hitherto unknown role for ACVRL1 in relation to genes modulating the functionality of the immune cell compartment. (lu.se)
CHRNA5 expression research findings from the laboratory to CHRNA5 was among the markers with in bronchial cel s modulates cell the population. (who.int)

These findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function. (wustl.edu)
Some findings showed critical genes, which modulate several aspects of verbal communication. (bvsalud.org)

This family consists of haemolysin expression modulating protein (Hha) from Escherichia coli and its enterobacterial homologues, such as YmoA from Yersinia enterocolitica, and RmoA encoded on the R100 plasmid. (wikipedia.org)

In molecular biology, the haemolysin expression modulating protein family is a family of proteins. (wikipedia.org)
These proteins act as modulators of bacterial gene expression. (wikipedia.org)
YmoA modulates the expression of various virulence factors, such as Yop proteins and YadA adhesin, in response to temperature. (wikipedia.org)
Living beings depend on genes, as they specify all proteins and functional RNA chains. (absoluteastronomy.com)

Expression of osteocalcin was 1,000‐fold elevated in glucocorticoid‐differentiated cultures in relation to nodule formation. (nyu.edu)

Interestingly, CBD significantly upregulates expression of autophagy receptor p62/SQSTM1. (thctotalhealthcare.com)
Interestingly, however, the null mutation leads to altered topology of cone opsin expression in the retina, with aberrant S-opsin overexpression and M-opsin underexpression in M cones. (wustl.edu)

A gene is a molecular unit of heredity of a living organism. (absoluteastronomy.com)

The next step for this research will be to investigate precisely how genes affect Treg function by simulating these interactions in the laboratory, which will provide more context for the development of new therapies. (sanger.ac.uk)
How genes are modulated so precisely is not well understood. (rcsb.org)

Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (nature.com)
Support vector machines are the classifier which has a potential to make a classification of the discriminatory genes and non-discriminatory genes. (researchgate.net)

Modulating the expression of disease genes with RNA-based therapy. (ox.ac.uk)
SVMRFE a modification of SVM ranks the genes based on their discriminatory power and eliminate the genes which are not involved in causing the disease. (researchgate.net)
The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target. (researchgate.net)
power and eliminate the genes which are not involved in causing the disease. (researchgate.net)
CHRNA3 gene expression disease associations. (who.int)

Conventional gene therapy has focused largely on gene replacement in target cells. (ox.ac.uk)
We therefore propose that DNA is a sequence-specific allosteric ligand of GR that tailors the activity of the receptor toward specific target genes. (rcsb.org)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. (absoluteastronomy.com)

In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)

This is the first indication of a direct interaction between a candidate gene for T1D and the activation of a specific downstream proapoptotic pathway in β-cells. (diabetesjournals.org)

Growth-cone collapse induced by ephrin-As, a family of repulsive axon guidance molecules, is impaired upon R62D expression, resulting in perseverance of ring-shaped F-actin filaments. (jneurosci.org)
Employing these actin mutants, we uncovered a function for actin signaling in growth-cone motility modulated by ephrin-A guidance cues. (jneurosci.org)
In the present study, we have evaluated this reciprocal relationship by examining the impact of c-Ha-ras(EJ) oncogene transfection on α-smooth muscle (SM) actin and α 18 -adrenoceptor (ADR) gene expression in vascular (aortic) smooth muscle cells (SMCs). (houstonmethodist.org)

The article is titled "Massive Horizontal Gene Transfer and the Evolution of Nematomorph-Driven Behavioral Manipulation of Mantids. (bioquicknews.com)

Taken together, CymMV and ORSV siRNAs played important roles in interplay with P. equestris by down modulating the expression levels of endogenous genes in host plant. (ppjonline.org)

No virulence factors were detected for any strain and only the non-transferable erm(49) gene, which confers resistance to erythromycin and clindamycin, was identified in the genome of B. longum KABP042. (frontiersin.org)
Pathogens' inhibition was mostly mediated by the production of organic acids, but neutralization experiments strongly suggested the presence of additional antimicrobial compounds in probiotic culture supernatants such as the bacteriocin Lantibiotic B, whose gene was detected in the genome of B. longum KABP042. (frontiersin.org)
Eighty-four AML patients with FHL2 and iASPP expression data from The Cancer Genome Atlas database were enrolled in the study. (nature.com)

A further 63 targets were found where there is drug tractability evidence - meaning a gene is suitable for drug development or there are already available drugs at some stage of clinical trials. (sanger.ac.uk)
Vocal comprehension and expression comprise development in the broadest sense employing verbal and non-verbal assessments. (bvsalud.org)

The ability of curcumin to mitigate the expression levels of age-associated genes in young flies suggests that the action of curcumin on these genes is a cause, rather than an effect, of its life span-extending effects. (escholarship.org)
In addition, cardiac lactate levels were significantly correlated to both PGC-1α and COX-IV cardiac gene expression . (bvsalud.org)
Collagenase gene expression was also greater than controls (fivefold) with the highest levels observed in mature cultures (day 35). (nyu.edu)

Transcriptomics analysis shows that CBD treatment significantly attenuates cGAS-STING-mediated activation of type I Interferon response genes (ISGs) in monocytic THP-1 cells. (thctotalhealthcare.com)
Upon 2'3′-cGAMP stimulation, CBD treated cells have rapid downregulation of phosphorylated-STING, leading to attenuated expression of ISGs. (thctotalhealthcare.com)
Lastly, CBD decreases ISGs expression upon HIV infection in THP-1 cells and human primary macrophages, leading to increased HIV RNA expression 24 hours after infection. (thctotalhealthcare.com)
Alkaline phosphatase and type I collagen expression were initially inhibited in proliferating cells, then increased after nodule formation to support further growth and mineralization of the nodule. (nyu.edu)

Regulation10

Regulates6

Modulation6

Chromatin2

Cellular5

Transcription5

Susceptibility3

Drosophila3

Regulatory8

Differentially expressed2

Lifespan2

20211

Protein-codin1

Induce4

Human macrophages1

Variants5

Neuronal3

Neurons2

Preventing the mRNA1

Inflammation2

MRNA3

Mice4

Abstract1

Transcriptional1

Inflammatory2

Predispose2

Cell12

Findings2

Escherichia1

Proteins4

Glucocorticoid1

Interestingly2

Organism1

Precisely2

Genetic1

Classification2

Disease5

Target3

Retina1

Synthesis1

Nuclear1

Interaction1

Actin3

Article1

Interplay1

Genome3

Development2

Levels3

Cells4