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  • proteins
  • Abraham SJ, Kobayashi T, Solaro RJ, Gaponenko V (2009) Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins. (springer.com)
  • inhibitors
  • Fortunately, the inhibitors and mimics targeted towards histone modification, DNA methylation, and miRNAs are now being tried for cancer and other chronic diseases, and better understanding of the role of epigenetics in diabetic retinopathy will open the door for their possible use in combating this blinding disease. (hindawi.com)
  • Here we report potent and selective KDM5 covalent inhibitors designed to target cysteine residues only present in the KDM5 sub-family. (ox.ac.uk)
  • Many inhibitors of DNA methylation as well as of histone methylation, have been successfully tested in preclinical studies and some are currently undergoing evaluation in phase I, II or III clinical trials, either as cytostatic molecules-reducing the proliferation of cancerous cells-or as tumor angiogenesis inhibitors. (mdpi.com)
  • peptide
  • Peptide arrays are powerful tools to characterize the specificity of PKMTs because methylation of several substrates with different sequences can be tested on one array. (jove.com)
  • This Histone H2B dimethyl Lys46 antibody was raised against a peptide containing dimethyl-lysine 46 of human histone H2B. (activemotif.com)
  • tyrosine
  • But the researchers noticed that, according to the docking results, fragments such as compound 4 could assume two different binding modes: in one, the carboxylate and phenol interacted with the iron atom, while in the other the carboxylate interacted with lysine and tyrosine residues in the protein. (blogspot.com)
  • patterns
  • These modifications are associated either with gene activation, repression, or a primed state of gene that supports more rapid and robust activation of expression after perception of appropriate signals (microbe-associated molecular patterns, light, hormones, etc.) 3-7 . (jove.com)
  • The predicted promoter regions of miRNA clusters at 14q32 locus showed no recurrent patterns of differential methylation, but Saos2 cells showed elevated histone deacetylase (HDAC) activity. (jove.com)
  • These patterns of chemical modification are mitotically transmitted and therefore become permanent for the cell line. (diabetesjournals.org)
  • Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. (biomedcentral.com)
  • External and intrinsic substances affect histone modifying enzymes which can lead to a heritable change in histone modification patterns. (biomedcentral.com)
  • In addition, several studies evaluated the 5-methylcytosine (5 mC) distribution patterns, which distinguish cancer cells from normal cells, and how CpG methylation contributes to the oncogenic phenotype. (intechopen.com)