Structure-Activity RelationshipQuantitative Structure-Activity RelationshipBuffersMolecular StructureInhibitory Concentration 50StereoisomerismDrug DesignOrganic Chemistry PhenomenaCombinatorial Chemistry TechniquesTrichosanthinThiadiazolesModels, MolecularAlkenesSmall Molecule LibrariesDrug Screening Assays, AntitumorMagnetic Resonance SpectroscopyThiazolesDrug Evaluation, PreclinicalMolecular ConformationDose-Response Relationship, DrugEnzyme InhibitorsAntineoplastic AgentsPeptidesHydrophobic and Hydrophilic InteractionsLigandsFlavonoidsAmino Acid SequenceMolecular Sequence DataCell LineCell Line, TumorBinding SitesChromatography, High Pressure LiquidProtein BindingOligopeptidesModels, ChemicalKineticsMass SpectrometryCell ProliferationCrystallography, X-RayMicrobial Sensitivity TestsAnti-Bacterial AgentsTromethamineHydrogen-Ion ConcentrationHEPESTime FactorsSeverity of Illness IndexReproducibility of ResultsCalciumOsmolar ConcentrationTemperatureTreatment OutcomeCattleElectrophoresis, CapillaryBicarbonatesSolubilityProspective StudiesPhosphatesSensitivity and SpecificityMolecular WeightDrug StabilityRabbits