• Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
  • Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
  • Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. (wikipedia.org)
  • Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. (mcw.edu)
  • The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344. (mcw.edu)
  • Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits. (mcw.edu)
  • A total of 337 F344 rats,20 Sprague Dawley rats, and 40 OF1 mice were all given initiating dose(s) of colon carcinogen, and were randomly allocated to experimental groups 7 d later. (aacrjournals.org)
  • PEG was active in F344 rats, in Sprague Dawley rats ( P =0.0005), and in OF1 mice ( P = 0.001). (aacrjournals.org)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • Models were also developed to show the accumulation of cristobalite in the lungs of Fischer 344 rats as the result of short-term exposures at three different concentrations. (nih.gov)
  • Walker 256 (W256) cells or vehicle were injected into the left upper thigh muscle of male Fischer rats, which were killed 7, 10 or 14 days later. (mcmaster.ca)
  • The influx of bone marrow-derived cells during tissue repair was monitored in wild-type inbred Fischer 344 rats reconstituted with bone marrow from transgenic F344 rats expressing hPLAP under the control of the ubiquitous R26 promoter. (uni-muenchen.de)
  • This study was conducted to investigate the chemopreventive potential of camel ( Camelus dromedarius ) and bovine milk as well as the impact of fermenting these milks with Lactobacillus acidophilus and Streptococcus thermophilus against early colon carcinogenesis as measured by the reduction of aberrant crypt foci (ACF) in azoxymethane (AOM)-treated Fischer 344 rats. (scialert.net)
  • Ten male Fischer rats with C6 glioma (body weight = 220 ± 15 g) were investigated with 18 F-FMISO PET and steady-state inhalation method of 15 O-labelled gases PET. (elsevierpure.com)
  • Age related changes of social memory/recognition in male Fischer 344 rats. (omeka.net)
  • Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. (omeka.net)
  • Pharmacokinetic studies showed that at 30,000 U/kg, streptokinase caused systemic fibrinolysis in the Fischer rat, as demonstrated by the thrombin time and fibrin plate lysis assay. (ox.ac.uk)
  • A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. (mcw.edu)
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
  • A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
  • A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. (lookformedical.com)
  • Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
  • Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus. (lookformedical.com)
  • A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT). (lookformedical.com)
  • A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. (nih.gov)
  • This strain is a model for Wilson's Disease (see HEPATOLENTICULAR DEGENERATION ). (nih.gov)
  • A three-day PEG treatment was sufficient to halve the number of azoxymethane-induced aberrant crypt foci in F344 rats ( P = 0.0006). (aacrjournals.org)
  • Analysis of the lyp phenotype in the F344 DNA recombinant rats helped us define the critical lyp interval as a region of approximately 33 Kb between D4Rhw6 (76.83 Mb) and IIsnp3 (77.16 Mb) containing Gimap1 , Gimap5 , and Gimap3 (formerly known as Ian2 , Ian5 , and Ian4 , resp. (hindawi.com)
  • P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
  • Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)
  • We have previously shown that dietary polyethylene-glycol (PEG)suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of colon carcinogenesis. (aacrjournals.org)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • In order to determine mechanisms contributing to persistent podocyte loss, we used a human diphtheria toxin transgenic rat model. (umich.edu)
  • In an HLA-B27 transgenic rat model repetitive dosing of HD5 reduced the expansion of pro-inflammatory CD4+ T-cells, and decreased the levels of soluble TNF and number of cell-surface B272 molecules. (ox.ac.uk)
  • Optimal Organ for Patient-derived Xenograft Model in Pancreatic Cancer and Microenvironment that Contributes to Success. (kyoto-u.ac.jp)
  • The purpose of this study was to evaluate the intratumoral perfusion and oxygen metabolism in hypoxic regions using the rat xenograft model. (elsevierpure.com)
  • Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. (kyoto-u.ac.jp)
  • Neuropathic pain in aged rats: behavioral responses and astrocytic activation. (omeka.net)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
  • Each of 60 weanling male rats was assigned to one of 6 experimental diet groups: Fermented and unfermented camel milk with AOM, fermented and unfermented bovine milk with AOM and positive (PC, AOM only) and negative (NC, saline vehicle only) control groups. (scialert.net)
  • Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats. (ufl.edu)
  • Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats. (ufl.edu)
  • Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats. (ufl.edu)
  • The goal was to develop an experimental model of the exposome by collecting biological samples during critical life stages of an exposed animal that are applicable to worker populations. (cdc.gov)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • The virus is responsible for a highly transmissible respiratory tract infection in mice, hamsters, guinea pigs, rats, and occasionally marmosets, with infection passing through both air and direct contact routes. (wikipedia.org)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
  • The 2003 EC proposal for the In the USA, laboratory animal use is federally reg- Registration, Evaluation and Authorisation of ulated by the Animal Welfare Act 1966 (amended in Chemicals (REACH), similarly aims to assess the 1985), which excludes laboratory-bred mice and toxicity of chemicals produced or imported in high rats, as well as non-mammals, from consideration quantities (15-20). (drugstorepdfsearch.com)
  • A new model for the study of spontaneous bone metastasis has been developed which allows for the quantification of metastatic tumor burden and cancer cell growth rate, and which describes the progressive changes in bone morphology. (mcmaster.ca)
  • Moreover, PEG is one of the most potent inhibitors of colon tumor in the standard rat model. (aacrjournals.org)
  • Nude rats bearing the LC-6 JCK tumor xenograft (LC-6 rats) exhibited high bone turnover and HHM. (unboundmedicine.com)
  • Streptokinase inhibits pulmonary tumor seeding in an animal experimental model. (ox.ac.uk)
  • To study this hypothesis, the effect of intravenous streptokinase on pulmonary tumor seeding was examined in a rodent model. (ox.ac.uk)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
  • Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. (mcw.edu)
  • Systematic Reviews of Animal Experiments DemonstratePoor Human Clinical and Toxicological Utility Animal Consultants International, London, UK Summary - The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. (drugstorepdfsearch.com)
  • Likely benefits would include, the greater selection of models truly pre- dictive of human outcomes, increased safety of people exposed to chemicals that have passed toxicity tests, increased efficiency during the development of human pharmaceuticals and other therapeutic interven- tions, and decreased wastage of animal, personnel and financial resources. (drugstorepdfsearch.com)
  • Rats, Inbred SHR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Positional cloning of rat mutant genes reveals new functions of these genes. (kyoto-u.ac.jp)
  • Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
  • Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
  • Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)
  • Since the adenoviral E1A gene has been shown to partially transform some epithelial cells from primary rat cell cultures, we constructed retrovirus vectors containing either the 12S or 13S E1A cDNA sequences to facilitate the transfer of these genes into a variety of primary cell types. (cshl.edu)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
  • Skin grafts showed that neonatal exposure of wild-type F344 rats to hPLAP transgenic F344 cells results in lifelong tolerance to hPLAP expressing tissues and cells. (uni-muenchen.de)
  • To examine the homing of intravenous hPLAP labeled BMC in MI we established a background-free syngeneic model for long-term histological cell tracking in the absence of immune-mediated rejection of labeled cells in immunocompetent animals. (uni-muenchen.de)
  • The virus is infectious for many cancer cell lines (see below), and has oncolytic properties demonstrated in animal models and in naturally-occurring cancers in animals. (wikipedia.org)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
  • Drosophila is a powerful model organism that displays a variety of SUD-like behaviors consistent with human and mammalian substance use, making flies a great candidate to study mechanisms of behavior. (bvsalud.org)
  • Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
  • The 12S E1A virus induced proliferation and immortalization of epithelial cells in rat kidney, liver, heart, pancreas, and thyroid primary cultures. (cshl.edu)
  • An animal model can be useful in the study of the exposome as external lifetime exposures can be easily controlled and adverse health outcomes measured. (cdc.gov)
  • To determine the consistency of this preventive effect, we carried out a long-term study in rats fed the standard American Institute of Nutrition 1976 diet, and 7 short-term prevention studies in rodents. (aacrjournals.org)
  • We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. (omeka.net)
  • They are used as study models for human diseases. (lookformedical.com)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
  • Using human placental alkaline phosphatase (hPLAP) as a genetic marker for cell tracking, we examined the therapeutic efficacy and the homing of intravenously administered, hPLAP labeled cells in marker tolerant, immunocompetent rats after induction of MI. (uni-muenchen.de)
  • Using this model of neonatally tolerized marker tolerant rats, we showed that only very few hPLAP labeled BMC injected intravenously one week post-MI homed to the infarction site. (uni-muenchen.de)
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury. (omeka.net)
  • The immune modulating effect of HD5 was tested in HLA-B27 transgenic rats. (ox.ac.uk)
  • The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3. (kyoto-u.ac.jp)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
  • Reply to the letter to the editor regarding "a clinical prediction model to assess surgical outcome in patients with cervical spondylotic myelopathy: Internal and external validation using the prospective multicenter AOSpine North American and International datasets of 743 patients. (illinois.edu)
  • In 20 reviews in which clinical utility was examined, the authors con- cluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one of which was contentious. (drugstorepdfsearch.com)
  • The poor human clinical and toxicological utility of most animal models for which data exists, in conjunction with their generally sub- stantial animal welfare and economic costs, justify a ban on animal models lacking scientific data clearly establishing their human predictivity or utility. (drugstorepdfsearch.com)
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. (omeka.net)
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • Non-animal models are generally required to pass formal scientific validation prior to their regulatory acceptance. (drugstorepdfsearch.com)
  • In contrast, animal models are simply assumed to be predictive of human outcomes. (drugstorepdfsearch.com)
  • The consistent application of formal validation studies to all test models is clearly warranted, regardless of their animal, non-animal, historical, contem- porary or possible future status. (drugstorepdfsearch.com)
  • This graph shows the total number of publications written about "Rats, Inbred SHR" by people in UAMS Profiles by year, and whether "Rats, Inbred SHR" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Rats, Inbred SHR" by people in Profiles over the past ten years. (uams.edu)
  • Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. (omeka.net)
  • SNP and haplotype mapping for genetic analysis in the rat. (mcw.edu)
  • Similar patterns of podocyte depletion were found in the puromycin aminonucleoside and 5/6 nephrectomy rat models of progressive end-stage disease. (umich.edu)
  • This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)
  • We discuss these data in light of the model of Spindler et al. (cshl.edu)
  • 2013. Distributed lag models for hydrological data . (hutton.ac.uk)