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  • disease
  • Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease. (ucl.ac.uk)
  • Pujades-Rodriguez M, Duyx B, Thomas SL, Stogiannis D, Rahman A, Smeeth L, Hemingway H. Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England. (ucl.ac.uk)
  • The obesity epidemic foreshadowed subsequent increases in incident type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD), supporting a role for obesity to promote or accelerate pathophysiologic processes underlying and potentially common to both conditions. (jci.org)
  • Professor Desai's interests also include global health, cardiovascular disease, and psychosocial epidemiology. (yale.edu)
  • Although elective percutaneous coronary intervention can alleviate the symptoms of angina in patients with stable coronary artery disease, numerous studies and meta-analyses have shown that it does not prevent myocardial infarction or death, as compared with optimal medical treatment alone. (bmj.com)
  • For a given disease model, we will identify the outcome measure with the smallest variance. (nc3rs.org.uk)
  • Currie GL, Macleod MR (2015) Increasing value and reducing waste in animal models of rheumatological disease. (nc3rs.org.uk)
  • Objective To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. (bmj.com)
  • Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Xicheng District, North Lishi Road No. 167, Beijing, 100037, China. (nih.gov)
  • Objective To estimate the potential cost effectiveness of a population-wide risk factor reduction programme aimed at preventing cardiovascular disease. (bmj.com)
  • Model Spreadsheet model to quantify the reduction in cardiovascular disease over a decade, assuming the benefits apply consistently for men and women across age and risk groups. (bmj.com)
  • 75) cardiovascular disease is avoidable. (bmj.com)
  • The UK government strategy for the primary prevention of cardiovascular disease therefore focuses on a dual approach. (bmj.com)
  • The effectiveness and cost effectiveness of population based dietary approaches to prevention of cardiovascular disease in the UK are less clear. (bmj.com)
  • Myocardial infarction (MI) occurs in almost a million people in the United States each year, and coronary heart disease is the leading cause of hospital admissions. (ahajournals.org)
  • Here, we describe the methods used to study bacterial colonization and histopathological changes in mouse models of Helicobacter pylori -related disease. (jove.com)
  • In most individuals it is easily treated and controlled, with effective control reducing deaths and disability from a number of conditions, including cerebrovascular, cardiovascular, and renal disease . (prolekare.cz)
  • methods
  • However, because of the dynamic and unpredictable nature of the atherosclerotic plaque, these methods often under detect myocardial ischemia because symptoms are unreliable, and/or continuous ECG monitoring was not utilized. (jove.com)
  • This work aims at identifying and analysing state-of-the-art risk prediction models in healthcare with regard to their specific application areas, applied algorithms and resulting accuracy to determine the suitability of different methods in different healthcare contexts. (springer.com)
  • Methods and Results- We prospectively compared subsecond imaging with routine breath-hold delayed contrast-enhancement cardiovascular magnetic resonance (standard) in consecutive patients. (ahajournals.org)
  • reperfusion
  • Here, we present an effective protocol for using the porcine MI model using a closed-chest coronary balloon occlusion of the left anterior descending artery (LAD), followed by reperfusion. (jove.com)
  • readmission
  • This can be done by using predictive risk models that are able to predict the risk of readmission to the hospital for individual patients using various data mining techniques and algorithms. (springer.com)
  • Based on these models and with the increasing amount of data collected in hospitals, clinicians and hospital management can be supported in their daily decision-making to reduce readmission rates. (springer.com)
  • patients
  • Therefore, using 12-lead ECG monitoring, the COMPARE Study (electro C ardiographic evaluati O n of ische M ia com P aring inv A sive to pha R macological tr E atment) was designed to assess the frequency and clinical consequences of transient myocardial ischemia, in patients with NSTEMI/UA treated with either early invasive PCI/stent or those managed conservatively (medications or PCI/stent following recurrent symptoms). (jove.com)
  • Diagnosing myocardial infarction (MI) is largely driven by detecting cardiac-specific proteins in patients' serum or plasma as an indicator of myocardial injury. (jove.com)
  • Sekhri N, Perel P, Clayton T, Feder GS, Hemingway H, Timmis A. R1 - A 10-year prognostic model for patients with suspected angina attending a chest pain clinic. (ucl.ac.uk)
  • Multilevel hierarchical logistic regression models examined the variation in patients' understanding across centers and operators after adjusting for patient characteristics, using median odds ratios. (bmj.com)
  • The possible interactions between antithrombotic drugs and proton pump inhibitors resulting in reduced antithrombotic effect and increased cardiovascular risk for patients receiving combination therapy has received much attention. (bmj.com)
  • 3 Owing to the gastrointestinal side effects associated with aspirin, proton pump inhibitors are widely used for the prevention of peptic ulcers in patients treated with aspirin, and guidelines advocate the use of proton pump inhibitors in a wide group of patients treated with aspirin after myocardial infarction. (bmj.com)
  • Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction," Journal of the American College of Cardiology , vol. 47, no. 8, pp. 1727-1730, 2006. (hindawi.com)
  • While use of rofecoxib (HR 1.57 (1.16 to 2.12)) and diclofenac (HR 1.35 (1.11 to 1.64)) was associated with increased cardiovascular risk in RA patients, there was no significant risk increase associated with use of other NSAIDs in these patients. (bmj.com)
  • Conclusions The cardiovascular risk associated with NSAID use in RA patients was modest and significantly lower than in non-RA individuals. (bmj.com)
  • Rao AK, Pratt C, Berke A, Jaffe A, Ockene I, Schreiber TL, Bell WR, Knatterud G, Robertson TL, Terrin ML (1988) Thrombolysis in Myocardial Infarction (TIMI) Trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. (springer.com)
  • preclinical studies
  • Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. (biomedsearch.com)
  • Our support will include systematic reviews and meta-analyses of preclinical studies, with calculation of summary effect sizes and determination in that model system of the impact of study design features and risk of bias items. (nc3rs.org.uk)
  • tissue
  • Myocardial connective tissue growth factor (CCN2/CTGF) attenuates left ventricular remodeling after myocardial infarction. (nih.gov)
  • Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering. (springer.com)
  • J. Leor, M. Patterson, M. J. Quinones, L. H. Kedes, and R. A. Kloner, "Transplantation of fetal myocardial tissue into the infarcted myocardium of rat: a potential method for repair of infarcted myocardium? (hindawi.com)
  • Noncontractile cells were retained into the myocardial wall of immunocompromised mice and were surrounded by a layer of fibrotic tissue, likely to protect from cardiac pressure and mechanical load. (jove.com)
  • Prior research has shown that stem cells can be isolated from adult cardiac tissue, expanded ex vivo, and have beneficial effects in small animal models of myocardial infarction (MI). (ahajournals.org)
  • Introduction The angiogenic neuropeptide Secretoneurin (SN) is upregulated by hypoxia in several tissues like neurones and skeletal muscle cells and SN gene therapy restores tissue integrity, function and perfusion in the mouse hind-limb ischemia model by induction of angiogenesis, arteriogenesis and vasculogenesis. (ahajournals.org)
  • clinical
  • He has a long standing academic interest in translational cardiovascular research, clinical trials in adult cardiac surgery, global cardiovascular leadership, and more recently in the preclinical development/testing of new cardiovascular drugs and biomedical devices at NHS standards. (bristol.ac.uk)
  • Here we report isolation, expansion, and delivery of cardiac-derived stem cells in a porcine model of MI using standard clinical techniques. (ahajournals.org)
  • By using standard clinical techniques, this approach provides a model that could be readily adapted to human subjects. (ahajournals.org)
  • mechanisms
  • Despite the notion that adult hearts are terminally differentiated organs without self-renewal potential undermined by the discovery of resident cardiac stem/progenitor cells, the endogenous regenerative mechanisms are too limited to sufficiently compensate for the cardiomyocytes loss occurring in pathological state (e.g., myocardial infarction) [ 1 - 3 ]. (hindawi.com)
  • Risk
  • Researches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting. (jove.com)
  • These figures may be valuable when a possible cardiovascular risk of hormone replacement therapy needs to be balanced with menopausal symptoms for the individual patient. (bmj.com)
  • Moreover, only a few of the individual NSAIDs were associated with increased cardiovascular risk. (bmj.com)
  • stem cells
  • Brown adipose was recently found to be a new source of cardiac stem cells, instrumental to myocardial regeneration. (hindawi.com)
  • So far various stem cell sources have been explored for myocardial regeneration, including embryonic stem, skeletal myoblasts, bone marrow mesenchymal stem cells [ 4 - 7 ]. (hindawi.com)
  • Different from other adult stem cells, cardiac stem cells represent a logical source to exploit in myocardial regeneration because of their likelihood to be intrinsically programmed to generate cardiac tissues in vitro and increase its viability in vivo. (hindawi.com)
  • injury
  • George I, Morrow B, Xu K, Yi GH, Holmes J, Wu EX, Li Z, Protter AA, Oz MC, Wang J. Prolonged Effects of B-Type Natriuretic Peptide Infusion on Cardiac Remodeling After Sustained Myocardial Injury: Am J Physiology. (columbiasurgery.org)