• The protocol has been used to test several mutant mice, including dystrophin-deficient mutants, transgenic models of amyotrophic lateral sclerosis and Alzheimer's disease, and a spontaneous mutant with degeneration of the cerebellum. (wikipedia.org)
  • Administration of LKE to the SOD1G93A mouse model of the motor neuron disease amyotrophic lateral sclerosis (ALS), reportedly slows progression of paralytic disease in this mouse. (wikipedia.org)
  • Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm. (frontiersin.org)
  • Each disease model was crossed to mice ubiquitously overexpressing wild-type GARS in order to determine whether the disease phenotype is caused by a loss of function in GARS. (bl.uk)
  • The worth of these mice as translational models is discussed, with focus on their construct and face validity. (mdpi.com)
  • Rapamycin treatment also resulted in prolonged healthspan in KO mice, as indicated by the offset of neurological damage, maintenance of weight and body fat, and the improvement of deleterious behavioral phenotypes. (washington.edu)
  • We developed separate models of respiratory and neurological disease following EV-D68 infection in AG129 mice that respond to antiviral treatment with guanidine. (quansysbio.com)
  • In 10-day-old mice infected intraperitoneally, EV-D68 causes a neurological disease with weight-loss, paralysis, and mortality. (quansysbio.com)
  • In our neurological model, guanidine treatment protects mice from weight-loss, paralysis, and mortality. (quansysbio.com)
  • Further studies on the mutant mice already prove the model to be very powerful. (news-medical.net)
  • In mouse models of myotonic dystrophy, the researchers found that treating newborn mice with a virus carrying the dCas9 enzyme reduced the prevalence of myotonia, prolonged muscle contractions commonly experienced by myotonic dystrophy patients. (ufl.edu)
  • One group demonstrated that PEA could alleviate, in a dose-dependent manner, pain behaviors elicited in mice-pain models and could downregulate hyperactive mast cells. (wikipedia.org)
  • Mouse models have frequently been used to study Down syndrome due to the close similarity in the genomes of mice and humans, and the prevalence of mice usage in laboratory research. (wikipedia.org)
  • Work on mouse and rats models, including a study of mice on board the final Space Shuttle mission (STS-135), has helped to confirm this potential value. (wikipedia.org)
  • Research using mice models found that KFDV primarily replicated in the brain. (wikipedia.org)
  • The disease is difficult to reproduce in mouse models because mice lack the developmental stages for an enlarged cerebral cortex that humans have. (wikipedia.org)
  • Most research utilizes mice models, but heterologous expression systems are utilized as well, including, but not limited to, Madin-Darby canine kidney cells and COS-7 Cells. (wikipedia.org)
  • It has been demonstrated that mice models lacking CST, CGT, or both are incapable of producing sulfatide indicating that CST and CGT are necessary components of sulfatide synthesis. (wikipedia.org)
  • Mice and rats have been used as model organisms in research for hundreds of years and have been a staple of experimental psychology for decades. (wikipedia.org)
  • A study describing the characterization and validation of two neural progenitor cell models and their ability to differentiate into multiple types of neurons. (atcc.org)
  • Using two new KO mouse models, we demonstrate that Miro1 is essential for development of cranial motor nuclei required for respiratory control and maintenance of upper motor neurons required for ambulation. (pnas.org)
  • At the cellular level, dysplastic hippocampal neurons in the MAM model were shown to have reduced potassium current function and expression for the Kv4.2 channel subunit These findings may contribute to the spontaneous seizures and reduced seizure thresholds seen in this model. (wikipedia.org)
  • Dizocilpine has shown effectiveness in protecting neurons in cell culture and animal models of excitotoxic neurodegeneration. (wikipedia.org)
  • To assess whether gait analysis is applicable to assess improvements by neuroprotective compounds, we applied a model calculation and approached common statistical problems. (nih.gov)
  • In addition, we demonstrated that drugs known to activate HIF-1 in cultured cells as well as in vivo had neuroprotective properties in this model of cerebral ischemia. (jneurosci.org)
  • This study demonstrated the metabolic recovery after DHI treatment by micro-PET imaging with 18 F-FDG and the neuroprotective effects of DHI in a rat model of cerebral ischemic-reperfusion injury. (hindawi.com)
  • Similarly to gedunin, a closely structurally related compound also found in Azadirachta indica, deoxygedunin has additionally been found to activate HSF1 and induce Hsp70, and was observed to possess neuroprotective effects in a model of Huntington's disease. (wikipedia.org)
  • In contrast to these results, numerous studies suggested that Epo had no neuroprotective benefit in animal models and EpoR was not detected in brain tissues using anti-EpoR antibodies that were shown to be sensitive and specific. (wikipedia.org)
  • Human disease modeling with iPSCs has enabled researchers to study the disease phenotypes of patient-derived cells directly in the lab. (eurekalert.org)
  • An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). (eurekalert.org)
  • While they have very different levels of severity, they are both reliable models of the human disease. (bl.uk)
  • Here, we see evidence that the zebrafish's central nervous system is suitable for modeling human neurological disease and we review and evaluate natural product research using zebrafish as a vertebrate model platform to systematically identify bioactive natural products. (mdpi.com)
  • Mature neuronal and glial cells derived from human pluripotent stem cells have emerged as a physiologically relevant model for the study of neurological development and disease. (stemcell.com)
  • The Reeler Mouse: A Translational Model of Human Neurological Conditions, or Simply a Good Tool for Better Understanding Neurodevelopment? (mdpi.com)
  • Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment. (biomedsearch.com)
  • Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. (biomedsearch.com)
  • The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes. (biomedsearch.com)
  • Our results demonstrate that this new fucosidosis mouse model resembles the human disease and thus will help to unravel underlying pathological processes. (biologists.org)
  • models like a mouse or even some human cells. (coursera.org)
  • Due to the close resemblance of the clinical and histological picture of human psoriasis, the new disease-model is ideally suited to study in detail all aspects of pathogenesis. (news-medical.net)
  • An effective human cellular model of AD would use the appropriate cell types and ideally neural circuits affected by the disease, would develop relevant pathology and would do so in a reproducible manner over a timescale short enough for practical use. (biomedcentral.com)
  • We review here current progress in applying this approach to generating human models of AD and the potential for such models in the AD field. (biomedcentral.com)
  • The PMFE is an anatomy-based inverse dynamic-static optimisation model aiming to fulfil the requirements for controlling a human-inspired rehabilitation robot via muscle forces. (springer.com)
  • We believe that the future of brain research will include less reliance on animals, more reliance on human, cell-based models. (medindia.net)
  • Now, a group of University of Florida Health researchers has found a way to block the transcription of those dysfunctional genetic sequences into RNA, in human cells and mouse models. (ufl.edu)
  • Although kindling is a widely used model, its applicability to human epilepsy is controversial. (wikipedia.org)
  • Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
  • In 1979, trisomy of the mouse chromosome 16 (Ts16) initially showed potential to be a model organism for human Down syndrome. (wikipedia.org)
  • The Ts65Dn mouse model was first introduced in 1993, and more specifically resembles human trisomy 21 than the Ts16 model. (wikipedia.org)
  • Unlike the Ts65Dn model, Dp(16)1Yu contains a duplication of only the parts of chromosome 16 that are homologous to human chromosome 21. (wikipedia.org)
  • At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. (wikipedia.org)
  • Computational biology has been used to help sequence the human genome, create accurate models of the human brain, and assist in modeling biological systems. (wikipedia.org)
  • These organoids can be used in experiments that current in vitro methods are too simple for, while also being more human applicable than rodent or other mammalian models. (wikipedia.org)
  • An in vitro human brain model would allow for the next wave in understanding of the human brain. (wikipedia.org)
  • A common argument against the medical model of ADHD asserts that while the traits that define ADHD exist and may be measurable, they lie within the spectrum of normal healthy human behaviour and are not dysfunctional. (wikipedia.org)
  • The holonomic brain theory, developed by neuroscientist Karl Pribram initially in collaboration with physicist David Bohm, is a model of human cognition that describes the brain as a holographic storage network. (wikipedia.org)
  • This model allows for important aspects of human consciousness, including the fast associative memory that allows for connections between different pieces of stored information and the non-locality of memory storage (a specific memory is not stored in a specific location, i.e. a certain neuron). (wikipedia.org)
  • Mao draws a comparison between the open distribution model of online information sharing and the neurological networks of the human brain. (wikipedia.org)
  • Neuroepidemiology is a branch of epidemiology involving the study of neurological disease distribution and determinants of frequency in human populations. (wikipedia.org)
  • This periodical is the only international journal devoted to the study of neurological disease distribution and determinants of frequency in human populations. (wikipedia.org)
  • Non-human models of intelligence can be used in individual differences research for study designs that are difficult or unethical to perform using human subjects. (wikipedia.org)
  • This study aimed to investigate neuroprotection of Danhong injection (DHI) in a rat model of cerebral ischemia using 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET). (hindawi.com)
  • Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. (frontiersin.org)
  • We developed models to predict these episodes 30 minutes in advance, and to predict long-term neurological outcome by using dynamic characteristics of continuous ICP and mean arterial pressure (MAP) monitoring. (biomedcentral.com)
  • Our phenogenetic map can be used to build new hypotheses in the field of neurological disease modeling, and to identify potential new opportunities to design novel drug strategies," said first author Ethan W. Hollingsworth, a neural stem cell research assistant at Ohio State's Wexner Medical Center and a hematology/oncology clinical research intern at Nationwide Children's Hospital. (eurekalert.org)
  • In addition to the other core areas of focus, Kennedy Krieger also provides training opportunitites to increase the number of qualified specialists in the field of neurological and developmental disabilities. (wikipedia.org)
  • In the present study, we examined the effects of neurological improvement after transient middle cerebral artery occlusion (MCAO) in rats by a novel therapeutic strategy with FGF-2 gene-transferred MSCs by the herpes simplex virus type 1 (HSV-1) vector. (ahajournals.org)
  • However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. (frontiersin.org)
  • This manifests in vitro, as the loss of metal ions results in increased SOD1 aggregation, and in disease models, where low metalation is observed for insoluble SOD1. (wikipedia.org)
  • Efficacy studies performed by JAX® In Vivo Services for ALS typically feature clinical observations, body weights, progressive neurological scoring, electrophysiological assessment of motor neuropathy, survival, tissue/blood collection and histological assessment of neuromuscular junctions and femoral nerves. (jax.org)
  • Progressive neurological disease is the hallmark of Niemann-Pick type C disease, and is responsible for disability and premature death in all cases beyond early childhood. (wikipedia.org)
  • With this aim, a variety of mathematical models has been proposed for a better insight into the kinetic rate laws that govern the microscopic processes of protein aggregation. (frontiersin.org)
  • Actually, it has been barely acknowledged that the vast majority of large-scale models have foundations on previous mathematical approaches that describe the chemical kinetics of protein replication and propagation. (frontiersin.org)
  • Polysaccharides are the topic of heightened curiosity this present day, and this publication is a concise and entirely up to date examine of the houses of nutrients polysaccharides, describing their interplay with water, the mass-volume-pressure-relationship, a variety of sorts of mathematical modeling, and the typical phenomenology lower than diversified combos of stimuli. (juridikinstitutet.se)
  • A third way is to hypothesize a theory of the functioning of the biological components of the neural system by a mathematical model, in the form of a set of mathematical equations. (wikipedia.org)
  • Gabor also developed a mathematical model for demonstrating a holographic associative memory. (wikipedia.org)
  • One of Gabor's colleagues, Pieter Jacobus Van Heerden, also developed a related holographic mathematical memory model in 1963. (wikipedia.org)
  • The researchers found that with TREX1 not functioning normally, all of the cell models displayed excess extra-chromosomal DNA and that a major source of the excess DNA came from LINE1 (L1) retroelements. (eurekalert.org)
  • This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. (biomedsearch.com)
  • We aim to study the influence of comorbidities and peri-OHCA event factors on neurological recovery and develop a model that can help clinicians predict neurological function among patients with post-OHCA admitted to the hospital. (bmj.com)
  • An interactive graphics-based model of the lower extremity to study orthopaedic surgical procedures. (springer.com)
  • Latent class modeling of US Food and Drug Administration Adverse Event Reporting System (FAERS) data was performed using indicators defined by the Medical Dictionary for Regulatory Activities neurologic and psychiatric high-level group terms, in a study dataset of FAERS reports ( n = 5332) of reactions to common antimalarial drugs. (springer.com)
  • In the present study, we evaluated the acute and extended protective effects of XST in different rat cerebral ischemic model and explored its effect on peroxiredoxin (Prx) 6-toll-like receptor (TLR) 4 signaling pathway. (hindawi.com)
  • Using two new mouse models and primary cells, the study demonstrates a specific role for Miro1 in upper motor neuron development and retrograde transport of axonal mitochondria. (pnas.org)
  • We will use the information obtained from this study information to develop a biopsychosocial prospective surveillance model, a method for early detection, intervention, and moderation of shoulder pain. (clinicaltrials.gov)
  • Biocybernetics - the study of an entire living organism Neurocybernetics - cybernetics dealing with neurological models. (wikipedia.org)
  • Drug high-throughput screening Cerebral organoids can be used as simple models of complex brain tissues to study the effects of drugs and to screen them for initial safety and efficacy. (wikipedia.org)
  • Since the publication of Reflections on the Dawn of Consciousness , a number of new studies have been published that also show bilateral temporal lobe ('bicameral') activation during auditory hallucinations, providing further support for Jaynes's neurological model specifically and his bicameral mind theory in general. (julianjaynes.org)
  • Adding information of the first 24 hours of ICP and MAP to known risk factors allows accurate prediction of neurological outcome at 6 months. (biomedcentral.com)
  • Various models have been proposed, however the dominant one is that of temporal difference learning, in which a prediction is made before a reward and afterwards adjustment is made based on a learning factor and reward yield versus expectation leading to a learning curve. (wikipedia.org)
  • Furthermore, a right-left temporal lobe interaction has been documented in numerous fMRI studies of auditory hallucinations, showing the validity of Jaynes's neurological model for the bicameral mind. (julianjaynes.org)