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  • morbidity and morta
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • tissue
  • Most recently, he has developed a novel method known as Tissue Expander Stimulated Lengthening of Arteries (TESLA) to lengthen the normal aorta in children with midaortic syndrome, allowing for aortic replacement without prothetic grafts. (childrenshospital.org)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • In an immunocompetent animal, like the mature chicken, the host immune cells attack the foreign tissue. (wikipedia.org)
  • Eventually, Murphy showed that the acceptance of tissue grafts was host-specific in immunologically competent animals. (wikipedia.org)
  • aplastic anemia
  • HCT is effective for a number of diseases including various hematologic malignancies, non-cancerous diseases including aplastic anemia, thalassemia, sickle cell anemia, and severe combined immunodeficiency ( 2 ). (frontiersin.org)
  • therapy
  • Gene therapy is still experimental and has largely only been tested in animal models until now. (wikipedia.org)
  • Treatment of the disease focuses primarily on management of symptoms to maintain quality of life, focusing on physical therapy to retrain and replace lost functions. (wikipedia.org)
  • animal
  • My interests and publications are focused on general clinicopathologic correlations in dermatopathology, mycosis fungoides, animal models of lupus erythematosus and graft vs. host disease, and immunoflourescence techniques in dermatopathology. (yalecancercenter.org)
  • inhibitor
  • In a previous study, prevention of cyclic adenosine monophosphate (AMP) hydrolysis by the phosphodiesterase-4 inhibitor rolipram, in combination with Schwann cell (SC) grafts, promoted significant supraspinal and proprioceptive fiber growth and/or sparing and improved locomotion. (cognizantcommunication.com)
  • acute myeloid
  • A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. (bloodjournal.org)
  • human
  • In human disease, alterations in numbers of regulatory T cells - and in particular those that express Foxp3 - are found in a number of disease states. (wikipedia.org)
  • increases
  • In another study, transplanted SCs transduced to generate a bifunctional neurotrophin (D15A) led to significant increases in graft SCs and axons, including supraspinal and myelinated axons. (cognizantcommunication.com)