• Conditional genetic approaches allow the engineering of mouse models of human cancer that have unparalleled similarity to the human disease. (aacrjournals.org)
  • We use quantitative genetic approaches to map complex traits, including the transcriptome, and study genotype-environment interactions. (wur.nl)
  • This formalism allows us to unify the modelling of both approaches, to take advantage of all results and tools in the field of high level Petri nets like the model checking tool Maria and to prevent the explosion of the number of places. (unice.fr)
  • Using this novel methodology, Knockout Rats and Mice can be generated in as little as four months, about one-third the time required to make a Knockout model using conventional Embryonic Stem Cell (ES cell) based approaches. (medindia.net)
  • Using data from two separate research projects, I propose to evaluate and integrate recent statistical approaches and models to construct a new synthetic approach that will allow the identification of environmental influences on the genetic structure of woody plant populations. (ucsb.edu)
  • This model will set the stage for future work that investigates therapeutic approaches for restoring TREM2 function. (sciencemag.org)
  • With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. (scienceblog.com)
  • Researchers have created a model that may explain the complexities of the origins of life. (nsf.gov)
  • Researchers from the Johns Hopkins University and other institutions have developed a new prediction model for genetic defects known as Lynch syndrome , which predisposes families to develop colorectal cancer. (medindia.net)
  • The structural and functional similarity of the larval zebrafish pronephros to the human nephron, together with the recent development of easier and more precise techniques to manipulate the zebrafish genome have motivated many researchers to model human renal diseases in the zebrafish. (mdpi.com)
  • This animal model could help researchers better understand abnormal brain function in autistic humans, which could help them identify and improve treatment strategies. (eurekalert.org)
  • Dr. Powell adds that the model gives researchers insight into mouse brains which share important parallels with brains of living humans, which can only be studied in limited ways with the use of new brain imaging tools. (eurekalert.org)
  • Researchers at UC San Francisco have developed a new genetic model of autism, using neurons created in the lab from patients' own skin cells. (ucsf.edu)
  • This "genetic toolbox" has enabled researchers to not only create mouse models mimicking human diseases, but also use techniques such as gene silencing to explore what a rat model is capable of. (criver.com)
  • The researchers sought to account for the composition of the genetic code, which allows proteins to be built from amino acids with high specificity based on information stored in a RNA or DNA genome. (astrobiology.com)
  • To do so, the researchers analysed the genetic diversity of a collection of 200 japonica rices, using the Ecomeristem model, which simulates rice growth under contrasting water supply conditions. (cirad.fr)
  • To do this, the researchers based their study on the genetic diversity that exists within the japonica group of rices. (cirad.fr)
  • The researchers used the Ecomeristem model, which simulates rice growth under contrasting water supply conditions, to explore these parameters within a collection of 200 japonica rices. (cirad.fr)
  • The combined, data-driven approach that includes validation allows researchers to systematically determine when models are too simple, too complex or just right-the "Goldilocks" approach. (phys.org)
  • The ease of genetic analysis allowed researchers to study processes to a degree not seen for other model organisms. (els.net)
  • DALLAS - June 26, 2017 - Using a new skin cell model, researchers have overcome a barrier that previously prevented the study of living tissue from people at risk for early heart disease and stroke. (eurekalert.org)
  • A team of researchers led by Sandra Seeher at the Institut für Experimentelle Endokrinologie, Charité - Universitätsmedizin Berlin in Berlin, Germany, set out to create mouse models to test whether Secisbp2 is essential for selenoprotein biosynthesis and to study the consequences of Secisbp2 deletion in tissues and the whole organism. (thyroid.org)
  • Researchers then compared Secisbp2 mice with similar mouse models lacking tRNA[Ser]Sec. They found that the phenotypes, as well as the consequences on selenoprotein level of our Secisbp2 mice are milder than in tRNA[Ser]Sec knockout mice. (thyroid.org)
  • Collectively, these topics will provide a pipeline for the use of animal models in understanding human craniofacial development and disease for clinical geneticist and basic researchers alike. (nih.gov)
  • A recently developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1 (NF1) successfully mimics the human condition and provides unique insight into tumor development, diagnosis and treatment, according to researchers at Washington University School of Medicine in St. Louis. (bio-medicine.org)
  • The new model, developed by Farrer and his team could offer the precise tool that researchers have long hoped would deliver the impact of LRRK2 inhibitors and other disease-modifying drugs. (medicalxpress.com)
  • In: Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease. (cdc.gov)
  • We discuss emerging technologies, including high throughput sequencing and genome editing, and new animal repository resources, and how their application can revolutionize the future of animal models in craniofacial research. (nih.gov)
  • Our results suggest that lentivirus-delivered sgRNA:Cas9 genome editing should be useful to engineer a broad array of in vivo cancer models that better reflect the complexity of human disease. (harvard.edu)
  • used CRISPR/Cas9 genome editing to generate a mouse model of FTD-like syndrome. (sciencemag.org)
  • Plant modelling serves to formalize, in the form of mathematical equations and by computer simulation, the processes that control plant growth, its regulation by its environment, in this case initial vigour, notably leaf emission, and its regulation by water stress. (cirad.fr)
  • A computer simulation system that embodies these concepts is described and the model is used to generate distributions of chromosome number/cell under various simulated conditions and in a variety of simulated biological settings. (aacrjournals.org)
  • iii) additive genetic, permanent environmental, residual and the animal as random effects. (ebscohost.com)
  • Genetic models of inheritance of colouration.Number of brown (red bar) and grey (grey bar) offspring colour morphs produced by different combinations of parental colour morphs (B×B, B×G and G×G). The first columns show the observations in the field, second, third and fourth columns show the expected number of offspring colour morphs according to models with brown dominance, grey dominance and an additive genetic model, respectively. (nih.gov)
  • We thus conclude from the above exercises on the basis of comparing fledglings' morphs with their parents' morphs that we find evidence for genetic dominance of brown over grey, whereas dominance of grey and purely additive genetic effects are not supported by this data. (nih.gov)
  • The main reasons why mouse models are important for retinal research include that rodents share a key retinal homology with humans and that genetic manipulation is relatively easily applicable for mice. (springer.com)
  • Because of this oddity, the mice could be valuable animal models for human disorders, such as Parkinson's and Alzheimer's diseases, according to geneticists at Cornell and Stanford universities. (innovations-report.com)
  • As an animal model, the mahoganoid mutant mice probably will not be useful to study spongiform encephalopathies like mad cow disease, Gunn believes, because rogue prions are not the cause of the mouse condition. (innovations-report.com)
  • E ) Genetic reduction of eEF2K corrects eEF2 hyperphosphorylation in hippocampal lysates from Tg19959 AD model mice. (jci.org)
  • Whichever research path has been taken to obtain a modified mouse, these animals can be used as the primary research focus, or they can be bred with other mice to generate models of greater complexity. (nih.gov)
  • Maximizing mouse cancer models using the various possibilities of inbred mice, engineered mice, and even humanized mouse models enables tremendous strides in understanding cancer biology and translating our understanding to human health. (nih.gov)
  • Through this Training Fellowship Dr Gago aims to replace transgenic mice used to investigate the genetic basis of ABPA pathogenesis with a human in vitro cellular model. (nc3rs.org.uk)
  • Dr Gago estimates that the Manchester Fungal Infection Group can replace over 50% of their animal use with the proposed in vitro models, with over 200 mice replaced in Dr Gago's studies alone. (nc3rs.org.uk)
  • DESCRIPTION (provided by applicant): Because the cardiovascular anatomy of swine is similar to humans with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine coronary arterial model is the standard for the preclinical evaluation of endovascular devices. (sbir.gov)
  • Cornell geneticist Teresa Gunn displays a mahoganoid mutant mouse, a possible animal model for brain disease in humans. (innovations-report.com)
  • Many genetic pathways which are associated with cancer and ageing are conserved across worms and humans. (wur.nl)
  • VSG induces loss of body weight and fat mass and improves glucose tolerance in humans and in rodent models ( 3 - 8 ). (diabetesjournals.org)
  • Such models are commonly used to study disease states in humans and play a key role in the drug discovery process. (medindia.net)
  • To supplement their clinical research, Gutmann's team developed a mouse model in which the animals, like humans with the disease, have one abnormal copy of the gene for NF1 in every cell in their body, while specific support cells in the brain called astrocytes have two abnormal copies of this same gene. (bio-medicine.org)
  • Muenke syndrome, defined by heterozygosity for a Pro250Arg substitution in fibroblast growth factor receptor 3 (FGFR3), is the most common genetic cause of craniosynostosis in humans. (biomedsearch.com)
  • We believe we've found an approach that is most relevant to humans, in that our models of gene dysfunction mimic the etiology of Parkinson's disease rather than its pathology- meaning its beginning rather than its end," says Matthew Farrer, the study's lead investigator and a researcher at the Djavad Mowafaghian Centre for Brain Health at UBC. (medicalxpress.com)
  • Over the last few years, great advances have been made, not only in the modeling techniques of genetic diseases in the zebrafish, but also in how to validate and exploit these models, crossing the bridge towards more informative explanations of disease pathophysiology and better designed therapeutic interventions in a cost-effective in vivo system. (mdpi.com)
  • Emerging data suggest that much of the genetic risk of Alzheimer's disease plays out in microglia, the brain's resident immune cells. (alzforum.org)
  • Thank you for your interest in spreading the word on Disease Models & Mechanisms. (biologists.org)
  • Message Body (Your Name) thought you would like to see the Disease Models & Mechanisms web site. (biologists.org)
  • New mouse models can help scientists study a rare disease, called SECISBP2 syndrome, that causes abnormal thyroid hormone metabolism, delayed bone maturation, as well as other abnormal characteristics that vary by individual, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada. (thyroid.org)
  • In recent years, great interest has been devoted to the use of Induced Pluripotent Stem cells (iPS) for modeling of human genetic diseases, due to the possibility of reprogramming somatic cells of affected patients into pluripotent cells, enabling differentiation into several cell types, and allowing investigations into the molecular mechanisms of the disease. (mdpi.com)
  • The potential applications using these rodent models of human disease could ultimately eliminate years of research time and save millions of lives," said Dr. Dave Smoller, President, Sigma Research Biotechnology. (medindia.net)
  • In a combined analysis of over 2500 diabetic patients with and without coronary artery disease, each extra point in the genetic risk score was associated with a 19% increase in the odds of having coronary artery disease. (sciencemag.org)
  • Even after adjustment for family history, the genetic risk score distinguished between those with and without coronary artery disease, which is in contrast to many previous studies in which similar risk scores lost predictive ability when family history was taken into account. (sciencemag.org)
  • Genetic susceptibility to coronary heart disease in type 2 diabetes. (sciencemag.org)
  • A new genetic risk score promises personalized risk prediction for cardiovascular disease in diabetics. (sciencemag.org)
  • However, less than 2% of asthma patients exposed to spores contract ABPA suggesting a genetic risk factor is involved in the pathogenesis of this disease. (nc3rs.org.uk)
  • Mouse models used in these studies are classified as severe, as they entail the development of severe lung disease and mild-to-moderate respiratory distress. (nc3rs.org.uk)
  • Until now, the best available experimental models of the disease were based on flooding the brain with alpha-synuclein-a protein in the brain that, when it accumulates abnormally into clumps, is linked to Parkinson's-or using neurotoxins to destroy dopamine-producing cells. (medicalxpress.com)
  • These conventional models exhibit the classic motor and behavioural symptoms of the disease, which is why they have been widely adopted by the Parkinson's field, but the sledgehammer approach to inducing the disease means the cells die-the guitar is smashed-before any of the subtle changes in the tune can be measured. (medicalxpress.com)
  • The model-known as a VPS35 D620N knock-in (VKI)-induces the biology of a disease-causing gene rather than the symptoms of the disease. (medicalxpress.com)
  • We're hoping to use PET imaging to provide a clinically relevant biomarker, which would be relevant beyond genetic forms of the disease. (medicalxpress.com)
  • For each genotype in the collection, they estimated the parameters of the equations in the growth calculation model (leaf emission and size, branching, sugar storage and structural growth), depending on the abiotic conditions (temperature, radiation and water). (cirad.fr)
  • Bayesian approach to model inference is employed enabling flexible definitions of a priori probability distributions of the model parameters. (igi-global.com)
  • If the modeled observable is non-linear in the parameters, there can exist a degeneracy of minimum \chi^2 in parameter space. (aas.org)
  • The Mean trend of milk yield or 305-day total yield can be modeled with different orders of orthogonal Legendre polynomial because Legendre polynomial produces the lower correlation between parameters than other functions . (thefreelibrary.com)
  • So the objectives of this study were estimation and assessment of genetic parameters and variance components of 305-day milk yield using repeatability and different RRM. (thefreelibrary.com)
  • Successful creation of OssabawLDLR -/- minipigs with evidence of enhanced dyslipidemia would justify submission of a Phase II STTR proposal focused on herd expansion, in-depth physiological characterization, and potentially commercialization of the model for sales to the biomedical research community. (sbir.gov)
  • The resulting "eye-in-a-dish" model took on physiological and molecular characteristics similar to native retinal cells, including a polygonal shape and pigmentation. (ucsd.edu)
  • However, to combine initial vigour and water stress tolerance, it is necessary to analyse the genetic diversity of characters that are not necessarily independent from a genetic and physiological point of view. (cirad.fr)
  • Genetic mouse models mimicking human diseases have been developed and utilized for retinal research in various topics, involving anatomy, physiology, biochemistry, and pathology. (springer.com)
  • Maeda A, Palczewski K (2013) Retinal degeneration in animal models with a defective visual cycle. (springer.com)
  • They plan to develop this retinal model for more people, and use it to investigate other genes involved in AMD. (ucsd.edu)
  • One of the experimental models in the lab is the tyrosinase gene, which encodes an enzyme that activates synthesis of the pigment melanin, which is regulated throughout development and is tissue-specific (expressed only in melanocytes and retinal pigment epithelium cells). (csic.es)
  • Identification of the potential tumor suppressor gene at the insertion site will reveal important information about the genetic basis of the zebrafish retinal tumors. (arvojournals.org)
  • This model includes only these two genes of the operon. (northwestern.edu)
  • To address those research gaps, Zhe Han, Ph.D., principal investigator and associate professor in the Center for Cancer & Immunology Research at Children's National, and colleagues systematically studied NS-associated genes in the Drosophila model, including seven genes whose renal function had never been analyzed in a pre-clinical model. (eurekalert.org)
  • These three genes help repair mismatches that can occur during the duplication of the genetic code when new cells are made, and are known as mismatch repair (MMR) genes. (medindia.net)
  • GENETIC model systems have a long-standing history as important tools to discover novel genes and processes in cell and developmental biology. (genetics.org)
  • The resulting cells behaved like microglia and expressed key microglial genes, the authors report, suggesting they might serve as a model for these ephemeral brain cells. (alzforum.org)
  • Anatoly Samoylenko, Seppo Vainio and colleagues describe a novel model to assay the roles of co-regulated genes in kidney development and renal carcinogenesis. (biologists.org)
  • This paper describes the effects of perturbations, which simulate the knock-out of single genes, one at a time, in random Boolean models of genetic networks (RBN). (aimsciences.org)
  • Our modeling studies suggest that the overrepresentation of individual oncogene-bearing chromosomes in aneuploid cell lines may require the activation of gene dose-dependent growth-promoting genes and is not likely to occur in cell lines in which at least two copies of each normal chromosome are required for cell survival. (aacrjournals.org)
  • To generate mouse models that carry novel, foreign, or modified genes and which are stably inherited, scientists have developed protocols that begin with preparation of the appropriate DNA segment, through injection or introduction of the prepared DNA into suitable recipient eggs or embryos, and ultimately the birth and characterization of the animals. (nih.gov)
  • Although this modelling is not exhaustive, it does show that the tawny owl phenotypic morph has a genetic architecture that relies on few genes with large effects, which is consistent with a Mendelian inheritance of colouration based on one locus with a 'brown' allele dominant over a 'grey' allele. (nih.gov)
  • A related article published by Weiss's group on Nov. 21, 2017, in Molecular Psychiatry developed a second novel genetic model of autism. (ucsf.edu)
  • We improve the shift-scheduling process by using nonstationary queueing models to evaluate schedules and two heuristics to generate schedules. (scielo.br)
  • We present a model for plant dispersal in agricultural landscapes to evaluate the gene dispersal from genetically modified (GM) plants. (comsol.com)
  • The model can help to evaluate co-existence management measures such as spatial isolation between GM and non-GM cultivars on the adventitious presence of GM in non-GM harvest. (comsol.com)
  • These cells will then be challenged with Aspergillus spores to evaluate the immune response to Aspergillus exposure in the genetic context of ABPA. (nc3rs.org.uk)
  • In addition, these genetic rodent models play a crucial role in testing and selecting potential therapeutics that can be used to treat ALS and/or other motor neuron disorders. (hindawi.com)
  • In addition and in an attempt to unravel the pathogenic mechanism(s) leading to ALS, a number of rodent models have been created starting from information on the genetic causes of ALS (Tables 2 and 3 ). (hindawi.com)
  • Powell, C.M. and Miyakawa, T. (2006) Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder? (scirp.org)
  • ST. LOUIS, Aug. 21 Sigma-Aldrich(R) (Nasdaq: SIAL) announced today that scientists at its new Sigma Advanced Genetic Engineering (SAGE(TM)) Labs in St. Louis will leverage its exclusive CompoZr(TM) Zinc Finger Nuclease (ZFN) gene editing technology (www.compozrzfn.com) to define, develop and offer a new generation of genetically-engineered rodent research models. (medindia.net)
  • While most of the associations between polymorphisms and gene expression were the same in the two cell types, the authors found differences as well, with some associations only showing up in the microglial model. (alzforum.org)
  • The research team identified predictive models of transcription-the first step in gene expression-when the yeast cell is responding to osmotic stress (salt), which greatly affects cell growth. (phys.org)
  • In this Phase 1 STTR we propose to generate a pig model of metabolic syndrome and rapid atherosclerosis by knocking out the low density lipoprotein receptor gene in a strain of minipigs (Ossabaw) with a genetic propensity for Type 2 diabetes. (sbir.gov)
  • The classical approach is then to generate all Petri nets corresponding to all remaining sets of parameter values and to confront each model to the available knowledge or hypothesis. (unice.fr)
  • The authors developed a genetic risk score on the basis of these five SNPs, with each SNP allele contributing 1 point, thereby giving a minimum score of 0 and maximum score of 10. (sciencemag.org)
  • This chapter discusses the relationships among the most commonly used GRN models that can enable effective integration of diverse types of sub-models. (igi-global.com)
  • Longitudinal traits can be analyzed by a multiple trait model which can allow different genetic correlation (commonly unstructured covariance) between records on the same individual. (thefreelibrary.com)
  • Our model will help identify individuals likely to have particular genetic defects. (medindia.net)
  • Multiple laboratories have attempted to develop a mouse model of alveolar rhabdomyosarcoma by expression of the Pax3:Fkhr oncogene in the early embryo, but in each case, birth defects precluded the somatic formation of muscle cancers. (aacrjournals.org)
  • During the past decade, considerable work has been carried out on several mouse mutants with genetic defects in and limited to the formation of myelin. (springer.com)
  • Panel B shows results limited to women in the lowest 20% of estimated risk, according to the inclusive model. (nih.gov)
  • The inset shows where this lowest 20% would be located in Panel A. Panel C shows results limited to women in the highest 20% of estimated risk according to the inclusive model. (nih.gov)
  • Historically, consumers have played a passive role in genetic testing: Physicians have ordered the tests, received and interpreted the results, and prescribed treatment. (businessinsider.com)
  • DTC genetic testing offers consumers the flexibility of sidestepping physicians - but results often aren't adequate to inform treatment decisions. (businessinsider.com)
  • The counseling process has typically involved at least two in-person visits - an initial visit to perform risk assessment and, if applicable, informed consent for genetic testing ("pretest counseling") and for those who underwent genetic testing, a posttest visit to disclose test results and discuss results' implications for cancer risk management in patient and family ( 10 ). (frontiersin.org)
  • Although they tend to return results that are better understood by image analysts, the induction of these models is difficult to build due to factors that affect training complexity, such as coexistence of visual patterns in same images, over-fitting or under-fitting and semantic representation differences among image analysts. (mdpi.com)
  • Overall, the results obtained using the model are consistent with a wide variety of flow cytometric and cytogenetic studies in human solid tumors. (aacrjournals.org)
  • These results in the Dravet mouse model using Stoke's ASO technology have been quite remarkable," said Lori Isom, Ph.D., Maurice H. Seevers professor and chair of pharmacology at the University of Michigan Medical School. (businesswire.com)
  • The results show that the composite source model provides a very realistic broadband source description for the Northridge earthquake. (scec.org)
  • There are no plans to give patients the results of genetic tests or questionnaires. (clinicaltrials.gov)
  • The results obtained for each of the three models showed that the higher heritability estimations were always obtained in the third test month. (ebscohost.com)
  • While the result amounted to a very small change in their genetic makeup, it perfectly mimicked the same small change occurring in some patients with human autism. (eurekalert.org)
  • Some of these models have been of great value to delineate potential pathogenic mechanisms that cause and/or modulate selective motor neuron degeneration. (hindawi.com)
  • Our model shows that today's genetic code probably resulted from a combination of selective forces and random chance," explained Justin Jee, a doctoral student at NYU School of Medicine and the paper's lead author. (astrobiology.com)
  • In conclusion, the TDMY trait use into the selective process will promote genetic changes similar to the ones obtained through the MY305. (ebscohost.com)
  • Such an approach will also allow more precise models about the factors which influence genetic diversity that can be used for the development of policies surrounding land and ecosystem management. (ucsb.edu)
  • The two projects, which have generated the opportunity for developing such models, both examine, on the landscape level, genetic diversity of woody plant species in Missouri and California, respectively. (ucsb.edu)
  • The objective of this research project is to identify a limited number of aquatic insects that can serve as model species for genetic diversity studies of the Delta region and similar aquatic habitats. (epa.gov)