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  • gene
  • Sebat acknowledges that the data presented is merely consistent with the rare mutation gene model and not direct proof of it. (scientificamerican.com)
  • In this Phase 1 STTR we propose to generate a pig model of metabolic syndrome and rapid atherosclerosis by knocking out the low density lipoprotein receptor gene in a strain of minipigs (Ossabaw) with a genetic propensity for Type 2 diabetes. (sbir.gov)
  • PUBLIC HEALTH RELEVANCE: This STTR proposes to create a pig model of metabolic syndrome and rapid atherosclerosis by knocking out the low density lipoprotein receptor (LDLR) gene in the Ossabaw minipig. (sbir.gov)
  • Using zebrafish as a model, Dr Yuk Fai Leung studies the gene networks behind ocular diseases. (purdue.edu)
  • Identification of the potential tumor suppressor gene at the insertion site will reveal important information about the genetic basis of the zebrafish retinal tumors. (arvojournals.org)
  • We believe we've found an approach that is most relevant to humans, in that our models of gene dysfunction mimic the etiology of Parkinson's disease rather than its pathology- meaning its beginning rather than its end," says Matthew Farrer, the study's lead investigator and a researcher at the Djavad Mowafaghian Centre for Brain Health at UBC. (medicalxpress.com)
  • The model-known as a VPS35 D620N knock-in (VKI)-induces the biology of a disease-causing gene rather than the symptoms of the disease. (medicalxpress.com)
  • Genetic removal of Mapt , the gene encoding tau, in AD models overexpressing amyloid-β (Aβ) decreases hyperexcitability and normalizes the excitation/inhibition imbalance. (jneurosci.org)
  • The research team identified predictive models of transcription-the first step in gene expression-when the yeast cell is responding to osmotic stress (salt), which greatly affects cell growth. (phys.org)
  • While efforts should be made to evaluate the predictive validity of these genetic rat models, we propose that they have the advantage (over mouse knockouts, for example) of better representing "normal" genetic, neurobiological and phenotype variation, thus allowing the study of associations among them by means of genetic mapping or gene expression studies. (scirp.org)
  • The study, published May 9, 2019 by Stem Cell Reports , revealed the importance of a specific genetic variation that affects expression of the VEGFA gene. (ucsd.edu)
  • Using this new model of AMD, the researchers determined that a specific genetic variation in a region of the genome that regulates expression of the VEGFA gene reduces the amount of VEGFA produced and directly contributes to AMD. (ucsd.edu)
  • We didn't start with the VEGFA gene when we went looking for genetic causes of AMD," said senior author Kelly A. Frazer, PhD, professor of pediatrics and director of the Institute for Genomic Medicine at UC San Diego School of Medicine and Moores Cancer Center. (ucsd.edu)
  • The genetic variant most closely associated with AMD was rs943080, a specific genetic variation that affects expression of the VEGFA gene by altering activity of a distant region of the genome. (ucsd.edu)
  • The second modelling is more compact since the unique place abstracts the cell in which each token represents a specific gene and its expression level. (unice.fr)
  • algorithm
  • In this research, a learning algorithm was implemented to determine the structure and the parameters of Bayesian networks that model GRNs from real data. (army.mil)
  • We present an exact forward-in-time algorithm that can efficiently simulate the evolution of a finite population under the Wright-Fisher model. (genetics.org)
  • Our algorithm is implemented in the C++ programming language and we simulate data sets under the Wright-Fisher model assumptions. (genetics.org)
  • We now sketch an intuitive algorithm that always provides a biologically feasible model consistent with the multi-level one. (springer.com)
  • Furthermore, a genetic algorithm is proposed for this portfolio optimization model. (hindawi.com)
  • At last, simulations are made on randomly chosen ten stocks for 60 days (during January 2, 2014 to April 2, 2014) from Wind database (CFD) in Shenzhen Stock Exchange, and the results indicate that the proposed model is reasonable and the proposed algorithm is effective. (hindawi.com)
  • disorders
  • Because of this oddity, the mice could be valuable animal models for human disorders, such as Parkinson's and Alzheimer's diseases, according to geneticists at Cornell and Stanford universities. (innovations-report.com)
  • In addition, these genetic rodent models play a crucial role in testing and selecting potential therapeutics that can be used to treat ALS and/or other motor neuron disorders. (hindawi.com)
  • It is recognized that developing valid animal models is essential for the research on the neurobiological mechanisms of (and treatments for) psychiatric disorders, even when these are as complex as schizophrenia. (scirp.org)
  • JUPITER, FL, - Working with a group of national and international researchers, scientists from the Florida campus of The Scripps Research Institute have developed a new genetic model of premature aging disorders that could shed light on these rare conditions in humans and provide a novel platform for large-scale screening of compounds to combat these and other age-related diseases. (healthcanal.com)
  • In the new study, which was published this month in the open-access publication PLoS ONE, the scientists found a way to use zebrafish (Danio rerio) to model two rare human genetic disorders: Hutchinson-Gilford Progeria Syndrome and laminopathies. (healthcanal.com)
  • The laminopathies are a cluster of at least 13 different genetic disorders, whose symptoms range from muscular dystrophy to premature aging. (healthcanal.com)
  • All these mutants share advantages for experimental study in that the pathology is limited to the myelin, their genetic nature presages likely abnormality of protein structure, serial developmental analysis is possible, and dilfereuees in both phenotype and genotype of myelin disorders have been shown. (springer.com)
  • variation
  • For example, last November, when the US Food and Drug Administration (FDA) approved a 23andMe DTC test that informs consumers whether their genetic variation could impact their ability to metabolize certain drugs, the FDA earmarked the approval with stipulations outlining that patients and providers should augment 23andMe's results with clinical testing before making treatment decisions. (businessinsider.com)
  • But we were surprised to find that, with samples from just six people, this genetic variation clearly emerged as a causal factor. (ucsd.edu)
  • Improved understanding of the assembly and maintenance of myelin is afforded by the study of animals in which interference with these processes occurs as a result of genetic variation, toxic exposure, immunological attack, viral infection, nutritional or endocrine deficiency, and physical or circulatory insult. (springer.com)
  • demonstrates
  • The collective evidence not only highlights the importance of IKKα in skin development, maintaining skin homeostasis, and preventing skin carcinogenesis, but also demonstrates that mouse models are extremely valuable tools for revealing the mechanisms underlying these biological events, leading our studies from bench side to bedside. (harvard.edu)
  • rodent models
  • A large number of rodent models are available that show motor neuron death and a progressive motor phenotype that is more or less reminiscent of what occurs in patients. (hindawi.com)
  • In this paper, we give a systematic overview of the most important genetic rodent models that show motor neuron degeneration and/or develop a motor phenotype. (hindawi.com)
  • In addition and in an attempt to unravel the pathogenic mechanism(s) leading to ALS, a number of rodent models have been created starting from information on the genetic causes of ALS (Tables 2 and 3 ). (hindawi.com)
  • predictive
  • We aimed to develop an RA prediction model capable of generating clinically relevant predictive data and to determine if it better predicted younger onset RA (YORA). (whiterose.ac.uk)
  • To be considered a valid analogue of the disorder, a given model should present good face validity ( i.e . similarity of symptoms), good predictive validity ( i.e . similarity of treatment effects and potential for discovering novel treatments) and enough construct validity ( i.e . the model should help discover neurobiological mechanisms underlying the disorder or some relevant symptoms). (scirp.org)
  • retinal
  • The resulting "eye-in-a-dish" model took on physiological and molecular characteristics similar to native retinal cells, including a polygonal shape and pigmentation. (ucsd.edu)
  • Next, the team collected molecular data, including RNA transcripts and epigenetic information, from the retinal models. (ucsd.edu)
  • They plan to develop this retinal model for more people, and use it to investigate other genes involved in AMD. (ucsd.edu)
  • Networks
  • GRNs can be modeled using statistical and logical techniques, more precisely using Bayesian networks. (army.mil)
  • Although the underlying molecular mechanisms are unclear, recent studies have implicated tau in the regulation of excitability and synchronization of neuronal networks in AD mouse models. (jneurosci.org)
  • Is the Subject Area "Genetic networks" applicable to this article? (plos.org)
  • Multi-level discrete models of genetic networks, or the more general piecewise affine differential models, provide qualitative information on the dynamics of the system, based on a small number of parameters (such as synthesis and degradation rates). (springer.com)
  • genes
  • Anatoly Samoylenko, Seppo Vainio and colleagues describe a novel model to assay the roles of co-regulated genes in kidney development and renal carcinogenesis. (biologists.org)
  • Although this modelling is not exhaustive, it does show that the tawny owl phenotypic morph has a genetic architecture that relies on few genes with large effects, which is consistent with a Mendelian inheritance of colouration based on one locus with a 'brown' allele dominant over a 'grey' allele. (nih.gov)
  • Genetic differences in BCG-induced resistance to Schistosoma mansoni are not controlled by genes within the major histocompatibility complex of the mouse. (springer.com)
  • This is a robust model system of human aging that corresponds directly to the human genes involved in these diseases," said Scripps Florida Assistant Professor Shuji Kishi, who led the study. (healthcanal.com)
  • approaches
  • This model will set the stage for future work that investigates therapeutic approaches for restoring TREM2 function. (sciencemag.org)
  • This formalism allows us to unify the modelling of both approaches, to take advantage of all results and tools in the field of high level Petri nets like the model checking tool Maria and to prevent the explosion of the number of places. (unice.fr)
  • experimental
  • Until now, the best available experimental models of the disease were based on flooding the brain with alpha-synuclein-a protein in the brain that, when it accumulates abnormally into clumps, is linked to Parkinson's-or using neurotoxins to destroy dopamine-producing cells. (medicalxpress.com)
  • But experimental and computational scientists developed methods to sift through all the complexity and improve the illusive process of prediction with a simple model. (phys.org)
  • Munsky and colleagues report their combined experimental and modeling prediction methods in the Feb. 1, 2013 edition of Science . (phys.org)
  • characterization
  • Successful creation of OssabawLDLR -/- minipigs with evidence of enhanced dyslipidemia would justify submission of a Phase II STTR proposal focused on herd expansion, in-depth physiological characterization, and potentially commercialization of the model for sales to the biomedical research community. (sbir.gov)
  • Functional characterization of a genetic variant linked to frontotemporal dementia in a murine model reveals deficits in cerebral immune response and metabolism. (sciencemag.org)
  • approach
  • These conventional models exhibit the classic motor and behavioural symptoms of the disease, which is why they have been widely adopted by the Parkinson's field, but the sledgehammer approach to inducing the disease means the cells die-the guitar is smashed-before any of the subtle changes in the tune can be measured. (medicalxpress.com)
  • Our novel modelling approach combined odds ratios for 15 four-digit/10 two-digit HLA-DRB1 alleles, 31 single nucleotide polymorphisms (SNPs) and ever-smoking status in males to determine risk using computer simulation and confidence interval based risk categorisation. (whiterose.ac.uk)
  • The combined, data-driven approach that includes validation allows researchers to systematically determine when models are too simple, too complex or just right-the "Goldilocks" approach. (phys.org)
  • The classical approach is then to generate all Petri nets corresponding to all remaining sets of parameter values and to confront each model to the available knowledge or hypothesis. (unice.fr)
  • study
  • Learning Objective: Understand the features of the unicellular eukaryote Saccharomyces cerevisiae (baker's yeast) that make it an ideal model genetic system to study how many highly conserved eukaryotic cellular processes are carried out. (slideserve.com)
  • Although the model shows no behavioral signs of Parkinson's, their new study found the changes in biology are clear and elegantly precise. (medicalxpress.com)
  • prediction
  • We developed multiple models to evaluate each risk factor's impact on prediction. (whiterose.ac.uk)
  • HLA and smoking provided strongest prediction with good discrimination evidenced by an HLA-smoking model area under the curve (AUC) value of 0.813 in both WTCCC and UKRAGG. (whiterose.ac.uk)
  • data
  • However, despite their inefficiency, forward simulations are necessary if we wish to simulate data sets under complex and realistic biological scenarios ( e.g. , natural selection at multiple linked loci) that are difficult to model accurately using the coalescent. (genetics.org)
  • The purely additive model also fitted the data poorly. (nih.gov)
  • We thus conclude from the above exercises on the basis of comparing fledglings' morphs with their parents' morphs that we find evidence for genetic dominance of brown over grey, whereas dominance of grey and purely additive genetic effects are not supported by this data. (nih.gov)
  • It's tough to quantify what proportion of genetic tests is fulfilled via hybrid models versus traditional and DTC models, but data suggests hybrid labs are eating up a big chunk of genetic testing: A large traditional laboratory recently reported that it's conducted 4 million genetic tests since launching in 1991, while a hybrid laboratory reported it's conducted 1.4 million tests since its founding in 2004. (businessinsider.com)
  • This data was incorporated into several models. (phys.org)
  • biological
  • There is a need to model biological systems to aid in medication and drug delivery. (army.mil)
  • Because of the complexity of the interweaving retroactions, the overall behavior is difficult to grasp and the development of formal methods is needed in order to confront the supposed properties of the biological system to the model. (unice.fr)
  • modulate
  • While the interaction between tau and network excitability is robust in AD models with Aβ or tau pathology, the ability of tau to modulate neuronal excitability in models without aberrant amyloid expression or tau hyperphosphorylation remains unknown. (jneurosci.org)
  • Some of these models have been of great value to delineate potential pathogenic mechanisms that cause and/or modulate selective motor neuron degeneration. (hindawi.com)
  • symptoms
  • Evidence is presented for the effects of genetic background on PPI (and other symptoms/phenotypes), as well as for environmental influences on genetic predisposition to enhanced apomorphine (mixed dopamine receptor agonist) effects. (scirp.org)
  • researchers
  • The new model, developed by Farrer and his team could offer the precise tool that researchers have long hoped would deliver the impact of LRRK2 inhibitors and other disease-modifying drugs. (medicalxpress.com)
  • mouse
  • Whether this effect of tau removal is specific to Aβ mouse models remains to be determined. (jneurosci.org)
  • Overview of spontaneous or induced mouse models showing motor neuron degeneration. (hindawi.com)
  • During the past decade, considerable work has been carried out on several mouse mutants with genetic defects in and limited to the formation of myelin. (springer.com)
  • dopamine
  • The lab's recent work to characterize the VKI model shows it is critically important in dopamine neurotransmission, where it regulates the activity-dependent recycling of the dopamine transporter. (medicalxpress.com)
  • simulations
  • Forward simulations, in contrast, model the evolution of all the sequences in a population exactly, forward in time and generation by generation. (genetics.org)
  • diseases
  • Finding the genetic root of ocular diseases allows for more accurate and effective treatment, and Leung explores both Western and Traditional Chinese medicine. (purdue.edu)
  • This model is ready now and can be used to screen and develop chemical compounds to treat these and other age-related diseases. (healthcanal.com)
  • functional
  • Ogilvie and MacKenzie, 1980) and of gastrointestinal helminthiases in sheep (Dargie, this volume) - which have attempted to define variations in resistance in functional and genetic terms. (springer.com)
  • humans
  • DESCRIPTION (provided by applicant): Because the cardiovascular anatomy of swine is similar to humans with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine coronary arterial model is the standard for the preclinical evaluation of endovascular devices. (sbir.gov)
  • System
  • Why Use the Yeast Genetic System? (slideserve.com)
  • The stable haploid state is essential for the utility of yeast as a genetic model system. (slideserve.com)
  • Moreover, when constructing the Boolean rules for the extended system, one naturally wishes to avoid transitions to these unfeasible states, in order to obtain a biologically significant model. (springer.com)
  • aims
  • The hybrid model aims to bridge this gap by offering consumers the convenience of DTC without compromising clinical usefulness. (businessinsider.com)
  • syndrome
  • However, a marked deficiency in current pig models is that they do not present with metabolic syndrome and significant atherosclerosis, underlying conditions that can drastically alter restenosis and thrombosis. (sbir.gov)
  • The ideal pig model would be of manageable size and manifest both metabolic syndrome and atherosclerosis at an early age. (sbir.gov)
  • second
  • Genetic models of inheritance of colouration.Number of brown (red bar) and grey (grey bar) offspring colour morphs produced by different combinations of parental colour morphs (B×B, B×G and G×G). The first columns show the observations in the field, second, third and fourth columns show the expected number of offspring colour morphs according to models with brown dominance, grey dominance and an additive genetic model, respectively. (nih.gov)
  • possible
  • Their probes turned up a few possible genetic suspects , but the findings were contradicted by those from other studies. (scientificamerican.com)
  • Munsky notes that it would be impossible to combine the infinite possible reactions at different scales into a single computational model. (phys.org)