• In silico modeling predicted differential binding of TCDD and leflunomide to the AHR paralogues. (oregonstate.edu)
  • In this work, several in silico models have been built with two classes of proteasome inhibitors (PIs) by using 3D-QSAR, homology modeling, molecular docking and molecular dynamics (MD) simulations. (fdocument.org)
  • In all contexts where today only experimental structures provide solid foundations, it would allow users to use quickly in-silico protein models safely: structural drug design, protein function analysis, interacting, antigenic behaviors and the rational conception of proteins with increased stability or novel functions. (rjpdft.com)
  • Several reviews and reports present the advantages and limitations of the currently available algorithms and software for in silico modelling of the drug dissolution/bioavailability, oral absorption rate/fraction, volume of distribution, path- ways, affinities or rates of metabolism, renal excretion rate as well as affinity for specific transporters [3-20]. (cdc.gov)
  • The sequences were analyzed in silico by BLAST searching for homologies with other DNAs deposited in the local and public data bases. (who.int)
  • Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence. (wikipedia.org)
  • Homology modeling can produce high-quality structural models when the target and template are closely related, which has inspired the formation of a structural genomics consortium dedicated to the production of representative experimental structures for all classes of protein folds. (wikipedia.org)
  • Because it is difficult and time-consuming to obtain experimental structures from methods such as X-ray crystallography and protein NMR for every protein of interest, homology modeling can provide useful structural models for generating hypotheses about a protein's function and directing further experimental work. (wikipedia.org)
  • Data derived from cephalopod studies can be used to compare and contrast known mechanisms underlying the development of analogous vertebrate structures. (europa.eu)
  • Homology modelling is sufficient to produce the atomic resolution structures of protein drug targets found in the human body. (pte.hu)
  • The course includes a series of biophysical research-related topics including practical introductions to the software tools available for the visualization and modeling of biomolecular structures and the bioinformatic analysis of biomolecular sequence and structural homology. (columbia.edu)
  • These methods aim to develop and model increasingly accurate three-dimensional structures of yet uncrystallized therapeutically relevant proteins e.g. (uth.edu)
  • Here, I will discuss the enhancement and validation of the ligand-steered modeling, originally developed by Dr. Claudio Cavasotto, via cross modeling of the newly crystallized GPCR structures. (uth.edu)
  • In cases where there are difficulty in obtaining experimental structures for a given protein, the comparative modeling of protein structures offers an efficient alternative to determining experimental structure. (rjpdft.com)
  • 14. Sander C, Schneider R. Database of homology-derived protein structures and the structural meaning of sequence alignment. (rjpdft.com)
  • To determine by experimental methods a representative set of macromolecular structures, including medically important human proteins and proteins from important pathogens and model organisms. (nih.gov)
  • Methods for homology-based modeling, related methods and validation of modeled structures. (nih.gov)
  • Pan-genome approaches afford the discovery of homology relations in a set of genomes, by determining how some gene families are distributed among a given set of genomes. (biomedcentral.com)
  • A challenge on this field is that of designing fast and adaptive similarity measures in order to find a suitable pan-genome structure of homology relations. (biomedcentral.com)
  • Homologous genes can be distinguished into paralogous, when homology occurs within the same genome, or orthologous, when homology occurs between different genomes. (biomedcentral.com)
  • Topics covered include various high-throughput genomics technologies (genome sequencing, DNA microarrays, proteomics), quantitative modeling of transcriptional and post-transcriptional regulatory networks, synthetic biology, and the world of RNA structure, dynamics, and function. (columbia.edu)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • These include the construction of synchrotrons and high-field NMR instruments, the MAD method of phase determination, high throughput cloning and recombinant expression, a flood of information from genome sequencing projects, and new bioinformatic methods for fold assignment, model building, and prediction of function. (nih.gov)
  • The sequence alignment and template structure are then used to produce a structural model of the target. (wikipedia.org)
  • These results show that human brain organoids can be applied as an in vitro model for CNS drug screening to evaluate structural, cellular, and molecular changes in the normal brains or brains of patients with neuropsychiatric disorders after drug treatments. (frontiersin.org)
  • The lack of structural information on PI3KC2α and related class II PI3Ks has also greatly hampered the development of isoform-selective pharmacological inhibitors for clinical applications. (nature.com)
  • For each of these factors we will construct isogenic non-polar mutations in the structural gene and test the mutants for decreased adherence in differential intestinal epithelial cell lines, freshly harvested human intestinal epithelial cells, and in a gnotobiotic piglet model of disease. (usda.gov)
  • Normally a model with an estimated RMSD of 1 to 4 to the experimental structure may be obtained if you find a structural template that is more than 50% identical to the query sequence. (rjpdft.com)
  • Development of methods for Structural Genomics. (nih.gov)
  • The integration of computational and experimental strategies has been of great value in the identification and development of novel promising compounds. (mdpi.com)
  • The Pharmacoinformatics in practice course offers the students an insight into the theoretical and practical aspects of computational molecular modelling. (pte.hu)
  • To attach the drug to its experimentally available (or homology modelled) structure, computational docking is widely used. (pte.hu)
  • In addition to the computational framework in our group, we also carry out different wet-lab experimental techniques to validate our modelling hypothesis and optimize our calculations. (ualberta.ca)
  • Five light-harvesting genes of Rice are identifying by using the Arabidopsis thaliana model plant in computational biology/ bioinformatics databases. (biomedres.us)
  • Our work is based on a variety of computational tools, ranging from classical (Monte-Carlo schemes within empirical potential approaches, Molecular Dynamics), semi-empirical (parametrized tight-binding schemes), quantum mechanical (implementations of the density functional theory also in conjunction with non-equilibrium Greens functions for quantum transport), and multiscale methodologies (coupled Langevin molecular-dynamics and lattice-Boltzmann method for modeling molecular motion in a fluid solvent). (uni-stuttgart.de)
  • We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)
  • This study evaluated the empirical studies of the Experimental School for Primates (ESP) in order to verify the consistency between their theoretical and empirical practices, especially the assumption of homology of behavioral processes among capuchin monkeys (Sapajus spp. (bvsalud.org)
  • It was noted that there are no empirical data supporting the homology proposal in the ESP theoretical proposition. (bvsalud.org)
  • We leverage a number of proprietary immunization strategies for tough target antibody discovery along with a suite of premium downstream characterization assays to ultimately deliver a panel of fully characterized lead molecules ready for development. (news-medical.net)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of preclinical data that supports the targeted, prophylactic immunosuppression regimen in the ongoing pheEDIT gene editing clinical trial in adults with phenylketonuria (PKU) and juMPStart gene therapy trial in adults with Hunter syndrome (MPS II). (advfn.com)
  • We are pleased to share our work outlining the impact immunosuppression regimens had on outcomes following AAVHSC dosing in NHPs, as it contributes to a key area of research in the gene therapy and gene editing field," stated Albert Seymour, Ph.D., President and Chief Executive Officer of Homology Medicines. (advfn.com)
  • It is suggested: 1) the development of empirical studies that validate the homology of behavioral processes among some human and capuchin monkeys repertoires, and 2) to initiate the application of basic research findings from ESP to develop procedures to teach relational repertoires for people with cognitive development delay. (bvsalud.org)
  • Protein drugs are increasingly important in drug development worldwide due their high specificity, potency, and low toxicity. (lu.se)
  • Homology also shared additional details of the optimized, in vivo gene therapy candidate HMI-204 for metachromatic leukodystrophy (MLD) during the 19th Annual WORLDSymposium™ Meeting. (advfn.com)
  • Dr. Seymour continued, "Also at WORLD, we presented the details of our optimized gene therapy development candidate for MLD, which showed the ability to cross the blood-brain-barrier following a single I.V. administration in the murine disease model and resulted in levels of enzyme activity predicted to lead to efficacy in vivo. (advfn.com)
  • Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
  • We propose to test whether quorum sensing is active in vivo by constructing an O157:H7 derivative that no longer responds to quorum sensing and testing it for colonization in a pig model. (usda.gov)
  • Homology candidate relations are integrated into a global network and groups of homologous genes are extracted by applying a community detection algorithm. (biomedcentral.com)
  • Modelling and simulation (M&S) can be a very useful strategy to mitigate risks and to make better-informed decisions. (pharmaceutical-business-review.com)
  • Model of Human Butyrylcholinesterase Tetramer by Homology Modeling and Dynamics Simulation. (acs.org)
  • PBBM / PBPK modeling & simulation software package which simulates all major dosing routes and drug-drug interactions (DDIs) in virtual human & animal population groups. (simulations-plus.com)
  • Flagship machine learning platform for ADMET modeling with extended capabilities for data analysis, metabolism prediction, high-throughput pharmacokinetic simulation (HTPK), and AI-driven drug design. (simulations-plus.com)
  • A detailed modeling & simulation program for in vitro metabolism & transport studies. (simulations-plus.com)
  • Based on the frequency of occurrence of molecular fragments (CH3, CH2, CH, C, C¼C, H, benzene ring and H in benzene ring structure) and exposure conditions, the available QSAR-PBPK models facilitate the simulation of tissue and blood concentrations for some inhaled volatile organic chemicals. (cdc.gov)
  • The overall goals of this program were to produce and distribute mutant models for infertility and to investigate underlying causes in order to identify new genes and pathways contributing to reproductive function. (jax.org)
  • The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)
  • Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)
  • In addition, we propose that Ppargc1a might play a role in regulating postnatal scleral development by interacting with a different set of genes at different scleral growth stages. (molvis.org)
  • All genes mapped within or near chromosomal locations with previously established homology to the corresponding human gene locations based on canine:human chromosomal synteny. (upenn.edu)
  • Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
  • Relative levels of gene expression throughout development were determined by quantitative polymerase chain reaction (PCR) analysis and in cases where sufficient specific gene sequence was acquired, ribonucleic acid (RNA) probes were generated to evaluate the spatial expression patterns during the period of organogenesis. (europa.eu)
  • Canine models can serve as large animal models intermediate between mouse and man for both gene discovery and the development of novel cataract therapies. (upenn.edu)
  • In this paper a homology model of PvLAP was generated using MODELLER v9.15. (simulations-plus.com)
  • 8. Homology model building: UniProt Database, BLAST search, Modeller program package. (pte.hu)
  • Like other methods of structure prediction, current practice in homology modeling is assessed in a biennial large-scale experiment known as the Critical Assessment of Techniques for Protein Structure Prediction, or CASP. (wikipedia.org)
  • Two of these factors have homology to previously described adhesins in other enteric pathogens and the third factor has no obvious homology to previously described adhesins. (usda.gov)
  • Hemodynamics and Anatomy of Elastase-Induced Rabbit Aneurysm Models: Similarity to Human Cerebral Aneurysms? (ajnr.org)
  • This Special Issue, "Plant Cell Wall Proteins and Development", will cover a selection of recent research topics in the field of cell wall biology focused on cell wall proteins and their roles during development. (mdpi.com)
  • The proteins should be amenable to high-throughput structure determination and/or should provide suitable targets to motivate new technology development. (nih.gov)
  • Siah proteins have been described to be both oncogenic and tumor suppressive in a variety of patient cohort studies and animal cancer models. (aacrjournals.org)
  • Topics covered will include high-throughput assay development, screening, chemical library creation, high-throughput chemistry, affinity purification of target proteins and target validation, protein microarrays, molecular evolution, protein engineering and synthetic biology. (columbia.edu)
  • Build innovative computer models for the immune checkpoints proteins. (ualberta.ca)
  • Build comprehensive models for protein ion channels and membrane proteins. (ualberta.ca)
  • The quality of the homology model is dependent on the quality of the sequence alignment and template structure. (wikipedia.org)
  • even the quaternary structure of a protein may be difficult to predict from homology models of its subunit(s). (wikipedia.org)
  • The method of homology modeling is based on the observation that protein tertiary structure is better conserved than amino acid sequence. (wikipedia.org)
  • The ligand-steered models were able to model, reasonably reproduce binding sites and the co-crystallized native ligand poses of the β 2 adrenergic and Adenosine 2A receptors using a single template structure. (uth.edu)
  • These models were validated by their ability to rationalize structure activity relationship data of two, inverse agonist and agonist, series of compounds. (uth.edu)
  • The ultimate goal of protein modeling is to predict a structure from its sequence with accuracy equivalent to the best experimentally obtained results. (rjpdft.com)
  • Homology Modeling and Generation of 3D-structure of Protein. (rjpdft.com)
  • 11. Szklarz, G.D., Halpert, J.R. Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450. (rjpdft.com)
  • To provide models based on sequence homology to significantly extend the coverage of structure space. (nih.gov)
  • With new articles being added to these collections on a daily basis, the collections serve as an ideal tool to keep researchers updated with new developments in the respective fields. (eurekaselect.com)
  • The students will get familiar with such programes and file format that are both used by industrial drug development and scientific researchers today. (pte.hu)
  • Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. (mdpi.com)
  • Development of homology modeling methods will remain an area of active research. (uth.edu)
  • 9. Validation of the homology model: Procheck, Ramachandran plot. (pte.hu)
  • Physiologically-based pharmacokinetic (PBPK) modelling refers to the development and evaluation of mathematical descriptions of the ADME of chemicals in biota based on proven/hypothetical mechanistic determinants [21]. (cdc.gov)
  • Quantitative Systems Toxicology (QST) software designed to be used during drug development to provide deeper insight into the mechanisms responsible for observed drug-induced liver injury (DILI) responses. (simulations-plus.com)
  • Quantitative Systems Pharmacology (QSP) software for mechanistic mathematical modeling of nonalcoholic fatty liver disease (NAFLD. (simulations-plus.com)
  • Quantitative Systems Pharmacology (QSP) software for mechanistic mathematical modeling of interstitial lung disease (ILD) associated with system sclerosis (SSc. (simulations-plus.com)
  • PBPK models essentially represent a systems biology approach to the study of ADME and are increasingly finding use in screening-level as well as quantitative risk assessments to reduce the uncertainties associated with interspecies, route-to-route, and high-dose to low-dose extrapolations of tissue dose of chemicals [21-24]. (cdc.gov)
  • The ahr2(hu3335) functional knockout line expands the experimental power of zebrafish to unravel the role of the AHR during development, as well as highlights potential activity of the other AHR paralogues in ligand-specific toxicological responses. (oregonstate.edu)
  • OBJECTIVES: Assessing the developmental neurotoxicity (DNT) of GenX or ADONA using zebrafish (Danio rerio) as an animal model. (cdc.gov)
  • Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. (cdc.gov)
  • In this regard, SARs, QSARs and QPPRs are potentially useful for computing the chemical-specific input parameters of PBPK models. (cdc.gov)
  • The application domain of existing QSARs for developing PBPK models is limited, due to lack of relevant data for diverse chemicals and mechanisms. (cdc.gov)
  • Even though this approach is conceptually applicable to non-volatile and high molecular weight organics as well, it is more challenging to predict the other PBPK model parameters required for modelling the kinetics of these chemicals (particularly tissue diffusion coefficients, association constants for binding and oral absorption rates). (cdc.gov)
  • Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors. (acs.org)
  • The demonstrated involvement of any of the three novel colonization factors in intestinal adherence would provide new targets for vaccine development. (usda.gov)
  • The presence of these cellular cartilaginous tissues outside the chordate lineage may indicate a common origin of cartilage as a metazoan tissue type (homology), or alternatively highlights constraints that animals face in the construction of internal cellular endoskeletons (convergence). (europa.eu)
  • Since models are limited to study the mechanism of the neurotoxicity of tranylcypromine, here we utilized an in vitro brain organoid culture system which mimics neurogenesis experimentally to investigate the mechanisms by studying the effect of brain development of tranylcypromine and monitoring the brain damage of different concentrations. (frontiersin.org)
  • As a result of this study, an investment model was developed in a shape of a cluster. (helsinki.fi)
  • The recent development of canine genomic resources make canine models a practical and valuable resource for the study of human hereditary cataracts. (upenn.edu)
  • The study resulted in two types of satisfactory 3D-QSAR models, i.e. , the CoMFA model (Q 2 = 0.462, R 2 pred = 0.820) for epoxyketone inhibitors (EPK) and the CoMSIA model (Q 2 = 0.622, R 2 pred = 0.821) for tyropeptin-boronic acid derivatives (TBA). (fdocument.org)
  • This study sought to elucidate phenotypic differences between the two diagnoses, in order to optimise patient management and pubertal development. (bvsalud.org)
  • The following aspects were analyzed a) the origin of the objectives and procedures of the studies, 2) whether the objectives were achieved or not, and 3) whether in the studies of ESP the issue of animal model and/or applicability of the procedures used to study humans were discussed. (bvsalud.org)
  • The general objectives of this study are related to the development and improvement of simple, rapid and reliable DNA tests for the diagnosis of cutaneous leishmaniasis in order to improve the management of patients and to provide a more accurate reporting, alert or counselling to the leishmanioses control program. (who.int)
  • Easy, fast, and powerful tool for parameter estimation in non-linear mixed effect models, model diagnosis and assessment, and advanced graphical representation. (simulations-plus.com)
  • Upon further assessment of their domain association, conservation profile, homology models and inter-atomic interaction, the mutant F389V was considered as the most impactful. (biorxiv.org)
  • In this assessment, the impact of various light on seed development and interconversion of phytochrome, production of biomass, seedling length on rice varieties Shandar, and IRR-6 were observed. (biomedres.us)
  • Our results advance our understanding of PI3K biology and pave the way for the development of specific inhibitors of class II PI3K function with wide applications in biomedicine. (nature.com)
  • Isoform-specific pharmacological inhibitors of class I PI3K activity have undergone clinical development as anticancer therapeutics and for the treatment of human disorders caused by PI3K pathway hyperactivation. (nature.com)
  • E3 ubiquitin ligases are therefore a more specific and effective target for drug development in comparison with general proteasome inhibitors to reduce treatment side effects and increase efficacies ( 1 ). (aacrjournals.org)
  • The chief inaccuracies in homology modeling, which worsen with lower sequence identity, derive from errors in the initial sequence alignment and from improper template selection. (wikipedia.org)
  • Moreover, protein models can only be obtained if experimental techniques fail. (rjpdft.com)
  • Our discovery workflow capitalizes on a proprietary hyperimmune mouse model that has been engineered for epitopic diversity and optimized response to traditionally difficult targets. (news-medical.net)
  • Due to our unique combination of engineered mouse models, proprietary immunization techniques, and premium high-throughput and high-content screening capabilities, we specialize in high homology targets, constrained epitope targeting, and tough cell surface targets, all of which exist within the immuno-oncological antibody research space. (news-medical.net)
  • These data also are helpful in guiding outbreak investigations and identifying targets for development of diagnostic assays and antivirals. (cdc.gov)
  • Build robust mathematical models for different immune checkpoints pathways. (ualberta.ca)
  • In the field of molecular modeling , docking is a method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex . (wn.com)
  • Today, as a variety of docking algorithms are available, an understanding of the advantages and limitations of each method is of fundamental importance in the development of effective strategies and the generation of relevant results. (mdpi.com)
  • Next, the application of this method to develop high-quality homology models of Cannabinoid Receptor 2, an emerging non-psychotic pain management target, is discussed. (uth.edu)
  • Animal models provide a mechanism for fundamental studies of the coupling between hemodynamics and pathophysiology in diseases such as saccular aneurysms. (ajnr.org)
  • 16 While in vitro systems such as parallel plate and T-chamber flow systems provide an opportunity for highly controlled investigations of cellular response to various types of hemodynamic stresses, such model systems are limited to short-duration studies. (ajnr.org)
  • 17 Furthermore, those systems typically only provide information about an isolated layer of endothelial cells, though recent coculture models have yielded results for the coupled response of multiple wall components. (ajnr.org)
  • 18 In contrast, animal models provide a mechanism for fundamental studies of the impact of chronically altered WSS on the intact vascular wall. (ajnr.org)
  • Further improvement in the timeliness of feedback through the development of a NESS website to allow access to historic data and to the information on circulating serotypes can provide additional incentives to public health laboratories to participate in NESS. (cdc.gov)
  • Combining these data with information about avian migratory patterns, landscape characteristics, and weather conditions, over space and time, will provide the foundation for developing spatial analytical and forecasting models to assess the risk for human illness. (cdc.gov)
  • Siah ubiquitin ligases play important roles in a number of signaling pathways involved in the progression and spread of cancer in cell-based models, but their role in tumor progression remains controversial. (aacrjournals.org)
  • CeGLD-3 contains four K-homology (KH) RNA-binding domains, which are divergent KH domains that lacks the RNA-binding GXXG motif. (nih.gov)
  • The model organism medaka comprises several species and deeply divergent lineages from the Oryzias latipes species complex. (elifesciences.org)
  • Compared with conventional mice model, this model can recapitulate the human brain development in vitro ( 20 ). (frontiersin.org)
  • The cerebral organoids, which can mimic the endogenous development of human brain, have been applied to different studies as in vitro models for a wide range of brain diseases ( 16 , 21 , 22 ). (frontiersin.org)
  • Clustering has become to be a crucial feature in nation's economic development. (helsinki.fi)
  • The different types of abiotic factors play an important role in the growth and development of plants, the light is one of the crucial abiotic factors that enhance plant development. (biomedres.us)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • However, animal models lack human genetic features and some brain region identities, such as outer subventricular zone, making it hard to figure out how these drugs affect central nervous system ( 7 , 8 ). (frontiersin.org)
  • Mutagenesis-generated mouse models of human infertility with abnormal sperm. (jax.org)
  • In this work, we evaluated the capability of an elastase-induced saccular aneurysm model in rabbits to reproduce the anatomic and hemodynamic features typical for human intracranial aneurysms. (ajnr.org)
  • Geometric features, including aneurysm height, width, neck diameter, aspect ratio, and NSI of all 51 rabbit aneurysm models fell within the range reported for human IAs. (ajnr.org)
  • Most hemodynamic and geometric features in a commonly used elastase-induced rabbit saccular aneurysm model are qualitatively and quantitatively similar to those seen in large numbers of human cerebral aneurysms. (ajnr.org)
  • A possible pathway that contributes to the postnatal development of the sclera was investigated using Ingenuity Pathway Analysis software. (molvis.org)
  • Preprint arXiv:1108.3206v2 Modeling and frequency domain analysis of nonlinear compliant joints for a passive dynamic swimmer ! (octave.org)
  • Cephalopods offer enormous opportunities for studies of the developmental genetics of complex organ systems within an invertebrate model. (europa.eu)
  • They also performed better than the choice of template, and crude models in a small scale high-throughput docking experiments and compound selectivity studies. (uth.edu)
  • Improving experimental drug success rate and accelerating clinical development are top priorities for pharmaceutical and biotech companies. (pharmaceutical-business-review.com)
  • The safety, efficacy, and side effects of different drugs have been extensively studied using current research models ( 6 ). (frontiersin.org)
  • In 2001 he got the Corvin Hansch Award from the Molecular Modeling Society, in 2005 he got the Research Award from Societ Chimica Italiana, in 2009 he was the recipient of the Novartis Research Award and finally in 2014 he was the recipient of the gold medal Angelo Mangini award from organic chemistry division of the Italian Chemical Society. (ldorganisation.com)
  • The concern about GenX and ADONA is relatively recent, so there is a big need to characterize the risk of those chemicals using animal models. (cdc.gov)
  • Therefore, SIV infection is an important animal model of AIDS. (cdc.gov)
  • The motor domain of MYH8 was modeled in order to know what are the interactions altered in the mutant protein. (eurekaselect.com)
  • However, bortezomib blocks all protein proteolysis by the proteasome without discrimination, causing various systemic toxicities and the development of resistance ( 1 ). (aacrjournals.org)