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  • Imaging
  • These models provide clinicians with valuable quantitative data not available from medical imaging alone. (purdue.edu)
  • It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. (onlinejacc.org)
  • The adaptation of ultrasound for imaging murine hearts, for example, has allowed characterization of the developing and adult rodent heart, making it an essential tool for the study of developmental biology and cardiovascular disease. (onlinejacc.org)
  • Hence, we present the first study aimed to directly compare this novel imaging modality with both conventional echocardiography and conductance catheter (CC) measurement techniques using an established murine model of ischemic heart disease. (onlinejacc.org)
  • numerical
  • While the main focus of our studies is on numerical simulations of the flow in cerebral aneurysms, we are also involved in modeling blood flow in other vascular territories as well as in design and optimization of biomedical devices, such as a Chemofilter device removing chemotherapy drugs from blood. (purdue.edu)
  • Feintuch A, Ruengsakulrach P, Lin A et al (2007) Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound and numerical modeling. (springer.com)
  • study
  • Eligibility criteria for study selection Studies describing the development or external validation of a multivariable model for predicting CVD risk in the general population. (bmj.com)
  • Our study demonstrates how pulmonary expression patterns are influenced by cardiovascular disease and provides insights into the mechanisms of ozone susceptibility differences among disease models. (epa.gov)
  • The study involved the application of current CVD risk models to the THIN dataset. (uea.ac.uk)
  • Researchers have developed a more accurate way to predict the risk of developing cardiovascular disease among women, according// to a study in the issue of JAMA. (bio-medicine.org)
  • A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance. (cellml.org)
  • This study establishes and validates a risk model to predict secondary cardiovascular events and cardiovascular death in outpatients with established atherothrombotic disease. (acc.org)
  • This is a well-designed contemporary investigator-initiated population study that assessed risk of future cardiovascular events among patients with one or more vascular disease event types. (acc.org)
  • The zebrafish ( Danio rerio ) has become a popular vertebrate model organism to study organ formation and function due to its optical clarity and rapid embryonic development. (biologists.org)
  • parameters
  • When cardiovascular parameters of age- and sex-matched A/J and C57BL/6J inbred mice were compared the C57BL/6J mice demonstrated eccentric physiologic ventricular hypertrophy, increased ventricular function, lower heart rates, and increased exercise endurance. (springer.com)
  • Toward this goal, a low-order theoretical model is presented, in which LV shape is represented using a small number of parameters, allowing rapid computational simulations of LV dynamics. (deepdyve.com)
  • Model parameters are largely based on literature values. (cellml.org)
  • pathways
  • The patient-oriented modeling approach has proven useful, as it has enabled a systematic observation on the emergence of various cardiovascular pathways based on patient attributes incorporated in the model. (uib.no)
  • heart
  • To understand these relationships, and to establish models in which the pathogenic processes can be studied longitudinally, it is necessary to direct the heart to stably synthesize, in the absence of other pleiotropic changes, the candidate protein. (revespcardiol.org)
  • This database contains CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients with heart failure. (nih.gov)
  • The Portuguese Heart Foundation funded a PhD scholarship to undertake the work on developing a CVD model for Portugal. (europa.eu)
  • This lumped pulsatile cardiovascular model consists of eight compartments of the body that include pumping heart, the systemic circulation, and the pulmonary circulation. (koreascience.or.kr)
  • The pumping heart is modeled by the time-dependent linear curves of compliances in the heart. (koreascience.or.kr)
  • mechanisms
  • Classically, pharma, biotech, and device researchers have relied on rodent models to discover and validate disease targets and mechanisms, as well as for the preclinical development of therapeutics. (mpiresearch.com)
  • Cardiovascular disease remains the leading cause of death in the United States and worldwide, indicating the continued need for basic science research into disease mechanisms and the development of therapeutics. (heart.org)
  • 1 Cardiovascular disease modeling using iPSCs has thus shed light on a multitude of disease mechanisms, and provided readily translatable insights into therapeutic resolution to disease progression. (heart.org)
  • We examined expressions of CVD genes in the lungs of rat models at baseline and following ozone exposure to reveal potential mechanisms of disease etiology and susceptibility to ozone. (epa.gov)
  • Cardiovascular disease states are difficult to diagnose due to a variety of underlying dysfunctions combined with reflex mechanisms. (canterbury.ac.nz)
  • strains
  • A word of caution, particularly when highly inbred mouse strains are used to develop transgenic models - not all strains of a particular species are created equal. (springer.com)
  • Naturally occurring variation in cardiovascular traits among inbred mouse strains. (springer.com)
  • algorithms
  • The authors note that although understanding of cardiovascular disease has changed dramatically in the past half-century, the algorithms (predictive models) for women are largely unchanged from those recommended 40 years ago. (bio-medicine.org)
  • Paul M Ridker, M.D., M.P.H., from Brigham and Women's Hospital, Boston, and colleagues, developed and validated cardiovascular risk algorithms for women based on a large set of traditional and new risk factors. (bio-medicine.org)
  • In these analyses, large proportions of women with 10-year risk estimates of 5 percent to less than 10 percent or of 10 percent to less than 20 percent based on current ATP-III (Adult Treatment Panel III) risk scores were reclassified at either higher or lower risk of total cardiovascular disease when either of the new algorithms was used," the researchers found. (bio-medicine.org)
  • Simple algorithms were developed for prediction of overall cardiovascular events and for cardiovascular death. (acc.org)
  • pulmonary
  • This abstract characterizes the baseline pulmonary complications as determined by expression analysis associated with genetic cardiovascular disease and shows that vascular response genes are differentially altered by ozone. (epa.gov)
  • cellular
  • iPSC technology is a valuable platform for modeling cardiovascular disease because the cellular source is human in origin, often reprogrammed directly from the somatic cells of an affected individual, the cells can be differentiated into any somatic cell type following reprogramming, meaning cardiomyocytes, vascular smooth muscle cells, and endothelial cells can each be investigated, and the cellular population can self-renew, allowing for an essentially endless supply of cells. (heart.org)
  • diabetes
  • The individual risk factor weighting is intuitive, but the body mass index of 2 , which increases risk comparable to a cardiovascular event in the past year and diabetes. (acc.org)
  • QRISK
  • Over the past two decades, numerous prediction models have been developed, which mathematically combine multiple predictors to estimate the risk of developing CVD-for example, the Framingham, 3 4 5 SCORE, 6 and QRISK 7 8 9 models. (bmj.com)
  • We have assessed 3 models for CVD risk using the THIN database: the standard Framingham model, and the more recent ASSIGN and QRISK models. (uea.ac.uk)
  • The latest model, QRISK, was developed using a primary care database and our work has reinforced the current debate over analysis methodology in such studies. (uea.ac.uk)
  • characterization
  • In the current literature, models of blood flow applied to the characterization of atherosclerotic plaques consider blood as a Newtonian fluid because of the characteristic length of the domain . (omicsonline.org)
  • Reduction
  • Participants from the prospective REduction of Atherothrombosis for Continued Health (REACH) Registry provided a global outpatient population with known cardiovascular disease at entry. (acc.org)
  • approaches
  • The two principal approaches to studying cardiovascular disease with iPSCs are to reprogram the somatic cells from an individual affected by the disease, thus creating disease-specific patient-derived iPSCs, or to employ genetic editing technologies on wild type control iPSCs to introduce disease phenotypes. (heart.org)