• Biomedical modeling - the process of building complex 3D models of body parts through a computer imaging process which allows for perfectly shaped acrylic or titanium inserts to be constructed to replace broken bones or other body parts. (wikipedia.org)
  • The goal is to create accurate real-time models of a system's response to environmental and internal stimuli, such as a model of a cancer cell in order to find weaknesses in its signalling pathways, or modelling of ion channel mutations to see effects on cardiomyocytes and in turn, the function of a beating heart. (wikipedia.org)
  • Studies in a wide variety of organisms have produced a general model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases. (duke.edu)
  • spatial effects are investigated by developing models that highlight the consequences that geographical restriction and species mobility may have on population development. (google.co.uk)
  • This unit builds on the foundation provided in Quantitative Methods in Biology to familiarise students with more advanced model building techniques including generalised linear, mixed and additive models, regression trees, bootstrapping methods, and non-linear regression. (edu.au)
  • The high growth rates, cell yields of the cultures, and the constitutive expression of an impressively efficient natural competence apparatus, amongst other properties, make some strains of the genus excellent laboratory models to study the molecular basis of thermophilia. (diva-portal.org)
  • Driven by the rapid development of the technology available to scientists in the laboratory, the quantity, scope and resolution of biological data continues to grow at an accelerating pace. (ddw-online.com)
  • Despite ever-growing computing power, computer simulations cannot be used for the modeling of large biomolecular systems over time scales long enough to be of biological interest. (uiuc.edu)
  • As reported recently , we have significantly improved the model for simulations of protein folding by re-parameterizing hydration of protein backbones, a critical factor for controlling the balance between unfolded and folded states of proteins. (uiuc.edu)
  • R esearchers in biology and the life sciences have yet to embrace modelling in the way that their peers in the fields of physics, chemistry and engineering have done. (ddw-online.com)
  • Modelling can provide the kind of intellectual frameworks needed to transform data into knowledge, yet very few modelling methodologies currently exist that are applicable to the large, complex systems of interest to biologists. (ddw-online.com)
  • This will require the development of modelling platforms that allow biological systems to be described using idioms familiar to biologists, that encourage experimentation and that leverage the connectivity of the internet for scientific collaboration and communication. (ddw-online.com)
  • There are some very good reasons for this, not the least of which is that the systems of interest to biologists tend to be far more refractory to modelling than the systems that are studied in these other fields. (ddw-online.com)
  • Model interpretations of the respirometric experiments are used to define the fate of slowly biodegradable COD. (iwaponline.com)
  • We quantify by means of global relative errors the extent to which the simplified models reproduce the main features of the original system dynamics and apply global sensitivity analysis to test the influence of model parameters on the errors. (springer.com)
  • The analysis of the sub-model dynamics allows us to identify the source of circadian oscillations. (springer.com)
  • Travelling wave solutions of the space and time fractional models for non-linear blood flow in large vessels and Deoxyribonucleic acid (DNA) molecule dynamics defined in the sense of Jumarie's modified Riemann-Liouville derivative via the first integral method are presented in this study. (aimsciences.org)
  • This paper reviews the framework of the endogenous decay model and summarizes the necessary COD fractionation and the kinetic information to be incorporated in this model as applied to a meat processing effluent. (iwaponline.com)
  • The input is a paragraph describing a biological process, and the goal is to answer questions that require an understanding of the relations between entities and events in the process. (semanticscholar.org)
  • This dissertation presents a continuum treatment of growth in biological tissue developed within the context of modern mixture theory. (umich.edu)
  • Driving forces in a biological context are usually referred to as rhythms, pulses or clocks. (uleth.ca)
  • The resulting context-free grammars are used to estimate structural pieces within biological sequences, which can in-turn be used as supplemental information to help guide various sequence analysis algorithms. (unl.edu)
  • INTRODUCTION: We previously reported models that characterized the synergistic interaction between remifentanil and sevoflurane in blunting responses to verbal and painful stimuli. (duke.edu)
  • Student performance is assessed by essays, mini projects, oral and poster presentations, a computer programming and biological database task, web development, the research project and an end-of-year viva. (ucl.ac.uk)
  • The method we've developed should expedite the development of more accurate parameters, which can be used to create more precise and predictable models of oscillatory biological systems. (bio-medicine.org)
  • Researchers at North Carolina State University have developed a new method for estimating the parameters used in such models which may advance modeling in research areas ranging from cancer to fertility. (bio-medicine.org)
  • Researchers then try to identify the parameters that would result in the closest 'fit' to those concentrations when plugged into the model. (bio-medicine.org)
  • The feasibility of our approach is demonstrated by the analysis of stability and bifurcations of several discrete biological models using implementations of algebraic methods. (springer.com)
  • The coarse-grained models are limited, therefore, in their use in studies of folding, aggregation, large conformational changes of proteins, or conformational features of intrinsically disordered proteins. (uiuc.edu)
  • Furthermore, the availability of plasmids and up to four thermostable antibiotic selection markers allows its use in physiological studies as a model for ancient bacteria. (diva-portal.org)
  • This concept is applied to solve several problems involving biological sequence analysis including multiple sequence alignment and phylogenetic clustering. (unl.edu)
  • An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. (duke.edu)
  • The results are used to construct a grammar based sequence distance metric which can be used to compare biological sequences by comparing their inferred grammars. (unl.edu)
  • The simplified models are easier to analyse, while retaining the main features of the original ones and their biological significance. (springer.com)
  • By following this idea, a hybrid model with its components represented at different levels of details has been developed. (uiuc.edu)
  • A dynamic computer model of intracellular signaling was the basis for Merrimack Pharmaceuticals to discover the target for their cancer medicine MM-111. (wikipedia.org)