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  • platform for modeling cardi
  • iPSC technology is a valuable platform for modeling cardiovascular disease because the cellular source is human in origin, often reprogrammed directly from the somatic cells of an affected individual, the cells can be differentiated into any somatic cell type following reprogramming, meaning cardiomyocytes, vascular smooth muscle cells, and endothelial cells can each be investigated, and the cellular population can self-renew, allowing for an essentially endless supply of cells. (heart.org)
  • phenotypes
  • In this series, we compare and contrast the top mouse models for metabolic diseases as well as discuss how these models recapitulate different phenotypes, and how diet and the environment impact disease progression. (jax.org)
  • Baseline differences in pathology of the heart, lung and kidney, antioxidants and gene expression, along with levels of systemic inflammation and coagulation markers were analyzed to understand distinct disease-related phenotypes. (epa.gov)
  • primary
  • The latest model, QRISK, was developed using a primary care database and our work has reinforced the current debate over analysis methodology in such studies. (uea.ac.uk)
  • mechanisms
  • Cardiovascular disease remains the leading cause of death in the United States and worldwide, indicating the continued need for basic science research into disease mechanisms and the development of therapeutics. (heart.org)
  • Classically, pharma, biotech, and device researchers have relied on rodent models to discover and validate disease targets and mechanisms, as well as for the preclinical development of therapeutics. (mpiresearch.com)
  • Cardiovascular disease states are difficult to diagnose due to a variety of underlying dysfunctions combined with reflex mechanisms. (canterbury.ac.nz)
  • cardiology
  • Leading researchers in engineering and cardiology at the Graeme Clark Institute are collaborating to develop medical technologies which will lead to optimum solutions for coronary diseases that affects many people every year. (edu.au)
  • consequent
  • Objectives To estimate the potential impacts of different Brexit trade policy scenarios on the price and intake of fruits and vegetables (F&V) and consequent cardiovascular disease (CVD) deaths in England between 2021 and 2030. (bmj.com)
  • modalities
  • MPI Research has established swine models of myocardial infarction and congestive heart failure, and has used these models to cost-effectively and quickly assess modalities from small-molecule therapeutics to biologics, devices, and stem cell regenerative therapies. (mpiresearch.com)
  • Developed methodology to reconstruct three dimensional computer models of arteries using medical imaging modalities. (edu.au)
  • Genes
  • We generated four different knock-in lines carrying distinct human cardiovascular-disorder-causing missense mutations in their zebrafish orthologous genes by combining CRISPR/Cas9 with a short template oligonucleotide. (biologists.org)
  • Moreover, we have also developed a unique heart failure model in zebrafish and identified several candidate genes as novel drug targets. (zqsp-mie-u.org)
  • Hypertension
  • The significant induction of S100C mRNA and protein expression was detected in the rat pulmonary hypertension and myocardial infarction model. (zqsp-mie-u.org)
  • 5 ] used the term "factors of risk" for the first time and proved that hypertension, hypercholesterolaemia and other risk factors precede the development of coronary heart disease [CHD] in humans. (springer.com)
  • therapeutic
  • These results demonstrate that introducing patient alleles in their zebrafish orthologs promises a broad application for modeling human genetic diseases, paving the way for new therapeutic strategies using this model organism. (biologists.org)
  • Computational
  • The computer implementation is based on a novel idea which will greatly reduce computation time as compared to other computational models of unknotting. (grantome.com)
  • assess
  • In this project such data was used to assess cardiovascular disease risk models. (uea.ac.uk)
  • Our aim is to assess the extent to which current care for CVD and COPD patients aligns with the CCM in Dutch healthcare practices in the early stages of implementing disease-management programmes, thereby revealing possible predictors that tell us whether certain patients are more likely to receive CCM-compliant care than others. (biomedcentral.com)
  • researchers
  • The zebrafish has emerged as an excellent model for cardiovascular research, with many researchers being attracted by the increasing availability of molecular, genetic and physiological research tools. (ismrm.org)
  • preventive
  • Many of the risk factors predisposing people to CVD are known, and there are a number of survival models to identify those who could benefit from preventive treatment. (uea.ac.uk)
  • pathways
  • In addition to neurovascular (e.g. small vessel disease) and neuropathological (e.g. amyloid disposition) processes, other biological pathways are thought to be involved, such as the nitric oxide (NO), inflammatory (e.g. interleukin-6) and oxidative stress pathways. (springer.com)
  • murine
  • Using a DNA microarray, a prominant upregulation of heme oxygenase-1 (HO-1) and heat shock protein (HSP) 72 mRNAs were observed in the basilar artery of a murine vasospasm model. (zqsp-mie-u.org)
  • effectiveness
  • Health care providers need to model future patterns of need for health services, and to identify the cost effectiveness of different intervention strategies. (biomedcentral.com)
  • heart
  • This database contains CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients with heart failure. (nih.gov)
  • The Portuguese Heart Foundation funded a PhD scholarship to undertake the work on developing a CVD model for Portugal. (europa.eu)
  • Our research aims to understand and address all medical questions associated with coronary heart disease. (edu.au)
  • However, unlike with mammalian models, live imaging of heart function remains challenging in the adult zebrafish1. (ismrm.org)
  • Besides providing a much clearer picture of the cells that populate the heart," Rosenthal notes, "this research offers new strategies to isolate and examine some of the less-studied cell types, such as Schwann cells ( cells that secrete the protective myelin sheaths along nerve axons) , to determine their role in cardiovascular health and disease. (jax.org)
  • A worked example is given calculating the 10-year coronary heart disease risk for a 57 year-old non-diabetic male with no personal or family history of cardiovascular disease, who smokes 30 cigarettes a day and has a systolic blood pressure of 137 mmHg, a total cholesterol (TC) of 6.2 mmol/l, a high density lipoprotein (HDL) of 1.3 mol/l, and a body mass index of 21. (biomedcentral.com)
  • This chapter may be relevant to those who are interested in using this heart failure model. (springer.com)
  • Balakumar P, Singh AP, Singh M (2007) Rodent models of heart failure. (springer.com)
  • research
  • Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine, New Haven, Conn. (heart.org)
  • Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
  • I am confident that the proposed research will provide the science necessary to help identify high-risk patients and will provide new knowledge to develop innovative tools to reduce the excess burden of disease in vulnerable segments of the population. (grantome.com)
  • Learn about the latest research breakthroughs in the fight against Alzheimer's, cancer and other devastating diseases. (jax.org)
  • LabChart provides streamlined software to measure and analyze changes in blood pressure, flow, and volume, as well as many additional functions for pharmacological and cardiovascular research. (adinstruments.com)