• Our study describes an in silico derived 3D model for bubaline pregnancy associated glycoprotein 2. (biomedcentral.com)
  • Our study describes the first 3D model for a PAG, using bubaline PAG2 ( bu PAG2) as a candidate, obtained through a combination of several in silico modeling approaches. (biomedcentral.com)
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • Using a homology strategy, in silico models based on the murine NEUROD1/E47 X-ray structure were established and also subjected to dynamics simulations. (proteopedia.org)
  • In the attached video 1, the TWIST1/TWIST1 in silico models are represented as yellow ribbons. (proteopedia.org)
  • Several reviews and reports present the advantages and limitations of the currently available algorithms and software for in silico modelling of the drug dissolution/bioavailability, oral absorption rate/fraction, volume of distribution, path- ways, affinities or rates of metabolism, renal excretion rate as well as affinity for specific transporters [3-20]. (cdc.gov)
  • The sequences were analyzed in silico by BLAST searching for homologies with other DNAs deposited in the local and public data bases. (who.int)
  • In this talk, we introduce a topological feature computed by persistent homology to characterize tumor progression from digital pathology and radiology images and examine its effect on the time-to-event data. (utsa.edu)
  • For any image construct simplicial complexes for selected groups of uniform LBP bins and calculate persistent homology invariants (e.g. number of connected components). (spie.org)
  • Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence. (wikipedia.org)
  • Homology modeling can produce high-quality structural models when the target and template are closely related, which has inspired the formation of a structural genomics consortium dedicated to the production of representative experimental structures for all classes of protein folds. (wikipedia.org)
  • Because it is difficult and time-consuming to obtain experimental structures from methods such as X-ray crystallography and protein NMR for every protein of interest, homology modeling can provide useful structural models for generating hypotheses about a protein's function and directing further experimental work. (wikipedia.org)
  • In the absence of experimentally determined protein structures, a homology-based model may serve as a good starting point for investigation of sequence-structure-function relationships. (biomedcentral.com)
  • Although homology-modeled structures may often not be accurate enough to allow characterization of protein-protein or protein-inhibitor interactions at the atomic level, they can suggest which sequence regions or individual amino acids are essential functional components of the protein. (biomedcentral.com)
  • In fact, substitution models can be developed for any biological characters that can be encoded using a specific alphabet (e.g., amino acid sequences combined with information about the conformation of those amino acids in three-dimensional protein structures [7] [8] ). (wikipedia.org)
  • Total of 131 homology structures with the Ramachandran favorable score above 95% were considered as reliable drug targets and were submitted to PMDB online database. (ijpsr.com)
  • This model, hereafter formation of three-dimensional protein structures. (lu.se)
  • In this work, homology models of both proteins were constructed and analyzed for a number of structural properties. (nih.gov)
  • These 396 proteins were employed in homology modelling through the SWISS Model. (ijpsr.com)
  • The modelled proteins were subjected to protein-ligand docking analysis with standard antibiotics such as Ribostamycin, Cefalotin, Pefloxacin, Penicillamine, Artenimol, Cycloserine against their respective drug targets. (ijpsr.com)
  • The homology model of the proteins generated in this study can be exploited in further research using computational drug discovery and design to accelerate the research on disease management and pathogen control of Erysipelothrix rhusiopathiae induced swine erysipelas. (ijpsr.com)
  • Computational methods bridge this sequence-annotation gap typically through homology-based annotation transfer by identifying sequence-similar proteins with known function or through prediction methods using evolutionary information. (rostlab.org)
  • PROT data base (6) of functional proteins, this method yields model containing only two amino acid types, hydrophobic and clear evidence for nonrandomness. (lu.se)
  • To under- denoted the AB model, consists of chains of two kinds of stand the statistical distribution of hydrophobicity along proteins ``amino acids'' interacting with Lennard-Jones potentials. (lu.se)
  • The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
  • I have to build a model by homology modelling for a protein(only sequence available) which builds a homodimer. (salilab.org)
  • We have established homology models of the human TWIST1 homodimer and heterodimers (formed with the E12 partner) bound to their target DNA sequences. (proteopedia.org)
  • These tasks were approached with computational methods: homology modeling, docking, ligand-based pharmacophore modeling and virtual screening. (helsinki.fi)
  • Different computational methods have been designed for estimating protein function based on the information generated from sequence similarity, subcellular localization, phylogenetic profiles, mRNA expression profiles, homology modelling etc. [ 15 ]. (biomedcentral.com)
  • It covers stencil computations, auto-tuning, optimizations of a computational kernel, sequence alignment and homology, and pairwise computations. (routledge.com)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • The resulting independently determined RH-map locations were compared with the corresponding gene locations from the draft sequence of the canine genome. (upenn.edu)
  • In addition, the resulting cataract gene locations, as determined experimentally by this study, were compared with those determined by the canine genome project. (upenn.edu)
  • the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)
  • Although the C-terminal sequences adjacent to the bHLH domain, constitute a protein interaction site essential for TWIST function [4] [5] , we reasoned that a structural model restricted to the bHLH domains should provide additional insights into the TWIST-DNA interface and highlight functional differences between TWIST1 complexes. (proteopedia.org)
  • The established homology models (including DNA sequences) were visualized with the VMD 1.9.1 software. (proteopedia.org)
  • Estimates of evolutionary distances (numbers of substitutions that have occurred since a pair of sequences diverged from a common ancestor) are typically calculated using substitution models (evolutionary distances are used input for distance methods such as neighbor joining ). (wikipedia.org)
  • Multiple sequence alignment (in this case DNA sequences) and illustrations of the use of substitution models to make evolutionary inferences. (wikipedia.org)
  • It is also necessary to assume a substitution model to estimate evolutionary distances for pairs of sequences (distances are the number of substitutions that have occurred since sequences had a common ancestor). (wikipedia.org)
  • These embeddings originate from deep learned language models (LMs) for protein sequences (SeqVec) transferring the knowledge gained from predicting the next amino acid in 33 million protein sequences. (rostlab.org)
  • permissive with respect to sequence specificity the protein folding process is, we have carried out the same analysis for a Section 1: Introduction toy model (7, 8), for which unbiased samples of folding and Hydrophobicity is widely believed to play a central role in the nonfolding sequences can be obtained. (lu.se)
  • In case of homologies identified with the other Leishmania species, these sequences were compared to L. major and/or L. tropica using MEGA software. (who.int)
  • The comparison of the models reveals that the higher stability of HydSL can be attributed to increased inter-subunit electrostatic interactions: the homology models reliably predict that HydSL contains at least five more inter-subunit ion pairs than HupSL. (nih.gov)
  • even the quaternary structure of a protein may be difficult to predict from homology models of its subunit(s). (wikipedia.org)
  • The results of both studies show that the topological features predict survival prognosis after adjusting clinical variables, and the predicted high-risk groups have worse survival outcomes than the low-risk groups. (utsa.edu)
  • Substitution models are also central to phylogenetic invariants because they are necessary to predict site pattern frequencies given a tree topology. (wikipedia.org)
  • Even though this approach is conceptually applicable to non-volatile and high molecular weight organics as well, it is more challenging to predict the other PBPK model parameters required for modelling the kinetics of these chemicals (particularly tissue diffusion coefficients, association constants for binding and oral absorption rates). (cdc.gov)
  • In the present report we have compared and contrasted structure- and sequence-based methods of prediction to over 5500 genes carrying nearly 24,000 nsSNPs, by employing an automatic comparative modelling procedure to build models for the genes. (biomedcentral.com)
  • All genes mapped within or near chromosomal locations with previously established homology to the corresponding human gene locations based on canine:human chromosomal synteny. (upenn.edu)
  • Rat models are frequently used for finding genes contributing to the arthritis phenotype. (medscape.com)
  • As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
  • Animal models provide a valuable tool for finding genes contributing to the susceptibility to and severity of RA. (medscape.com)
  • The concern about GenX and ADONA is relatively recent, so there is a big need to characterize the risk of those chemicals using animal models. (cdc.gov)
  • Substitution models are used to calculate the likelihood of phylogenetic trees using multiple sequence alignment data. (wikipedia.org)
  • These site patterns are used to calculate the likelihood given the substitution model and a phylogenetic tree (in this case an unrooted four-taxon tree). (wikipedia.org)
  • The topological features are represented in functional space and used as functional predictors in a functional Cox proportional hazards model. (utsa.edu)
  • Techniques to decipher sequence-structure-function relationship, especially in terms of functional modelling of the HPs have been developed by researchers, but using the features as classifiers for HPs has not been attempted. (biomedcentral.com)
  • Anatomical homologies - Throughout the domains of life, organisms show a distinct pattern of constraints based on homology in the development and construction of the body. (rationalwiki.org)
  • Lysine-specific crosslinking mass spectrometry provided distance constraints to select a homology model of the DNAJB6 monomer, which was subsequently used in crosslink-assisted docking to generate a dimer model, revealing that a peptide-binding cleft lined with S/T-residues is formed at the monomer-monomer interface. (lu.se)
  • To calculate the models with Swiss-Model we used the [ Webserver ]. (tu-muenchen.de)
  • Swiss-Model also give same scores to give the user the possibility to estimate the quality of the predicted model, which are showed in the next paragraphes. (tu-muenchen.de)
  • Bioinformatic databases such as Uniprot KB, Drug Bank, PMDB and online tools such as BLASTp, SWISS Model and Ramachandran plot analysis and software such as Autodock4 and Pymol were used to perform this study. (ijpsr.com)
  • Since models are limited to study the mechanism of the neurotoxicity of tranylcypromine, here we utilized an in vitro brain organoid culture system which mimics neurogenesis experimentally to investigate the mechanisms by studying the effect of brain development of tranylcypromine and monitoring the brain damage of different concentrations. (frontiersin.org)
  • RESULTS An increased artemisinin resistance phenotype is accompanied by one non-synonymous substitution. (gla.ac.uk)
  • The CGC tool was developed by combining genomic regions in the rat, associated with the autoimmune experimental arthritis phenotype, with rat/human gene homology data, and with descriptions of phenotypic gene effects and selected keywords. (medscape.com)
  • We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)
  • Considering the widely acknowledged Accordingly, theoretical models of the MG state invariably invoke importance of protein-solvent interactions for stability and fold- a substantial internal hydration20-22. (lu.se)
  • Like other methods of structure prediction, current practice in homology modeling is assessed in a biennial large-scale experiment known as the Critical Assessment of Techniques for Protein Structure Prediction, or CASP. (wikipedia.org)
  • Therefore, we do not have a prediction result for high identical template and target. (tu-muenchen.de)
  • is a refereed journal which publishes high-quality papers in the general area of homotopy theory and algebraic topology, as well as applications of the ideas and results in this area. (intlpress.com)
  • OD results were recorded for isolated from human patients. (cdc.gov)
  • Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available to probe its biology. (asm.org)
  • These results show that human brain organoids can be applied as an in vitro model for CNS drug screening to evaluate structural, cellular, and molecular changes in the normal brains or brains of patients with neuropsychiatric disorders after drug treatments. (frontiersin.org)
  • However, animal models lack human genetic features and some brain region identities, such as outer subventricular zone, making it hard to figure out how these drugs affect central nervous system ( 7 , 8 ). (frontiersin.org)
  • Compared with conventional mice model, this model can recapitulate the human brain development in vitro ( 20 ). (frontiersin.org)
  • The cerebral organoids, which can mimic the endogenous development of human brain, have been applied to different studies as in vitro models for a wide range of brain diseases ( 16 , 21 , 22 ). (frontiersin.org)
  • The recent development of canine genomic resources make canine models a practical and valuable resource for the study of human hereditary cataracts. (upenn.edu)
  • MEASUREMENTS AND MAIN RESULTS: Clusters were determined by hierarchical clustering on principal components using principal component analysis of admission characteristics including plasma interleukin-6, human histocompatibility leukocyte antigen-DR expression rate on blood monocytes (HLA-DR) monocytic-expression rate (mHLA-DR), and the extent of lung parenchymal lesions. (bvsalud.org)
  • Physiologically-based pharmacokinetic (PBPK) modelling refers to the development and evaluation of mathematical descriptions of the ADME of chemicals in biota based on proven/hypothetical mechanistic determinants [21]. (cdc.gov)
  • Because of this, we decided to calculate a model with 3HN3 as template, which was the next template with a little bit more sequence identity. (tu-muenchen.de)
  • 6. Calculate observable properties of stars, including e.g. their magnitudes, using analytic stellar models and homology. (lu.se)
  • The sequence alignment and template structure are then used to produce a structural model of the target. (wikipedia.org)
  • The quality of the homology model is dependent on the quality of the sequence alignment and template structure. (wikipedia.org)
  • The method of homology modeling is based on the observation that protein tertiary structure is better conserved than amino acid sequence. (wikipedia.org)
  • A molecular model of the FMDV 3A protein, derived from the nuclear magnetic resonance (NMR) structure of the poliovirus 3A protein, predicted a hydrophobic interface spanning residues 25 to 44 as the main determinant for 3A dimerization. (asm.org)
  • In the next step we used Modeller to model the 3D structure of the protein. (tu-muenchen.de)
  • We decided to model the 3D structure with the template structure which has a very low sequence identity. (tu-muenchen.de)
  • Therefore, we decided to model the structure with 3LUT. (tu-muenchen.de)
  • Sadly, Swissmodel could not model the structure with this template, because Swissmodel was not able to create an alignment which can be used as basic for the model. (tu-muenchen.de)
  • In addition, a homology model of Raf-1 was also constructed using the crystal structure of the kinase domain of B-Raf isoform with one of the most active Raf-1 inhibitors (48) inside the active site. (unboundmedicine.com)
  • The results of best 3D-QSAR model were compared with structure-based studies using the Raf-1 homology model. (unboundmedicine.com)
  • As no experimental structure is available, we provide a model of the TMPRSS2 equilibrium structure and its fluctuations by relaxing an initial homology structure with extensive 330 microseconds of all-atom molecular dynamics (MD) and Markov modeling. (rsc.org)
  • It is expected that the results from these collaborations will contribute to understanding many basic and biomedically important research problems as well as to our fundamental understanding of protein structure. (nih.gov)
  • Based on the frequency of occurrence of molecular fragments (CH3, CH2, CH, C, C¼C, H, benzene ring and H in benzene ring structure) and exposure conditions, the available QSAR-PBPK models facilitate the simulation of tissue and blood concentrations for some inhaled volatile organic chemicals. (cdc.gov)
  • In biology, a substitution model , also called models of DNA sequence evolution , are Markov models that describe changes over evolutionary time. (wikipedia.org)
  • This method combines a generative, profile hidden Markov model (HMM) with a discriminative classification algorithm known as a support vector machine (SVM). (columbia.edu)
  • Through Markov modeling, we describe the binding process of both drugs and a metabolic product of camostat (GBPA) to TMPRSS2, reaching a Michaelis complex (MC) state, which precedes the formation of a long-lived covalent inhibitory state. (rsc.org)
  • The resulting algorithm, when tested on its ability to recognize previously unseen families from the SCOP database, yields significantly better remote protein homology detection than SVM-Fisher, profile HMMs and PSI-BLAST. (columbia.edu)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • We demonstrate here the transcytosis ability of aprotinin and peptides derived from Kunitz domains using an in vitro model of the BBB and in situ brain perfusion. (aspetjournals.org)
  • The in vitro model consists of a coculture of bovine brain capillary endothelial cells (BBCEC) and rat glial cells. (aspetjournals.org)
  • Therefore, we present here the results of the modelling with 3HN3, whereas by the other methods, we used 3LUT. (tu-muenchen.de)
  • Currently, one of the most powerful such homology detection methods is the SVM-Fisher method of Jaakkola, Diekhans and Haussler (ISMB 2000). (columbia.edu)
  • Research to practice potential : results of this study will emphasize importance of cleaning turnout gear, and proper handling of AFFF waste. (cdc.gov)
  • a typical model has ~1-2 Å root mean square deviation between the matched Cα atoms at 70% sequence identity but only 2-4 Å agreement at 25% sequence identity. (wikipedia.org)
  • The chief inaccuracies in homology modeling, which worsen with lower sequence identity, derive from errors in the initial sequence alignment and from improper template selection. (wikipedia.org)
  • The majority of substitution models used for evolutionary research assume independence among sites (i.e., the probability of observing any specific site pattern is identical regardless of where the site pattern is in the sequence alignment). (wikipedia.org)
  • These 7 species are approximately identical in DNA homology studies. (cdc.gov)
  • Nevertheless, homology models can be useful in reaching qualitative conclusions about the biochemistry of the query sequence, especially in formulating hypotheses about why certain residues are conserved, which may in turn lead to experiments to test those hypotheses. (wikipedia.org)
  • A subgroup of rice and maize NIPs has small residues in three of the four positions in the ar/R tetrad, resulting in a wider constriction. (biomedcentral.com)
  • The results of 3D-QSAR and docking studies validate each other and provided insight into the structural requirements for activity of this class of molecules as Raf-1 inhibitors. (unboundmedicine.com)
  • The K a /K s ratio (also called ω in codon substitution models) is a parameter of interest in many studies. (wikipedia.org)
  • BACKGROUND: Inconsistent results from COVID-19 studies raise the issue of patient heterogeneity. (bvsalud.org)
  • BACKGROUND: Previous studies demonstrated that coronary artery lesions (CALs) resulting from Kawasaki disease (KD) can improve over time. (cdc.gov)
  • In most studies, however, limitations in the number of animals result in a low resolution. (medscape.com)
  • It concludes with chapters on dataflow frameworks, the Charm++ programming model, scan algorithms, and a portable intracore communication framework. (routledge.com)
  • Our results demonstrate a novel mechanistic model for ROS-mediated inhibition of Orai1 and identify a candidate residue for pharmaceutical intervention. (nature.com)
  • Homotopy theory is also intended to be interpreted broadly, including algebraic K-theory, model categories, homotopy theory of varieties, etc. (intlpress.com)
  • The author then introduces a number of other significant categorical constructions in homotopy theory, such as operads, iterated loop spaces, and functor homology. (maa.org)
  • A more optimized cavity system and amino acid replacements resulting in increased conformational rigidity may also contribute to the higher stability of HydSL. (nih.gov)
  • Homology models of 105 MIPs from all three plant species were built. (biomedcentral.com)
  • Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
  • Homology also shared additional details of the optimized, in vivo gene therapy candidate HMI-204 for metachromatic leukodystrophy (MLD) during the 19th Annual WORLDSymposium™ Meeting. (advfn.com)
  • Dr. Seymour continued, "Also at WORLD, we presented the details of our optimized gene therapy development candidate for MLD, which showed the ability to cross the blood-brain-barrier following a single I.V. administration in the murine disease model and resulted in levels of enzyme activity predicted to lead to efficacy in vivo. (advfn.com)
  • The results obtained with in vitro and in vivo models provided evidence for greater passage of aprotinin across the BBB than of holo-transferrin. (aspetjournals.org)
  • The most important score in the following table is the QMEAN4 score, because this score consists of the scores above and give the user the possibility to compare different results. (tu-muenchen.de)
  • In particular, the author introduces some classical results about simplicial sets, for example that they provide a combinatorial model for topological spaces, but also includes topics that are of much current interest, such as quasi-categories, Segal sets, and symmetric spectra. (maa.org)
  • We investigated image quality discriminating characteristics of these simplicial complexes by computing these models for a large dataset of face images that are affected by the presence of shadows as a result of variation in illumination conditions. (spie.org)
  • The concept will be rapidly prototyped for a proof-of-concept experiment, for feasibility evaluation, and for providing a preliminary design and demonstration plan for Phase II, which will involve development, building, and testing of a brass-board model of the optical security system. (nsf.gov)
  • Canine models can serve as large animal models intermediate between mouse and man for both gene discovery and the development of novel cataract therapies. (upenn.edu)
  • Both of the models consisted of six features (hydrogen bond acceptors, hydrogen bond donor and hydrophobic feature) besides the exclusion volumes. (helsinki.fi)
  • The interaction pair for this hydrogen bond donor feature was not observed in the homology model. (helsinki.fi)
  • These results establish K. marxianus as a synthetic biology platform comparable to S. cerevisiae , with naturally more robust traits that hold potential for the industrial production of renewable chemicals. (asm.org)
  • The application domain of existing QSARs for developing PBPK models is limited, due to lack of relevant data for diverse chemicals and mechanisms. (cdc.gov)
  • PBPK models essentially represent a systems biology approach to the study of ADME and are increasingly finding use in screening-level as well as quantitative risk assessments to reduce the uncertainties associated with interspecies, route-to-route, and high-dose to low-dose extrapolations of tissue dose of chemicals [21-24]. (cdc.gov)
  • The results are in accord with the general observation that with increasing temperature, the role of electrostatic interactions in protein stability increases. (nih.gov)
  • Emphasis shifted to treat the tracial stability result on pincushion graph products as the main result with no significant change in content. (arxiv.org)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • Swiss-Modeler also returns some pictures, which show the qualitity of the model. (tu-muenchen.de)
  • The proposed model enables interpretable inference about the association between topological shape features and survival risks. (utsa.edu)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of preclinical data that supports the targeted, prophylactic immunosuppression regimen in the ongoing pheEDIT gene editing clinical trial in adults with phenylketonuria (PKU) and juMPStart gene therapy trial in adults with Hunter syndrome (MPS II). (advfn.com)
  • Creationists reject common descent as it implies an evolutionary model. (rationalwiki.org)
  • [1] These models describe evolutionary changes in macromolecules (e.g. (wikipedia.org)
  • The evolutionary distance equation ( d 12 ) is based on the simple model proposed by Jukes and Cantor in 1969. (wikipedia.org)
  • A PSI-BLAST (Position Specific Iterated-Basic Local Alignment Search Tool) [ 7 ] search with default parameters was performed against the Protein Data Bank (PDB) to find a suitable template for homology modeling. (biomedcentral.com)
  • [2] Substitution models are also necessary to simulate sequence data for a group of organisms related by a specific tree. (wikipedia.org)
  • Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. (cdc.gov)
  • This study was done with two aims: (1) to identify the difference between the two isozymes, (2) to create pharmacophore models for selective 11β-HSD2 inhibitiors. (helsinki.fi)
  • Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. (ijpsr.com)
  • Errors in side chain packing and position also increase with decreasing identity, and variations in these packing configurations have been suggested as a major reason for poor model quality at low identity. (wikipedia.org)
  • The hybrid/heterogeneous nature of future microprocessors and large high-performance computing systems will result in a reliance on two major types of components: multicore/manycore central processing units and special purpose hardware/massively parallel accelerators. (routledge.com)
  • EXPECTED RESULTS: We are expecting that: GenX or ADONA exposure will result in a decrease in locomotor activity compared to PFOA. (cdc.gov)
  • GenX/PFOA or ADONA/PFOA exposures will results in synergistic effect compared to single chemical exposure. (cdc.gov)
  • Results:- Time of exposure is 0-5 years and in most of the cases the forced expiratory volume in one second is 70% + 5 but peak expiratory flow rate is markedly decreased which shows that lung functions are deteriorated to a considerable extent. (who.int)
  • For example, branch lengths, especially when those branch lengths are combined with information from the fossil record and a model to estimate the timeframe for evolution. (wikipedia.org)
  • Multilevel structural equation modeling was used to estimate the hypothesized relationships at the individual and work-unit levels. (bvsalud.org)
  • Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
  • Nevertheless, while Q44R led to recovery of viruses that maintained the mutation, Q44D resulted in selection of infective viruses with substitution D44E with acidic charge but with structural features similar to those of the parental virus, suggesting that Q44 is involved in functions other than 3A dimerization. (asm.org)
  • Thus, substitution models are central to maximum likelihood estimation of phylogeny as well as Bayesian inference in phylogeny . (wikipedia.org)
  • Most of the work on substitution models has focused on DNA/ RNA and protein sequence evolution. (wikipedia.org)
  • Detailed evolution of high- and low-mass stars from numerical models. (lu.se)
  • Would you like email updates of new search results? (nih.gov)
  • Table representation of search results timeline featuring number of search results per year. (nih.gov)