Model organism for nervous system. Medical search. Frequent questions

After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
The junior research group leader joins a long-standing tradition at the campus in Buch - the famous geneticist Nikolay Timofeev-Ressovsky likewise used Drosophila as a model system. (mdc-berlin.de)
Using the fruit fly model organism (Drosophila melanogaster), the researcher investigates how genes are regulated during the embryonic development of the nervous system. (mdc-berlin.de)
Later Drosophila embryo (stage 11, ventral view, anterior left) undergoing developing nervous system. (mdc-berlin.de)
In the model organism of our lab, the fruit fly Drosophila , we can manipulate genes and nerve cells with great precision, and map the neuronal circuits from sensory input to motor output. (unifr.ch)
We use the fruit fly Drosophila melanogaster as a model organism as many of the major cell signalling pathways in mammals are conserved (and were in fact first discovered) in flies. (edu.au)
We are using Drosophila models to determine which cell types underly the altered neuronal excitability seen prior to onset of symptoms in motor neuron disease. (edu.au)
Intriguingly, human Hu proteins can substitute for ELAV in a Drosophila model for alternative splicing regulation. (findaphd.com)
We aim to dissect how ELAV activity is regulated by phosphorylation in Drosophila genetic and cell culture cell models for neurodegeneration. (findaphd.com)
This project will incorporate a wide range of molecular and cell biology techniques, which will be applied by using the genetic model organism Drosophila and various cell culture models. (findaphd.com)
Drosophila research has contributed to our understanding of nervous system development ( Doe, 2008 and Hartenstein et al. (erk-signaling.com)

I received an NINDS F31 Ruth L. Kirschstein National Research Service Award to support my work on nervous system development using the zebrafish as a model organism. (nih.gov)
He states, "My research is currently focused on social behavior in zebrafish, a model organism for studying neuroscience due to their simplified nervous system and similar genetics to humans. (coherent.com)
Model organisms including mice and zebrafish have previously enabled scientists to gain some insights into human gastrulation. (scitechdaily.com)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
A variety of model organisms such as Caenorhabditis elegans, zebrafish, and mice are being analyzed using genetic, biochemical, and bioinformatic approaches to explore fundamental developmental mechanisms of the nervous system, epithelial organs, the hematopoietic system and other tissues. (ucsd.edu)
To complement the in vivo system of chick embryos, we employ patient omics data, single cell RNA sequencing, human and mouse embryos, human cancer cell cultures, human pluripotent stem cells, chick embryo neural crest-derived in vitro crestosphere cultures, and zebrafish and mouse in vivo models. (lu.se)
A small tropical aquarium species zebrafish (Danio rerio) is used as a model organism to investigate the effects of endocrine disruptors. (unios.hr)
Research shows how endocrine disruptors affect the sexual, hormonal, sensory and nervous systems and also the behavior of zebrafish individuals. (unios.hr)

We encourage applications from theoretical neuroscientists and experimental neuroscientists working on a variety of model organisms, including mouse, fish, fly and worm. (cshl.edu)

A single fertilized egg cell develops into a complex organism with extremely differentiated cells and tissues that assume highly specialized tasks in spite of identical genetic material. (mdc-berlin.de)
In the model organism NC cells generate an amazing array of tissues, including peripheral and enteric nervous systems, cranial bones and cartilage, some cardiac muscle and virtually all pigmented cells in the body. (ca.gov)
Patients with arthralgias have been found to have the organism in the synovial tissues. (medscape.com)

Food odors have demonstrated influence on proteostasis (balance between formation and degradation of proteins), finds a study carried out in the roundworm Caenorhabditis elegans , a key model organism in biomedical research. (medindia.net)
In this paper, we search for anatomically defined multi-neuron modules in the Caenorhabditis elegans nervous system. (biomedcentral.com)

Hodgkin-Huxley is a mathematical model that describes how action potentials in neurons are initiated and propagated. (brown.edu)
Instead of a brain, hydra have the most basic nervous system in nature, a nerve net in which neurons spread throughout its body. (newscientist.com)
They want to get such a complete understanding of the way its neurons fire that they can use a computational model to predict its behaviour just from its neural activity. (newscientist.com)
A new Tel Aviv University study finds a mechanism exhibited in nematodes allows the nervous system cells -neurons-to communicate with germ cells , the cells that contain the information (genetic and epigenetic) that is transmitted to future generations . (medicalxpress.com)
Also, the study showed that out of 358 neurons that comprise of the nematode nervous system, two of them are part of the olfactory system that is significant for odor perception. (medindia.net)
It has a pared-down nervous system-each worm harbors exactly 302 neurons and approximately 7,000-8,000 synapses-and all individuals of the standard lab strain have an identical, readily modifiable genetic code, giving researchers hope of "solving" the genetic underpinnings of the animal's entire brain. (the-scientist.com)
These systems generally use a low-power microscope objective for tracking the whole animal, coupled with a separate high-power objective for zooming in on a particular location in a worm's brain to observe neurons that have been genetically manipulated to fluoresce when active. (the-scientist.com)
Neurons are interconnected in neural networks {added, Jun 4: cf. visualisation here }, and onward to form the brain and wider nervous system. (uncommondescent.com)
To date, however, genome-wide unbiased screens are not feasible in mammalian central nervous system neurons except in vitro, which fails to capture the relevant disease pathologies, and no genome-wide screens have yet been conducted in the mammalian central nervous system. (mendeley.com)
There is little doubt that neurons are elementary building blocks of the nervous system [ 1 ]. (biomedcentral.com)
We choose C. elegans as a model organism because its wiring diagram is largely known, including the identities of all 302 neurons and most synapses between them [ 4 - 6 ]. (biomedcentral.com)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

In February 2020, the US Centers for Disease Control and Prevention (CDC) Center for Global Health (CGH) activated the Measles Incident Management System (MIMS) to accelerate the ability to detect, mitigate and respond to measles outbreaks globally and advance progress towards regional measles elimination goals. (cdc.gov)

One of the first model systems for molecular biology was the bacterium Escherichia coli, a common constituent of the human digestive system. (wikipedia.org)
These areas are approached by investigations that span from structural characterization of single molecules, macromolecular interactions and supramolecular assemblies, over mapping of molecular pathways in different model organisms, to whole genome sequencing of human pathogens. (ki.se)
Many of the molecular processes we investigate are evolutionarily conserved from fly to man, which allows us to draw direct, testable inferences not only about nervous system development specifically, but also about tissue development in general" the scientist explains. (mdc-berlin.de)
To obtain mechanistic insights into how phosphorylation impacts on alternative splicing regulation we will combine available structural information for molecular modelling of ELAV multimerization and RNA binding to instruct experimental validation. (findaphd.com)
Further, this project will apply statistical analysis of data and we willl use molecular modelling of available structural information to make predictions how phosphorylations impacts on ELAV multimerization and RNA binding. (findaphd.com)
Diverse model systems are welcome as well as different cellular, biochemical and molecular approaches. (frontiersin.org)
At the Living Systems Institute, we collaborate with biophysicists using super-resolution microscopy to describe these signalling processes in a quantitative way on a molecular level. (exeter.ac.uk)
said Vamsi Mootha , senior author of the study, an institute member at the Broad, professor of systems biology and medicine at Harvard Medical School, and professor of molecular biology at Massachusetts General Hospital. (broadinstitute.org)
Because of evolutionary conservation of gene function and experimental tractability, C. elegans represents an ideal "model organism" to study basic genetic and molecular mechanisms of human development and disease. (ku.edu)

At the MDC, he investigates how the nervous system in fruit flies develops and how the corresponding genes are regulated. (mdc-berlin.de)
Combinatorial regulation thereby allows hundreds of TFs to control the spatio-temporal transcription of tens of thousands of genes - a prerequisite for the proper development and existence of an organism. (mdc-berlin.de)
The small RNAs produced in the parents' nervous system influenced this behavior, as well as the expression of many germline genes that persisted through at least three generations," explains Prof. Rechavi. (medicalxpress.com)
The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. (nih.gov)
We have developed a novel algorithm (PVP) which augments existing strategies by using the similarity of the patients phenotype to known phenotype-genotype data in human and model organism databases to further rank potential candidate genes. (plos.org)
1) elucidating the role of neuroblastoma associated protein HIF-2a in neural crest development and its potential role in tumor onset, 2) how trunk neural crest specific genes can function as tumor suppressor genes in neuroblastoma, and 3) develop inducible tumor models using chick embryos. (lu.se)

Although biological activity in a model organism does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
Similarly, direct injection of viruses into the cerebrospinal fluid (e.g., via lumbar puncture in humans) also permits targeting of the peripheral (PNS) and central nervous systems (CNS). (frontiersin.org)
Signalling between cells in the nervous system is highly conserved between flies and humans. (edu.au)
Though the planarian nervous system is simple, these flatworms display an immense array of complex behaviors-making planarians an ideal candidate with which scientists can study how the brains of more complex organisms, such as humans, function. (oup.com)
Animal models can respond differently to certain drugs: the anti-morning sickness drug thalidomide, for example, passed clinical trials after testing in mice but subsequently led to severe birth defects in humans. (scitechdaily.com)
Earthworms as inexpensive, noncontroversial animal models (without ethical concerns) are not vectors of disease do not harbor parasites that threaten humans nor are they annoying pests. (hindawi.com)
[3] In humans and most mammals, the autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis are the two major systems that respond to stress. (wikipedia.org)

This ancestor is referred to as the urbilaterian ancestor, as it is the relative of all bilaterally symmetric, multicellular organisms on the planet, including invertebrates (insects, nematodes, sea urchins) and vertebrates (mammals, fish, birds, reptiles). (ku.edu)
Planaria are bilaterally symmetric animals, with a complex central nervous system and two eye spots. (scienceinschool.org)

As soon as transcription starts in the fruit fly embryo, the process of cellular specification commences and within only a few hours a pool of pluripotent cells develops into differentiated components of the nervous system. (mdc-berlin.de)
The quick developmental progression as well as the excellent genetic and biochemical accessibility of the fruit fly embryo are some of the reasons why Robert considers these insects to be an ideal model organism for his research. (mdc-berlin.de)
The model resembles some key elements of an embryo at around 18-21 days old and allows the researchers to observe the processes underlying the formation of the human body plan never directly observed before. (scitechdaily.com)
During gastrulation, three distinct layers of cells are formed in the embryo that will later give rise to all the body's major systems: the ectoderm will make the nervous system, mesoderm the muscles, and endoderm the gut. (scitechdaily.com)
Our main model organism is the chick embryo, ideal for functional and translational studies on neural crest development. (lu.se)

We focus on the childhood tumor form neuroblastoma, originating from cells of the sympathetic nervous system (SNS) in turn derived from the transient neural crest stem cell population. (lu.se)
These cancers originate from cells of the sympathetic nervous system (SNS), in turn derived from the transient embryonic neural crest stem cell population. (lu.se)
The sympathoadrenal medullary (SAM) axis may activate the fight-or-flight response through the sympathetic nervous system , which dedicates energy to more relevant bodily systems to acute adaptation to stress, while the parasympathetic nervous system returns the body to homeostasis. (wikipedia.org)

This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. (wikipedia.org)

Dynamical systems allow researchers to investigate the functions and characteristics of the nervous system on a computer instead of in a model organism. (brown.edu)
The fellowship will provide support to develop her research project including laboratory space, animals, equipment and other supplies for a summer in the prestigious MBL Dr. Martínez will investigate how factors regulate retina degeneration and restrict its regeneration in a model organism. (cienciapr.org)
In this activity, students can investigate how these organisms react to stimuli of light, food, and touch. (scienceinschool.org)

Animal models especially invertebrates (e.g., fruit flies, nematodes, and earthworms are inexpensive, require less ethical concerns, and are therefore noncontroversial) are crucial to understanding mechanisms that underlie biological processes. (hindawi.com)
We focus these methods on cognitive information processing in the "simple" nervous systems of invertebrates. (cuny.edu)

Neural Systems for control and coordination of behavior: BioMimetic Robotics, Quantitative Animal Behavior, Biological and Artificial Neural networks architectures. (cuny.edu)
We make quantitative measures of the behavior of live animals and use those to infer models of the underlying cognitive information processing mechanisms. (cuny.edu)

We outline in this short monograph the steps needed to implement a methodology that allows for genome-wide genetic screening in the central nervous system of mice to study both normal and degenerative disease gene function. (mendeley.com)
To complement the in vivo system of chick embryos, we also employ human cell cultures, chick neural crest derived in vitro crestospheres and in vivo mice models. (lu.se)
The aim of the article is to determine the effect of digoxin, sodium valproate, and celecoxib per se, as well as the combination of digoxin with sodium valproate on the content of cyclooxygenase 1 and 2 types, prostaglandins E2, F2α, I2, thromboxane B2, 8-isoprostane and neuron-specific enolase in the brain of mice in the pentylenetetrazole-induced kindling model. (bvsalud.org)

Freshwater planaria, nonparasitic invertebrate animals belonging to the phylum Platyhelminthes, the flatworms, are organisms that are well-suited to educational purposes. (scienceinschool.org)

James Miller introduced the living systems theory 4 , where each system must include a number of critical subsystems, dealing with their structure, interaction, behavior and development, that can be applied from simple cells to full organisms. (nature.com)
In general, I am interested in how the nervous system controls and coordinates behavior. (unifr.ch)
The core concept in our studies is to use constrained models of behavior implemented in robots or in simulations to evaluate hypotheses of nervous system function. (cuny.edu)
We focus on the behavior of whole organisms. (cuny.edu)

This is particularly enticing for neuronal conditions, as the nervous system is renowned for its intransigence to therapeutic targeting. (frontiersin.org)
Similarly, brain organoid models are providing information on neuronal development and how this is altered in disease, while assembloids are providing insights into cell-cell interactions and circuit assembly. (sfn.org)
We are particularly interested in how neuropeptides regulate animal growth, how cells in the olfactory system detect odour information, and how neuronal cell signalling goes wrong in motor neuron disease. (edu.au)
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. (findaphd.com)

However, even a simple model can give insight for new approaches in complex systems and suggest new experimental tests, focused in its predictions and interpreted under a new paradigm. (nature.com)
As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)
Oxygen restriction is an exciting experimental modality, and it's now been shown to have pretty potent beneficial effects across multiple models of aging and disease," said Robert Rogers, first author on the PLOS study, postdoctoral fellow in Mootha's lab, and an instructor in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital. (broadinstitute.org)
Benchmark Dose Model--A statistical dose-response model applied to either experimental toxicological or epidemiological data to calculate a BMD. (cdc.gov)

A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. (wikipedia.org)
Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. (nih.gov)
Species studied and modeled include cephalopods (octopuses and cuttlefishes) and crustaceans ( lobsters, crabs and crayfishes). (cuny.edu)
The cross-species differences and similarities of the solutions provide insight into the design of nervous systems as computational devices. (cuny.edu)

In most model organisms, when new hypotheses are needed to explain a cellular process, genetic screens are the tool of choice. (mendeley.com)

Every animal group and system is being scrutinized revealing levels of biological organization from developmental/functional molecules to organs to systems to organisms. (hindawi.com)
Earthworms have somewhat been crucial in understanding these developmental organizations and are worthy of critical attention for analyzing the nervous, immune and endocrine systems. (hindawi.com)
Developmental Toxicity--The occurrence of adverse effects on the developing organism that may result from exposure to a chemical prior to conception (either parent), during prenatal development, or postnatally to the time of sexual maturation. (cdc.gov)
Adverse developmental effects may be detected at any point in the life span of the organism. (cdc.gov)

This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)

Predictive models are similar to a particular human disease in only a couple of aspects, but are useful in isolating and making predictions about mechanisms of a set of disease features. (wikipedia.org)

When deciding on what to study for my PhD, I became fascinated by synthetic biology, the idea that biological systems can be rewired both to solve real world problems and to yield insight into how biological systems work. (wrfseattle.org)

Nematodes, worms found in virtually all environmental habitats, are among the most studied model organisms. (medicalxpress.com)

Does the C. elegans nervous system contain multi-neuron computational modules that perform stereotypical functions? (biomedcentral.com)
We attempt to answer this question by searching for recurring multi-neuron inter-connectivity patterns in the C. elegans nervous system's wiring diagram. (biomedcentral.com)
Over-represented patterns (or motifs) are candidates for computational modules that may perform stereotypical functions in the C. elegans nervous system. (biomedcentral.com)
We look for motifs in the wiring diagram of the C. elegans nerve ring (a large fraction of the nervous system) assembled in two datasets [ 6 ]. (biomedcentral.com)

Here, we demonstrate the PhenomeNET Variant Predictor (PVP) system that exploits semantic technologies and automated reasoning over genotype-phenotype relations to filter and prioritize variants in whole exome and whole genome sequencing datasets. (plos.org)

In his pioneering work, Jacques Loeb 3 considered that physicochemical biology completely and correctly explained the development of organisms and all participating processes. (nature.com)
The unravelling of the structural arrangement of investigated proteins supports the building of a synapse model and therefore helps to understand the relation between structure and function in neural transmission processes. (uni-wuerzburg.de)
This is a hugely exciting new model system, which will allow us to reveal and probe the processes of early human embryonic development in the lab for the first time. (scitechdaily.com)
The relative roles of instinctive ( or "hard-wired" ) versus plastic ( or "learned" ) processes in the self organization of developing behavioral systems is central to our approach. (cuny.edu)
We will try to show that this belief disregards the central characteristics of the complex self-organized adaptive evolutionary processes of organisms in general. (bvsalud.org)

We assume that the organism coordinates food intake and effective degradation this way', commented first author Dr. Fabian Finger, who was recently awarded with the Klaus Liebrecht Prize of the UoC for his work. (medindia.net)

Anthrax is caused by the gram-positive Bacillus anthracis , which are toxin-producing, encapsulated, facultative anaerobic organisms. (msdmanuals.com)

Since March 2013, he heads the junior research group "Systems biology of neural tissue differentiation" at the MDC's Berlin Institute for Medical Systems Biology (BIMSB). (mdc-berlin.de)
Since I am passionate about basic research and all we know in Biology and Medicine stems from basic research, I try to teach with research in mind, according to the Humboltian model of higher education. (unifr.ch)

You have to ask: is this an animal that's going to join the fruit fly, worm and mouse as a model organism to look at in the quest to better understand the nervous system? (newscientist.com)
In taxonomic terms, planarians belong to a large class of organisms called Vermes, the Latin term for "worm. (oup.com)
Even the isolated tip of a tail from a planarian can develop into a full grown worm that possesses a brain and central nervous system. (oup.com)
Worm trackers are not yet available as an off-the-shelf tool, but researchers can build some of the dozen or so different models using instructions, software, and parts lists found online. (the-scientist.com)
The two smaller models show a whole worm with extended pharynx, along with a highly magnified flame cell. (wardsci.com)

However, it is debated whether bacteriophages should be classified as organisms, because they lack metabolism and depend on functions of the host cells for propagation. (wikipedia.org)
The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
The system reaches homeostasis, with a depolarized core (proliferative cells) surrounded by a rim of polarized cells (non-proliferative in this condition). (nature.com)
The Warr group studies how cells in the nervous system receive and respond to signals from the environment. (edu.au)
Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a new model to study an early stage of human development using human embryonic stem cells. (scitechdaily.com)
However, these models may behave differently from human embryos when the cells start to differentiate. (scitechdaily.com)
The signalling molecules are delivered directly to the receiving cells by a direct-contact model and parameters such as cytoneme length or speed of filopodia formation dictate local Wnt concentration. (exeter.ac.uk)

In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)

This theory would deal with the way an organism spontaneously grows from a single cell to a complete and complex organism, introducing organization at the different development stages and homeostasis for a mature organism. (nature.com)

By observing these remarkable creatures, students can explore organ systems, reproductive strategies, and the relationship between structure and function in living organisms. (scienceinschool.org)
[ 14 ] In short, although Whipple disease represents a systemic condition, only a few organ systems of the body are affected overtly. (medscape.com)
Other organ systems (ie, pulmonary, cardiac system, central nervous system) are also frequently involved. (medscape.com)

Aberrant regulation of their activity or expression results in a range of neurological phenotypes including learning deficits, epilepsy, synaptic growth defects and neurodegeneration in model organisms. (findaphd.com)
Advances in light microscopy, digital image processing, and the development of powerful fluorescent probes present expanding opportunities for investigating the nervous system, from synaptic spines to networks in the brain. (cshl.edu)

Together, we develop a robust mathematical model for the distribution of signal molecules on the basis of signalling filopodia. (exeter.ac.uk)

The main benefit over current methods is that these tools can be easily used in cell models that are relevant to study heart or lung disease, which has been an important limitation in the field. (bu.edu)
To look for other possible regimens, Mootha's team, in their latest study, tested seven different hypoxia treatments in the same mouse model of Friedreich's ataxia and included animals in later stages of the disease. (broadinstitute.org)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

In the early 20th century, scientists began looking for organisms with which they could test the principles of Mendelian genetics. (oup.com)

The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st centuries. (wikipedia.org)
Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)

Below, The Scientist explores the latest technology that researchers are using to monitor the brains of four classic model organisms as the animals, which vary in their neuro-complexity, react to different stimuli. (the-scientist.com)

I joined X. William Yang's lab at the University of California, Los Angeles to learn the technical skills and rationale required for generating mouse models of neurodegenerative diseases. (nih.gov)

My job is to learn from the patients' samples what is required to induce our immune system to make these super-effective antibodies. (wrfseattle.org)

With thousands of clinical trials to date, gene therapy is a flourishing strategy with great promise for the treatment of diseases impacting the nervous system. (frontiersin.org)
Apert syndrome), diseases of nervous system (e.g. (ca.gov)
Homoeopathy is one of the alternative medicinal systems used globally, which employs drugs prepared from natural origin for the management of diseases. (ijpsonline.com)

We are interested in how the nervous system fulfills this role and how it interacts with the reproductive organs and the rest of the body during the different mating strategies of the two sexes. (unifr.ch)

The availability of such a theory represents a fundamental progress in explaining both normal and pathological organism development. (nature.com)
Theories of organism development have a long history and many contributions were proposed, starting from diverse premises and centering in different views. (nature.com)
For this reason it is important to develop better models of human development. (scitechdaily.com)
Supported by the National Institutes of Health, AIM-AHEAD seeks to establish coordinated partnerships to increase the participation and representation of researchers and communities currently underrepresented in the development of artificial intelligence/machine learning (AI/ML) models and to enhance the capabilities of this emerging technology. (wsu.edu)
Chick embryos are easily accessible, and their nervous system development is similar to that of human embryos at comparable stages. (lu.se)

In a healthy organism, this coordination depends on a dynamic balance between formation and degradation of proteins (proteostasis). (medindia.net)
Friedreich's ataxia is a rare, inherited disease that causes progressive nervous system damage, impairing balance and coordination and leaving patients unable to walk by early adulthood. (broadinstitute.org)
Now, researchers at the Broad Institute of MIT and Harvard have found that treatment with continuous hypoxia - low-oxygen conditions comparable to levels at a Mount Everest base camp - restores balance and coordination in a mouse model of Friedreich's ataxia. (broadinstitute.org)

He defended that complex organization is a universal feature of all systems. (nature.com)
This suggests the animal has evolved distinct networks for each reflex - a primitive arrangement, much less complex than our own interconnected nervous systems. (newscientist.com)

Research using animal models has been central to many of the achievements of modern medicine. (wikipedia.org)
[ 1 , 2 ] Although the first descriptions of the disorder described a malabsorption syndrome with small intestine involvement, the disease also affects the joints, central nervous system, and cardiovascular system. (medscape.com)
Patients with severe cases also require supportive therapy and careful management of renal, hepatic, hematologic, and central nervous system complications. (medscape.com)
Papaya also contains a chemical called carpain, which seems to be able to kill certain parasites and might affect the central nervous system. (medlineplus.gov)

Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country.epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (who.int)

Phys.org) -- Researchers working at a lab at Berkeley University, led by Nicole King, have uncovered the first example of a kind of bacteria that causes a single celled organism to form a colony, a finding that has implications for researchers looking into the origins of multi-celled organisms in general. (phys.org)
The findings have added importance because researchers have long thought that choanoflagellates are animals closest relative, which means that it's possible that bacteria and the molecules they produce, could conceivably be part of the reason that single celled organisms first began to form colonies, leading eventually to multi-celled beings that evolved over time into all of the animals that are alive today. (phys.org)
Not everyone is onboard with that idea however, as over time, choanoflagellates have evolved just as have all the organisms that evolved from whatever the first multi-celled organisms actually were, but this new finding does hint at the possibility that we all owe our existence to a bacteria similar to A. machipongonensis living all those years ago. (phys.org)

The larger models, each 18" long and 5" wide, depict dorsal dissections of the nervous system and of the reproductive system, with a cross section of the digestive and excretory systems, enlarged 25X. (wardsci.com)

Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system. (frontiersin.org)

An arsenal of genetic tools permits the investigation Rapamycin datasheet of the complexity of the nervous system in unprecedented detail. (erk-signaling.com)

Gastrointestinal (including oropharyngeal) infection may occur after ingestion of inadequately cooked meat containing the vegetative forms of the organism, usually when a break in the pharyngeal or intestinal mucosa facilitates invasion. (msdmanuals.com)

Hands-on optics and building exercises are an important component of the course, enabling students to develop an intuitive understanding of optical principles, assemble their own two-photon microscope, and gain experience with a variety of state-of-the-art commercial systems. (cshl.edu)

Bioconcentration Factor (BCF)--The quotient of the concentration of a chemical in aquatic organisms at a specific time or during a discrete time period of exposure divided by the concentration in the surrounding water at the same time or during the same period. (cdc.gov)
The organism is typically transmitted via exposure of mucous membranes or abraded skin to the body fluid of an acutely infected animal or by exposure to soil or fresh water contaminated with the urine of an animal that is a chronic carrier. (medscape.com)

Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)

This experiments will be crucial to understand how factors may limit the regenerative capacitive of the nervous system. (cienciapr.org)

In the vast majority of individuals, infection is asymptomatic, as a competent immune system is sufficient to keep the organism in a latent tissue cyst state. (medscape.com)
Focusing on earthworms grew by serendipity from an extensive analysis of the earthworm's innate immune system. (hindawi.com)
I then decided to pursue a Ph.D. in viral immunology at the University of Cambridge where I learned a lot about the immune system and vaccine models. (wrfseattle.org)
The patient's immune system reacts by incorporating the organisms into tissue macrophages. (medscape.com)

Many of these questions are addressed in studies of the developing nervous system and in the mature brain. (ki.se)
The SAM and HPA axes are regulated by several brain regions, including the limbic system , prefrontal cortex , amygdala , hypothalamus , and stria terminalis . (wikipedia.org)

10%. The BMD is determined by modeling the dose response curve in the region of the dose response relationship where biologically observable data are feasible. (cdc.gov)

Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. (wikipedia.org)
Subsequent research in model organisms led to further medical advances, such as Frederick Banting's research in dogs, which determined that the isolates of pancreatic secretion could be used to treat dogs with diabetes. (wikipedia.org)
Their research together suggested that inner narrations underlie our conscious sense of unity as an organism. (sfn.org)
A wide range of technical platforms and model organisms are applied to pursue relevant research topics. (ki.se)
The team's research centers on choanoflagellates, single celled organisms that swim around in water using their tails. (phys.org)

Anatomy27

Organisms42

Diseases22

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes85

Disciplines and Occupations10

Information Science20

Health Care4

Drosophila11

Zebrafish8

Variety of model organisms1

Tissues3

Caenorhabditis2

Neurons12

20201

Molecular9

Genes6

Humans7

Bilaterally symmetric2

Embryo5

Sympathetic nervou3

Pathways1

Investigate3

Invertebrates2

Quantitative2

Mice3

Flatworms1

Behavior4

Neuronal4

Experimental4

Species4

Hypotheses1

Developmental4

Embryogenesis1

Mechanisms1

Insight1

Nematodes1

Elegans4

Genome1

Processes5

Coordinates1

Anthrax1

Biology2

Worm5

Cells8

Vitro1

Homeostasis1

Organ systems3

Synaptic2

Mathematical model1

Study3

Genetics1

Biological2

Brains1

Neurodegenerative diseases1

Antibodies1

Diseases3

Organs1

Development5

Coordination3

Complex2

Central4

Extent1

Bacteria3

Digestive1

Fate1

Complexity1

Intestinal1

Principles1

Exposure2

Cell1

Crucial1

Immune system4

Brain2

Feasible1

Research5