Model of myocardial ir injury myocardial reperfusion ischemia reperfusion. Medical search. Frequent questions

Following myocardial infarction (MI), elderly patients have a poorer prognosis than younger patients, which may be linked to increased coronary microvessel susceptibility to injury. (jci.org)
Myocardial ischemia-reperfusion (I/R) injury is an important health concern in myocardial infarction and situations such as angioplasty and cardiac surgeries. (usask.ca)
SIGNIFICANCE: KLK8 plays a crucial role in cardiac remodeling after myocardial infarction. (bvsalud.org)
B. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, reduces infarction volume and neurological deficits in an embolic model of stroke. (ac.ir)
IPC suppressed IR-induced infarction in wild type (WT) mouse hearts whereas overexpression of GFP-MG53 fusion protein reduced hypoxia- or H 2 O 2 -induced cell death [ 8 ]. (biomedcentral.com)
1. Danesh Sani SH, Eshraghi A, Shahri B, Vejdanparast M. No-reflow phenomenon in patients with STelevation acute myocardial infarction, treated with primary percutaneous coronary intervention: a study of predictive factors. (razavihospital.ir)
Intracoronary adenosine administered during percutaneous intervention in acute myocardial infarction and reduction in the incidence of "no reflow" phenomenon. (razavihospital.ir)
6. Brosh D, Assali AR, Mager A, Porter A, Hasdai D, Teplitsky I, Rechavia E, Fuchs S, Battler A, Kornowski R. Effect of no-reflow during primary percutaneous coronary intervention for acute myocardial infarction on six-month mortality. (razavihospital.ir)
14. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW, Investigators A-I. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). (razavihospital.ir)
Myocardial infarction (MI) denotes the death of cardiac myocytes due to extended ischemia. (aku.edu)
MI model was also associated with increase in the neutrophil polymorphs number in the infarction related myocardium as compared to the re-perfused myocardium. (aku.edu)
Hashmi, S & Al-Salam, S 2015, ' Acute myocardial infarction and myocardial ischemia-reperfusion injury: A comparison ', International Journal of Clinical and Experimental Pathology , vol. 8, no. 8, pp. 8786-8796. (uaeu.ac.ae)
This timing makes postconditioning relevant from the clinical perspective, in which limitation of irreversible myocardial damage following a coronary thrombosis and ST-elevation myocardial infarction remains a major objective [3]. (justia.com)
4] disclose in Cardiovasc Drugs Ther (2007) 21:253-256, that GLP-1 alone did not decrease myocardial infarction but in combination with the GLP-1 breakdown inhibitor valine pyrrolidide (VP) a significant reduction in myocardial infarction occurred. (justia.com)
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. (researchgate.net)
Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). (ijbs.com)
Acute myocardial infarction (MI) can lead to sudden cardiac death, which is one of the leading causes of death and disability worldwide [ 1 ]. (ijbs.com)

The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)
Apoptosis of the cardiomyocytes has been demonstrated in animal models with coronary artery occlusion [ 1 ], and experimental evidence suggests that myocardial cells are able to undergo apoptosis during ischemia followed by reperfusion [ 2 ]. (ac.ir)
Both ischemic and reperfused rat myocardium can undergo apoptotic cell death, however the myocardium, which is subjected to ischemia followed by reperfusion, undergoes accelerated apoptosis [ 3 ]. (ac.ir)
6. Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X, Zhang S. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. (ac.ir)
7. Yuan Y, Guo Q, Ye Z, Pingping X, Wang N, Song Z. Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (ac.ir)
PM2.5 exposure leads to hepatic insulin resistance (IR) that was accompanied by endoplasmic reticulum (ER) stress-induced apoptosis (Laing et al. (deepdyve.com)
In conclusion, myocardial damage in MI is mainly due to ischemic necrosis and inflammatory mechanisms while apoptosis is the main mechanism of cell death in IR in addition to limited ischemic necrosis. (aku.edu)
Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
The effect of turmeric on myocardial apoptosis and cardiac function was examined in an ischemia and reperfusion model of myocardial injury. (sydneyaviationtheory.com.au)

Isolated rat hearts (n=48) were perfused in the retrograde mode with modified Krebs-Henseleit buffer, and following the induction of 30 min global ischemia, ascorbate (150 µM) and/or catechin (5 µM) were added directly into the perfusate during 90 min reperfusion. (usask.ca)
In our experimental model, rat heart subjected to heterotopic transplantation, low temperature global ischemia (2 h) was followed by an in vivo reperfusion (60 min). (unifi.it)

These pleiotropic effects thus have a major role in protecting the myocardium against ischemic injury. (ac.ir)
18. Wang CX, Yang T, Shuaib A. An improved version of embolic model of brain ischemic injury in the rat. (ac.ir)
20. Zhao H. The protective effect of ischemic postconditioning against ischemic injury: from the heart to the brain. (ac.ir)
These findings may provide better understanding of the pro-apoptotic role of miR-195 in MI and suggest that BDNF/miR-195/Bcl-2 axis may be beneficial for limiting myocardial ischemic injury. (ijbs.com)

and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
Reperfusion has the potential to salvage ischemic myocardium but paradoxically can cause injury, a phenomenon called as 'reperfusion injury' (IR). (aku.edu)
Our IR model showed enhanced pro-apoptotic mediators like cleaved caspase-3 (P=0.005) and cytochrome c in the myocardium as compared to the MI model. (aku.edu)
Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)

Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (phypha.ir)
Kidney-lung cross-talk and acute kidney injury. (phypha.ir)
9. Doi K, Ishizu T, Fujita T, Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. (phypha.ir)
Remote organ failure in acute kidney injury. (phypha.ir)
Parametric MRI detects aristolochic acid induced acute kidney injury. (charite.de)
Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)

Thirty Wistar rats were selected and divided into three groups (n = 10): acute ischemia-reperfusion (I/R) group, acute ischemia-reperfusion and treated with atorvastatin group and sham-operated group. (ac.ir)
Pretreating the rats with simvastatin 18 hour prior to the induction of ischemiareperfusion has been shown to reduce cardiac dysfunction and improve coronary flow [ 7 ]. (ac.ir)
2. Ren C, Yan Z, Wei D, Gao X, Chen X, Zhao H. Limb remote ischemic postconditioning protects against focal ischemia in rats. (ac.ir)
4. Ren C, Gao X, Niu G, Yan Z, Chen X, Zhao H. Delayed postconditioning protects against focal ischemic brain injury in rats. (ac.ir)
Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. (ac.ir)
Ischemic postconditioning may not influence early brain injury induced by focal cerebral ischemia/reperfusion in rats. (ac.ir)
13. Zhang W, Miao Y, Zhou S, Jiang J, Luo Q, Qiu Y. Neuroprotective effects of ischemic postconditioning on global brain ischemia in rats through upregulation of hippocampal glutamine synthetase. (ac.ir)
16. Wang Q, Zhang X, Ding Q, Hu B, Xie Y, Li X, Yang Q, Xiong L. Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats. (ac.ir)
Rats with SAH induced using the established double hemorrhage model were administered with or without LIG treatment. (alexbotsaris.com.br)
Healthy male Sprague‑Dawley rats were used in the present study to examine the radioprotective effect of a type of pan-caspase inhibitor, z-VAD-fmk, following radiation, to investigate the effects of caspase blockade in a model of the nucleus of the abducens nerve. (spandidos-publications.com)
Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
The aim of this study was to investigate the effect of 8 weeks of aerobic training on the expression of PGC-1α and VEGF genes in male healthy rats' myocardial muscle by fundamental experimental method. (sportrc.ir)
This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)

In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
MG53 KO mice lack IPC-mediated cardioprotection as evidenced by a failure of IPC to reduce IR-induced myocardial infarct size. (biomedcentral.com)

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. (ac.ir)
2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
Possible mechanisms for these effects are discussed, in any case the present results indicate that PARP inhibition has an overall beneficial effect against myocardial reperfusion injury, mainly due to prevention of energy depletion. (unifi.it)
Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)

Atorvastatin has been shown to be cardioprotective in ischemia-reperfusion (I/R) injury. (ac.ir)

An intravital model for imaging the adult and aged IR-injured beating heart in real time in vivo was used to demonstrate heightened basal and injury-induced neutrophil recruitment, and poorer blood flow, in the aged coronary microcirculation when compared with adult hearts. (jci.org)
IR injury was induced by ligating the left anterior descending coronary artery for 1 h and subsequent reperfusion. (bvsalud.org)
Myocardial reperfusion is the restoration of coronary blood flow after a period of coronary occlusion. (aku.edu)
Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model[J].J Atheroscler Thromb, 2013, 20( 1) : 32-45. (alliancepress.org)

Priming with Toll-like receptor 4 agonists have been shown to augment neutrophil antimicrobial responses and enhance resistance against infection after severe burn injury in mice. (vumc.org)
KKAy mice, a genetically susceptible model of type II diabetes mellitus, were administered intra-cerebroventricularly with IKK2 inhibitor (IMD-0354) and were exposed to either concentrated PM2.5 or filtered air (FA) for 4 weeks simultaneously via a versatile aerosol concentration exposure system. (deepdyve.com)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
ND6-P25L mitochondria function normally, except for their lack of RET ROS production, and ND6-P25L mice are protected against cardiac IR injury in vivo. (ox.ac.uk)

Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)

KEY FINDINGS: KLK8 overexpression enhanced cardiac diastolic dysfunction, fibrosis, and hypertrophy after IR injury, indicating that KLK8 accentuated cardiac remodeling in response to IR injury. (bvsalud.org)
A wealth of studies now confirm that PQQ's cell-signaling activity translates into substantial protection against degenerative and age-related conditions, such as mitochondrial dysfunction, 1 heart degeneration, 18-20 brain injury, and cognitive decline. (lifeextension.com)
There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)

Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
Standard histologic, immunohistochemical and Elisa techniques were used to study the histopathologic, oxidative, apoptotic and inflammatory changes in MI and IR. (aku.edu)
Myocardial antioxidant and oxidative stress changes due to sex hormones. (phypha.ir)
Recent data from animal models have revealed the actions of nesfatin-1 on cardiac modulation and blood pressure through various signaling pathways which affect the mechanical properties of the cardiac muscle, inflammation and oxidative stress, sympathetic activation and nitric oxide (NO) production, among others. (biomedcentral.com)
Thus, this single point mutation in complex I, which does not affect oxidative phosphorylation but renders the complex unable to catalyse RET, demonstrates the pathological role of ROS production by RET during IR injury. (ox.ac.uk)

Persistent myocardial ischemia and hypoxia will cause malignant cardiac remodeling and subsequent heart failure. (hindawi.com)
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)

Numerous apoptotic cardiomyocytes were found in ischemic fields in ischemia-reperfusion groups and werent observed in the sham-operated group. (ac.ir)
Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)
A comparison of IR hearts with two controls, sham (perfused for a 15 min stabilization period) and continuous perfusion (perfused for 135 min), showed in most but not all measurements that this was a suitable model of IR injury. (usask.ca)

Postconditioning in reperfusion injury: a status report. (ac.ir)
21. Zhao H. Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. (ac.ir)
Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)

Regarding cardiac and mitochondrial signaling, prior to ischemia HCD heart had a decreased dependence on insulin-dependent AMPK and increased inflammation via upregulated p38, whereas GRT treatment presented with decreased insulindependent PKB and AS160 signaling (together with increased FA OxPhos compared to carbohydrates, however showed more mitochondrial uncoupling, decreasing basal metabolic rate and thereby potentially less ROS production), inhibited GSK3β and conferred an anti-inflammatory effect by significantly reducing p38 activation. (sun.ac.za)
Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
In inflammatory-mediated kidney injury, a variety of T cells (γδT cells, NKT cells, regulatory T cells) infiltrate the kidney, and the number and subset composition of infiltrating T cells varies among the different forms of kidney injury [ 13 ]. (biomedcentral.com)

Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
The renal MDA level of male increased during 3h reperfusion but not seen in females. (phypha.ir)
The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
Animal Models of Renal Pathophysiology and Disease. (charite.de)
The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)

It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)
Z-Ligustilide (LIG), the primary lipophilic component of the Chinese traditional medicine Radix Angelica Sinensis, has been shown to reduce ischemic brain injury via anti-apoptotic pathways. (alexbotsaris.com.br)
Additionally, treatment reduced the number of apoptotic cells in the surrounding brain injury site which accompanied a marked down-regulation of pro-apoptotic proteins, p53 and cleaved caspase-3. (alexbotsaris.com.br)

The objectives of this study were to 1) determine the extent to which ascorbate or catechin alone at levels which could be in blood after dietary supplementation, can protect myocardial tissue in the reperfusion phase of I/R injury, and 2) evaluate the possible cooperative or synergistic protective effect of ascorbate and catechin when given together. (usask.ca)
Recent studies have demonstrated that supplementation of nitric oxide (NO), or increased expression of endothelial NO-synthase (eNOS) protects against both IR-injury and fibrosis ( 5 , 6 ). (frontierspartnerships.org)

Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. (ox.ac.uk)

The phenomenon may be modelled in an experimental setting, in this case on an isolated rat heart. (justia.com)

MATERIALS AND METHODS: KLK8 overexpressing transgenic rat (KLK8-TG) was used as the animal model. (bvsalud.org)

While prompt reperfusion and advances in in-hospital care have led to a decline in short term mortality, sustained damage to the ventricle, along with reperfusion injury, can lead to progressive deterioration in cardiac function. (vcu.edu)

Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
However, the role of γδT cells in CaOx-mediated kidney injury remains unclear. (biomedcentral.com)
Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)

Mitochondrial ROS production is implicated as one of the major contributors to cell death in the reperfused heart and the importance of mitophagic processes (mitochondrial housekeeping) could be a potential therapeutic target to prevent ischemia/reperfusion injury (I/R-I). Aspalathus linearis (commonly known as rooibos) is an indigenous South African plant grown exclusively in the Western Cape fynbos region. (sun.ac.za)

Our findings provide evidence that PDE1C elevation links SMC senescence to AAA development in both experimental animal models and human AAA, suggesting therapeutical significance of PDE1C as a potential target against aortic aneurysms. (rochester.edu)

IPC activates the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways to protect the heart against IR injury. (biomedcentral.com)
2012). Our previous study demonstrated that PM2.5 exposure led to hyperglycemia and IR, which were accompanied by hypothalamic inflammation evidenced by increased mRNA levels of Interleukin-6 (IL-6), tumor necrosis factor α (TNFα), Inhibitor kappa B kinase 2 (IKK2), and enhanced microglial/astrocyte reactivity (Song et al. (deepdyve.com)

Venous thrombosis (sometimes called DVT, deep vein thrombosis) leads to a blood clot in the affected part of the body, while arterial thrombosis (and, rarely, severe venous thrombosis) affects the blood supply and leads to damage of the tissue supplied by that artery (ischemia and necrosis). (wikipedia.org)
AIMS: Tissue kallikrein-related peptidase8 (KLK8) has been found to mitigate acute myocardial ischemia-reperfusion (IR) injury. (bvsalud.org)
However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)

Mortality, neurobehavioral evaluation, brain water content, blood brain barrier (BBB) permeability, and vasospasm assessment of the basilar artery were measured on days 3 and 7 after injury. (alexbotsaris.com.br)

Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)

In conclusion, this study showed strong protection by ascorbate, which could be used in clinically relevant situations, and is the first to report the protection by catechin at this dose under conditions of myocardial ischemia-reperfusion injury. (usask.ca)

The IL-6 levels in the LV of the MI group were significantly raised as compared to the IR group (P=0.0008). (aku.edu)
Plasma IL-6 was also significantly increased in the MI group as compared to the IR group (P=0.031). (aku.edu)
Nesfatin-1 significantly correlated to hsCRP (r = − 0.287, p = 0.036), HOMA-IR (r = − 0.587, p = 0.007) and hyperlipidemia (r = − 0.331, p = 0.034). (biomedcentral.com)

14. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. (ac.ir)

11. Dinapoli VA, Rosen CL, Nagamine T, Crocco T. Selective MCA occlusion: a precise embolic stroke model. (ac.ir)

This figure outlines the time course for normoxic (A) and ischemia-reperfusion (B) experiments. (justia.com)

However, the effect of KLK8 on cardiac remodeling in response to IR injury has not been determined. (bvsalud.org)
The Bohannon lab utilizes multiple post-burn murine infection models, including a Pseudomonas aeruginosa burn wound infection as well as Staphylococcal aureus and Candida albicans systemic infections, to assess the effect of various TLR agonists on mediating protection against infection. (vumc.org)
We investigated the effect of 3-aminobenzamide (3-AB), an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), against early ischemia/reperfusion (IR) injury in heart transplantation. (unifi.it)
As a result, the present study aimed to investigate changes in the expression of X-linked IAP (XIAP) induced by radiation injury, the activity and expression of caspase members following radiation and the effect of caspase blockade. (spandidos-publications.com)

The functional and morphological changes of the heart were examined 14 days after the injury. (bvsalud.org)

and 3) Monitor the impact of chronic serelaxin therapy on bio-active sphingolipid biology in a murine model of ischemic heart failure. (vcu.edu)

Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation. (frontierspartnerships.org)

Moreover, KLK8 overexpression increased epidermal growth factor (EGF) release and promoted the phosphorylation of EGF receptor (EGFR) and ERK1/2 in the heart after IR injury. (bvsalud.org)

We first demonstrated the presence of IL-36(α/β) and its receptor (IL-36R) in ischemia/reperfusion-injured (IR-injured) mouse hearts and, interestingly, noted that expression of both increased with aging. (jci.org)

In addition to its function in skeletal muscle, MG53 has been shown to have protective effects on various forms of cardiac muscle injury. (biomedcentral.com)
The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)

We assessed whether donor preservation with S-NO-HSA affects isograft injury and myocardial expression of GATA2 as well as miR-126-3p, which are considered protective against vascular and endothelial injury. (frontierspartnerships.org)

In the organ crosstalk, the combination of AKI with acute lung injury remains a formidable challenge for clinicians treating critically ill patients. (biomedcentral.com)

Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
Chronic allograft injury (CAI), consisting of vasculopathy and interstitial fibrosis, affects approximately 50% of patients after 10 years and limits long-term survival following heart transplantation ( 1 ). (frontierspartnerships.org)

Recently, the role of inflammation in the central nervous system, particularly the hypothalamus in diet-induced IR progress, has been noted in rodent models and human (Posey et al. (deepdyve.com)

KLK8 accentuates cardiac fibrosis after IR injury, possibly mediated by EGFR signaling in CFs. (bvsalud.org)

We therefore systematically investigated this issue in a genetic diabetic model subjected to air pollution exposure along with ICV treatment of IKK2 inhibitor. (deepdyve.com)

She became junior faculty in 2015 and now has her own research program aimed at investigating immunomodulatory therapies for the prevention of infection and sepsis following a severe burn injury. (vumc.org)

The major components of this syndrome include cardiomyocyte death, myocardial stunning, arrhythmias and no-reflow [1]. (justia.com)

In addition, it has been shown that atorvastatin can protect the isolated mouse heart against reperfusion-induced injury [ 6 ]. (ac.ir)
This means that the mouse models engineered to capture human disease cannot recapitulate the interactions mediated by these microRNAs. (pharmaceuticalintelligence.com)
CaOx crystal mouse model was established by glyoxylate injection. (biomedcentral.com)

Anatomy27

Organisms13

Diseases46

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes34

Disciplines and Occupations1

Information Science2

Health Care7

Infarction17

Apoptosis11

Global ischemia2

Ischemic Injury4

Myocardium4

Acute kidney10

Rats15

Infarct size2

Inhibition5

Cardioprotective1

Coronary4

Mice6

Vivo2

Dysfunction4

Oxidative6

Subsequent2

Sham3

Postconditioning3

Inflammatory3

Renal9

Apoptotic3

Supplementation2

Reactive oxygen2

Isolated rat heart1

Transgenic1

Cardiac function1

Kidney injury3

Mitochondrial1

Experimental1

Kinase2

Tissue3

Mortality1

Protects1

Conclusion1

Significantly3

Artery1

Occlusion1

Experiments1

Effect4

Functional1

Heart Failure1

Murine1

Overexpression1

Receptor1

Effects2

Endothelial1

Organ1

Chronic2

Inflammation1

Fibrosis1

Inhibitor1

Prevention1

Syndrome1

Mouse3