• Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage has been extensively explored for treating ischemic stroke. (springer.com)
  • The treatment of ischemic stroke is to administer tissue plasminogen activator (t-PA) within 4.5 h of stroke onset, and only 5-8% of patients qualify for this therapy (Liaw and Liebeskind 2020 ). (springer.com)
  • We investigated whether plasma FA composition was related to stroke severity and functional outcome in acute ischemic stroke patients. (j-stroke.org)
  • ω3-PUFAs are potential blood biomarkers for prognosis of acute non-cardiogenic ischemic stroke patients. (j-stroke.org)
  • 9 A decreased proportion of linoleic acid is also associated with ischemic stroke. (j-stroke.org)
  • Onwuekwe IO, Ezeala-Adikaibe B. Ischemic stroke and neuroprotection. (amhsr.org)
  • Greater understanding of the pathophysiology of neuronal damage in ischemic stroke has generated interest in neuroprotection as a management strategy. (amhsr.org)
  • This paper aims to review the current concept and place of neuroprotection in ischemic stroke. (amhsr.org)
  • Neuroprotection is an increasingly recognized management strategy in ischemic stroke that promises to assist clinicians in reducing stroke mortality rates and improving the quality of life of survivors. (amhsr.org)
  • 5 ‑ 8 ] An ischemic stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. (amhsr.org)
  • Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. (nottingham.ac.uk)
  • Stroke or cerebrovascular accident is defined as an acute focal or global neurological deficit lasting longer than 24 h or leading to death and which is of no aetiology other than vascular. (amhsr.org)
  • Ischemia causes loss of membrane potentials (anoxic depolarisation) and in its mildest form (brief focal ischemia) kills uniquely vulnerable neurones such as the pyramidal neurons in the CA1 and CA4 zones of the hippocampus while sparing other neurons and all glial cells. (amhsr.org)
  • During my time at Leicester I was Head of the School for Psychology (2013-2017) and deputy Head of the College of Life Sciences before moving to the University of Nottingham in 2018. (nottingham.ac.uk)
  • Stroke is a leading cause of death and disability worldwide (Guzik and Bushnell 2017 ). (springer.com)
  • 8 In terms of stroke, low levels of circulating ω3-PUFAs in the blood is a risk factor for ischemic and hemorrhagic stroke. (j-stroke.org)
  • Stroke is classified as being either hemorrhagic or ischemic in nature depending on the underlying pathological process responsible. (amhsr.org)
  • An alternative surgical approach reduces variability following filament induction of experimental stroke in mice Disease Models & Mechanisms. (nottingham.ac.uk)
  • This study focuses on the neuroprotective bioactivity of docosanoid mediators: Neuroprotectin D1 (NPD1), Resolvin D1 (RvD1), and their combination in experimental stroke. (springer.com)
  • Lower proportions of EPA (β=-0.751), DHA (β=-0.610), and Σω3-PUFAs (β=-0.462) were independently associated with higher NIHSS score, after adjusting for stroke subtype, hemoglobin, high density lipoprotein, high sensitivity C-reactive protein, fasting glucose, 16:0 palmitic acid, and Σsaturated fatty acids. (j-stroke.org)
  • Moreover, a lower proportion of DHA (odds ratio [OR]: 0.20, 95% confidence interval [CI]: 0.04-0.88), and Σω3-PUFAs (OR: 0.22, 95% CI: 0.05-0.84) showed an independent relationship with poor functional outcome after adjusting for age, sex, smoking status, NIHSS score, stroke subtype, and 16:0 palmitic acid. (j-stroke.org)
  • Several studies have documented that the ischemic subtype accounts for the greater number of stroke cases. (amhsr.org)
  • 10 Compared to normal controls, stroke patients with moderate-to-severe intracranial arterial stenosis or occlusion had decreased levels of DHA. (j-stroke.org)
  • Inflammation is a prime target to modulate because it can be both detrimental and beneficial after stroke (Marcheselli et al. (springer.com)
  • We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. (springer.com)
  • The only currently approved medical stroke therapy, tissue plasminogen activator (tPA), is a thrombolytic that targets the thrombus within the blood vessel. (amhsr.org)
  • When ischemia lasts more than 1 h, this zone of infarction beginning in the central zone of lowest blood flow progressively enlarges in a circumferential fashion towards its maximum volume over 6-7 h in primates and an undetermined time in humans. (amhsr.org)
  • The impact of gender on stroke pathology and treatment. (nottingham.ac.uk)
  • Neuroprotective agents, another approach to stroke treatment, have generated as much interest as thrombolytic therapies. (amhsr.org)
  • 1 In addition, FAs modulate vascular inflammation, a key mechanism of atherosclerosis, cerebral small vessel pathologies, and stroke, by altering intracellular signal transduction or controlling lipid mediators such as prostaglandins, thromboxanes, or leukotrienes. (j-stroke.org)
  • 2019 ). Despite active stroke research, all treatments have failed to show favorable clinical outcomes. (springer.com)
  • 3 ] Findings from South West Nigeria show that the incidence of stroke rises with age reaching a peak in the 8th decade in males and 7th decade in females. (amhsr.org)
  • A recently completed EXTEND trial showed that this could be extended up to 9 h after stroke onset guided by CT or MRI perfusion images, thus allowing more patients eligible to receive tPA beyond the 4.5-h time window (Ma et al. (springer.com)
  • I am particularly interested in developing novel MRI methodologies for examining brain function, investigating the role of sex and steroid hormones in ischaemic stroke/cognitive decline and increasing the translational relevance of experimental models of CNS injury and disease. (nottingham.ac.uk)
  • Mutations in the ATP1A2 gene are implicated in familial hemiplegic migraine type II and increase the severity of ischemic brain injury in animal models. (springeropen.com)