Model neonatal hypoxia ischemia. Medical search. Frequent questions

Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. (jneurosci.org)
Our aim was to identify antepartum risk factors for neonatal hypoxic ischemic encephalopathy, with a focus on maternal body mass index and height. (nih.gov)
Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). (frontiersin.org)
IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model. (llu.edu)
14. Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. (llu.edu)
Hypoxic-ischemic encephalopathy (HIE) following intrauterine ischemia (IUI) is one of the leading causes of brain injury in neonates, and the effects can endure until adulthood [ 1 , 2 ]. (hindawi.com)

Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)
These results collectively indicate the chronicity of oxidative stress and an inadequate antioxidant response after a cerebral hypoxia-ischemia event and have motivated the development of preventive and therapeutic approaches against oxidative stress. (hindawi.com)

1. Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats. (llu.edu)
7. Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model. (llu.edu)
11. RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats. (llu.edu)
17. Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats. (llu.edu)
In neonatal hypoxia-ischemia, an increase in reactive oxygen species (ROS) is known to occur in the brain at 96 h after a hypoxic-ischemic episode, to which the antioxidant system responds by increasing the activity of superoxide dismutase (SOD) and catalase (CAT) at postnatal day (PND) 11, which decreases afterward [ 5 ]. (hindawi.com)
Prematurity and other perinatal complications including early-onset systemic infections, neonatal meningitis, or hypoxic/ischemic episodes can induce severe neurological deficiencies including cerebral palsy and are associated with an increased risk of neuropsychiatric sequelae such as autistic and schizophrenic syndromes in later life. (biomedcentral.com)
Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)

2. Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE. (llu.edu)
10. Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE. (llu.edu)
Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
This results in a considerable improvement in injury caused by oxidative stress produced by different ischemia of cerebral areas of brain. (healthandhydrogen.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
Among them, it has the most significant effect on diseases with oxidative stress, such as neonatal brain hypoxia, Parkinson's disease, tissue ischemia-reperfusion injury, etc. (gdcawolo.com)

Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)

Methods: The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. (virascience.com)
Fortunately, hypoxia ischemia can be modeled in neonatal rats via carotid artery ligation, followed by a period of induced hypoxia. (uconn.edu)
Here we showed in neonatal rats exposed to P3C that the migration of neutrophils into the CSF, which occurred through the choroid plexuses, is abolished following administration of the antioxidant drug N-acetylcysteine. (biomedcentral.com)
N-acetylcysteine reduced the injury induced by hypoxia-ischemia in P3C-sensitized neonatal rats. (biomedcentral.com)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

Those insults to the brain occurred during the foetal, neonatal or early post-neonatal periods, and although the specific mechanisms are complex and vary, all are related to cerebral hypoxia and ischemia, and reperfusion (Hilario E. Current Pediatr Review 2006;2:131). (redsamid.net)

Blood purine concentrations were ∼2-3-fold elevated following hypoxia in mice [2.77 ± 0.48 μM (Control) vs. 7.57 ± 1.41 μM (post-hypoxia), p = 0.029]. (frontiersin.org)
We also found that female mice sustained smaller infarcts than males three months post- ischemia . (nih.gov)
We previously described that peripheral administration to neonatal mice of the TLR2 ligand PAM3CSK4 (P3C), a prototypic Gram-positive bacterial lipopeptide, induces the migration of innate immune cells to the CSF. (biomedcentral.com)
Retinal vascular recovery revealed by retinal imaging following neonatal hypoxia ischemia in mice: Is there a role for tyrosine kinase receptor modulation? (wisc.edu)
In guidance in the notion that far too much autophagy is detrimental adhering to stress filled disorders, Atg7 deficient mice subjected for the Rice-Vanucci design of cerebral neonatal hypoxia ischemia have significantly less hippocampal pyramidal neuron death vs. wild-type (Koike et al. (calcium-channel.com)
2007). Even further clouding our sex-specific understanding of the involvement of autophagy next injury, feminine mice subjected to cerebral neonatal hypoxia ischemia have improved cortical LC3BII concentrations compared to males (Weis et al. (calcium-channel.com)
This is also replicated in a mouse model of bipolar disorder in which GSK-3B is upregulated in genetically altered mice. (jeffreydachmd.com)

Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
During extended myocardial ischemia combinations of hypoxia and acidosis drive cardiac cell loss by apoptosis and necrosis that contribute importantly to myocardial infarction (MI). (biomedres.us)
Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
Our group reported that severe chronic hypoxia alone does not cause apoptosis of cardiac myocytes in culture. (biomedres.us)
Important roles of inflammatory mediators in cardiac cell death by ischemia with or without reperfusion are well established [12-14]. (biomedres.us)

A rat model of myocardial I/R injury was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with GRh2. (spandidos-publications.com)
Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)

Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. (molecularhydrogenstudies.com)

The fetal sheep asphyxia model also suggests a six-hour window post asphyxia in which hypothermia will have greatest benefit. (wikipedia.org)
We hypothesize that the neuroprotection afforded by the oral administration of bovine Lf can boost therapeutic effects of hypothermia in a rodent model of neonatal HI. (binc-geneva.org)

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)
The lack of a suitable fetal animal model that reproduces the motor deficits of CP has hampered definition of these mechanisms. (jneurosci.org)

In summary, data suggest that sex steroid hormones , such as progesterone and 17ß estradiol , improve morphological and cellular outcomes following neonatal HI. (bvsalud.org)

These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
Purines including adenosine are released during brain injury such as hypoxia and are also present in biofluids. (frontiersin.org)
This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
These mechanisms underlie its potent tissue protective effects in experimental models of stroke, cerebral hemorrhage, traumatic brain injury, neuroinflammatory and neurodegenerative disease. (biomedcentral.com)

In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. (jneurosci.org)
To elucidate the mechanisms of IP, we and others have modeled IP in vitro . (jneurosci.org)

SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion, tMCAo). (nih.gov)
SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent models of transient middle cerebral artery occlusion (tMCAo), with clinically relevant long-term outcomes and in models with common stroke comorbidities (i.e., aging, hypertension, diabetes, hyperlipidemia, obesity, etc. (nih.gov)
In our studies, the feasibility of using PAI for estimating the spatial distribution of oxygen saturation is examined, in models of occlusion reperfusion and adrenalin-dependent vasoconstriction in humans. (lu.se)

However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
We assessed two groups of infants with HIE who were (i) monitored prior to the introduction of TH in our neonatal intensive care unit (NICU) (pre-TH group) and (ii) monitored following the introduction of TH in our NICU, where all infants with moderate and severe HIE received TH (TH group). (nature.com)

However, oxygen therapy might cause the accumulation of distal bronchial viscous secretions because of positive pressure ventilation mode, and thus increase airway resistance, aggravate systemic hypoxia [15]. (researchgate.net)
HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
IUI alters cerebral metabolism because it causes a deficiency of oxygen and nutrients essential for maturing the neurochemical circuitry in the neonatal phase, particularly the glutamatergic and GABAergic pathways in the cerebral cortex [ 8 , 9 ]. (hindawi.com)
There are several factors (low temperature, hypoxia, strong ultraviolet light, and dryness) at high altitudes that affect the survival of mammals especially deoxygenated atmosphere which leads to inadequate oxygen reaching the animal's body. (scielo.br)
Ngb is a neuronal hemeprotein that shares its capability for oxygen binding while Hif-1α is a transcription factor that responds to decreases in available oxygen in the cellular environment or hypoxia. (scielo.br)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)

This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)
However, the combined effect of prophylactic zinc administration and therapeutic taurine treatment on intrauterine ischemia- (IUI-) induced cerebral damage remains unknown. (hindawi.com)
From 2007 to the end of 2017, people used a variety of animal models and clinical observations, and successively determined that hydrogen had different degrees of therapeutic effects on more than 200 diseases, of which 17 were clinically observed. (gdcawolo.com)

9. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. (llu.edu)
PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. (jneurosci.org)
Obligatory roles for acidosis in promoting apoptosis confirmed our previous reports that hypoxia alone does not confer a lethal signal. (biomedres.us)
Acidosis with or without hypoxia increased apoptosis that was paralleled by elevated miR-126, increased phosphorylation of p38-MAPK and JNK, enhanced expression of IL-6, IL-8, and TNF, and downregulation of Bcl-2. (biomedres.us)
In animal models, increased apoptosis accompanies both phases of ischemia and reperfusion [8]. (biomedres.us)

LEAG: study conception, de datos PubMed y Cochrane, se incluyeron artículos originales, estudios aleatorizados y de revisión, en español y en inglés, manuscript design, publicados entre 2017-2021. (bvsalud.org)

In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)

An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
Up to now, there are seven preliminary clinical research reports of hydrogen treatment diseases, namely type 2 diabetes, metabolic syndrome, hemodialysis, inflammation/mitochondrial myopathy, brain stem ischemia, side effects of radiotherapy and systemic lupus erythematosus. (gdcawolo.com)

and IL-1β}, abstract = { Background: Neonatal asphyxia is a respiratory failure during and just after birth. (undip.ac.id)

We recently reported that neonatal ischemia induces microglia/macrophage activation three days post- ischemia . (nih.gov)

Our results showed that taurine alone or in combination with zinc provides neuroprotection in the IUI rat model. (hindawi.com)

In the present study, a new neurobehavioral battery of tests was used to characterize the motor performance of newborn pups after sustained hypoxia-ischemia to the preterm rabbit fetus at 67-70% gestation. (jneurosci.org)
This model offers the distinct advantages that, similar to the human newborn, the newborn rabbit has immature locomotor function and the cerebral hemispheres are not fully myelinated. (jneurosci.org)
Uterine ischemia in the dams resulted in a distinct neurobehavioral phenotype in the newborn pups, which was characterized by an increase in forelimb tone that was significantly correlated with histological evidence of persistent injury to subcortical motor pathways involving the basal ganglia and anterior thalamus. (jneurosci.org)

The severity of these disabilities depends on the ischemia duration, damage expansion, and the affected brain region. (hindawi.com)

At present, preliminary clinical research has been carried out on cerebral ischemia and Alzheimer's disease. (gdcawolo.com)

Preterm fetuses (67-70% gestation) were subjected to sustained global hypoxia. (jneurosci.org)
Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. (jneurosci.org)

Hypoxia-ischemia (H-I) is also associated with subsequent cerebral injury in a disproportionately high percentage of the survivors of premature birth ( Volpe, 2001 ). (jneurosci.org)
Background: Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. (virascience.com)
The use of antioxidant molecules have proved useful to protect the neonatal brain from injury. (biomedcentral.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)

In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor regulating EPO expression. (jneurosci.org)
We provide evidence for the following signaling cascade: HIF-1 is activated rapidly by hypoxia in astrocytes. (jneurosci.org)

Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. (molecularhydrogenstudies.com)
It was discovered in 2007 that inhaled hydrogen had genuine protection against brain damage caused by ischemia and reperfusion because of its anti-inflammatory and anti-apoptotic properties (Fukuda et al. (healthandhydrogen.com)

We report a rabbit model of in utero placental insufficiency, in which hypertonia is accompanied by marked abnormalities in motor control. (jneurosci.org)
[ 2 , 10 ] In murine models, placental ischemia appears to be associated with an increased susceptibility to seizures and cerebrospinal fluid (CSF) inflammation. (medscape.com)

This systematic review with meta-analysis aims to verify the efficacy of sex steroid hormones in preventing HI-induced brain damage in rodent models. (bvsalud.org)

For that reason, a person with neonatal resuscitation. (msdmanuals.com)

Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)

2-3) Lithium was also found protective in stroke and traumatic brain industry animal models models. (jeffreydachmd.com)

The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)

Blood purines were measured in a mouse model of neonatal hypoxia and infants with NE using a novel point-of-care diagnostic technology (SMARTChip) based on the summated electrochemical detection of adenosine and adenosine metabolites in the blood. (frontiersin.org)
This animal model can produce brain injuries that roughly equate to functional injuries seen in term infants with HI when performed on P7, and also leads to similar cognitive and behavioral impairments. (uconn.edu)
Multichannel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72 h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction of TH in our neonatal unit. (nature.com)

and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)

cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1. (llu.edu)
Optimal Organ for Patient-derived Xenograft Model in Pancreatic Cancer and Microenvironment that Contributes to Success. (kyoto-u.ac.jp)

Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke. (nih.gov)

Protective effect of sex steroid hormones on morphological and cellular outcomes after neonatal hypoxia-ischemia: A meta-analysis of preclinical studies. (bvsalud.org)

Using this P7 HI model to assess behavioral outcomes, our lab has previously reported deficits in HI males on a Morris water maze task (a measure of simple spatial learning and memory). (uconn.edu)
A report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. (brainimmune.com)

Previous studies showed that intravascular injection of the HUCB significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). (virascience.com)

However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)

4. Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE. (llu.edu)
13. The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage. (llu.edu)

Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
Cells of the germinal matrix are rich in mitochondria and, therefore, are quite sensitive to ischemia. (medscape.com)

8. Viral-mediated gene delivery of TMBIM6 protects the neonatal brain via disruption of NPR-CYP complex coupled with upregulation of Nrf-2 post-HI. (llu.edu)

Anatomy3

Organisms3

Diseases10

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes3

Encephalopathy6

Cerebral hypoxia-ischemia2

Hypoxic8

Oxidative6

Reperfusion injury2

Rats5

Related to cerebral1

Mice7

Cardiac6

Myocardial4

Parkinson's1

Hypothermia2

Fetal2

Outcomes followin1

Brain injury4

Vitro2

Occlusion3

Severe2

Oxygen6

Therapeutic3

Apoptosis5

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Tissue2

Systemic3

Abstract1

Microglia1

Neuroprotection1

Newborn3

Severity1

Alzheimer's1

Preterm2

Injury5

Astrocytes2

Hydrogen2

Placental2

Rodent1

Resuscitation1

Cardiomyocytes1

Traumatic1

Adult1

Infants3

Insults1

Contributes2

Inflammatory1

Morphological1

Deficits2

Significantly1

Protective effect1

Pathway2

Cells2

Protects1