• In conclusion, the finding that the mutant phenotype Jeff is much more severe than the knock-out show that a mutation in the manifest Jeff gain-of-function and loss-of-function effects on both embryonic and adult stages. (mugen-noe.org)
  • Examination of rescue patterns in over 50 clock mutants showing either short periods, long periods or arrhythmia revealed restoration to WT phenotype in all mutants. (wikipedia.org)
  • In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
  • In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
  • Zebrafish cilia mutants frequently develop curly body axis phenotype due to motile cilia defects in the spinal cord [18]. (innovation-ecosystems-agora.com)
  • In this work, we explore the gaps in the spatial pattern of expression and extracellular matrix, adhesion and gap junction protein between wild-type and Nkx2-5 + / RG mutant mice. (mugen-noe.org)
  • Injecting the virus into the brains of mice that make mutant huntingtin improves their ability to move their limbs, although it does not prolong their lives. (scienceblog.com)
  • Although other researchers have shown that various intrabodies can protect cells from mutant huntingtin, the Emory team was the first to examine the effects of an intrabody in living mice, says senior author Xiao-Jiang Li, PhD, professor of human genetics at Emory University School of Medicine. (scienceblog.com)
  • Even though the intrabody only travels within the cytoplasm, it still alleviated the motor problems of mice that make mutant huntingtin when injected into the striatum, the scientists found. (scienceblog.com)
  • Mutant mice in which the LKB1 pathway is inactivated display progressive degeneration of axons, thus modeling AxD in disease. (buffalo.edu)
  • Using tumor models in mice, they were also able to demonstrate the development of the immune environment over the course of the disease. (dkfz.de)
  • in the absence of GABP b 1L, mice largely failed to succumb to disease, demonstrating that telomerase was essential to cause fatalities in this well-established model of brain cancer. (uab.edu)
  • It is incredibly risky to "keep all your mice in one basket", but it is all-too-often the case that investigators maintain a single breeding colony of models with no insurance or backup in the event of a catastrophic loss. (taconic.com)
  • Finally, by establishing a CVB4 infection model in A/J mice, we demonstrated that the vaccine virus could also protect against CVB4 infection. (unl.edu)
  • Recently, the laboratory has observed analogous prefrontal hypo-connectivity in three well-characterized mouse models of ASD, namely CNTNAP2 null mice 2 , SHANK3 null mutants (unpublished data), and mice carrying a hemizygous deletion syntenic to 16p11.2 deletion syndrome (unpublished data). (sfari.org)
  • To this aim, they will measure connectivity in two additional mouse models of ASDs that recapitulate core autism traits in mice, namely mice with triple genetic dosage of UBE3A (a model for dup15q syndrome) and TSC2 heterozygous mice (a model for tuberous sclerosis complex). (sfari.org)
  • Many of these tissues and organs are known to be affected in mutant mice lacking CBP and in patients with Rubinstein-Taybi syndrome. (medscape.com)
  • Mutant proteins have a region consisting of the same amino acid (glutamine) many times, called poly-glutamine, which makes the proteins clump together inside brain cells. (scienceblog.com)
  • Our goal here was to create a tool that could distinguish between the accumulation of mutant proteins in the nucleus and the cytoplasm," he says. (scienceblog.com)
  • The mutant phenotypes being all caused by a single amino acid substitution on one of the aforementioned genes determined that Kai proteins play a significant role in the Synechococcus circadian clock. (wikipedia.org)
  • I used live imaging to study fluorescently tagged synaptic proteins in a sod-1 loss of function model and a wild-type model. (sens.org)
  • In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
  • Additionally, such circadian periods seen in kaiC in vivo mutants were also observed in in vitro strains. (wikipedia.org)
  • AHR1A-dependent CYP1A immunohistochemical expression in the liver provided in vivo confirmation of the in silico docking studies. (oregonstate.edu)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
  • this exercise serves as a model for future efforts employing both in vitro and in vivo models against possible pandemic pathogens. (cdc.gov)
  • To model the effect in vivo, the authors used a transgenic mouse which over-expressed UMOD leading to salt-sensitive hypertension and interstitial nephritis . (medscape.com)
  • Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
  • As curator of K-State's International Fungal Genetics Stock Center , McCluskey is engaged in diverse efforts including the development of big data for living collections in cooperation with the World Data Centre for Micro-organisms of the World Federation for Culture Collections, and the Phytobiome Initiative of the American Phytopathological Society. (k-state.edu)
  • This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic tractability compared with many model organisms. (portlandpress.com)
  • For over 80 years, Carolina has been providing the highest-quality living organisms and cultures available. (carolina.com)
  • Caring for your living organisms is critical to your success in the classroom. (carolina.com)
  • 2 − 6 These nuclease-resistant polymers persist in live organisms for days and are typically designed to recognize 25-base sequences that span intron-exon junctions or translational start sites. (cdc.gov)
  • Efficient proximity labeling in living cells and organisms with TurboID. (lu.se)
  • We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
  • The resulting blockade of RNA splicing or translation allows loss-of-function phenotypes to be determined within days, contrasting the months that can be required to obtain homozygous mutants. (cdc.gov)
  • Professor Forsburg studies how chromosome duplication and maintenance contributes to overall genome stability using a simple model genetic system, the fission yeast Schizosaccharomyces pombe . (usc.edu)
  • As part of this project, a novel chromosome translocation was identified, which provides a model for Robertsonian translocation. (usc.edu)
  • IDH-mutated tumors have a very high incidence of seizure activity, and if we look at preclinical models we can see that vorasidenib can help decrease that seizure activity, and if we're thinking about our 21-year-old college student, this can have a significant impact on the quality of life," he said. (medscape.com)
  • And what we end up seeing from a practical perspective is when these patients with low-grade tumors are treated with radiation therapy, as they live for a number of years we can see that there is diffuse atrophy and wear and tear on the white matter tract in the brain, and that's something we desperately want to prevent in this patient. (medscape.com)
  • Adjuvant chemoradiotherapy has become the standard of care for patients with IDH-mutant grade 3 gliomas and patients with IDH-mutant grade 2 tumors who are thought to be a high risk for early progression. (medscape.com)
  • Defactinib is a selective inhibitor of focal adhesion kinase (FAK), which reduces stromal density in preclinical pancreatic cancer models and in liver metastases from pancreatic cancer patients. (pancan.org)
  • Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
  • Several novel therapies have shown efficacy in animal models, but have not been studied in ARPKD patients due to the absence of safe and reliable measures of CHF progression. (pkdcure.org)
  • VS-6766 is a unique RAF/MEK clamp with demonstrated preclinical and clinical anti-tumor efficacy against KRAS mutant cancers. (pancan.org)
  • Moreover, characterization of the cyanobacterial clock demonstrated the existence of transcription-independent, post-translational mechanisms of rhythm generation, challenging the universality of the transcription-translation feedback loop model of circadian rhythmicity. (wikipedia.org)
  • The subsequent characterization of the model is an even greater investment, often taking years' effort in the laboratory. (taconic.com)
  • With scheduled presentations on the "U.S. Culture Collection Network in the context of the World Federation for Culture Collections" and "Genome Anaylsis for Mutant Characterization in a Model Plant-Associated Fungus," McCluskey will bring the perspective of valuable living microbe collections of plant pathogens. (k-state.edu)
  • Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse models and in patients with extrahepatic metastasis. (nature.com)
  • We also observed fatty liver and decreased cytochrome P450 expression at diagnosis in tumour-free livers of patients with pancreatic cancer who later developed extrahepatic metastasis, highlighting the clinical relevance of our findings. (nature.com)
  • Artegiani says, "We used healthy human liver organoids, mini-livers grown in the lab, in our research. (medicalxpress.com)
  • Our overall goals are to gain a better understanding of how GSK-3 regulated splicing contributes to development of MDS and to investigate whether inhibiting GSK-3 is a viable treatment for splicing factor mutant MDS. (lls.org)
  • The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now. (illinois.edu)
  • The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
  • Mathematical modelling based on scarce empirical evidence and key assumptions has driven isolation and testing policy, but real-world data are needed. (bvsalud.org)
  • The model was also successfully applied to E. coli K12, used for the authors' original modeling, as well as for two other E. coli strains. (iucr.org)
  • Methods and Results: Biofilm formation on plastic and cFn-coated surfaces by the wild-type M1 and M41 strains, and their isogenid sc/1-inactivated mutants, we compared spectrophotometrically following crystal violet staining. (cdc.gov)
  • Biofilm formed on nECM was comparable to that formed on commercial cFn and there was a statistically significant decrease in biofilm formed by both scl1 mutants as compared with the WT strains. (cdc.gov)
  • Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
  • Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
  • Advances in genetic engineering and genome editing technologies resulted in the generation of thousands of genetically engineered mouse and rat models. (taconic.com)
  • Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
  • We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
  • Also when such colonies are the sole source of the model, there is risk of losing the line altogether to unanticipated death, disease, infertility, genetic drift, or microbial contamination. (taconic.com)
  • By comparing the results from these studies with the previous data collected from assessments of CNTNAP2, SHANK3 and 16p11.2 deletion mouse models, these experiments will provide detailed insight into the determinants and significance of connectivity aberrancies associated with genetic mutations underlying ASDs. (sfari.org)
  • These heterozygous mutations drive monoallelic expression and are common in many cancer types, but are especially prevalent in glioblastomas, melanomas, myxoid liposarcomas, liver cancers, and bladder cancers. (uab.edu)
  • The combination of VS-6766 with defactinib has shown clinical benefit with good tolerability for patients with KRAS mutant lung and ovarian cancers and has received FDA Breakthrough Therapy Designation for treatment of patients with low-grade serous ovarian cancer. (pancan.org)
  • My group recently discovered that the liver kinase B1 (LKB1) pathway regulates many metabolic components in oligodendrocytes, which are central to the support of axons," Beirowski says. (buffalo.edu)
  • 2015). Importantly, the long isoform, GABP b 1L, regulates a restricted subset of genes, and in a mouse xenograft model of glioblastoma regulates expression from mutant TERT promoters (Mancini et al. (uab.edu)
  • Third, we successfully developed a novel live-attenuated vaccine virus (Mutant 10 or Mt 10), bearing the single amino acid substitution H790A in CVB3 VP1. (unl.edu)
  • Jeff mutant mouse is a mouse model for OM identified a single gene on the screen deaf as part of an ENU mutagenesis program at MRC Harwell. (mugen-noe.org)
  • An ASNA1 point mutant identified using CRISPR-mediated mutagenesis abolishes both the cytoprotective effect of Retro-2 against ricin and its inhibitory effect on ASNA1-mediated ER-targeting. (elifesciences.org)
  • The cellular body is modeled, as previously described, by an ellipsoid with multiple shells. (iucr.org)
  • Yet, this single mutation caused a rather mild effect on the overall cellular and molecular behavior of the liver cells. (medicalxpress.com)
  • He then moved on to Harvard Medical School where he completed his MD and PhD in genetics studying the host pathogen interaction using C. elegans as a model system. (edu.au)
  • Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant. (princeton.edu)
  • C. elegans might serve as a model for studying the molecular genetics of mammalian tissue decline. (princeton.edu)
  • I joined Dr. Anne Hart's lab, where I began studying synaptic dynamics at the neuromuscular junction in a C. elegans ALS model. (sens.org)
  • Cryopreservation preserves structurally intact, living cells and tissues for storage at very low temperatures. (taconic.com)
  • Further sequencing revealed 19 total kaiABC specific mutants, 14 of which had mutations in kaiC, 3 in kaiA, and 2 in kaiB. (wikipedia.org)
  • There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
  • Congenital heart disease (CHD) affects nearly one percent of all live births. (mugen-noe.org)
  • Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. (scienceblog.com)
  • Li says finding an antibody that prefers to bind mutant, aggregated protein could also prove useful in the study of other neurodegenerative disorders, such as Alzheimer's disease or Creutzfeldt-Jakob disease. (scienceblog.com)
  • Autosomal Recessive Polycystic Kidney Disease (ARPKD) affects approximately 1/20,000 children and has two main features, polycystic kidneys and the liver disease, congenital hepatic fibrosis (CHF). (pkdcure.org)
  • Our collaborative research team (Drs. Dell & Flask) has been studying novel MRI methods to assess ARPKD kidney and liver disease progression for over a decade. (pkdcure.org)
  • To address this important limitation, our group has applied and optimized a novel technique, MR-Fingerprinting (MRF), to study both ARPKD kidney and liver disease. (pkdcure.org)
  • With supplemental funding, we obtained initial liver MRF images, showing that mean T1 values are significantly higher in ARPKD patients with advanced CHF vs. both healthy volunteers and ARPKD patients with milder disease. (pkdcure.org)
  • The Specific Aims are to evaluate T1-MRF across a spectrum of ARPKD liver disease and compare T1-MRF with US measures of liver scarring. (pkdcure.org)
  • Her clinical and translational research program has focused on identifying novel MRI biomarkers of ARPKD kidney and liver disease progression. (pkdcure.org)
  • History of Irritable Bowel Syndrome (as defined by the Rome III criteria or medical diagnosis) or gastric ulcer disease) or enteric, pulmonary, cardiac, liver or renal disease. (who.int)
  • This allowed our colleagues in the Institute of Cardiovascular and Medical Sciences to design mutant viruses that do not bind FX and therefore may be used to target efficiently different organs for gene therapy. (gla.ac.uk)
  • Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington's. (scienceblog.com)
  • The team found that worms treated with trichostatin A, LY-294002, allantoin and rapamycin stayed healthier and lived longer. (ibtimes.com.au)
  • This year we have an incredibly exciting program with global thought-leaders sharing their latest insights into aging and how we target aging process ensuring everyone lives a healthier and longer life. (fightaging.org)
  • Notably, tumour EVP education enhanced side effects of chemotherapy, including bone marrow suppression and cardiotoxicity, suggesting that metabolic reprogramming of the liver by tumour-derived EVPs may limit chemotherapy tolerance in patients with cancer. (nature.com)
  • Fig. 1: Remote primary tumours induce metabolic dysfunction in the liver. (nature.com)
  • Fig. 2: Tumour-derived EVPs induce liver metabolic dysfunction. (nature.com)
  • The transformation of a 44 hour long-period clock mutant, C44a, with wild-type (WT) genomic DNA library in a plasmid vector allowed testing for "rescue clones" with a normal period of 25 hours. (wikipedia.org)
  • Phytochrome mutants grow very differently from wild type plant (upper left) under the same conditions. (phys.org)
  • As part of an effort to create plants that can tolerate different growth conditions, Richard Vierstra the George and Charmaine Mallinckrodt Professor in Arts & Sciences at Washington University in St. Louis has been developing a library of phytochrome B mutants, including ones that are much more or less sensitive to light than the wild type plant. (phys.org)
  • Previously, we found that collagens are required for insulin signaling mutants' long lifespan and that overexpression of specific collagens extends wild-type lifespan. (princeton.edu)
  • complementation of Scl1 expression in the mutant restored biofilm to wild-type level. (cdc.gov)
  • In this review, we summarize how impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression. (hindawi.com)
  • The revised model succeeded in fitting USAXS/SAXS and differently contrasted VSANS/SANS data of E. coli ATCC 25922 over four orders of magnitude in length scale. (iucr.org)
  • It has been proved earlier in animal models that calorie restriction helps slow down ageing. (ibtimes.com.au)
  • In mutant worms, the drugs worked in a similar fashion as calorie restriction would. (ibtimes.com.au)
  • Newer ultrasound (US)-based elastography methods, that measure liver stiffness (scarring) can distinguish mild vs severe CHF but may lack sensitivity to detect and measure early CHF, when therapies are most likely to be effective. (pkdcure.org)
  • Measurements of elasticity showed that long-lived daf-2 mutants were considerably better at preventing progressive mechanical changes with age. (princeton.edu)
  • Granted B chord amnesty by King of the Mutants (Long live the king). (chordie.com)
  • 1987. Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model. (cdc.gov)
  • MRD measurements at different pH values show that ionization of Glu-66 or Lys-66 is not accompanied by penetration of long-lived water molecules. (lu.se)
  • The results of this study really suggest that in selected patients with IDH mutant low-grade gliomas we can potentially delay the use of these toxic chemotherapies and radiation, maybe for years if not many years, and as a result delay the long-term toxicities of those therapies in a group of patients who typically are experiencing long-term survival," Lesser added. (medscape.com)
  • The fatty acid cargo of tumour EVPs-particularly palmitic acid-induced secretion of tumour necrosis factor (TNF) by Kupffer cells, generating a pro-inflammatory microenvironment, suppressing fatty acid metabolism and oxidative phosphorylation, and promoting fatty liver formation. (nature.com)
  • Fig. 5: Tumour EVPs suppress liver drug metabolism and enhance chemotoxicity. (nature.com)
  • With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
  • The research team believes that since testing anti-ageing interventions in humans is not a practical option, it would be best to develop computational models that predict the longevity of the drugs. (ibtimes.com.au)
  • Although the potential of cryopreservation was recognized as early as the 17th century, cryopreservation of living cells had invariably resulted in lethality until a mislabeled reagent bottle led to the discovery that freezing chicken sperm in a solution of glycerol preserved their viability 1 . (taconic.com)
  • In silico modeling predicted differential binding of TCDD and leflunomide to the AHR paralogues. (oregonstate.edu)
  • We will test whether these drugs are effective in mouse models of MDS. (lls.org)
  • Coated viruses are then sequestered in the liver. (gla.ac.uk)
  • Employment of experimental models to assess the pandemic risk of emerging zoonotic influenza viruses provides critical information supporting public health efforts. (cdc.gov)
  • The overall transmission outcomes for both viruses across 11 laboratories were concordant, suggesting the robustness of the ferret model for zoonotic influenza risk assessment. (cdc.gov)
  • The exponential growth of the use of rodent models in pre-clinical research over the last decade is outpacing vivarium capacity. (taconic.com)
  • The prevalence of Rubinstein-Taybi syndrome in the general population is approximately 1 case per 300,000 persons and is as high as 1 case per 10,000 live births. (medscape.com)
  • Thyroid status in children and adolescents living in areas contaminated with radioactive materials after the Chernobyl accidents. (cdc.gov)
  • Fibrolamellar carcinoma (FLC) is a type of liver cancer, mostly affecting adolescents and young adults. (medicalxpress.com)
  • 1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)
  • [ 11 ] reported that no phenotypic differences were observed among patients with partial deletion, complete deletion, and nondeletion, supporting a haploinsufficiency model for Rubinstein-Taybi syndrome. (medscape.com)
  • Artegiani and Hendriks constructed the liver organoid models by modifying the protein kinase A (PKA) using CRISPR-Cas9. (medicalxpress.com)
  • CRISPR/Cas9 screens, which have revolutionised human and model organism research, have not yet been implemented in malaria parasites due to the need for more complex CRISPR/Cas9 gene targeting vector libraries. (portlandpress.com)
  • Notably, Kupffer cell ablation or TNF blockade markedly decreased tumour-induced fatty liver generation. (nature.com)
  • It has proven to be an important model for cell division. (usc.edu)
  • Fission yeast is a simple, single-celled organism with chromosomes very similar to those in humans, and has proven to be an important model for cell division. (usc.edu)
  • In glioblastoma, liver cancer, and bladder cancer cell lines, mutant TERT promoters recruit the housekeeping transcription factors GABP a & GABP b 1 (Bell et al. (uab.edu)
  • An important debate in understanding ALS pathogenesis is whether mutant SOD1 causes cell death from loss of its normal function or from gaining some toxic function. (sens.org)
  • Further, histological analysis suggested that multiple cysts developed in the mutant liver due to cell apoptosis. (innovation-ecosystems-agora.com)
  • We have established a method allowing to study the cell-specific secretome of pericytes in vitro-using Turbo-ID, a mutant non-toxic biotin ligase (6). (lu.se)
  • By modeling the interaction at atomic resolution we determined a list of key amino-acids on the capsid surface that mediate the interaction. (gla.ac.uk)
  • Li and his colleagues showed that cultured cells that make both the intrabody and mutant huntingtin are able to get rid of the mutant protein faster and have fewer clumps of huntingtin. (scienceblog.com)
  • Fig. 3: Uptake of tumour-derived EVPs by Kupffer cells induces fatty liver formation. (nature.com)
  • Fig. 4: Palmitic acid in tumour EVPs induces TNF secretion from Kupffer cells and promotes fatty liver generation. (nature.com)
  • We propose to test whether these drugs kill MDS cells in living animals. (lls.org)
  • Human brain vascular pericytes treated with either scrambled or RGS5 targeting siRNA, will be co-cultured in a spheroid model of the BBB together with human brain endothelial cells and human astrocytes. (lu.se)
  • sod-1 is a gene encoding superoxide dismutase 1 (SOD1), and mutant forms of this protein are responsible for some cases of familial ALS. (sens.org)
  • The organoids contained the so-called mutant fusion gene DNAJB1-PRKACA. (medicalxpress.com)
  • 2. Any prior exposure to ETEC (including LSN03-016011/A) or cholera occupationally or received LT (Or any mutant forms of LT (e.g. (who.int)
  • These mutant lines are generated with great excitement and passion, and researchers often prefer to maintain live breeding colonies to secure their investment. (taconic.com)
  • Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. (wjgnet.com)
  • CHF results in progressive deleterious changes in the bile ducts of the liver and can be associated with significant, life-threatening complications, including portal hypertension (leading to severe bleeding), bile duct infection or cancer. (pkdcure.org)
  • Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer. (medicalxpress.com)
  • Spark the scientific breakthroughs that innovate treatments to improve the lives of patients. (pancan.org)
  • Schematic model represents the overview of the autophagy process. (hindawi.com)
  • Oneill Mutant 4/3 with removable hood - Large/Short - $60 firm. (wblivesurf.com)
  • Created by comic book artists Kevin Eastman and Peter Laird, Teenage Mutant Ninja Turtles or TMNT for short, focuses on four anthropomorphic mutant turtles that live in the sewers and fight various evil people or groups. (bigbadtoystore.com)