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  • warm ischemia
  • The study of AKI/ATN has relied heavily on one particular animal model: the warm ischemia-reflow model (often referred to as "ischemia-reperfusion injury"), in which one of the renal arteries is transiently ligated off for a set period of time while body temperature is maintained, then opened up and allowed to reperfuse the kidney. (blogspot.com)
  • Some the important differences between mouse and human AKI: First, while the warm ischemia-reperfusion model tends to initially target the S3 segment of the proximal tubule and typically leads to overt tubular necrosis, in human AKI necrosis is not always present, and when it is tends to be patchy and most commonly affecting the distal nephron (in particular: the medullary thick ascending limb and medullary collecting ducts). (blogspot.com)
  • Second, in clinical practice it is COLD ischemia which is often the mechanism of injury (e.g., surgical procedures in which the aorta is cross-clamped is often performed in the setting of a lowered core temperature, and donated kidneys are typically stored on ice prior to transplantation), rather than warm ischemia. (blogspot.com)
  • These findings support the role of EO in IRI and suggest that rostafuroxin pre-treatment of patients before partial nephrectomy with warm ischemia may reduce IRI, particularly in those with high EO. (mdpi.com)
  • Myocardial Infarction
  • Recent studies have identified signature expression patterns of miRNAs associated with pathological cardiac hypertrophy, heart failure, and myocardial infarction in humans and mouse models of heart disease [ 11 ]. (medsci.org)
  • liver
  • Ischemia-reperfusion injury in rat steatotic liver is dependent on NF κ B P65 activation," Transplant Immunology , vol. 26, no. 4, pp. 201-206, 2012. (hindawi.com)
  • The aim of this study is to explore the hepatoprotective effect of intraportal prostaglandin E1 (PGE1) on liver ischemia reperfusion (IR) injury using an extrahepatic cholestatic model, observing oxidative stress markers, proinflammatory factors, apoptotic marker proteins, and an adhesion molecule. (hindawi.com)
  • Prostaglandin E1 (PGE group) or normal saline (NS group) was continuously infused from 15 min before liver ischemia to 1 h after reperfusion. (hindawi.com)
  • After reperfusion, histopathological evaluation of the liver was performed, as were measurements of bilirubin, biochemical enzymes, oxidative stress markers (GSH and MDA), proinflammatory factors (MPO, TNF- α , and IL-1 β ), apoptotic marker proteins (Bcl-2 and Bax), and the adhesion molecule (ICAM-1). (hindawi.com)
  • The aim of this study is to evaluate the hepatoprotective effect of intraportal PGE1 on liver IR injury in a common bile duct ligated rat model. (hindawi.com)
  • Ischemia-reperfusion (I/R) injury associated with living donor liver transplantation impairs liver graft regeneration. (sigmaaldrich.com)
  • The MSC group showed peak luciferase activity of transplanted MSCs in the remnant liver 24 h after reperfusion, after which luciferase activity gradually declined. (sigmaaldrich.com)
  • protects
  • Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling," International Journal of Clinical and Experimental Medicine , vol. 8, no. 9, pp. 14793-14804, 2015. (hindawi.com)
  • transplantation
  • To demonstrate the clinical efficacy of autologous mitochondrial transplantation in preparation for translation to human application using an in vivo swine model. (ovid.com)
  • Ischemia and reperfusion (I/R) injury is a major cause of AKI, frequently occurring as a result of hypotension, hypovolemia, sepsis, or following renal transplantation [ 1 ]. (hindawi.com)
  • Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. (spiedigitallibrary.org)
  • Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. (biomedcentral.com)
  • vivo
  • We believe this model has the potential to revolutionise the approach researchers in cell biology and drug safety toxicity can take to evaluate ischemic reperfusion and to reduce the dependency for in vivo animal models. (ddw-online.com)
  • In vivo cardioprotection by pitavastatin from ischemic-reperfusion injury through suppression of IKK/NF- κ B and upregulation of pAkt-e-NOS," Journal of Cardiovascular Pharmacology , vol. 58, no. 2, pp. 199-206, 2011. (hindawi.com)