Model hepatocyte nuclear factor 6. Medical search. Frequent questions

BACKGROUND: Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. (rug.nl)
We demonstrate that curcumin effectively suppressed HFFA-induced production of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in hepatocytes. (spandidos-publications.com)

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
2022. Development and testing of a mechanistic model for wetland treatment of neutral and polar organic contaminants in oil sands process-affected water: Application to the Kearl Treatment Wetland in Alberta, Canada. (sfu.ca)

Transcript-specific and gender-selective effects on selenoprotein mRNA abundance were greater in Secisbp2-deficient hepatocytes than in tRNA[Ser]Sec-deficient cells. (nih.gov)
The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, zonula occludens (ZO)-1, Beclin-1 and autophagy-related (atg) 5 mRNA was evaluated by quantitative PCR, and the expression of ZO-1, microtubule-associated proteins 1A/1B light chain 3B (LC3B) I and, LC3B II protein by Western blot. (karger.com)
Similarly, incubation with 1,25(OH)2D3 increased levels of Cyp24a1/CYP24A1 and Cyp7a1/CYP7A1 mRNA in mouse and human hepatocytes, and reduced levels of Shp mRNA in mouse hepatocytes. (nih.gov)
Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells. (bioservuk.com)
With this cell model, it was reported that CYP2Cs significant levels of mRNA, protein, and activity t Induces the therapeutic reagents, glucocorticoid hormones Like the D, vitamin and endogenous metabolites Lithochols ure, Which has been shown to induce CYP2C8. (c-kitinhibitors.com)
The induction of mRNA and protein of CYP2C19 shows a large interindividual variability en t In the human liver. (c-kitinhibitors.com)

Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. (taconic.com)
These recent studies showed that curcumin inhibited HSCs activation, and suppressed hepatic fibrogenesis in vitro and in vivo ( 6 , 7 ). (spandidos-publications.com)
This model recapitulates an in vivo process in which AEC transition from one differentiated cell type to another during regeneration following lung injury. (huji.ac.il)
In addition to pathogen resistance, many other factors contribute to poor treatment outcome including sub-therapeutic in vivo concentrations of antimicrobials or drug-drug interactions. (proteasepathway.com)
We studied these processes in mice in vivo and mouse and human hepatocytes. (nih.gov)
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin. (ifado.de)
6] Rosuvastatin displays cardioprotective effects in vivo. (bioservuk.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
To model the effect in vivo, the authors used a transgenic mouse which over-expressed UMOD leading to salt-sensitive hypertension and interstitial nephritis . (medscape.com)

P10 will use transgenic mice that express or lack nuclear ATF6 specifically in hepatocytes (nATF6liv) to understand how local increase of active ATF6 affects the immune system in HCC. (uni-freiburg.de)
METHODS: Hepatocyte-specific G6pc knockout (L-G6pc-/-) mice were treated with AAV-shChREBP to normalize hepatic ChREBP activity. (rug.nl)
RESULTS: Hepatic ChREBP normalization in GSD Ia mice induced dysplastic liver growth, massively increased hepatocyte size, and was associated with increased hepatic inflammation. (rug.nl)
Furthermore, nuclear levels of the oncoprotein Yes Associated Protein (YAP) were increased and its transcriptional targets were induced in ChREBP-normalized GSD Ia mice. (rug.nl)
Hepatic ChREBP normalization furthermore induced DNA damage and mitotic activity in GSD Ia mice, while gene signatures of chromosomal instability, the cytosolic DNA-sensing cGAS-STING pathway, senescence, and hepatocyte dedifferentiation emerged. (rug.nl)
As ChREBP has been proposed as a pro-oncogenic molecular switch that supports tumour progression, we hypothesized that ChREBP normalization protects against liver disease progression in hepatic GSD Ia.METHODS: Hepatocyte-specific G6pc knockout (L-G6pc-/-) mice were treated with AAV-shChREBP to normalize hepatic ChREBP activity.RESULTS: Hepatic ChREBP normalization in GSD Ia mice induced dysplastic liver growth, massively increased hepatocyte size, and was associated with increased hepatic inflammation. (rug.nl)
Despite the massive reduction of Dio1 and Sepp1 mRNAs, significantly more corresponding protein was detected in primary hepatocytes lacking Secisbp2 than in cells lacking tRNA[Ser]Sec. Regarding selenoprotein expression, compensatory nuclear factor, erythroid-derived, like 2 (Nrf2)-dependent gene expression, or embryonic development, phenotypes were always milder in Secisbp2-deficient than in tRNA[Ser]Sec-deficient mice. (nih.gov)
The postnatal TG mice displayed significant reduction in serum glucose levels and in hepatocyte glycogen storage without increased serum levels of ketone bodies and free fatty acid suggesting that they are not undergoing a starvation response. (duke.edu)
In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle. (duke.edu)
For induction of endotoxic AKI, C57Bl6 mice received an intraperitoneal shot of LPS (10 mg/kg) that within 6 hours SCR7 inhibitor database induced AKI characterized by oliguria or anuria, BUN increase, and a dramatic upregulation of renal AKI biomarker genes, including and TNF-were observed early after the injection of LPS (Number 1A, Supplemental Number 1A). (bms-911543.com)

Hepatocyte growth factor activator inhibitor type 1 (HAI-1), encoded by the Spint1 gene, is a membrane-bound serine protease inhibitor expressed on the epithelial cell surface. (oncotarget.com)
Embryonic mouse models have demonstrated that ROCK protein inhibitor decreases the number of terminal lung buds. (medscape.com)

7(6)2021 12. (bvsalud.org)
2021. Fugacity-Based Trophic Magnification Factors Characterize Bioaccumulation of Cyclic Methyl Siloxanes within an Urban Terrestrial Avian Food Web: Importance of Organism Body Temperature and Composition . (sfu.ca)
2021. Deconvoluting thermodynamics from biology in the aquatic food web model . (sfu.ca)
2021. Lipid Normalizing the Biomagnification Factor . (sfu.ca)

In the HAI-1-deficient intestine, inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, were upregulated in normal mucosa. (oncotarget.com)
Vesicular high transcription, by paper, is 10,000 proteins lower than the factor of the mutant( sponteneously 10 Interleukin-15). (erik-mill.de)
The number of welding years correlated with decreased respiratory system reactance and increased serum levels of matrix metalloproteinases 9, interleukin 6, and hepatocyte growth factor. (lu.se)

Hepatic GSD Ia is characterized by constitutive activation of Carbohydrate Response Element Binding Protein (ChREBP), a glucose-sensitive transcription factor. (rug.nl)
Method】 The sequence of TLR 4 gene CDS in Cygnus olor was amplified by PCR and cloned.NCBI-BLAST and Mega-X were used for sequence comparison and phylogenetic tree construction.The structure and function of TLR4 protein and its interaction with host protein were predicted using ProtParam,SWISS-MODEL,etc. (chvm.net)
Conclusion】 TLR4 gene in Cygnus olor was closely related to Anser anser and Anser cygnoides ,with obvious codon species selectivity,and contained 6 consecutive rare codons.TLR4 protein had transmembrane domains and signal peptides,and was closely related to innate immune response,signal transduction and stress response. (chvm.net)
For instance, N -acetyl- p -benzoquinone imine (NAPQI) protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis , danger-associated molecular patterns (DAMPs) are released to elicit sterile inflammation , and certain growth factors contribute to liver regeneration. (zju.edu.cn)
Although there are often found on insulin-like growth factor-1 binding protein excretion or indirectly. (lorenzopetrantoni.com)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
However, as opposed to what seen in the AKI model, IFN-treatment induced a moderate but significant reduction in HNF-1protein manifestation (Number 2C), whereas protein levels were drastically decreased (six- to seven-fold) when gene manifestation was inhibited with an siRNA, suggesting that these conditions did not fully recapitulate the condition where HNF-1protein large quantity is probably controlled by multiple cytokines. (bms-911543.com)
Lung measurements were performed with standard spirometry and new methods: airspace dimension assessment (AiDA), oscillometry, blood serum biomarkers (club cell secretory protein 16, surfactant protein D, matrix metalloproteinases, fibroblast, hepatocyte growth factor, interleukins), and one urine biomarker (desmosine). (lu.se)

Interrogation of histone marks over time revealed enrichment of specific transcription factor binding motifs within regions of changing chromatin structure. (huji.ac.il)
We studied the regulation of Shp by Vdr using reporter and mobility shift assays in transfected human embryonic kidney 293 cells, quantitative polymerase chain reaction with mouse tissues and mouse and human hepatocytes, and chromatin immunoprecipitation assays with mouse liver. (nih.gov)
After the activation by exposure to xenobiotic nuclear receptors bind to influence response elements as monomers or homo or hetero dimers recruit school coactivators chromatin structure and the transcription of target genes. (c-kitinhibitors.com)

Hepatology , 37 (6), 1414-1424. (duke.edu)
Hepatology 37, no. 6 (June 2003): 1414-24. (duke.edu)

This syndrome is characterized by steatosis in hepatocytes and elevated serum levels of free fatty acids (FFAs) ( 1 ). (spandidos-publications.com)
Welders had significantly higher respiratory system resistance assessed with oscillometry, serum levels of metalloproteinases 9 and hepatocyte growth factor, compared with controls. (lu.se)
It was speculated that early discharge of term infants (before their serum bilirubin concentration peaks) could be a factor in the reemergence of this devastating neurologic affliction, and medical research focused on developing surveillance and treatment paradigms to eliminate the condition. (medscape.com)

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. (ifado.de)
Transforming growth factor-beta1 suppresses hepatitis B virus replication primarily through transcriptional inhibition of pregenomic RNA. (sinica.edu.tw)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)

Furthermore, increased nuclear translocation of NF-κB was observed in both normal mucosa and tumor tissues of HAI-1-deficient Apc Min/+ intestines, and an NF-κB target gene, such as urokinase-type plasminogen activator, was upregulated in the HAI-1-deficient tumor tissues. (oncotarget.com)
In hepatocyte-specific conditional mouse models, Secisbp2 gene inactivation is less detrimental than tRNA[Ser]Sec inactivation. (nih.gov)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
Several nuclear receptors have been identified xenobiotic-induced activation of gene transcription human CYP2C are involved. (c-kitinhibitors.com)

CAR constitutively active ligand and without many xenobiotics primarily act by inducing its nuclear translocation t would, as a ligand. (c-kitinhibitors.com)

To circumvent the hepatic functional redundancy of the Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) promoter functioned to increase hepatocyte expression of the Foxa2 cDNA. (duke.edu)

Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam). (spandidos-publications.com)
Together, these data suggest that curcumin protects hepatocytes from HFFA-induced lipoapoptosis and mitochondrial dysfunction, which partially occurs through the regulation of mitochondrial biogenesis. (spandidos-publications.com)
Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)

These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. (bu.edu)
Conditional deletion of Secisbp2 in hepatocytes significantly decreased selenoprotein expression. (nih.gov)
Objective】 The purpose of this study was to investigate the regulatory role and expression mechanism of TP53 apoptotic effector factor (PERP1) in follicular development. (chvm.net)
PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)
Our findings further strengthen the view of transcription factor involved in the mitochondria biogenesis or function, continues to be emphasized,10 but how PPARGC1A activity and expression are modulated at the first levels of AKI continues to be largely unknown. (bms-911543.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)

Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)

MATE transporters are present in all the three domains of life, i.e., bacteria, archae, and eukarya [6]. (proteasepathway.com)
Although bacteria, Degenerating hepatocytes were noted (GenBank accession no. (cdc.gov)

MATE transporters efflux organic cations in exchange with protons across the luminal membrane of renal proximal tubule cells and the canalicular membrane of hepatocytes, thereby enabling excretion of organic cations into urine and bile. (proteasepathway.com)

Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. (bu.edu)
Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)

In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-α, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. (karger.com)
The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)

that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)
Nuclear receptor-mediated transcriptional activation of genes by drugs CYP2C in Liver transcriptional activation of most P450 genes is mediated by nuclear receptors sensitive drugs, the transcription factors of detecting foreign matter are Rpern. (c-kitinhibitors.com)

METHODS Single factor test and response surface methodology were adopted to investigate the effects of ethanol volume fraction， extraction time， solid-liquid ratio and extraction times on the heating reflux extraction technology of total triterpenoids ethanol extract using the extraction rate of total triterpenoids of C. minima as indexes， optimize the extraction technology and carry out validation. (bvsalud.org)

But modest Promotoraktivit t In cellular Ren reporter assays based on typical erh Ht, probably because the CAR accumulates in the nucleus of immortalized cells, w While they Haupt Normally in the cytoplasm of primary Ren hepatocytes and liver. (c-kitinhibitors.com)

Cross-referencing of these motifs with pathways showing transcriptional changes revealed known regulatory pathways of distal alveolar differentiation, such as the WNT and transforming growth factor beta (TGFB) pathways, and putative novel regulators of adult AEC differentiation including hepatocyte nuclear factor 4 alpha (HNF4A), and the retinoid X receptor (RXR) signaling pathways. (huji.ac.il)

In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)

Citation: Chickarmane V, Enver T, Peterson C (2009) Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility. (lu.se)

The nuclear receptor CAR is responsible for transcriptional activation of CYP2C9, CYP2C8 and CYP2C19. (c-kitinhibitors.com)
GATA-1 and PU.1 then initiate the presumed cascade of It governs the erythroid - myeloid lineages and demonstrates both transcriptional changes that culminate in the specification of the commitment as well as priming features [6,7]. (lu.se)

We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)

Nuclear corepressor SMRT acts as a strong regulator of both ß-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. (bu.edu)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
MLE-12 cells were induced by LPS to construct an ARDS model in vitro. (karger.com)
We established a stable culture model for isolated primary human glioma cells. (aacrjournals.org)
C) HeLa cells were caught the Rabbit polyclonal to Aquaporin2 G1/S transition with Mimosine (T1), released and harvested every 3 hrs for 6 hrs (T2 and T3). (irjs.info)
The cells were then caught in M phase with Nocodazole, released and harvested every 2 hrs for 6 hrs (T4CT6) for immonoblotting. (irjs.info)
Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Here, we employed a mouse model of diet-induced obesity to characterize molecular features of the interplay between host epigenome, gut microbiota, and diet. (biomedcentral.com)

Our incorporation of epigenetic data allowed specific identification of transcription factors that are potential direct upstream regulators of the differentiation process, demonstrating the power of this approach. (huji.ac.il)
Integration of epigenomic data with transcriptomic profiling has broad application for the identification of regulatory pathways in other models of differentiation. (huji.ac.il)
Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)

The hepatocyte nuclear factor-1-beta and display the evidence of abnormal platelet of available. (lorenzopetrantoni.com)

In a model of chronic inflammation-induced liver cancer, the PIs were able to show that the specific knock-out of ATF6 in hepatocytes abrogates liver cancer formation. (uni-freiburg.de)

Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury. (ifado.de)

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. (bu.edu)
We performed the first characterization of a Bckdhb-/- mouse model, which recapitulates the severe human phenotype of MSUD with early-neonatal symptoms leading to death during the first week of life with massive accumulation of MSUD biomarkers. (stanford.edu)
Solated prim Ren human hepatocytes, which are listed in Table 1. (c-kitinhibitors.com)
The vitamin D receptor has been reported to produce a modest 2 times the induction of CYP2C9 in prime Ren human hepatocytes by 1,25 dihydroxyvitamin D3. (c-kitinhibitors.com)

Taking N-acetyl cysteine by mouth for at least 6 months seems to decrease flare-ups by about 40% in people with moderate to severe COPD. (medlineplus.gov)

Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. (bu.edu)
We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. (bu.edu)
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily - Update 2023. (bu.edu)
An element of type nuclear receptor response of two half pages related AGGTCA hexamer of 3 6 bases are separated. (c-kitinhibitors.com)

HBV replication is significantly reduced by IL-6. (sinica.edu.tw)

Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)

Curcumin treatment inhibited the lipoapoptosis, ROS production and ATP depletion elicited by HFFA in primary hepatocytes. (spandidos-publications.com)

Mouse models are needed to understand selenoprotein-dependent processes underlying the patients' pleiotropic phenotypes. (nih.gov)
We report the first Secisbp2 mutant mouse models. (nih.gov)
Transgenic mouse models pro- fection. (who.int)

and (6) the value of genetic counselors. (bvsalud.org)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
Genetic factors can be inherited or result from conditions in utero (called genetic imprinting). (msdmanuals.com)

In this study, we focused on the role of nuclear factor-κB (NF-κB) signaling in the HAI-1 loss-induced tumor susceptibility. (oncotarget.com)

Taking N-acetyl cysteine by mouth seems to reduce homocysteine levels, a possible risk factor for heart disease. (medlineplus.gov)

These findings suggest that the gut microbiome, under specific dietary exposures, stimulates a reprogramming of the enhancer landscape in the colon, with downstream effects on transcription factors. (biomedcentral.com)

Anatomy20

Organisms8

Diseases5

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Health Care1

Glucose-6-phosphata2

20222

MRNA6

Vivo9

Mice10

Inhibitor2

20214

Interleukin3

Protein8

Chromatin3

Hepatology2

Serum3

Inhibition3

Gene5

Translocation1

Promoter1

Mitochondrial3

Expression7

Oxidative2

Fibroblast growth1

Bacteria2

Excretion1

Proteins2

Apoptosis2

Humans1

Receptors2

METHODS1

Assays1

Growth factor1

Hypertension1

Induce1

Hepatic1

Citation1

Transcriptional2

Genes2

Cells8

Molecular1

Identification3

Platelet1

Liver cancer1

Phosphorylation1

Human4

Severe1

Receptor4

Significantly1

Cytokines1

Primary1

Mouse3

Genetic3

Tumor1

Levels1

Dietary1