Model for cellular differentiation cellular differentiation. Medical search. Frequent questions

Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
13-16 Such signalling cascades are deemed essential for a multitude of cellular processes, including differentiation and proliferation. (genengnews.com)
Since the discovery of autophagy-related ( Atg ) genes in the 1990s, there has been a proliferation of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models. (nature.com)
These models have revealed that ERG expression alone in certain contexts can promote proliferation and inhibit cellular differentiation. (sloankettering.edu)
Development of oral cancer is associated with excessive cell proliferation, deregulation in cellular differentiation, insufficient apoptosis and genomic instability. (ijpsonline.com)
It is involved in numerous cellular processes: cell proliferation and differentiation, copper homeostasis and cell signaling, among others. (ibecbarcelona.eu)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
This occurs naturally through a process known as mechanotransduction, which is the conversion of mechanical factors into biochemical changes, and can influence cellular functions such as proliferation, differentiation, migration, and apoptosis. (washington.edu)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)
Among these, the neoplastic tumor-suppressor genes (nTSGs) have been shown to fulfill two significant functions requisite for organ size control: first, establishing apicobasal cell polarity as a principle of epithelial tissue organization and appropriate timing of terminal differentiation and, second, exerting cell-proliferation control as a primary factor in tissue growth. (fsu.edu)
In summary, the three major areas of research in my lab are independent yet connected-proper differentiation of follicle cells is key to the establishment of oocyte polarity, and cell competition involves intercellular communication and regulation of cell proliferation. (fsu.edu)
Through the study of temporal and spatial regulation of important genes and pathways in our model systems, we will develop a more comprehensive picture of the molecular mechanisms orchestrating egg development and gain a deeper understanding of how basic cellular functions such as proliferation, differentiation, and growth are regulated in development. (fsu.edu)
A sub line of our research deals with how proliferation dynamics, at defined cellular stages, associate with these processes. (lu.se)

In this model, the senescence-sensitive promoter from the cyclin-dependent kinase inhibitor 2A ( Cdkn2a ) gene, also known as p16 INK4a , drives expression of 3MR, a fusion protein that is composed of luciferase and red fluorescent protein (RFP) reporters and herpes simplex virus-1 thymidine kinase, which converts ganciclovir (GCV) into an apoptosis inducer. (jax.org)

Here, we utilized microarrayed patterns to provide a controlled biochemical and biomechanical microenvironment for mouse liver progenitor cell differentiation. (elifesciences.org)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
During progenitor cell differentiation and ageing, PcG silencer EZH2 attenuates, causing loss of PRC binding and transcriptional activation of INK4b and INK4a . (biomedcentral.com)

In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. (wikipedia.org)
This noroviruses has been limited by our inability to propagate level of cellular differentiation was achieved by growing the these viruses in vitro ( 12 ). (cdc.gov)

Thus, Julia Chifman's research aims to understand the cause of iron dysregulation in breast cancer through the study of certain cellular signaling pathways that affect iron homeostasis. (american.edu)
Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
namely, defects in the oncogenic pathway are noted to induce modifications in cellular iron homeostasis. (american.edu)
Blumental-Perry's research is focused on the adaptive and non-adaptive age-dependent reprogramming of cellular homeostasis in the lungs of smokers. (buffalo.edu)
Cellular senescence, that is the loss of proliferative capacity, has a complex role in homeostasis. (jax.org)

A specialized type of differentiation, known as terminal differentiation, is of importance in some tissues, including vertebrate nervous system, striated muscle, epidermis and gut. (wikipedia.org)
During terminal differentiation, a precursor cell formerly capable of cell division permanently leaves the cell cycle, dismantles the cell cycle machinery and often expresses a range of genes characteristic of the cell's final function (e.g. myosin and actin for a muscle cell). (wikipedia.org)
Differentiation may continue to occur after terminal differentiation if the capacity and functions of the cell undergo further changes. (wikipedia.org)

Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
On the basis of sequence diversity of the lack of suitable tissue culture or animal models, the true capsid gene, noroviruses can be classified into 8 genetic nature of norovirus pathogenesis remains unknown. (cdc.gov)

Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
In vivo, stable ERα expression has been reported in patient-derived xenograft (PDX) models, especially in tumor cells introduced via intraductal transplantations 8 , 9 and these findings have suggested a strong microenvironment-dependent dynamic component in the regulation of ERα expression. (nature.com)
Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. (stanford.edu)
I joined Roswell Park Cancer Institute as an assistant professor in 2008 and since established an independent laboratory that explores T cell biology using tumor and transplantation models. (umaryland.edu)

The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
These oncogenic transcription factors regulate a transcriptional program that determines cellular lineage, specifies the responses to external stimuli, and contributes to the oncogenic cellular context in prostate cancer. (sloankettering.edu)
The stimulus-sensor interactions typically regulate cellular functions to adapt to an abnormal environment, for example the diabetic condition. (lu.se)

To avoid iron toxicity, yet to deliver adequate amounts of iron for biological processes, life on Earth has evolved to have sophisticated machinery that regulates iron at both the systemic and the cellular levels. (american.edu)
Investigating the molecular and cellular processes underlying the Retinal Ganglion Cells' differentiation in the vertebrate neural retina, using Danio rerio (Zebrafish) as model system. (uni-potsdam.de)
We have developed and applied FACS-based high-resolution cell fractionation procedures to map the differentiation processes from HSCs. (lu.se)

The aim of this research is to create an in-vitro model to mimic the 3D microenvironment of a neural circuit for locomotion to understand and find treatments for NMDs. (ibecbarcelona.eu)

Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
Next, we will focus on the molecular and cellular mechanisms underlying stem cell priming and differentiation as well as interactions between stem cells and host cells. (utmb.edu)
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. (uni-ulm.de)

We investigated the impact of downstream signaling, showing that peripheral biliary differentiation is dependent not only on Notch and TGFβ but also E-cadherin, myosin-mediated cell contractility, and ERK. (elifesciences.org)
Based on these findings, the Campisi team proposes that PDGF-AA derived from senescent cells stimulates local myofibroblast differentiation, allowing for greater contractility and more efficient wound closure. (jax.org)

Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. (wikipedia.org)

Taken together, our data suggest that Mahjong and Lgl belong to a molecular pathway that plays an evolutionarily conserved role in regulating cellular competitiveness. (fsu.edu)

Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
They often involve afferent and efferent pathways of the Peripheral Nervous System, and their effects might be reflected in the mechanosensory-motor circuit at different cellular levels (including sensory and motor neurons, glia and muscle dysfunctions), and in the connexion among them. (ibecbarcelona.eu)
In the absence of cellular transformation, these pathways operate. (biomedcentral.com)

On the other hand, senescence is hypothesized to underlie the cellular dysfunction that is associated with aging. (jax.org)
In their study, the Campisi team developed a transgenic mouse model to label and eliminate cells undergoing cellular senescence. (jax.org)

In this paper, we present and analyze a mathematical model for polarization of a single macrophage which, despite its simplicity, exhibits complex dynamics in terms of multistability. (biorxiv.org)
Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (wikidata.org)

Therefore, we propose a study model where primary spinal motor- or dorsal root ganglia sensory- neurons are cultured in 3D in different compartments together with optogenetically sensitive myocytes (a channelrhodopsin-2 positive cell line). (ibecbarcelona.eu)
At cellular level, the telencephalon is populated by a large diversity of neurons, including glutamatergic projection neurons, GABA (γ-aminobutyric acid)-ergic interneurons and projection neurons, as well as cholinergic interneurons and projection neurons. (intechopen.com)
In the central nervous system, lower motor neurons are selectively affected, whereas pathology of patients and animal models also indicates involvement of skeletal muscle including loss of fasttwitch type 2 fibres and increased slow-twitch type 1 fibres, together with a glycolytic-to-oxidative metabolic switch. (kennedysdisease.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)

Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. (wikipedia.org)
To address these questions in the endogenous tissue context we have built several genetically engineered mouse models that are designed to express the TMPRSS2-ERG fusion protein in a spatiotemporally controllable manner and in cooperation with other oncogenic drivers. (sloankettering.edu)
Cell cultures derived from nervous system tissue have proven to be powerful tools for elucidating cellular and molecular mechanisms of nervous system development and function, and have been used to understand the mechanism of action of neurotoxic chemicals. (nih.gov)
If we can understand how cells are guided by mechanics, then we can alter or direct cellular properties and responses in order to influence large changes in tissue and organs. (washington.edu)
The process of bone repair is an event finely regulated and characterized by different phases with predominance of specific cellular types, aiming at the formation of tissue in the affected area. (bvsalud.org)
The focus of my research is exploring neurodevelopmental disorders in human brain tissue models. (lu.se)
The expression-defined model achieved an overall accuracy of 94.05% (AUC = 0.96) in classifying invasive ductal carcinomas from histologically normal tissue and benign lesions (n = 185). (cdc.gov)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

A broader interest of our laboratory is to understand the molecular regulation of HSCs both from the perspectives of self-renewal and differentiation, and how these features become altered upon disease-causing or disease-associated perturbations. (lu.se)

Accordingly, pregnancy success rates currently achieved by natural or assisted conception for women at high-risk for EPL or RPL can only be increased by an improved understanding of the cellular and molecular mechanisms that control endometrial function during the periimplantation period. (frontiersin.org)
To this end, we have focused on investigating the cellular and molecular mechanisms governing T cell differentiation, activation and effector function after allo-HCT. (umaryland.edu)
Specifically, we are studying cancer patients and mouse models to delineate the roles and mechanisms by which the beta2-adrenergic signaling pathway, the CD27/CD70 pathway, and the perforin/granzyme pathway impact the GVH and GVT responses. (umaryland.edu)
Because the functional roles of miRNAs have not been previously elucidated in a model of chemical sensitization, these data contribute to the understanding of the potential immunologic mechanisms of chemical-induced allergic disease. (cdc.gov)

Our model can provide detailed information on altered biosynthetic paths, with potential for advancing treatments for glycosylation-related diseases and glyco-engineering of cells. (york.ac.uk)
However, metabolic composition does get altered quite dramatically where stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation. (wikipedia.org)
Representative models of differentiated human intes- transmission are ingestion of contaminated food and water tinal epithelium can be established by growing cells in 3 and person-to-person contact ( 5 ). (cdc.gov)
Molecular analysis of melanocytes and melanoma cells from mouse models: transcriptomics, bioinformatics, proteomics. (ubc.ca)
Her laboratory is using exposure to cigarette smoke and to nicotine as model systems for environmentally induced physiological stressors in exposed cells, animals and humans. (buffalo.edu)
A 3-component transgenic mouse model to track and manipulate senescent cells in vivo . (jax.org)
Senescent cells supply beneficial growth factors which promote myofibroblast differentiation. (jax.org)
We further showed that stem cell-derived motor nerve cells, when grafted, sent projections to reach muscle targets, and stem cell grafts improved motor function in rat models with acute and chronic spinal cord injury. (utmb.edu)
Using a brain injury model, we also found that stem cell grafts prevented injury-induced cognitive impairment (memory loss) by secreting trophic factors to protect injured nerve cells. (utmb.edu)
We found that INK4b and INK4a , but not ARF , are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells. (biomedcentral.com)
Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
The treatment with the pituitary adenylyl cyclase-activating polypeptide (PACAP), a neuropeptide with a proven protective effect in a mouse model of SBMA, recovered chloride channel current alterations in SBMA cells. (kennedysdisease.org)
The granulosa cells of the ovary secrete inhibin, which plays a role in cellular differentiation. (medscape.com)
Islet cells express various cellular molecular sensors, for example ion channels. (lu.se)
Our research focuses on characterizing the properties of the cellular molecular sensors in islet cells and controlling the sensors' activities through multidisciplinary and advanced technologies, such as molecular biology, genetics, and nanotechnology. (lu.se)
Our goal is to understand, at cellular and molecular levels, what controls HSCs and the fate of other immature blood cells. (lu.se)

We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)

Acetylation and deacetylation of histones, carried out by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively, affects cellular division, differentiation, death and survival. (lu.se)

More striking, the pancreas in these mice appeared relatively normal, with well-demarcated islets, suggesting that Pax4 misexpression was inducing an orderly and spatially correct program of cellular conversion that probably recapitulated the normal cellular differentiation process. (medscape.com)

This is an important development in the field of glycan modeling, which revealed biological insights about the glycosylation machinery in altered cellular states. (york.ac.uk)
In vitro differentiation of small intestinal epithelium that nausea, vomiting, and watery diarrhea within 12-24 hours approaches physiologic functionality of the in vivo host of exposure and typically remain symptomatic for 1-2 may allow for the development of a pathogenesis model days ( 5 ). (cdc.gov)
Despite the need for novel ERα pathway-targeting drugs, only a few ERα + preclinical models are available for the drug discovery, development and testing. (nature.com)
As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and pattern formation in the Drosophila wing disc. (bvsalud.org)
By studying murine transgenic leukemia models developed in our laboratory, we are currently exploring the relationships between hematopoietic progenitor cell identities and the development and progression of acute leukemia. (lu.se)

Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. (wikipedia.org)

Cellular iron levels and iron associated proteins are differentially expressed in many cancers, and recently, it was reported that high expression levels of iron importer and low levels of iron exporter were associated with a poor prognosis in breast cancer patients. (american.edu)
Going forward, we will utilize these mouse models to screen for other genetic lesions that cooperate with ERG expression and to define the cell of origin of ERG- positive prostate cancer. (sloankettering.edu)
Expression of the INK4b-ARF-INKa locus during cellular ageing and differentiation . (biomedcentral.com)
Increased expression of multiple miRNAs during toluene 2,4- diisocyanate (TDI) sensitization was observed, and several putative mRNA targets identified for these miRNAs were directly related to regulatory T-cell (Treg) differentiation and function, including Foxp3 and Runx3. (cdc.gov)

While this work is motivated by cellular differentiation, we derive a tractable model that provides flexible densities for any data (coupled with an appropriate noise model) that arise from continuous evolution along a latent nonparametric tree. (arxiv.org)
We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)

When iron metabolism ceases to function properly, the resulting iron excess or deficit can lead to serious faults in other cellular structures and regulatory systems. (american.edu)

After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)

We combined stochastic modeling with Bayesian fitting that enables rigorous comparison to experimental data despite starting with uncertain initial parameters. (york.ac.uk)
The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
In this context, it should be necessitate in broadening the understanding of the anticancer potential of linalool in experimental oral cancer model, which could be beneficial in anticancer therapy. (ijpsonline.com)
In the Cell Biomechanics Lab, we address these questions with new experimental techniques and modeling approaches in order to build up a knowledge base on cell mechanics. (washington.edu)
microRNA in experimental models of chemical sensitization. (cdc.gov)
This has allowed for direct assessments of the molecular properties that associate with distinct developmental stages of hematopoiesis, and represents a powerful experimental paradigm when for instance applied to the study of experimental transgenic models. (lu.se)

These radicals react with intra- and inter-cellular machinery, often generating undesired biochemical effects. (american.edu)

Molecular and Cellular Neuroscience. (lu.se)

The oncogenic transformation potential of ETS factors is exceptionally dependent on the cellular context. (sloankettering.edu)
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. (bvsalud.org)
MMPs are an important family of metal-dependent endopeptidases and represent the major class of enzymes responsible for the degradation or resorption of all components of the extra-cellular matrix (ECM) 38 . (bvsalud.org)

After losing interest in molecular biology she decided to apply her knowledge of genetics to cellular biology, more specifically pattern formation and regeneration in the hydra, a genus of freshwater polyps. (wepapers.com)

Traditionally, the differentiation process is seen as one involving a well-defined hierarchy of cell types . (copewithcytokines.org)
Traditionally, such evaluations have been made using transplantation-based models, but recent and ongoing studies, including from our laboratory, have shown that HSC function in this setting is fundamentally different from normal HSC function. (lu.se)

Depending on the candidate's preferences, there will also be opportunities to gain proficiency in working with mouse models of diabetes. (lu.se)
Having prior expertise in the following areas can be highly advantageous for this role: cell biology, diabetes research, beta-cell differentiation, proficiency in microscopy techniques, hands-on experience with mouse models, and a strong background in bioinformatic analysis, particularly in RNA sequencing and ChIP sequencing. (lu.se)

2-8 Hence the interest in generating more biologically relevant in vitro models, such as three-dimensional (3D) culture systems. (genengnews.com)
In vitro models may be useful for the rapid toxicological screening of large numbers of chemicals for their potential to produce toxicity. (nih.gov)
Recently, it has been suggested that in vitro models could be used to screen for chemical effects on critical cellular events of neurodevelopment, including differentiation and neurite growth. (nih.gov)

We found acetylation of histones and probably other proteins to be dramatically reduced in degenerating photoreceptors in the rd1 human homologous mouse model for RP. (lu.se)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)

1 At present, cell-based research is often performed on a variety of planar surfaces that have been modified to promote the growth of two-dimensional (2D) cellular monolayers. (genengnews.com)

The p16-3MR mouse model was created and backcrossed to C57BL/6J ( 000664 ) using a "speed congenic" approach. (jax.org)
I went on postdoctoral training in Dr. Timothy Ley's laboratory at Washington University where I developed mouse models to study cancer immunology. (umaryland.edu)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)

A major barrier to the understanding of the ERα-pathway biology and therapeutic discoveries is the restricted repertoire of luminal ERα + breast cancer models. (nature.com)

Understanding of the pathogenesis of human cate in a physiologically relevant 3-dimensional (3-D), organoid model of human small intestinal epithelium. (cdc.gov)
We present cultured in the RWV bioreactors, with the rotation speed the results of our first attempts to infect a physiologically adjusted to maintain the cell aggregates in suspension dur- relevant 3-D small intestinal epithelium model (INT-407) ing the entire culture duration (18-20 rotations/min ini- with genogroup I and II human noroviruses. (cdc.gov)
Human G protein-coupled receptor 54 (GPR54) receptor model. (medscape.com)
My current focus is to develop an in vitro human brain model of Gauchers disease, the most common form of lysosomal storage disorder. (lu.se)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)

In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)

Here, we develop and validate a computational model for glycan biosynthesis to probe how the biosynthetic machinery creates different glycan profiles. (york.ac.uk)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
Citation: Chickarmane V, Enver T, Peterson C (2009) Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility. (lu.se)

Recently has been demonstrated that most of these functions are based in misinterpretation of the mice models and need to be reevaluated. (ibecbarcelona.eu)

These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)

Some differentiation occurs in response to antigen exposure. (wikipedia.org)

Moreover, USP7 knockdown suppressed disease phenotypes in SBMA and spinocerebellar ataxia type 3 (SCA3) fly models, and monoallelic knockout of Usp7 ameliorated several motor deficiencies in transgenic SBMA mice. (kennedysdisease.org)

Anatomy54

Organisms10

Diseases7

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes70

Disciplines and Occupations2

Information Science4

Proliferation14

Apoptosis1

Progenitor cell differentiation3

Level of cellular differentiation2

Homeostasis5

Terminal differentiation3

Gene3

Tumor4

Regulate3

Processes3

Neural1

Interactions4

Contractility2

Multicellular1

Role in regulati1

Pathways3

Senescence2

Macrophage2

Neurons4

Tissue8

Regulation1

Mechanisms4

Cells16

Epithelial1

Survival1

Normal cellular1

Development5

Stem cell1

Expression4

Derive2

Metabolism1

Progression1

Experimental6

Biochemical1

Neuroscience1

Dependent3

Regeneration1

Traditionally2

Diabetes2

Vitro models3

Proteins1

Experimentally1

Growth1

Mouse2

Murine1

Cancer1

Human5

Phenotype1

Computational3

Functions1

Findings1

Exposure1

Transgenic1